THE ROCKEFELLER UNIVERSITY 1230 YORK AVENUE - NEW YORK, NEW YORK 10021 October 19, 1979 Dr. J. Poirier President Institut de Recherches SERVIER Science Union et Cie 14 rue du Val d'Or 92150- Suresnes . France Dear Dr. Poirier: Please accept my apologies for the delay in responding to your letter of August 6, 1979. During this period, the Rockefeller University administration has been considering ways in which to authorize my study of Cyclomunin without conflicting with existing policies. Administrative approval has now been granted. Unfortunately, in the interim, I have acyuired extensive responsibilities for committee work on National Institutes of Health study sections and site review visits, so that I feel that I could no longer complete the evaluation of this coapound within a reasonable period of time without neglecting my primary labora- tory duties. I must withdraw from our agreement, and will return the samples of Cyclomunin to Dr. Leibowitch. I very uch regret the inconvenience caused to you and to Dr. Leibowitch by the delay and by the change in plans. Thank you for your kind invitation to participate in the evaluation of this Most interesting compound. Sincerely, Carl F. Nathan, M.D. c.c.: Dr. Jacyues Leibowitch