B D Davis 11/11/89 Transcription bias [mark to note, makes perfect sense.] (I just saw PNAS July). It's just a pity we don't have any really crisp and persuasive and well controlled experiments. It's awful to have to analyze week-old agar plates; and God knows what selective and metabolic circumstances. Hot off the press -- Mellon and Hanawalt have pretty well corroborated the concept. Differential DNAse-I sensitivity would be a similar parameter (look at Stalder, Cell 20: 451 (1980); Weintraub Cell 42: 705 (1985) -- but I don't have in front of me.) Joshua. encl: P27x orig [symbol] 11/13/89