* v 9 Ti U \J dX REPRINTED KROIVT UNIVERSITY Medical Magazine. EDITED UNDER THE AUSPICES OT THE 'ALUMNI AND FACULTY OF MEDICINE EDITOr.IAL STAFF Editorial Committo*: < •a ESSKS^rr-. *sa!s:.aKssr “ CONTENTa r«srss sss r.?:."*. * i-||p:l Si^£'~:r—• ':■■ 5 MAY, 1896 CYSTIC DISEASE OF THE CHORION : WITH A TABULATION OF ONE HUNDRED CASES. BY W. A. NEWMAN DORLAND, M.D., Assistant Demonstrator of Obstetrics, University of Pennsylvania ; Instructor in Gynecology, Philadelphia Polyclinic, AND T. PERCEVAL GERSON, M.D., Of Johns Hopkins University, Baltimore, Md. CYSTIC DISEASE OF THE CHORION: WITH A TABU- LATION OF ONE HUNDRED CASES.1 By W. A. Newman Dori*4nd, M.D., Assistant Demonstrator of Obstetrics, University of Pennsylvania; Instructor in Gynecology, Philadelphia Polyclinic. AND T. Perceval Gerson, M.D., Of Johns Hopkins University, Baltimore, Md. On the morning of July 20, 1895? there appeared at the Gyneco- logic Dispensary of the Pennsylvania Hospital D. C., a tall, well-devel- oped Russian Jewess, who intellectually was much superior to others of her class, and who gave the following history : She was 25 years of age, and was at that time three and a half months advanced in her fifth pregnancy. She had given birth to three children at term and one miscarriage; her youngest child was years of age. Her labors had been of ordinary severity. She stated that she was averse to having more children, and that for the past two years she had been adopting measures to prevent conception, including the practice of onanism, and the use of vaginal injections. She was exceedingly weak and emaciated, and markedly anemic at the time of her visit, but had formerly enjoyed excellent health. Her menstrual periods had been regular. Notwithstanding her efforts at enforced sterility she had conceived, and gestation had to all appearances advanced in a perfectly normal manner until the ninth week. At this time she began to have a slight bleeding, which persisted as an almost daily show until the date of her visit to the hospital, five weeks later. The constant flowing was unattended with pain at first, but later she had 1 Read before the Barton Cooke Hirst Obstetrical Society, of the University of Pennsylvania. 2 IV. A. Newman Borland and T. Perceval Gerson. suffered with slight colicky pains in the lower abdomen, of sufficient intensity, however, to excite considerable apprehension,—hence her application for relief. An examination made at this time elicited all the signs of early gestation, including a very soft cervix and a moderate degree of uterine enlargement, about corresponding to, or perhaps, a little over that of the supposed period of pregnancy. The cervix was somewhat patulous and there was a moderate flow of red blood. The diagnosis of a threatened abortion was made, and the patient was given one dram doses of the fluid extract of viburnum prunifolium three times daily, and ordered to confine herself to bed until the flow had ceased. Three days later, the bleeding having persisted, but without any appreciable increase in the amount, she was given a suppository of the aqueous extract of opium night and morning. In two days’ time she reported that there had been no amelioration of her symptoms. The treatment was continued, and after an absence of nine days she returned on the morning of August 3, reporting that there was at that time but a slight flow, and that she was feeling considerably im- proved. It was noted, however, that there was a progressive emacia- tion with marked sallowness of the skin. Eleven days passed when she again appeared in a decidedly worse condition, with a return of the bleeding, and the addition of severe abdominal pain. She stated that she had been discharging small clots for the past two or three days. She was also suffering exceed- ingly from hemorrhoids. An examination made at this time revealed a still more patulous condition of the external os, and the finger, gently introduced, detected dilatation of the internal os, and the presence of a spongy material feeling very much like placental tis- sue. It was also noted that the fundus of the uterus was much enlarged, reaching well up to the umbilicus. The amount of abdomi- nal resistance did not permit a close study of the degree of consistence of the uterine tumor. A diagnosis of placenta previa was made, and the patient was given my address and commanded to send for me at once should there appear any considerable increase in the amount of hemorrhage. This was the morning of August 14. Four days later, at 5.30 a.m,—the patient now being four and a half months pregnant,—I was hastily summoned by note which stated that the woman was bleeding to death. When I reached her the hemorrhage had ceased, but the bed, bedclothing, and floor were drenched with blood, and her mother showed me a chamber-pot half filled with clotted blood, but containing no membranes or other por- tion of an ovum. A glance was sufficient to show that the patient was almost exsanguinated. A careful examination revealed the os Cystic Disease of the Chorion. 