2/20/50
Dear Josh,
Am still thinking about in the theoretical[?] welter surrounding proteins.  It's death curve (X-Ray) like that of coli is single list as you know.The part of the chromatic bodies in the cells of these bacteria would (as you suggested in your review) lead us to expect a two bit curve.  Question: Are the two bodies in the bacterial cells the parts of just one functional "nucleus", or is killing in these cases largely due to the production of dominant lethals - perish the thought?  Arrh! : let's run a killing curve on your everspliting heterozygote. Would it be suitable for this kind of work i.e. are the cells quite discrete and easily handled so long as you keep them on a minimal medium?
The curves I know have of diploid and haploid yeast (two and one bit resp.) and macromedia[?] w/ Neurospora (ca. 6 lit[?]) make me quite confident that death in these organisms is due to recurring lethal mutation (or the equipment) and that the Proteus and B/2 phenomena are of
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another sort.  If bacterial death with radiation is like that of these other we have every reason to expect a multiple bit relatimate[?]. Are you or anyone in your lab planning to do this?  If not  I would be very pleased to undertake it.  I would fill out the contours of my problem and should be of considerable interest to you as well.  Lemme know, eh?
But regards to yourself and Esther Ed and Spork send theirs.
Sincerely yours
Carl