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September 5, 1967

ISTITUTO DI GENETICA
UNIVERSITA DI PAVIA

Tel. 23.029; 29.038 - Indirizzo telegrafico: Istgenetica -— Pavia

VIA SANT’ EPIFANIO, 14

27100 pavia

Dr. J. Lederberg
Department of Genetics
Stanford Medical School
Stanford University

Palo Alto, California

Dear Josh:

I have gone trough all the data on TLD that I had
or that Sergio has sent me. It is not very easy, at
least for me, to understand some experiments without
discussing the pros and the cons. However, I am enclos-
ing an outline of the experiments that could be discussed
in a paper on the effect of try analogs on TLD. The only
experiment that is still necessary (but I am sure that
Sergio has done it or is considering to do) is one showing
@ normal polysomal profile in cells that are not under-
going TLD for the presence of 50HT: or 5MET.

If you agree on such an outline, I could write up
a draft of the paper in a couple of weeks.

You are probably aware of a paper on the uptake of
poly-U by "soniplasts" of E. coli and a "specific"
stimulation of phenylalanine incorporation (J. Bact. 94,
232). The evidence seems to me rather unconvincing but
emphasizes the need to round up our data. I think that
Sergio has in mind to check the uptake of poly-U by
EDTA-treated cells. This is something that I wanted
to do but never did,
26

We have got a majority in the "commissione" for
the competition so that I have good hopes to be "ternato"
sometimes in November or December. Whatever will be
the outcome, I am quite ready to start making plans for
a second stay in Palo Alto. What about a period of 4-6
months beginning next summer? Or do you think that I
should wait for the approval of the Pavia-Stanford
project?

We have a vague recollection that you hinted a
possible visit to Europe this fall. Is it true?

Qnio

Best regards.

(Myas(D