MAR 2 4 :976 S018 DEPARTMENT OF HEALTH, EDUCATION, AND WELFARE PUBLIC HEALTH SERVICE NATIONAL INSTITUTES OF HEALTH BETHESDA, MARYLAND 20014 March 14, 1975 NATIONAL HEART AND LUNG INSTITUTE Dr. Joshua Lederberg Professor of Genetics Stanford University Medical Center Stanford, California 94305 Dear Dr. Lederberg: Your request for information on membrane oxygenators was referred to me from the Public Inquiries and Reports Branch of the National Insti- tutes of Health. The Division of Lung Diseases of the National Heart and Lung Institute is currently supporting a collaborative clinical program to determine the indications for the use of the membrane oxy- genator and its efficacy for the support of patients with acute res- piratory failure. I have enclosed a copy of our clinical protocol and a list of partici- pating centers. I have also enclosed several reprints of articles which should provide you with background information including the latest summary of world experience (Dr. Gille) and the largest experience in the United States (Dr. Hill) as well as information on some of the technical advances and problems associated with long-term membrane oxygenation. Several phone attempts to determine your specific informational needs were unsuccessful. I hope that this material suits your requirements. Please do not hesitate to call or write for other information Sincerely yo 3 Ff kur E. es Britt, M.D. ECMO Froject Officer Division of Lung Diseases Enclosures