STANFORD UNIVERSITY MEDICAL CENTER
STANFORD, CALIFORNIA 94305 « (415) 321-1200

 

STANFORD UNIVERSITY SCHOOL OF MEDICINE
Departinent of Genetics
Professor Joshua Lederberg

Jear Dr. MHiller-~

Do you know of any studies on the possibility that

smoking may be the Ieukemoyen? (for congenital Leukemia).

Pinning a 15.4% reduction on cautions on obstr., X-rays
seems to imply 1) a drastic reduction in exposure (can it
be more than lr per capita?), and 2) a sensitivity
>> 197? per r, which is not particularly borne out by
the Hiroshima data.

Your earlier papers seemed more skeptical about this
particulwr etiology; anything new to change your mind?

I think you pointed out yourself that the X-ray
“users! would be an atypical sample; it would be interes-
tine and important to derive specific correlations be-
tween X-ray exposure and use of various/ drugs, smoking,
ete. The NINDS perinatal morbadity study should he very
good for that, even if not large enourh to be too fruit-
ful vis-a-vis leukemic outcome.

Sinverely,