New Developments in Biotechnology, 3 GENETICALLY ENGINEERED ORGANISMS IN THE ENVIRONMENT 29 May, 1987 Biological Applications Program Office of Technology Assessment Congress of the United States OTA DRAFT: DO NOT CITE, QUOTE, OR REPRODUCE New Developments In Biotechnology Advisory Panel Bernadine P. Healy, Panel Chair The Cleveland Clinic Foundation Cleveland, OH *imothy B. Atkeson teptoe & Johnson Nashington, DC avid Blumenthal . igham and Women's Hospital Corporation soston, MA on. Edmund G. Brown, Jr. eavis & McGrath “os Angeles, CA ancy L. Buc eil, Gotshal & Manges ashington, DC Mark F. Cantley Foncertation Unit for Biotechnology in Europe Brussels, Belgium plexander M. Capron pniversity of Southern California os Angeles, CA perry ry D. Caulder Mycogen Corporation San Diego, CA Lawrence I, Gilbert The University of North Carolina Chapel Hill, NC Conrad A. Istock The University of Arizona Tueson, AZ Edward L. Korwek eller and Heckman ashington, DC Tsune Kosuge University of California, Davis Davis, CA Richard Krasnow Arlington, VA of Technology Assessment. Sheldon Krimsky Tufts University Medford, MA Joshua Lederberg The Roekefeller University New York, NY William E. Marshall Pioneer Hi-Bred International, Inc. Johnston, [A Ronald L. Meeusen Rohm and Haas Company Spring House, PA Robert B. Nicholas Blum, Nash & Railsback Washington, DC Eric J. Stanbridge University of California, Irvine Irvine, CA James M. Tiedje Michigan State University East Lansing, MI Kunio Toriyama ZEN-NOH Tokyo, Japan Pablo D.T. Valenzuela Chiron Corporation Emeryville, CA Thomas E. Wagner Ohio University Athens, OH Luther 8S. Williams Atlanta University Atlanta, GA OTA is grateful for the valuable assistance and thoughtful critiques provided by the Advisory Panel members. The views expressed in this OTA report, however, are the sole responsibility of the Office New Developments in Biotechnology OTA/National Science Foundation Workshop Environmental Applications of Recombinant DNA Organisms: Genetic Issues November 21-22, 1985 David T. Kingsbury, Worksiiop Chair National Seience Foundation Washington, DC Deb K. Chatterjee Environmental Protection Agency Gulf Breeze, FL Ron Chiarello IGB Products, Ltd. San Leandro, CA Michael T. Clegg University of California, Riverside Riverside, CA William KR. Engels University of Wisconsin Madison, WI Garrett Hardin University of California, Santa Barbara Santa Barbara, CA Bruce Levin University of Massachusetts Amherst, MA Lois K. Miller University of Georgia Athens, GA Stephen J. O'Brien National Cancer Institute Frederick, MD Mark Obukowicz Monsanto Company St. Louis, MO Philip Regal University of Minnesota Minneapolis, MN James A. Shapiro University of Chicago Chieago, IL James Tiedje Michigan State University East Lansing, MI Richard G. Wiegart University of Georgia Athens, GA OTA is grateful for the valuable assistance and thoughtful critiques provided by the Workshop participants. The views expressed in this OTA report, however, are the sole responsibility of the Office of Technology Assessment. OTA DRAFT: DO NOT CITE, QUOTE, OR REPRODUCE Genetically Engineered Organisms In The Environment OTA Project Staff Roger C. Herdman, Assistant Director, OTA Health and Life Sciences Division Gretchen S. Kolsrud, Biological Applications Program Manager Gary B. Ellis, Project Director Luther Val Giddings, Study Director Robyn Y. Nishimi, Analyst Kevin W. O'Connor, Analyst Support Staff Sharon Kay Oatman, Administrative Assistant Linda S. Rayford, Secretary/Word Processing Specialist Barbara V. Ketchum, Clerical Assistant Editor Stephanie L. Forbes ; Contractors David A. Andow, University of Minnesota, St. Paul, MN John M. Boyle, Louis Harris and Associates, Inc., Washington, DC William A. Check, Medical & Scientific Communications, Atlanta, GA Ellen W. Chu, Kirkland, WA David C. Coleman, University of Georgia, Athens, GA C. N. Dahm, University of New Mexico, Albuquerque, NM Andrew P. Dobson, University of Rochester, NY Patrick W. Flanagan, National Science Foundation, Washington, D.C. James R. Gosz, University of New Mexico, Albuquerque, NM Fred Gould, North Carolina State University, Raleigh, NC Susan S. Hirano, University of Wisconsin, Madison, WI Robert E. Hodson, University of Georgia, Athens, GA Conrad A. Istoek, University of Arizona, AZ Kathleen H. Keeler, University of Nebraska, Lincoln, NE D. Matthew Knain, Louis Harris and Associates, Inc., Washington, DC Richard E. Lenski, University of California, Irvine, CA Bruce R. Levin, University of Massachusetts, Amherst, MA Simon A. Levin, Cornell University, Ithaca, NY Adrianne Massey, North Carolina State University, Raleigh, NC Elliott A. Norse, Washington, DC Stuart L. Pimm, University of Tennessee, Knoxville, TN Frances E. Sharples, Oak Ridge National Laboratory, TN S.S. Snapp, University of Minnesota, St. Paul, MN P.S. Teng, University of Minnesota, St. Paul, MN Christen D. Upper, University of Wisconsin, Madison, WI Gabor Vali, University of Wyoming, Laramie, WY Acknowledgment to Other OTA Staff Robert Friedman, Senior Associate, Oceans and Environment Program OTA DRAFT: DO NOT CITE, QUOTE, OR REPRODUCE Lo Tee