UNIVERSITY OF ILLINOIS

DEPARTMENT OF BACTERIOLOGY

362 NOYES LABORATORY OF CHEMISTRY
URBANA

March 13, 1958

Dear Dr. Lederberg:

Thank you very much for your thoughtful suggestion to
March 18th, Just at the same time on Monday, I received a letter
from Japan, informing me of unexpected approval to extend my stay
for an additional few months, which was requested by Dr. Luria, if
possible, but I thought & to be almost impossible though I, after
hesitating, wrote a letter to Japan ,inquiring possibility. Since
I thought it would be impossible, I continued preparing everything
for going back to Japan and after having packed almost everything
for sending back, I got the letter. The unexpected became possible.
I felt very unbalanced, but at last decided to stay here until the
middle of June.

However, I have to let mywife and son go back ahead as
we have already planned, since she is very anxious to see our
daughter left in Japan, who hes been ill in bed in hospital since
last December. Unfortunately my wife can hardly speak English,
so I have to arrange everything forvher in advance before she
leaves here. Hence and, in addition, since I have now almost
exhausted sptitituaily and physically, I taink I had better arrange
to meet you sometime later. If you attend the General Meeting of
the S.A.B. in Chicago, it would be very nice to see you there.

Or if you have any better idea, I shall appreciate your letting
me know it.

Many apologies for a sudéen change and I hope vou will
understand the situations.

a

HH PAUL IV

I think you have already noticed my paper "Conversion

of somatic antigens...." in Virology vol.5, No.l. I shall
appreciate your opinions. I heave now some mutants of phage 215
and have been analysing the nature of their mitations. It is
still at the beginning stage, being too early to make up any definite
theory or genetic map, but the accumulating deta seem very interesting.
One of the mitants converts antigens from 3,10 to 3,(10),15, and the
second from 3,10 to 3,15 which are not identical with 3,15 of ¢15-
lysogenic cells. The third does not convert antigens to 3,15 by
lysogenization and lysogenizec cells remetn in 3,10 structure.
They also still adsorb phage eld, The fourth is very peculiar in
thet lysogenized cells lose even antigens 4,10 and gain antigen T,
which has ever,found only in group B Salmonella, while sensitive

(heen /tann

oe
UNIVERSITY OF ILLINOIS

DEPARTMENT OF BACTERIOLOGY

362 NOYES LABORATORY OF CHEMISTRY
URBANA

cells are infected with ths pnage, infected cells: form antigen 15
temporarily. I also have some evidence suggesting that the preprophece
or the inactivated phage is capable of operating its genetic functions.
When I meet you, I will tell you the details.
With best regards to Iino-san and Hirota-san,
Yours sincerely,

Hisao Uetake