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Dr. Carl C. Lindegren

Departaent of Bacteriology
University of Southern California
Los Angeles, California

Doar Lindegren:

We have hed rather good luck with the Neurosporas.
I alveys know they were fine bugs to work with but I never fully
avpreciated all their advantages. We've worked out the normal
nutrition requirements and find that they (three species) can
aynthesize all the vitamins they need except biotin. In other
words, they'll all grow on a medium containing salts, sugar and
biotin. We have one X-ray mutent that seems not to be able to
make one of the B vitamins but we haven't yet finished the
analysis of this. It would be good fun to run the mutants for
visible charncters through our nutrition mill and see if they
are like the normel in this respect. Would you be willing to
send us stocks of your mutant strains for this purpose? I don't
know just how we could reciprocate, but we're doing a good bit
of X-raying and if we should find useful mutants, we'll be glad
to send them to you for linkage analysis. We are looking perti-
cularly for mutants concerned with nutrition but should pick up
some others on the way. We're not planning to go in for linkage
analysis, although I regard it as very worthwhile and hope you
are planning to continue your work along this line.

I am sending this to both Missouri and U.S.C. since I'm
not sure whore you sre at the nonent,

With best regards to you and Mrs. Lindegren, I am

Sincerely yours,

G. W. Beadle