A CASE OF REFLEX NEURALGIA, ASSOCIATED WITH URETHRAL CONTRACTIONS AND A RARE FORM OF URINARY SINUS. WITH A DESCRIPTION OF THE COLD-WATER C OIL BY FESSENDEN N. OTIS, M. D., CLINICAL PROFESSOR OF GENITO-URINARY DISEASES, COLLEGE OF PHYSICIANS AND SURGEONS, NEWYORK. [.REPRINTED FROM THE NEWYORK MEDICAL JOURNAL, FEB., 1875 ] (Illustrated.) D. APPLETON & COMPANY, NEWYORK: 54 9 & 55 1 BROADWAY. 1875. THE POPULAR SCIENCE MONTHLY, (Established May, 1873,) Conducted by Prof. E. L. TO UMAE'S. The Popular Science Monthly was started to promote the diffusion of valuable sci- entific knowledge, in a readable and attractive form, among all classes of the community, and has thus far met a want supplied by no other periodical in the United States. The great feature of the magazine is, that its contents are not what science was ten or more years since, but what it is to-day, fresh from the study, the laboratory, and the experiment: clothed in the language of the authors, inventors, and scientists themselves, which comprise the leading minds of England, France, Germany, and the United States. Among popular articles, covering the whole range of Natural Science, we have the latest thoughts and words of Herbert Spencer, and Professors Huxley, Tyndall, and R. A. Proctor. Since the start, it has proved a gratifying success to every friend of scientific progress and universal education; and those who believed that science could not be made any thing but dry study are disappointed. The press all over the land is warmly commending it. We subjoin a few encomiums from those recently given: “ That there is a place for The Popular Sciesce Monthly, no one can doubt who has watched the steady increase of interest in scientific investigation manifested in this country, not only by a select class, but by the entire community,'’—New York Times. “ This is a highly-auspicious beginning of a use- ful and much-needed enterprise in the way of pub- lication, for which the public owe a special debt of obligation to Messrs. D. Appleton & Co.”—Boston Gazette. “ This new enterprise appeals to all who are in- terested in the laudable effort of diffusing that in- formation which Is best calculated to expand the mind and improve the conditions and enhance the worth of life.”—Golden Age. “Just the publication needed at the present day.”—Montreal Gazette. “ This new magazine, in our estimation, has more merit than the whole brood which have preceded it.”— Oswego Press. “In our opinion, the right idea has been happily hit in the plan of this new monthly.”—Buffalo Courier. “ This is one of the very best periodicals of its kind published in the world. Its corps of contribu- tors comprise many of the ablest minds known to science and literature. It is doing a great and noble work in popularizing science, promoting the growth of reason, and leveling the battlements of old su- perstitions reared in the childhood of our race be- fore it was capable of reasoning.”—The American Medical Journal, St. Louis, Mo. “This magazine is worth its weight in gold, for its service in educating the people.”— The American Journal of Education, St. Louis, Mo. “This monthly enables us to utilize at least sev- eral years more of life than it would be possible were we obliged to wait its publication in book-form at the hands of some compiler.”—The Writing Teacher and Business Advertiser, New York. “A journal which promises to be of eminent value to the cause of popular education in this country.”—New York Tribune. “It is, beyond comparison, the best attempt at journalism of the kind ever made in this country.” —Home Journal. “ The initial number is admirably constituted.” —Evening Mail. “We think it is not too much to say that this is the best first number of any magazine ever pub- lished in America.”—New York World. “It is just what is wanted by the curious and progressive mind of this country, and ought to be widely circulated.”—New York Evening Post. “ It is the first successful attempt in this countiy to popularize science in the pages of a monthly.”— N. Y. School Journal. “Not the less entertaining because it is instruc- tive.”—Philadelphia Age. “The Monthly has more than fulfilled all the promises which the publishers made in the pro- spectus of publication.”—Niagara Falls Gazette. “It places before American readers what the ablest men of science throughout the world write about their meditations, speculations, and discov- eries."