DEPARTMENT OF THE ARMY
WALTER REED ARMY INSTITUTE OF RESEARCH
WALTER REED ARMY MEDICAL CENTER
WASHINGTON, D.C. 20012

 

IN REPLY REFER TO

July 19, 1971

Dr. J. Lederberg

Dept. of Genetics

Stanford Univ. Seh. of Med.
Palo Alto, Calif. 94305

Dear Josh:

Your eomments in Science on the report by M. W. Eklund et al.
prompted me to send you the enclosed reprint (Doorenbos, W.,
Ann. Inst. Past. 48:457-469, 1932). We recently came across
this paper while examining Bhaskaran's Vibrio eholerae mating
system.

It looks like Doorenbos in 1932 anticipated some of our pres-
ent experiments and implicated eholera phages in hemolysin
production, antigenic changes, and indol formation. He evid-

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ently found these supposedly phage influenced traits to he un- ~/

stable which strikes me as a bit suspicious. I suppose my
skeptical nature prevents me from concluding that his observ-
ations were correct (at least until I can eonfirm some of them

myself).

With best regards,
Yours,
BOrw
LS S. BARON

Dept “OY Baeterial Immunology

 

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