et rn One ge enn meen coe STANFORD UNIVERSITY SCHOOL © STANFORD MEDICAL CENTER 300 PASTEUR DRIVE, PALO ALTO, CALIFORNIA MEDICINE DEPARTMENT OF GENETICS Professor Joshua Lederberg JUL 6 1970 Dear Hy-- Just after I wrate Dr. Scott, I saw the NYT clip, and it occurred to me that DMC might be very well set up now for the study of the effects of the Hb gene on intellectual performance, The clinic will have ascertained segregating families, and you will be able to contrast all o Senotypes (a/a a/s and s/s) in the same family. Actually, the important study would use col- laterals, where the parents are a/a and a/s respectively, and the comparison of these among the progeny would be untinged by the actual occur rence of s/s disease. But that variable also is interesting (the economic and social drain...) (However, on rigorous consideration, I have to remark that a/s x a/s matings may npt be exactly comparable to a/a x a/s.) Can you take this on? Yours, ports. eyo