—Providence Journal. The Popular Science Monthly is published in a large octavo, handsomely printed on clear type, and, when the subjects admit, fully illustrated. Each number contains 128 pages. Terms: $5 per Annum, or Fifty Cents per Number. Postage free to all Subscribers in the United States, from January 1, 1875. A new volume of the Popular Science begins with the numbers for May and Novem- ber each year. Subscriptions may commence from any date. Back numbers supplied. Now Ready, Vols. 1., 11., 111., IV., and V., of The Popular Science Monthly, embracing the Numbers from 1 to 80 (May, 1873, to October, 1874). 6 vols., Bvo. Oloth, $3.50 per voh Half Morocco, $6.50 per vol. For Sale, Binding Cases for Vols. 1., 11,, 111., IV., and, V., of The Popular Science Monthly. These covers are prepared expressly for binding the volumes of The Populab Science Monthly as they appear, and will be sent to Subscribers on receipt of price. Any binder can attach the covers at a trifling expense. Price, 50 cents each. JD. APPLETON 8f CO., Publishers, 549 & 561 Broadway, New York. RARE FORM OF URINARY SINUS, ABSCESSES, Etc. (Reversed from original drawing.) A, Stump of cedeinatons prepuce. B, Urinary abscess. C\ Urethral fistulsc. A CASE OF REFLEX NEURALGIA ASSOCIATED WITH URETHRAL CONTRACTIONS AND A RARE FORM OF URINARY SINUS. WITH A DESCRIPTION OF THE COLD-WATER COIL. BY FESSENDEN N. OTIS, M. D., CLINICAL PROFESSOR OP GENITO-URINARY DISEASES, COLLEGE OF PHYSICIANS AND SURGEONS, NEW YORK. {REPRINTED FROM THE NEWYORK MEDICAL JOURNAL, FEB., 1875.] (Illustrated.) NEW TOEK: D. APPLETON & COMPANY, 549 & 551 BROADWAY. 1875. A CASE OF REFLEX NEURALGIA, ASSOCIATED WITH URETHRAL CONTRACTIONS, AND A RARE FORM OF URINARY SINUS; WITH SUBJOINED DESCRIPTION OF THE “COLD-WATER COIL.” X. Y., physician, aged fifty-seven years; has never had any form of venereal disease; no vicious habits from early childhood. Had a very redundant prepuce, which, from fre- quent attacks of balanitis, became more or less adherent to the glans penis. Up to the age of nineteen years could only un- cover one-half the glans. By systematic effort, however, dur- ing a period of six months, the adhesions between the glans and the internal reflexion of the prepuce were completely broken up. He had no further trouble up to the age of twenty- two years, when married. On first intercourse, the frenum (which was very long and attached at the inferior edge of the meatus) was ruptured, occasioning severe haemorrhage, and a considerable degree of soreness for several days. He remem- bered no further annoyance up to the year 1857, when, at the age of fifty years, he had what was then supposed to have been an attack of “ dumb ague ” (irregular chills and fever), which, in spite of the usual antiperiodic remedies, continued for a space of two months. To this a jaundice succeeded, and, at about the same time, the left side of the scrotum became swol- len, red, and heavy; not sore to the touch, except on firm pressure. Heavy aching pain felt in the tumor at times, without apparent cause. Xo treatment resorted to except 4 that of supporting the mass with an ordinary suspensory band- age. This condition of things remained, without any marked change, for five and a half years, when (in September, 1873, being in low condition from overwork) a small carbuncle made its appearance on his nose, and was soon followed by another, three inches in diameter, on the left side of the neck, which lasted, with much suffering and debilitation, for about three weeks. At this time a circumscribed cellulitis occurred at the most dependent portion of the swollen and indurated scro- tum. After a few days’ poulticing an opening occurred in the integument, which discharged pus, and was filled with shreds of disorganized tissue, similar in appearance to those which had characterized the debris of the antecedent carbuncles. For this reason the scrotal lesion was considered by the patient and his attending surgeon to be of a carbuncular nature; there was, however, but a single opening. Under simple treatment this supposed carbuncular abscess was discharged fully in about a week, and, by the close of the third day following, had filled and perfectly cicatrized. In about a week from this time, another