FEDERAL SECURITY AGENCY PUBLIC HEALTH SERVICE WASHINGTON 25, D. C. IN REPLYING, ADDRESS THE PUBLIC HEALTH SERVICE REFER TO: Tuberculosis Research laboratory, 411 East 69th St., New York 21, N. Y. December 13, 1951. Dr. Joshua Lederberg, Department of Genetics, The University of Wisconsin, College of Agriculture, Madison 6, Wisconsin. Dear Dr. Lederberg: Many thanks for your letter of December 6th. We shall try to isolate a penicillin resistant mutant in one of the auxotroph lines that you mention. As soon as we have it, we shall send it to you. We would certainly like to take advantage of your offer to try to put it into a heterozygote and test for possible dominance. Sincerely yours, Henry J. Vogel Ca HJV/h1 P.S. — I don't want to accept your 2:1 wager because I also expect sensitivity to be dominant.