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OF SYNTEX (USA) INC.
3407-ALLVIEW AVENUE
O ALTO, CALIFORNIA 94304

INSTITUTE OF BIOLOGICAL SCIENCES

SYNTEX EARCH
Divisi

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January 4, 1980

Dy. Joshua Lederberg, President
The Rockefeller University

1230 York Avenue

New York, NY 10021

Dear Josh:

I enjoyed very much the opportunity to talk with you during our recent
visit to New York. Subsequently, I gave your secretary over the tele-
phone the names of the individuals you may wish to consider for the posi-
tion in Bethesda that you called to my attention.

As I indicated, I am enclosing the following information regarding the
MacArthur Foundation:

John D. and Katherine MacArthur Foundation
1000. Sunset Ridge Road
Northbrook, IL 60062

Dr. John Corbally, President

Subsequent to my conversation with you, I have learned that they are
accepting proposals and providing some information regarding the scope
of the programs that they wish to support. JIn*my opinion, in view of
the rather large sum of money that they should distribute in 1980, they
might consider an endowment fund in the name of Jolin and Katherine
MacArthur or your plans for a library. This is only a surmise on my
part.

Edna and I look forward to seeing Marguerite and you, if your schedules
permit, on our next visit to New York.

I might add that in talking with Mary Sherman and Sam Silverstein, I

have learned that their program on plasminogen activator and inhibitor

is proceedingwell. Dr. Sherman is ready with her portion of a potential
patent application that you may wish to consider as soon as Dr. Silver-
stein has prepared hits portion of the joint program. I mention this since,
as you are aware, Syntex has a very major interest tn antithrombotic

agents and at present we are testing a variety of compounds in both in

~ vitro and in vivo assays. Therefore, when the data from Sloan-Kettering

and Rockefeller have been filed and can be discussed, I might suggest
that the next step would be a visit out here by Dr. Sherman and Dr.

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January 4, 1980

Silverstein. I believe that this is a program that Syntex would support.

I mentioned briefly to you the question of whether faculty members at
Rockefeller could serve as consultants to Syntex. Perhaps I put it incor-
rectly when I indicated that this might be a method of our learning some-
thing about ongoing programs at Rockefeller. Rather, I know that the
intent is to pick selected programs in which there is an interest here

and to suggest that the senior investigator in charge of that specific
program become a consultant to Syntex. This obviously, at an approriate
time, should be discussed by you with John Fried.

Edna joins me in sending warmest regards and all best wishes to Marguerite
and you for a happy and healthy New Year.

Yours,

Ge

Abraham White
AW:ib