circumscribed cellulitis appeared on the scrotum, about an inch above the first, passing through the same phases, and healing completely in about the same time. Another in- terval of a week, and a third abscess, precisely like the previous ones in accession and course, occupied the superior portion of the scrotum, after the complete healing of which, the entire scrotum was left quite free from inflammation, induration, or any abnormal appearance. During the yext week, another lesion apparently of the same nature occurred on the corre- sponding side of the penis, three-quarters of inch from the root, giving more pain than any of the previous abscesses. This, after opening, did not heal, but ran along under the in- tegument of the dorsum anteriorly for about an inch, when it there “ broke through and discharged carbuncular debris.” O o The two openings were united by a division of the intervening integument, which was thin and red. The burrowing of pus continued along the dorsum penis to the fossa glandis, when the prepuce became completely phimosed. An opening into the preputial cavity in the vicinity of the fossa glandis soon occurred, and pus was freely discharged from the preputial 5 orifice. In trying to wash out the prepuce with a syringe, it was found that the injected fluid traversed the entire length of the dorsum penis, and emerged at the first opening. A small collection of pus was found on the right side, which likewise opened into the preputial cavity. At this time the prepuce was very oedematous, and urination was difficult and painful; the pain extended beyond the penis, into the thighs, the calves of the legs, and even occupying the entire heels, not only when urination was attempted, but at night when the patient was endeavoring to sleep. Opiates were given, Mc- Munn’s elixir of opium or chlorodyne, but in small doses, from ten to thirty drops, two or three times during the night; larger doses were not well borne, aggravating the unrest. After some weeks the doctor took a sea-voyage, hoping for benefit from change, as his general health had become greatly impaired. After being at sea for some twenty days, with no perceptible benefit, the swelling of the prepuce suddenly in- creased, and a purple spot appeared on the integument of the dorsum, just behind the glans. The tissues at this point soon gave way, exhaling a fetid odor, and an opening occurred about the size of a dime, which became permanent. The tension of the tissues was now somewhat relieved, but urina- tion continued difficult, and the pains in the thighs, legs, and heels, which had hitherto been felt chiefly at night, now con- tinued throughout the day, and were severe, almost beyond endurance, notwithstanding the use of opiates internally and various local appliances. Returning from the voyage after an absence of forty-four days (March, 1814), his surgeon di- vided the prepuce superiorly from border to base, the incision terminating at the gangrenous opening before mentioned. This gave great relief to the dysuria, and somewhat mitigated* the pains in the thighs, etc., which were described as of a heavy, aching character, as from cramp, or excessive muscu- lar tension. An aggravation of his trouble now occurred from the performance of duties which devolved upon him (as the presiding officer of a State medical convention), which in- duced him to submit to further surgical procedure. A por- tion of the swollen prepuce was removed; as much as was thought essential to completely relieve constriction, and to get 6 at the bottom of the sinuses, for treatment. The cut surfaces of the prepuce were left open and healed kindly, with the exception of a small opening under the base of the glans, through which, finally, a communication was established with the urethral canal. This fistula was followed in the course of three or four days by a second, from within outward, and alongside the first, on the opposite side of the median line. After the second opening was established there was some relief to the passage of urine, but none to the aching pain of the extremities- The supposed carbuncular troubles on the scrotum and on the penis were each preceded by a distinct cir- cumscribed induration, involving the thickness of the integu- ment and not movable over the cellular tissue. Similar in- durations, smaller in size, now