April 22, 1949

Dr. Joseph FE, Smadel

Army Medical Department

Research and Graduate School

Dept. Yirus and Rickettsial Diseases
Washington 12, D. C.

Dear Dr. Smadel:

Dr. A, F. Resemssen suggested that I write to you concerning
viristetic acridine deriv:.tives,

I have been interested in "disinfecting" lysogenle becteria
of the bacteriophage which is tenaciously associated with them. te
have had only very sporadic and unre»roducible results with ultra-
violet radiation, It was thought that we might huve more success
with the help of compounds which would impede virue growth more than
that of the host. For this purpose Dr. Rasmussen suggested the nitro-
acridine derivatives which he had worked with on the influenza viruses,
and referred me to you for possible supply.

If available for this purpose, I would greatly appreciute samples
of 100 me - 1g. of Nitroakridin 3582, 2enitro-5-aminoacridine, and
any other compounds that you think mirsht be worth testing, Any
additional suggestions would also be appreciated,

Sincerely yours,

doshua Lederberg,
Assistant Professor of Genstics

jw