April 14, 1970 Dr. Fred L. Soper 4104 Rosemary Street Chevy Chase, Maryland 20015 Dear Dr. Soper: I very such appreciate your critical and constructive cowments. Some of the faults of the pieces I had written I might shrug aside as inevitable in such an abbreviated article, but it is certainly true that there were several matters on which I had an insufficiently sharp focus, and I waa quite delighted to be brought short on then. A newspaper column does not allow much latitude for corrections of detail, but I will shortly be preparing a set of my columns for publication in book form. Would you be agreeable to my incorporating part of your letter as a corrective comment? Might I urge you to write you the "fextbook" on yellow fever for which you would be so uniquely qualified? I find that we are in a very small minority to share an urgent concern about the recrudescence of major epidemics, and I think it is most vital to reawaken the interest of a broader community on these matters. The relative silence of the public health officitaldom has generated a very per- vasive but, I think we must beth agree, a totally unwarranted sense of compla- cency. I am sure there must be many pecple whe would welcome, as much as I, an authori- tative exposition at a semi-technical level, like that of your letter. Has Aedes aegypti in fact been litereAlgyeradicated in Mexico or in Brazil? I would be grateful if you could point me to the appropriate literature to substantiate eradication to a level of rigor such that one would insist that any specimin was necessarily a reintroduction. I offer this comment in all innocence ~ some of my ecological friends have insisted to me that no inver- tebrate pest had ever been intentionally eradicated over a significantly large area. Do you see any prospect of getting sufficient cooperation from the other hold-outs in and around the Caribbean to warrant a final conclusive effort on our own tertitory? Yours sincerely, Joshua Lederberg Professor of Genetics Dr. Fred L. Soper April 14, 1970 Page 2 P.S. I webld be very pleased were you to recast your letter to me in the form of a letter to the editor of the Washington Post, which should have a high probability of being accepted for publication in what is, as you know, an influ- ential community. I would even be glad to be the stalking horse for a public expression of the same criticism you were courteous enough to send me privately; others might be confused into believing that this was a polemic, however, and I think you could mhhe the same points even more effective by describing them as an amplification of the remarks in my own column. Space is an eternal problem, and a piece not longer than my own column would stand the most chance of being taken up for publication. Joshua Lederberg