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FEB 1 171

Date! January 28, 1971

: Professor Joshua Lederberg

: Harry S. Mosher

Preprints on Chirality Notation

I have now looked over the material you sent me on your
chirality notation "Dendral III -- Draft". My reaction is that
this looks very good but that I am not the one who really is in
a position to evaluate this very critically. However, there are
two people who would be very interested in this, especially
Professor Jacques DuBois [Lab. de Chimie Organique Physique,

Faculte des Sciences, 1, rue Guy de la Brosse, 75 -- Paris -- 5€]
and Professor E. Ruch [Instittit fur Quantenchemie, Freie Univer-
sitdt Berlin, Holbeinstrasse 48, 1 -- Berlin 45 (D.B.R.)].

Professor DuBois has been concerned with almost exactly the
same sort of treatment and I am sure he would be interested in
receiving this material from you which he is not all that familiar
with. In addition, I know that he has done a lot of studies which
he has not published and you might be interested in his approaches.

Professor Ruch is interested in a much more deeply mathematical
and less computer sort of treatment and I am enclosing a reprint
which he sent me that you might be interested in looking at. He
has a long series of publications of this type, the mathematics of
which are beyond me, but the concepts of which are of considerable
interest to me; namely, with respect to asymmetric syntheses. I
am quite certain that Professor Ruch is the one person in the world
most competent in this field of mathematical treatment of molecular
geometry on a sophisticated level.

I think that you will find it interesting and perhaps useful
to correspond with these people.

   

Har /s. Mosher
sp
Enclosure
P.S. Another person who has recently published on this subject is

Ivar Ugi, who is at the University of Southern California. See
Angew. Chem., Internat. Edit., 9, 703-730 (1970).

O ah, Fo Tit Beta (4288-309 1490 — hate coves

14: 225-IBt 1970 — Tlarny Le Levick late fool Tevse

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