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Rockefeller \ THE ROCKEFELLER UNIVERSITY

O

A University is 1230 YORK AVENUE NEW YORK, NY 10021
> > June 3, 1981
Y S35 ° '

JOSHUA LEDERBERG

PRESIDENT

Mr. Rodman Rockefeller
Ibec, Inc. =

1230 Avenue of the Americas
New York, New York 10020

Re: Breakthrough in Fish Breeding

Dear Rodman:

"Clone" here has different implications than what we
discussed before. It is not the propagation of a (high
performing) existing individual. Rather it is the ability

a) to establish genetically homozygous ? ?

b) propagate these as such (i.e. the clone)

and also

c) hormonally alter? of one clone to serve as%Y”’ ,
thus to cross-breed 2 clones. The hybrid vigor of

these progeny should be a great practical advantage,
just as with corn.

At any rate there is a good chance of moving straight

on to salmon! Only very bad luck could stand in the way of
its working.

Would you like me to “introduce” you to Prof. Streisinger?
I have been acquainted with him over 30 years; but I did not

know till this article that he had switched to fish (from bac-
teriophage) for his research.

Yourg, sincerely,

   

Nature Vol. 291 28 May 1981 293
enlarge eee

Production of clones of homozygous diploid
zebra fish (Brachydanio rerio)

George Streisinger, Charline Walker, Nancy Dower, Donna Knauber & Fred Singer
Institute of Molecular Biology, University of Oregon, Eugene, Oregon 97403, USA

 

Homozygous diploid zebra fish have been produced ona large scale by the application of simple physical treatments. Clones
of homozygous fish have been produced from individual homozygotes. These clones and associated genetic methods will

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