OFFICE MEMORANDUM © STANFORD UNIVERSITY © OFFICE MEMORANDUM e STANFORD UNIVERSITY © OFFICE MEMORANDUM

To

From

SUBJECT:

SFP 2 7 1977

Date: September 23, 1977

Joshua Lederberg

Larry Kedes b

DNA sequence program in SUMEX 4) oot

Harold Brown is approaching the end of the first stage of developing
for us a DNA sequence storage and search program. Though we can already
see the need for modification and expansion of the program it may be useful
now to consolidate the program and our storage files into our own directory
so that we can gain more experience with it. The program itself is currently
in Brown's files as <BROWN>DNA3S. If you agree, this will require expanded
file space over our current page allocation in the GENET directory.

Also, we should now consider the long term usefulness of this program
to ourselves and others and whether a more permanent affiliation with
SUMEX-AIM is appropriate. One additional consideration is the possibility
of creating a DNA/RNA sequence storage file <DNABANK>., <DNABANK> could,
as a minimum serve as a repository for nucleotide sequences and as a medium
for insertion of such sequences into search, structure and evolutionary tree
programs. I am interested in the possibility of undertaking such a project
including seeking support for it. I am not sure how such a proposal would
overlap with MOLGEN itself. I would appreciate your comments and especially
your advice on these matters.

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