appeared on the under surface of the penis, to the number of three, which each resulted in a urethral fistula, through which urine passed at every urina- tion. These were about half an inch from the junction of the penis with the anterior border of the scrotum, and just to the right of the median line. Nothing further was done in the way of surgical interference, and no improvement occurred either in the urinary difficulty or the pains in the inferior ex- tremities. Consultations, with more than a dozen surgeons to whose notice the case was brought, failed to afford the patient any relief. Not one had ever seen any thing like it. The general opinion was opposed to the idea of malignant trouble. The difficulty was considered of furuncular origin and to have arisen from poverty of the blood, dependent upon overwork. No treatment was advised, except that addressed to the gen- eral building up of the system. One surgeon advised ampu- tation of the penis. The patient then decided to come to New •York for relief, arriving on September 17, 1871, with letters to the principal surgeons of this city. lie was seen by several. The opinions which an examination of his condition elicited, were in perfect accord with those already mentioned, viz., a disease “ resulting from poverty of the blood from malaria, etc., and excessive use of opium ”—causing the neuralgic pains, etc., from which the patient continued to suffer night and day, and so severely and constantly that a complete de- moralization of the patient was imminent. 7 Priapism added a new element of distress, and -with only the hope of obtaining a possible relief from this new complica- tion, by means of the cold-water coil {see note at p. 11, descrip- tive of tin’s apparatus of my own contrivance), he was referred to me. An examination of the penis revealed the condition represented in the woodcut Ho. 1 on the frontispiece, executed from a drawing which I made at the time of the patient’s first visit. I found the glans exceedingly sensitive to touch. The patient was passing his water chiefly through a fistulous open- ing at the base of the glans, interiorly. The meatus urinarius was contracted to 13 f. Bulbous sound 13 f. was passed with much pain, hugged closely for one inch until it emerged from the first fistulous opening. This opening was also terribly sen- sitive ; an attempt to examine it causing a profuse perspiration and much complaint. It admitted with difficulty Ho. 26 f., and then passed down without force 2j inches, where it wTas arrested by a stricture. Bulb Ho. 23 f. passed through, and was felt to be free at 2f inches. My own view of the case, based upon the experience acquired from previously observed cases, where exactly the same character and locality of pain had been found to be dependent upon urethral contrac- tions, determined me to advise complete division,of all urethral contractions as the best and only means of relief. The doctor after becoming fully cognizant of my views and reasons for operation, consented to submit himself wholly to whatever was deemed necessary to carry out the proposed operative procedure. The operation was set down for the following day, October 2T, 18T4, By my invitation, Prof. Thos. M. Mar- ine and Dr. Geo. A. Peters were present. The patient was put under the influence of chloroform (which he had often taken for relief of his pains, and with perfect impunity) by my assistant, Dr. Fox ; and I proceeded first to divide, fully and freely, the contraction from the meatus urinarius to the first fistulous opening, which was of calibre 13 f. This was done so that 31 f. bulbous sound could be easity passed. I then divided the orifice of the main fistulous opening, so that the same bulb could readily enter. An examination of the deeper urethra was now instituted, and it was found that adarge- sized probe passed down for one and a half inch, and 8 thence out of the urethra, to the right, until it entered easily the urinary abscess situated at the root of the penis (marked in the cut), and which had existed for several months. (The patient complained that he always felt pain on urinating, in this locality.) The stricture at 2J inches was then defined by 23; and by aid of my small urethrotome this stricture was dilated to 30 f., and divided; 31 solid-steel sound was then passed from the