NOV 20 1973

  

VETERANS ADMINISTRATION
HOSPITAL

3801 MIRANDA AVENUE
PALO ALTO, CALIFORNIA 94304

     
 

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November 28, 1973 REFER TO:

Dr. Joshua Lederberg

Department of Genetics

Stanford University School of Medicine
Palo Alto, California 94305

Dear Dr. Lederberg:

I should be very pleased if you were able to obtain through
the National Institutes of Health a GC/MS facility which could be
shared jointly by members of the Stanford University faculty.

At present, I am being funded under grant DA-00424-01 for a
study of the metabolism of marihuana. We have made significant
progress in our methods of extracting metabolites, in isolating
new ones by thin-layer chromatographic techniques, and by purify-
ing them to some degree as determined by GLC. The big bottleneck
has been the lack of ready access to a GC/MS set-up which would
permit further characterization of the metabolites.

Our needs would be primarily for GC/low resolution MS, for
which we have extensive need, perhaps the analysis of 15-25 samples
per month. Depending on the outcome of these analyses, we might
have 1 to 2 samples per month requiring GC/high resolution MS. We
anticipate having little need for high resolution MS without GC
because of the fact that our samples are isolated from complex
mixtures and are nearly impossible to purify.

If there is any way in which I could assist in helping obtain
such a facility for the University, please let me know.

Sinceyely yours,

Lr. & Nhe

Leo E. Hollister, M.D.
Associate Professor of Medicine

LEH: bh

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