3 dilated to the size of a quarter of a dollar, but filled with a protruding mass of spongy material which I judged to be placental tissue. The patient informed me that on the previous morning she had suffered from a smart hemorrhage, and had passed a fragment of meat-like substance that had contained one or two bladder-like structures. Fearing a renewal of the hemorrhage if I should displace this plug, I sent for Dr. Alfred C. Wood, who etherized the patient. When completely anesthetized I dilated the os and removed with the fingers a large mass—over two quarts—of a substance very closely resembling boiled tapioca, and which I at once recognized as cystic degeneration of the chorion. But very little bleeding attended the evacuation of the mass, and the uterus contracted firmly as the cavity was emptied. After giving a hypodermatic injection of ergotin and an intrauterine douche of mercuric-chloride solution (1:3000), a strip of iodoform gauze was introduced and the patient placed in bed. An examination of the removed uterine contents revealed no trace of a fetus, and but a small portion of placental tissue—about two by two inches in size— was found. The cysts, which varied in size from a very minute vesicle to one as large as a small-sized grape, were white or pinkish-white in color, and translucent. They were not pedunculated, but seemed to be loosely grouped together without any special relationship to one another. The progress of the case was very satisfactory. The evening temperature on the day of delivery was ioi° F., and the next morning ioo° F., with a pulse of 102. The following morning the lochia be- came exceedingly offensive, although there was no elevation of tem- perature over ioo° F,, and the pulse remained but moderately accel- erated. Under the use of mercuric-chloride douches of 1:2000 strength, the fetor was destroyed and the patient steadily regained her strength and color. She remained in bed for two weeks, at the expiration of which time she was practically well, the uterus being well advanced in involution and sunk beneath the pelvic brim. Two weeks later she again visited the hospital to report progress, and even at that early period had regained considerable flesh and color. Shortly before this time, Kehrer,1 of Heidelberg, had published a paper containing the reports of fifty hitherto unpublished cases of cystic disease of the chorion, which he had gathered in two years’ time, from forty-eight midwives and physicians in the lowlands of Baden. It was the opinion of all with whom he had corresponded that the disease was one of considerable rarity. His object in gather- ing unreported cases was to arrive, if possible, at a more accurate knowledge of the peculiarities of the disease, for he believed that the 1 Archiv fiir Gynakologie, 1894, Band xlv, Heft 3. 4 W. A. Newman Norland and T. Perceval Gerson. cases that found their way into the medical journals were more prob- ably those that had terminated favorably, and would not, therefore, present a true picture of the gravity of the disease. Admitting that there was much truth in Kehrer’s arguments, it being deplorably true that medical men are not apt to report their failures, I was stimulated, however, by this interesting case in my own practice, and by my perusal of Kehrer’s paper, to put the matter to the test. At the expense of much time and trouble, therefore, and with the kind assistance of Dr. T. Perceval Gerson, of Johns Hop- kins Hospital, and Dr. George C. Kiisel, of this city, I have collected from current medical literature 100 reported cases of the disease, which I have tabulated, and from which I have formulated conclu- sions. These I have compared with the studies of Kehrer with the following results : In the first place, as regards the age af the time of the molar birth. In 15 per cent, of the cases the age of the woman is not stated, but from the histories of the cases in eight instances in which the patients were described as “young” married women, it is fair to pre- sume that they were under 30 years of age. In 8 per cent, the patient was under 20 years, the youngest being a single girl of 13. The larger percentages occurred between 20 and 40 years of age; thus, between 20 and 30 years one-third of the cases (33 per cent.) are noted, or, if we include here the eight women whose ages are not given, but who were presumably under 30, we have a percentage of 41 occurring in the third decade of life. Twenty-seven per cent, of the women were between 30 and 40 years of age, and n per cent, between 40 and 50 years, while but 5 per cent, were over 50; the two