Tel. 23.029; 29.038 - Indirizzo telegrafico: Istgenetica - Pavia

April 9, 1963

 

ISTITUTO DI GENETICA

VIA SANT'EPIFANIO, 14 Stanford University
PAVIA Medical Center

Department of Genetics
Palo Alto, Calif,

Dear Joshua,

this is to answer toyour letter of April
the end.

I really forgot to collect the available data
on tetracycline phosphate. I will do it just after Easter
and mail to you everything before the end of this month.

Our joint projects seem to proceed now sati-
sfactorily.

1) 3 F metilmethionine for trying to introduce CF, in position 6
of tetracyclines has been produced by Dr. Testa and we are now
starting the biological work,

2) F- Dap. Testa has practically done the complete synthesis
but he got some trouble to go from the F pimelic acid to the

F - Dap. We got only so far a couple of intermediate which were
supplied to us immediately after having being synthesized be-
cause of their instability and they proved to be slightly
effective (5-10 \/m1). All the bunch of intermediates will be

given to us together with the final product, I hope in a month
or go.

3) Fluoropoiesis. We had some difficulties for the physical set
up which haw been now overcome. The apparatus has now been wor-
king in reconstruction experiments (without F derivatives) for
26

about two weeks. Still the conditions of operation are not
the optimal ones, Little by little we are avoiding all the
troubles (explosions, loss of pressure, suddenty increase

of pression in critical moments ecc.). In spite of this dif-
ficulties, aminated product, an aminoacid and probably also
Some cyclic derivatives have been already produced. We plan
to do the first flucoropoiesis, the latest, before the end

of this month,

AS ever,

Yours

. Coe fee TU te tte

G.E, Magni