meatus, through the entire urethra, and into the bladder, without force. When the patient came out from the influence of the anaesthetic, he expressed himself as feeling better than for a long time. Bleeding was slight. The first attempt at urinating was painful, but urine was passed more freely than for years. Without opium or any other nar- cotic, he passed a comfortable night, sleeping for nine hours. On the following morning he stated that he had entire free- dom from all the pains so long endured, and that for a similar night’s rest he “ would be willing to submit to a similar opera- tion every night of his life.” There was no return of his pains in the thighs, legs, etc. After two days, I attempted to pass an instrument for the purpose of keeping open the divided strictures; but the pain was so great that I desisted, believing it better to wait until the sensitiveness had subsided, even at the risk of speedy contraction of the deeper stricture. In a week, the patient was out. Went to Brooklyn on a visit. A pair of tight pantaloons, and an evening spent in playing billiards, caused some return of his nervous disturbance in the inferior extremities; but applications of warm cloths to the penis soon relieved him. I then proposed to examine the con- dition of the urethra, and found, as I had expected, a recon- traction of the deeper stricture. On Sunday, November Bth, Drs. Peters, Mcßirney, and Fox present, I again divided the deep stricture under chloroform. From that time to the patient’s departure to his home, December Ist, he had no further trou- ble. His recovery seemed to have been complete. He left with the promise to communicate with me at once if he had any return of his trouble. I have not since heard from him. Among the other results of the operation, the urinary abscess on the right side of the root of the penis disappeared entirely, and this within ten days after the first operation. 9 My own view of the origin of the trouble in this case is that, from some unrecognized cause, a follicle in the scrotal por- tion of the urethra became the subject of inflammatory action; that this follicular inflammation finally resulted in ulceration and the formation of a fine and somewhat tortuous sinus, ex- tending, from the follicular point of exit in the urethra, down to the bottom of the scrotum ; that the “ dumb ague,” which the patient complained of as occurring at about this time, was a urethral fever, and marked the progress of the sinus, Diagbam showing the Locality of the Deep Stbictueb, Course of the Ukinabt Sinus, and Locality of the Abscesses. A, Deep stricture. 1, First abscess, connected wi’tb 2, 3, 4, and 5, the succeeding abscess- es, by the sinus, which commenced at A, the point of stricture, and extended down to 7, the bottom of the scrotum. which, after reaching the most depending portion of the scro- tum, remained in great degree quiescent for five and a half years; and that the depressed condition of health, resulting from general causes, finally brought about an active inflam- mation, terminating in a primary abscess at the bottom of the sinus ; that when the urinary abscess, occurring at the bottom of the scrotum, supervened, the cellulitis accompanying it closed the sinuous tract for an inch, and, after the first abscess had healed, a second cellulitis occurred at the point to which the sinus had been closed by the previous inflammation, and 10 the second abscess resulted. The inflammation attendant upon this, closing the sinus for another inch or so, after a brief period the third abscess occurred. In the same time and in the same manner a fourth; finally the integument of the body of the penis became involved in the ulcerative process, pro- ceeding to the anterior portion of the organ. Inflammatory paraphymcteis, and the consequent tension of all the tissues at this point, naturally gave rise to the urethral fistulse which appeared in this vicinity. The dependence of urinary sinus upon antecedent inflam- mation and ulceration of urethral follicles is claimed by Dittel (Pitha and Billroth’s “ Handhuch der allgemeinen und spe- ciellen Chirurgie,” Band iii., Ahtheilung ii., Lief, vi., p. 191), and several cases are reported by him, illustrating, in their course, and also in post-mortem examination, the follicular origin of small urinary sinuses. Two such cases were