FEDERAL SECURITY AGENCY PUBLIC HEALTH SERVICE WASHINGTON 25, D. C. IN REPLYING, ADDRESS THE PUBLIC HEALTH SERVICE REFER TO: Tuberculosis Research Laboratory, 41] Kast 69th St., New York 21, N. Y. December 5, 1951. Dr. Joshua Lederberg, Department of Genetics, The University of Wisconsin, College of Agriculture, Madison 6, Wisconsin. Dear Dr. Lederberg: In connection with projected studies on the mechanism of anti~bacterial action of penicillin, I am very anxious to know whether sensitivity to penicillin is dominant in E. coli under conditions where a dominance phenomenon might be expected to manifest itself. If you have any results along these lines, no matter how fragmentary, I would consider it a great favor if you would enlighten me. Very sincerely yours, Henry J. 4 HJV/h1