3900 WISCONSIN AVE., N.W. «© WASHINGTON, D.C. 20016 BioSclENCE ATES 202/244-5581 7 o - = SS 14 October 1970 Ge SEY Dr. Joshua Lederberg Dept. of Genetics Stanford University School of Medicine Palo Alto, California 94305 Dear Dr. Lederberg: With the recent monumental achievements in molecular biology, such as gene isolation and synthesis, many noted molecular biologists have alluded to the possibility of manipulating genetic material in mammalian cells, per- haps in man. Although usually discussed in muted tones, this subject is receiving increasing exposure and examination. Most of the discussion has been carefully couched in the more comfortable generalities surround- ing the often talked about "social responsibility of scientists;" but a few, Beckwith, Shapiro, Luria, and Nirenberg for example, have raised om- inous warnings of an Orwellian world if future genetic achievements are used as weapons by the Government. As one who has presented the “positive” side of the picture, would you comment on your view of potential genetic engineering and how it may best be applied? What sort of safeguards could be developed to prevent — any harmful uses of this knowledge? I realize that scientists are re- luctant to delve into the realm of the subjunctive and they are prone to avoid such futuristic thinking, but your views would be greatly ap- preciated. Would it be possible to send me a copy of your testimony presented be- fore the House of Representatives on behalf of the proposed Task Force on human genetic diseases? At the present time, I am collecting information for a possible feature on this subject. Sincerely AD albert Hite Walter G. Peter III Features & News Editor BioScience WGP :acm