oldest women having each attained the age of 53. It will thus be noted that 68 per cent, of the cases occurred between 20 and 40 years of age, while only 8 per cent, were under, and 16 per cent, over, this period, leaving 7 per cent, undetermined. Two per cent, of the cases occurred in colored women, one 29 years of age, and the other a mulatto of 42, and 5 per cent, occurred in single women, four of these being under 20 years (13, 16, 17, and 17), and one 24 years of age. These figures very closely approximate those of Kehrer, who found in his fifty cases that 4 per cent, happened before the twentieth year, 38 per cent, between 20 and 30 years, 36 per cent, between 30 and 40 years, 18 per cent, between 40 and 50, and 4 per cent, over 50 years of age. It will be noted that 74 per cent, of Kehrer’s cases occurred between the twentieth and fortieth year as compared with 68 per cent, of my own table. Sixteen per cent, of my cases occurred in advanced years,—that is, after 40 years of age,—while 22 per cent, of Kehrer’s cases occurred during the same period. This goes to prove the rela- Cystic Disease of the Chorion. 5 tive frequency of the molar births late in life as compared to normal childbirth. Number of Previous Pregnancies.—ln 9 per cent, of my cases it is not stated whether the patient had previously given birth to chil- dren. In 24 per cent, the molar birth occurred in primiparas, as com- pared with 10 per cent, of Kehrer’s table. Of the remainder, 8 per cent, were multiparse, the number of previous children not being noted; 14 per cent, had given birth to one child ; 7 per cent, to two children; 6 per cent, to three children ; 5 per cent, to four children ; 2 per cent, to five children; 4 per cent, to six children; 4 per cent, to seven children; 2 per cent, to eight children; 3 per cent, to nine children ] 3 per cent, to ten children; 1 per cent, to eleven children; 2 per cent, to twelve children ; 2 per cent, to thirteen children ; 2 per cent, to fourteen children; and 1 per cent, to fifteen children. Eighteen per cent, of the women, or per cent, of the multiparas, had aborted one or more times. Previous Health.—ln 36 per cent, of the cases no mention is made as to the previous condition of health. Forty per cent, of the women had always enjoyed excellent health and presented normal menstrual histories, while in 25 per cent, of the cases the record is that of poor health. Most of these delicate women suffered from anemia and irregular menstruation, with periods of suppression or a history of too profuse flow. One was of the scrofulous diathesis; one had suffered from an attack of typhus fever one year before ; one had had a gastric ulcer; one was insane, believing herself to have hydro- phobia ; one was melancholic and attempted suicide by cutting her throat; and one was suffering from a chronic cardiac disease. It would appear from these statistics that the previous condition of health exerted little, if any, influence upon the development of the chorionic disease. Symptoms during the Pregnancy.—Fifty per cent, of the women suffered from nausea and vomiting during the molar pregnancy, in many the symptoms being more or less constant and severe. Gen- erally it became more marked towards the close of the gestation. Eight per cent, of the women did not present this symptom, and in 42 per cent, no statement is given. This cannot, therefore, be regarded as an especially characteristic clinical manifestation of cystic degen- eration of the chorion. One woman presented the symptom of pica in an aggravated form. Fully half of the women suffered from anemia and debility to a marked degree, and a number of these were prostrated to such an extent as to necessitate their confinement to bed for a portion of the pregnancy. It would seem very evident, therefore, that women with 6 W. A. Newman Borland and T. Perceval Gerson. this abnormal condition in the uterine cavity are especially prone to suffer from an undue debility which is probably largely dependent upon the hemorrhages from which they suffer. Albuminuria and edema of the lower extremities or general anasarca were noted in 19 per cent, of the cases, a frequency sufficient to attract attention and to call for a closer study as to the coexistence of renal derangement and cystic disease of the ovum. It would be fair to state that renal insufficiency, or the kidney of pregnancy, is at least three times as frequent in this condition as in normal gestation. Abdominal pain was a marked symptom in 38 per cent, of the women, and when present was usually first noted towards the close of the gestation. It partook of the character of labor pains, and in some instances was exceptionally severe. Thirteen per cent, of the women had absolutely no pain before the onset of labor, while in almost half of the cases no mention of this