THE ROCKEFELLER UNIVERSITY 1230 YORK AVENUE NEW YORK. NY 10021 JOSHUA LEDERBERG July 15, 1983 PRESIDENT Dr. Alejandro Zaffaroni President and Director of Research ALZA Corporation 950 Page Mill Road Palo Alto, California 94304 Dear Alex: I am going to impose on you to take a quick look at some of the very practically oriented research that Ernst Friedheim has been doing in tropical medicine: specifically a one dose prophylactic/therapeutic answer to the threats of sleeping sickness and filariasis in Africa. Friedheim is one of the great pioneers -~ following almost directly on Paul Erhlich! -- in the practical development of these chemotherapeutic approaches. He has made many important advances in the past and this current proposal may be one of comparable importance. It has a great deal to do with the engineering of release rates of the drug. So l thought that your company's technical expertise, coupled with your own compassion for the victims of these parasites, could help bring about the most efficacious reduction to practice. I will be in Palo Alto during the month of August and hope that I may find you in town during at least part of that time | so that we might renew our old acquaintanceship and perhaps discuss this and other specific proposals. I trust you do understand that this preliminary work is offered for your personal consideration in confidence. Yours sincerely, Joshua Lederberg