STANFORD UNIVERSITY MEDICAL CENTER

DEPARTMENT OF GENETICS
December 6, 1978

 

Joshua Lederberg, President
The Rockefeller University
New York, N.Y. 10021

Dear Joshua,

The Perlow paper is quite interesting. I am sorry I do not seem
to find easily a report of my early attempts. They were all
carried out on newborn mice as recipients - (including some
strains with genetic cerebellar defects) by injecting cells .
from brains of other newborn mice of the same strain, whose
mothers had been treated with 3H thymidine when pregnant.

The emphasis was not on detecting change in function, but on
detecting the capacity of cells marked by 3H in the donor to
survive in the receiver. Although there were cells found with
radioactive tracers in the recipients killed several weeks or
even months after the graft, there was no case of bonafide
labelled neurons found.

Let us know when you are here.

Sincerely,
~“

Wa LAA :
L. L. Cavalli-Sforza
Professor of Genetics

LLCS :mc

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