symptom is made. It is probable that the origin of this pain is the extreme and rapid develop- ment of the uterine tumor which was noted in 85 per cent, of the cases. By the time of the third or fourth month in the vast majority of the cases the abdominal distention and uterine growth were equal to that of the sixth or seventh month of normal gestation, the fundus uteri reaching to or extending slightly above the umbilicus. On pal- pation the tumor was generally noted to be of a greater consistence than the cystic tumor of pregnancy, non-fluctuating, but of a peculiar doughy or mushy feel. Absence of the uterine souffle is the rule. A number of the women claimed to have felt fetal movements. Uterine hemorrhage is a constant symptom, in many instances occurring as an excessive flow at irregular intervals, or, as in my own case, persisting as a daily stillicidium until the final profuse hemor- rhage ushering in the expulsion of the mole. Generally the bleeding does not commence before the second or third month, and at times it partakes rather of the nature of a watery or sanguineous discharge than of a true hemorrhage. Once established, the flowing persists in increasing amounts at irregular intervals. Kehrer believes that the hemorrhage results from imperfect attachment of the diseased chori- onic villi to the decidual tissue. Time of Birth.—The month of pregnancy in which the expulsion of the mass occurs varies. In my own table in 6 per cent, of the cases the time is not given. In 6 per cent, it occurred during the second month; in 20 per cent, during the third month; in 31 per cent, during the fourth month; in 12 per cent, during the fifth month; in 15 per cent, during the sixth month; in 2 per cent, during the seventh month; in 4 per cent, during the eighth month; and in 3 per cent, at term. Sixty-three per cent, of the cases, therefore, Cystic Disease of the Choi'ion. 7 occurred from the third to the fifth months inclusive, as compared to 74 per cent, in Kehrer’s table. But 3 per cent, of my cases arrived at term, while Kehrer showed a percentage of 4. The time required for the expulsion of the mass was usually short, not exceeding four to six hours in most of the cases. The labors, however, as far as suffering was concerned, closely resembled the normal. The pains were inter- mittent, colicky, and often severe, and attended with profuse bleeding in most of the cases. Size and Nature of the Mole.—Almost without exception the mass discharged was of considerable bulk, varying from a pint to over a gallon. The description of the size varies. In one instance it filled a dinner-plate; in others it is described as immense or enormous; repeatedly it was said to half fill or to fill completely an ordinary chamber-pot or hand basin. In one case it was said to weigh six or seven pounds ; again, four pounds, and again, between two and three pounds. In one case it was described as one and a half times as large as a fetal head at term. Generally the mole consisted of the usual clear or translucent vesicles of a whitish or pinkish-white color, and varying in size from a pin’s head to a walnut. These cysts contained the characteristic watery fluid. In 1 per cent, of the cases the disease had occurred at a preceding pregnancy. In 21 per cent, of the cases fragments of placental tissue and fetal membranes were discovered, and in 6 per cent, of the cases an embryo or fetus either preceded or followed the discharge of the mass. The mole was expelled spontaneously in 39 per cent, of the cases, and in the remainder of the patients was driven out either /by strong uterine contractions induced by the action of ergot, or was removed by the hand or curette. Sepsis.—There is a great tendency to the manifestation of septic intoxication after the delivery of an hydatidiform mole. In my table 31 per cent, of the women, or nearly one-third of the cases, developed a certain degree of sepsis, as shown by an elevation of temperature, rigors, and fetid lochia. Five of the cases resulted fatally. Mortality.—The mortality as shown by my table is probably a little under the usual percentage, thus proving the truth of Kehrer’s statement that fatal cases, as a rule, are not reported. The table shows a mortality of 10 per cent., 3 per cent, perishing from hemor- rhage at the time of delivery; 2 per cent, succumbing shortly after .delivery to the effects of perforation of the uterine wall; and 5 per cent, dying at varying periods during the puerperium of septic infec- tion. A tabular arrangement of the cases is appended. 8 W. A. Newman Borland a7id T. Perceval Gerson. Number. Reporter. Reference. Name. Social State. 6 00 < Previous Pregnan- cies. Abortions. Previous Health. Gastric Symptoms. General Symptoms. Pain. Hemorrhage. AbdominalEnlarge- ment. I Ander- son, W. Lond Med. Reposit., 1827, XXVIII, 4°3 • Mrs. E. M. 22 2 0 Sparehabit a fright when 2 mos.preg- nant. Felt quicken- ing Some bear- ing down. First at 7th mo.; slight in amount. Great. 