Appendix Be Letters from Collaborators

LILLY RESEARCH LABORATORIES

OIVISION OF ELI LILLY ANO COMPANY « INDIANAPOLIS, INDIANA 46206 + TELEPHONE (317) 636-221

May 6, 1976

Dr. Ray Carhart
Department of Computer Sciences
Stanford University

Stanford, California 94305

Dear Ray:

We are pleased to have an opportunity to offer our support
and encouragement of your CONCEN effort,

We are using CONGEN to aid us in the SOlution of current
structure clucidation problems. When used at an early stage,
we find that the program is invaluable in Suggesting the
various compound types which are consistent with the extant
data. In one case, for example, CONGEN generated a list of
possible heteroaromatic ring systems. Such a list is par-
ticularly useful in the elucidation of the structures of
pharmaceutical molecules, in that it allows us to correlate
these possibilities with the physical and biological properties
of a vast number of known Pharmaceuticals.

In short, we have been quite pleased with our experience with
CONGEN. Owing to Possible security problems, we have not used
the program as much as we would like. If the program were
available in exportable form, I believe that usage would
increase dramatically. Probably the full potential of the
program will not be realized until this occurs. Even in its
present form, however, CONGEN is a valuable contribution to

chemistry.
Sincerely,

LILLY RESEARCH LABORATORIES

Douglas E. Dorman, Ph.D.
Physical Chemistry Research
Department MC525

LA