reported by me under the title of “Urethral Follicular Sinuses” in a paper on “Chronic Urethral Discharges,” which appeared in the New York Medical Journal of June, 18JO. The reflex troubles in this case appear to me to he in ex- act accordance with those often found associated with urethral stricture, especially at or near the meatus urinarius. They are dependent, possibly upon implication and irritation of nerve- fibres in the cicatricial tissue, or upon long-continued interfer- ence with the discharge of urine, in persons debilitated by in- fluences calculated to depress the sympathetic nervous sys- tem.1 1 In a paper read before the New York Academy of Medicine in Feb- ruary, 1874 (not yet published), entitled “Reflex Irritation of the Genito- urinary Tract resulting upon Urethral Contractions, congenital or acquired,” nineteen cases are reported, and the very scanty literature of the subject is noted. Some space is also devoted to a consideration of the various ways in which such reflex irritations are produced. A tolerably full abstract of this paper may be found in the Charleston Medical Journal and Review, July, 1874. 11 The Cold-water Coil in Inflammation of the External Male Genital Apparatus, and as an Antiphlogistic after Operations on the Penis.I—The1—The apparatus which I have des- ignated the “Cold-Water Coil” is formed of a line of the small-sized India-rubber tubing of one-sixteenth of an inch calibre, and six or seven yards in length. At the middle por- tion this tubing is coiled upon itself, so that, by half a dozen turns or more, it presents sufficient capacity to loosely encircle the entire penis or scrotum. This coil, with the length of tubing proceeding from it, forms an apparatus through which, on placing one extremity of the tubing in a bowl or tumbler of ice-water, exhausting OTTO-REYNDERS N.Y. its contained air (by suction, or by drawing the tube through the finger), a siphonic current is established through the coil. The discharge-pipe being placed on a lower plane than the water-supply, the current may be kept up until the vessel is emptied. The rapidity of the flow can be regulated either by raising or lowering the end of either tube, which is the simpler plan ; but the more convenient one is by a tapering, double silver tube, attached to the discharge-pipe, a sponge being fitted to the inner tube. This sponge, when the inner tube is pushed down into the smaller end of the outer tube, becomes com- pressed and gradually obstructs the flow of water, until not a 1 Reprinted from the New York Medical Record, January 9, 1875. 12 drop will exude. This contrivance may be regulated so that either a free stream can pass, or that the single drops shall follow each other, more or less rapidly, with the regularity and precision of a timepiece. By means of tfyis arrangement, I have been able to apply cold to the penis or scrotum continuously and conveniently both to the patient and myself. The coils of tubing are re- tained in position by a band of cotton or linen cloth. A ready method of constructing this apparatus is by placing a strip of thin cloth, six inches in length and two in breadth, length- wise, upon a large speculum or a four or six ounce vial. The tubing, taken at the middle of a piece six or seven yards long, is wound around the vial, and, after the requisite number of turns are made, the projecting ends of the cloth are doubled over the coils and stitched to the under layer between the turns of tubing. If, after completion, the turns are found too small, they may be readily enlarged by drawing the tubing through the cloth to any desired extent. I have found this simple contrivance of essential service in the acute form of gonorrhoea, reducing inflammatory action promptly, and thus giving relief to painful micturition and erections. It has proved of great value in keeping down inflammation and in preventing erections after the operation of circumcision. I habitually use it for the same purpose in operations for stricture, and with results more prompt and satisfactory than those hitherto attained by any medication or application with which I am familiar. 108 West Thirty-fourth Street, New York, February 12, 1875. MEDICAL WORKS PUBLISHED BY D. APPLETON Si CO. Anstle on Neuralgia, 1 vol., 12mo. Cloth, $2.50. Bartholow’s I'reatise on Therapeutics, (In press.) Barker on Puerperal Diseases. 