Request for advice CRITICAL STUDIES ON THE PORTRAYAL OF SCIENCE IN FICTION For a number of convergent reasons, I am interested in getting into the literature on this theme. It is already obvious how various cultural trends are reflected (even perhaps in part created) by the fictional por- trayal of scientific and other heroes. In the late thirties, as I can re- call myself, Sinclair Lewis ARROWSMITH resonated with a kind of folk-hero: based on the enormous humanitarian accomplishments of Pasteur and Koch. Re- cently, when I mentioned the book to a class I teach on "Health as human ecology", only a minority of my students had heard of it. Nor could one expect to see such a work on today's best-seller lists, except perhaps for one that focussed on the moral dilemmas of proving a risky, therapeutic in- novation. One difficulty in finding the pertinent literature is the confusion with the encrmous body of writing in and about science fiction of the utopian or fantasy-oriented variety; nor indeed is there a sharp boundary. I would be most grateful for references to comprehensive literary-critical or sociological studies of the portrayal of scientists as characters in fiction having a quasi-contemporary (as against sf) orientation. Checklists of titles and themes would also be helpful to me in recalling my own readings of repre- sentative works of this kind. Mark Schorer depicts ARROWSMITH as the precedent for the genre (excepting a minor work of H.G.Wells -- The Marriage); and I would be interested also in comments on this point. Thank you, Joshua Lederberg Dept. Genetics Stanford University Medical School Stanford, Ca. 94305