aA : f " i
dapowntin + Sper
Dr. Joshua Lederberg . Feb 4th, 1991
Rockefeller University New York, N. ¥.

Dear Josh,

as you know I have been in Miami for a week for a COGENE
meeting and the Winter Symposium, but f nave not
contacted you for a variety of reasons: a few weeks ago
Arturo told me that you were going to India, but then the
day before I left (Jan. 25) I met him in Rome and he told
me that you were not going, only that in the meanwhile I
had made my trip schedule and bought my reduced rate
ticket for a direct flight Milano-Miami and return. In
Miami, Norton told me that you were indeed in the States,
not in N.Y. but busy and unapproschable in Washington. So
1 did not even try to contact you. Well, I am back in
Pavia and I have just found your letter of Jan. 18
alluding to a faces which I never received: it refers to
your intention to go to India from Jan. 28 to Feb. 9,
which I understand is no longer valid, but it mentions
also an apartment on campus. And this is relevant and
wonderful! So my plans are ag follows: I shall be in N.
Y. next August with Valeria (my younger daughter) and
Paola (my companion) as touriste. In September they will
return to Italy, and I would start my sabbatical with
you: your generous offer and the appeal of doing some .
writing and some science with you make up an irresistable
cocktail. So you can consider me in N.Y. since the |
“beginning of next September. In April I will come to
Georgetown University, Washington, D. C. for a Fidia
Research Foundation Symposium “Ethical Issues in
Research" (the topic I have been assigned ia fraud, false
and data misappropriation in science: have you any
suggestions on the subject in term of papers, books
ete?). On that ocoasion I am available to come and see
you in N. Y. immediately either before or after April 29-
30: please let me Know about your availability. I would
treasure that opportunity to discuss with you research
programs (cairnism? HAC ~i.6. human artificial
chromogomes-?...7) and any other detail. In May I will
not be able to see you in Pavia since I am in Crete for 4
EEC workshop on the Human Genome Project, for which G.
Bernardi from Paris and myself are proposing a fantastic
program: the cloning in YAC or in E. coli F-based
plasmids of the "GC rich isochores", namely those
sequences amounting to & few percent of the human genome,
produced by mild shearing and containing the great
majority of the genes: since this will be obtained via
the; homopolymeric tailing procedure (an abstract will
reach you soon) there should be no co-cloning nor any
bias due to sequence-based cutting. It's the
gubstantiation of cDNA cloning with genomic fragments! It
ig aimply a fantastic idea: your comments and suggestions
will make it even better. I am eager to hear from you,
after you receive more details,

Most sincerely yours,

Vittorio Sgaramella