1 vol. Cloth, 15.00. Barker on Sea-/Sickness, t vol., 16mo. Cloth, 75 cents. Barnes9s Obstetric Operations. 1 vol., Bvo. Cloth, $4.50. Bellevue anil Charity Hospital Reports. 1 vol., Svo. Cloth, $4.00. Rennet’s Winter anil Spring on the Mediterranean. 1v01.,12m0. Cloth, $8.50. Bennet on the Treatment of Pulmonary Consumption. Ivol., Svo. Cloth,sl.so. Billroth’s General Surgical Pathology and Therapeutics, 1 vol., Bvo. Cloth, $5.00; Sheep, $6.00. Bastian on the Common Forms of Paralysis from Brain Disease. (In press.) Bulkley’s (L. D.) Acne ; its Pathology, etc. Combe on the Management of Infancy. 1 vol., 12mo. Cloth, $1.50. Carpenter’s Mental Physiology. $3.00. Chauveaw’s Comparative Anatomy of the Domesticated Animals, Edited by George Fleming, F. R. O. S., M. A. I. I vol., Svo, with 450 Illustrations. Cloth, $6.00. Davis’s (Henry G.) Conservative Surgery. Cloth, $B.OO. Dickson on Medicine in Relation to the Mind. Cloth, $3.50. Elliot’s Obstetric Clinic. 1 vol., Svo. Cloth, $4.50. Ecker’s Convolutions of the Brain, Price, $1.25. Flint’s Physiology. 5 vols. Svo. Cloth, per vol., $4.50; Sheep, $6. Flint’s Manual on Urine. 1 vol., 12mo. Cloth. $l.OO. Flint’s Relations of Urea to Exercise. 1 vol., Bvo. Cloth. $2.00. Frey’s Histology and Histo-Chemistry of Man. Cloth, $5.00. Hoffmann’s Manual of Medicinal Chemicals. Cloth, $3.00. Hammond’s Diseases of the Nervous System. 1 vol.. Svo. Cloth, $5.00. Ha mmond’s Physics and Physiology of Spiritual ism. 1 vol., 12ino. Cloth, $1 Holland’s (Sir Henry) Recollections of Past Life. 1 vol., 12ino. Cloth, $2.00. Howe on Emergencies. 1 vol., Svo. Cloth, $3.00. Howe on the Breath, and, the J> is cases which give it a Fetid Odor; Cloth, price $l, Huxley on the Anatomy of Vertebrated Animals. 1 vol. Cloth, $2.50. Huxley and Youmans’s Physiology and Hygiene. 1 vol., 12mo. Cloth, $1.75. Hammond’s Insanity in its Relations to Crime. 1 vol., Svo. Cloth, $l.OO, Hammond’s Clinical Lectures on Diseases of the Nervous System. Hamilton’s (A. Mel,.) Electro-Therapeutics. 1 vol.. Svo, cloth, $2.00. Johnston’s Chemistry of Common Life. 2 vole., 12mo. Cloth, $3.00. Letterman’s Recollections of the Army of the Potomac. 1 vol., Svo. Cloth, $l. Lewes’s Physiology of Common Life. 2 vols., 12mo. Cloth. $3 00. Markoe on Diseases of the Bones. 1 vol., Svo. Cloth, $4.50. Maudsley on the Mind,. 1 vol., Svo. Cloth. $3.50. Maudsley’s Body and Mind. 1 vol., 12mo. Cloth. $l.OO. Maudsley on Responsibility in Mental Disease. Meyer’s Electricity. 1 vol.. Svo. Cloth, $4.30. Niemeyer’s Practical Medicine. 2 vols., Svo. Cloth. $0.00; Sheep, $ll.OO. Neftel on. Gnlvano-Therapeutics. 1 vol., 12mo. Cloth, $1.50. Nightingale’s Notes on Nursing. 1 vol., 12mo. Cloth, 75 cents. Neumann on Skin Diseases. 1 vol.. Svo. Cloth, $4.00. Nciv York Medical Journal $4.00 per annum. Specimen copies, 25 cents. Peaslee on Ovarian Tumors. 1 vol., Svo. .Cloth. $5.00. Pereira’s Materia Med lea and Therapeutics. 1 vol., Svo. Cloth, $7; Sheep, $3. Sayre’s Club-foot. 1 vol., 12mo. Cloth, $l.OO. Sell roeder on Obstetrics. 1 vol.. Svo. Cloth. $3.50. Steiner’s Compendium of Children’s Diseases. Cloth. Price. SB.TO. Stroud’s Physical Cause of the Death of Christ. 1 vol.. 12mo. $2.00. Swett on Diseases of the Chest. 1 vol., Svo. Cloth, $3.50. Simpson’s (Sir Jas. 17) Complete Works. Vol. I. Obstetrics and Gynaecology. Svo. Vol. IT. Anaesthesia, Hospitalism, etc. Svo. Vol. 111. The Diseases of Women. Per vol' Cloth, $3.00: Sheep. $4.00. Tilt’s Uterine Therapeutics. 1 vol.. Svo. Cloth, $8.50. Van Buren on Diseases of the Rectum. 1 vol., 12mo. $1.50. Van Bnren and, Keyes’s Gcnito-Urinary Diseases, with Syphilis. Cloth, $5 : sheep $6.00. Vogel’s Diseases of Children, 1 vol.. Svo. Cloth. $4.50 : Sheep, $5.50. Wells on Diseases of the Ovaries. 1 vol.. Svo. Cloth. $5:00. Wagner’s Chemical Technology. 