1% University of Pittsburgh GRADUATE SCHOOL OF PUBLIC HEALTH Department of Epidemiology November 16, 1977 Dr. Joshua Lederberg Stanford University School of Medicine Department of Genetics Stanford, CA 94305 Dear Dr. Lederberg: At the hearings in Palo Alto about the Rasmussen Report Last week, you commented on the fact that patients with ankylosing spondylitis might have a predisposition to cancer, and their radiation risk may not be typical. T mentioned our studies which showed that the patients not given x-ray had no excess of cancer. In view of your interest I thought you might Like to have the enclosed reprints which address this particular issue. IT am the new chatunan of the National Academy of Sciences BEIR Committee, to neplace Dr. Arthur Upton, and I will transmit your concerns about the possible genetic effects of radiation exposure to the committee at our meeting next week. Sincerely YOuNs , 2 ) 9 fusurk A aid P. Radford, M.D. Progessor of Environmental EpidemtoLlogy EPR: fh Enclosure PITTSBURGH, PA. 15261 (412) 624-3054