April 1, 1959 Dr. Charles Brinton Department of Biophysics University of Pittsburgh Pittsburgh 13, Pennsylvania Dear Dr. Brinton: I'm sorry that it has taken us so long to come to a definite conclusion concerning the possible availability of some space for your work here. In the light of your letter of the twenty-first and of some uncertainties that still pre- vail here, I think perhaps it might be to your best advantage to accept the position in the Microbiology Department. I hope we will have an opportunity to discuss the possibility of collaboration at a later date, when our space and staff situation has resolved itself. Apart from specific questions of the genetics of Pili, I anticipate that there would be many opportunities for the development of biophysical techniques in work in microbial genetics. I will look forward to hearing from you from time to time concerning the progress of your own plans. a With best regards, Yours sincerely, Joshua Lederberg Professor of Genetics Ei i