1 vol.. Svo. $5.00. Walton’s Mineral Springs of the United States anil Canada, With Analyses and Notes on the prominent Spas of Europe. Cloth, price. $2.00. *** Any of these works will be mailed, post-free, to any part of the United States, on receipt of the price. Descriptive Catalogue forwarded on application. A large and carefully-selected stock of Medical Works, American and Foreign, constantly on hand. Special Terms given on large orders. Physicians are invited to send their mines and addresses. D. APPLETON CO., Publishers, 549 & 551 Broadway, New York. APPLETON S’ JOURNAL, FOR 18V5. Appleton's’ Journal will sustain, during the ensuing year, its reputation for general excellence. The publishers will endeavor, more strenuously than ever, to furnish a pe- riodical of a high class, one which shall embrace a wide scope of topics, and afford the reader, in addition to an abundance of entertaining popular literature, a thorough sur- vey of the progress of thought, the advance of the arts, and the doings in all branches of intellectual effort. As the design is to make a superior literary engravings will be employed only when they serve to illustrate the text, and never merely as pic- tures. Without adhering too rigidly to any set plan, the contents will be grouped approxi- mately as follows: I. Literature op Romance, consisting of popular serial novels, from both American and Knglish writers, and the best short stories obtainable, whether from native or foreign writers. 11. Travel, Adventure, and Discovery, embracing papers deseflptive of places, tales of advent- ure and discovery, with notes of all that is doing in the way of exploration, or that is brought to light of new and unfamiliar countries. 111. Nature and Natural History, under which will be given entertaining papers on tbe charac- teristics of the earth’s surface, tbe habits of animals, and all that pertains to the physical world around us. IV. Social Themes, including papers expressing the ideas of capable observers on social progress, the arts and felicities of the household, and such matters as pertain to our daily lives. V. Tub Arts, embracing criticisms of new paintings, new architecture, etc.; observations on dec- orative and household art, and a general survey of the progress of the arts in all their branches. VI. Miscellany will cover selections from new books, brief translations from Continental journals, and extracts giving the core of the more noteworthy papers in the F.nglish magazines. VII. Science and Invention will consist of popular papers on subjects covered by these terms, and will record the progress made therein. VIII. New Boons will be carefully and impartially reviewed, in the sole interest of the reader; and notes will be subjoined, affording intelligence in regard to literary matters here and abroad. IX. Current Topics will consist of the editor’s glances at themes occupying the public mind; at various utterances by leading spirits in literature, philosophy, and criticism; and at the gay- eties and amusements of society. It is designed to make this department notable for its entertaining vivacity. The broad purpose of the editors will be to make a magazine of weekly issue, that shall rival in interest and vai-iety the regular monthly publications ; and for this purpose the space at their command enables them to give much more material for the same yearly subscription than that contained in the largest of the monthly magazines. Published Weekly. Price 10 Cents per Number; or $4 per Annum, in advance. By the recent Post-Office Liw, the postage on all periodicals, after January 1, 18*75, ■must he prepaid bg the publishers. Subscribers, therefore, will hereafter receive their num- bers without charges for postage. Any person procuring’ Five Yearly Subscriptions, for weekly numbers, and remitting $20.00, will be entitled to a copy for one year graft \ in remitting by mail, a post-office order or draft, payable to the order of D. Atom.Eton & Co., is preferable to bank-notes, as, if lost, the order or draft can be recovered without loss to the sender. Volumes begin with January and July of each year. Apple-toss' Journal and either Harper's Weekly, Harper's Bazar, Harper's Magazine, Lippin- co*t's Maaazine, the Atlantic Monthly, Scribner's Monthly, or the Galaxy, for one year, on receipt of $7.50, which includes prepayment of postage; Apple-tons’ Journal and Littell's Living Age. for $10.50, including postage; the Journal and Popular Science Monthly, for $3, including postage prepaid by the publishers. For those who prefer it, the Journal is put up in Monthly Parts, and in this form its scope and variety, as compared with other magazines, become conspicuously apparent. Subscription price, $4.50 per annum, including postage prepaid by the publishers. D. APPLETON & CO., Publishers, New York.