DEPARTMENT OF HEALTH, EDUCATION, AND WELFARE
PUBLIC HEALTH SERVICE
HEALTH SERVICES AND MENTAL HEALTH ADMINISTRATION

 

November 13, 1978 NATIONAL INSTITUTE OF MENTAL HEALTH
DIVISION OF SPECIAL MENTAL HEALTH RESEARCH, IR

SAINT ELIZABETHS HOSPITAL - WAW BUILDING
Our Reference: SMRC WASHINGTON, D.C. 20032 ,

AREA CODE 202 TEL: B74~7572
Dr. Joshua Lederberg gocreteiten Gi
Office of the President
The Rockefeller University
1230 York Avenue
New York, New York 10021

    

Dear Dr. Lederberg:

In addition to whatever help I can be to you with your clinical research
planning, we might discuss the enclosed two papers when we meet on

December 1. The first paper describes in abstract form how two vulner-

ability factors might come together to produce a disorder such as schizo-
phrenia. In this case, low monoamine oxidase activity and being a

heterozygote for PKU impact on the formation and metabolism of phenyl-
ethylamine.

The second paper deals with the issue of partial brain grafts which may
ultimately be of use in treating neurologic disorders. It not only
raises many scientific issues but ethical ones as well.

Best wishes and,

Sincerely yours,

Richard J. Wyatt, M.D.
Chief, Laboratory of
Clinical Psychopharmacology

Enclosure