STANFORD UNIVERSITY SCHOOL OF MEDICINE
STANFORD MEDICAL CENTER
300 PASTEUR DRIVE, PALO ALTO, CALIFORNIA

DEPARTMENT OF GENETICS
Professor Joshua Lederberg

Dear Gene-—

In completing the DENDRAL system, the question came
up (and rather incidentally) whether one needed proe
vision for cis-trans isomerism of:

(~co-N

iN (CBr),
(Cm ¢ S

h,m2s

I gather that trans-cyclooctaene is realizable, but
I wondered whether ring fusion across a trans - ene
warrmanted any consideration.

Lr. JosepH P. KENNEDY, Jr. LABORATORIES FOR MOLECULAR MEDICINE
dedicated to the study of mental retardation

Molecular Biology Heredity Neurobiology Developmental Medicine