February 21, 1958

Dr. U. Taubeneck

Institut fur Mikrobiologie und
Experimentelle Theraple

Beuthenbergstr. 11

Jena, Germany

Dear Dr. Taubeneck:

Thank you very mich for your message of January 6th. Your
technique is most ingenius and I would indeed appreciate the favor,
which you offered, of receiving one of the glass matrices.

I had in fact experimented briefly with the use of an electron
microscope grid for such a purpose but found it to be quite unsatis-
factory for obvious reasons. However it had not occurred to m to
use a replica of the sort you indicate and I think that procedures
should not be too difficult to develop which could furnish even
smaller areas well marked ani conceivably even numbered.

As a matter of fact, would it not be possible to obtain a
reticule by photographic reduction which would have well marked and
even previously numbered fields for your manipulation? There are,
I know, photographic techniques for the preparation of spectro
gratings which I think should be applicable for the production of
a suitable matrix.

It is easy to foresee a wide range of applicatitns for your
simple and ingenius technique.

Yours sincerely,

Joshua Lederberg
Professor of Medical Genetics

JLfew