RNEFELLER Unive
THE ROCKEFELLER UNIVERSITY/** (WAY. 10 1978

1230 YORK AVENUE: NEW YORK, NEW YORK 10021 Or, <
Fice Ed
OF THE PR

 

E,FRIEDHEIM MAY 7, L979

Dr. JosHuA LEDERBERG
PRESIDENT

ROCKEFELLER UNIVERSITY
New York/N.Y,

DEAR Dr, LEDERBERG,
THANK YOU VERY MUCH FOR YOUR THOUGHTFUL
LETTER OF MAY 3 AND LITER&TURE ON THE BLOOD BRAIN BARRIER,

Cur1@us PARADOX: THE LITERATURE STRESSES LIPID SOLUBILITY
AND UNIONIZED NEUTRAL STRUCTURES AS PRIME CONDITIONS FOR
PASSAGE/ THE EXPERIENCE WITH AFRICAN SLEEPING SICKNESS
INDICATES THAT ONLY LIPID INSOLUBLE IONIZED ANIONIC —
STRUCTURES REABH THE TRYPANOSOMES IN THE C,.S.F., WHILE LIPID
SOLUBLE CATIONIC STRUCTURES DO NOT, IT IS NOT KNOWN WHICH
BOUNDERY THE TRYPANOCIDES PASS,

T AM LOOKING AT THESE QUESTIONS,

THANK YOU AGAIN,

 

E .FRIEDHEIM L

ee