OFFICE MEMORANDUM e STANFORD UNIVERSITY e@ OFFICE MEMORANDUM ¢@ STANFORD UNIVERSITY © OFFICE MEMORANDUM

To

FROM

SUBJECT:

Date: November 26, 1973

Joshua Lederberg, Department of Chemistry
Carl Djerassi, Department of Chemistry

Sumner M, Kalman

Mass Spectrometry, Your Memo of November 20, 1973.

A central facility for mass spectrometry and GC/MS would be
highly desirable from my point of view. We often need to identify
metabolites of drugs that interfere with our assays, and that represent
research problems as well. Frequently we need to check the purity of
a reference material which is in short supply. I have received much
help from both your laboratories in the past and would welcome the
opportunity to use an expanded facility. For many of our problems low
resolution MS is satisfactory and I hope you mean to provide this
service too.

With respect to your questions I anticipate that
(1) Yes.

(2) We would probably use GC/MS once a month or more. We
would use MS at about the same rate.

(3) Yes.

Sincerely yours,

Seth. Kellen, A.

Sumner M. Kalman, M.D.
Professor of Pharmacology
Director, Drug Assay Lab

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