DEPARTMENT OF THE ARMY
WALTER REED ARMY INSTITUTE OF RESEARCH
WALTER REED ARMY MEDICAL CENTER
WASHINGTON, D.C. 20012

REPLY TO
ATTENTION OF;

 

September 27, 1974

Dr. J. Lederberg

Dept. of Genetics

Stanford Univ. Sch. of Med.
Palo Alto, Calif. 94305

Dear Josh;

Thanks for the copy of Emilio Weiss' letter; we agree in all
respects with his comments. In regard to the point you raise,
all of our experience has been with extrachromosomal elements,
and if the situation in Proteus involved one copy per chromo-
some (like a lysogenic phage), we would no doubt miss it with
the experiments we did. Of course, we could have missed it
even if it was extrachromosomal since we have run across some
presumed plasmid-containing strains from which we are unable
to turn up a circle for some unknown reason.

In any case, I just meant to indicate that it wasn't likely to
be anything obvious from ‘yhat we could see. I dou st that we
will ve doing much sore with it.

With best regards,

Yours,

ae

L. S. BARON

Dept. Or Bacterial Immunology

'S'1'Nodd