2 Andrew, John. Glasgow Med. Journ., 1832,v, 68- 74- M.R. S. 16 0 0 Poor for 6 mos-,spit- ting of blood; mental depres- sion. Weak; ane- mic ; at- tempted suicide at 6th month by cutting throat. Irregu- lar bear- ing down. None. Rapid; size of eighth month of gestation. 3 Ibid. Ibid. Mrs F. M. 22 mos. 1 1, at three mos. Nau- sea. Slight spit- ting of blood. Slight. None. Greater than at the sixth month of pregnan- 4 Ibid. Ibid. Mrs. S. M. 6 mos. 0 0 Poor. Nau- sea. Violent cough; slight spit- ting of blood. None. cy • Marked; firm to the touch. 5 Ibid. Ibid. S. H. S. 17 0 0 Good. Nau- sea ; occa- sional vom- iting. None. Size of 7th month of gestation; hymen in- tact. 6 Arm- strong, J. Liverpool and Man- chester M. & S. Re- porter, 1874, 53- Mrs. X. M. 1 0 Good con- stitution ; inclined to obesity; menstru- ation pro- fuse ; se- vere uter- ine hem- orrhage after birth of fifth and suc- ceeding children. Fluid dis- charges of a dirty white color, at times offen- sive. Rapid in- crease. 7 Ashley, W. H. London Lancet, 1850,11,319 -321. Mrs. F. M. 18 years. 36 15 6 Nausea and vom- iting, at times se- vere. Anemia; hys- teria ; ex- treme debil- ity; dyspep- sia; moder- ate emacia- tion ; vision impaired; bedridden forovertwo years. Severe. Considera- ble. 8 Atthill, L. Brit. Med. Journ., 1878.1,334- Very deli- cate ; suf- fering with ulcer of stom- ach. First at 12th week; re- peated and profuse af- ter that date. Size of 7th month of gestation. 9 B., J. Prov. M. & S. J., Lon- don, 1842, Mrs. X. M. 52 Large family. Repeat- ed vom- Much weak- ened. %o Barnes, Robert. v, 328. Irans.Obst. Soc., Lon- don, 1865, vn, 117- 120. A.W. M. 42 II 3, last at third mo., one year pre- vious- ly. Ring. Consid- erable nau- sea and vom- iting. Edema of legs; ane- mic ; urine scanty, highly-col- ored ; felt quickening. Abdomen promi- nent; tu- mor more to right side, and reaching to umbili- cus ; firm, elastic, tender. History of the Pregnancy. Cystic Disease of the Chorion, 9 History of Molar Birth. c o Puerperium. "rt m € o o3 bo cd Description of Mole. Treatment. nd 0) tt V bo Result. o ,g c o § .s c3 a* u u O B V X .2 CO rt Q u u o B a> X U > V ptH Term. Sixth. Slight- Slight. Consider- able. Weight of mass upward of five pounds; great quantity of fluid; vesicles size of hazel nuts; piece of placental tissue size of wal- nut. Discharged a sac the size of a new- born child’s head, containing clear fluid; one hour later a large mass of hydatids; two hours later another mass. Expelled spon- taneously. Expelled spon- taneously. Usual time. Thirteen days. No. No. Recovery. Recovery. Fourth. Fourth. Five and a half. Severe. Severe; labor- like. Severe; irregu- lar. Slight. Consider- able. Consider- able flood- ing. Discharged a large sac containing clear fluid, and soon after a large mass of vesicles, weighing about seven pounds; vesicles con- tained a glairy fluid; no fetus nor placenta. Discharged a fleshy mass resem- bling placen ta,with a number of small vesicles on its surface; no cord or fetus; shortly after ex- pelled a bag containing fluid ; a little later passed a hand basin- ful of vesicles, size of a pea to a large hen’s egg, containing a glairy fluid; the next day nearly as much more was discharged. Discharged a large bag containing a glairy fluid, and shortly after a mass of vesicles. Expelled spon- taneously. Partially spon- taneous ; manual ex- traction. Partially spon- taneous ; manual ex- traction. Two weeks. Twelve days. Usual time. Slight. No. Slight for two days. Recovery. Recovery. Recovery. Not given. Severe. Profuse. Mass of hydatids containing a watery fluid. Manual extrac- tion. Death at time of delivery, of hemorrhage. Not known. Severe; bearing- down. Consider- able. Discharge of solid masses looking like lard, with cysts, at intervals for a month ; about four ounces of solid matter and a large amount of fluid. Expelled spon- taneously. Four or five months. No. No. Gradual recov- ery. Fourth. Some. Size of mass not given. Ergot, tarn- Usual Rapid recov- penning, and hot-water in- jections. time. ery. Profuse. i Mass of hydatids of sufficient size to fill a wash hand-basin. Considerable mass of cysts, some as large as a walnut; discharged in several sections. Expelled under „ Slight. Yes. Recovery good. a half. Six and a half. Labor- like. Some. actionof large doses of er- got. Galvanism; tampon; finally spon- taneous ex- pulsion. Death evening of delivery, of sepsis(stupor, retching, vom- iting); uterus contained fibroid tumor size of large orange. 10 W. A. Newman Norland and T. Perceval Gerson History of the Pregnancy—Continued. G d cn s CO a 0) be G rG O 0 d ft & G 6 u CD a g CD w ! Number. u So s .2 Vh O < B s .0 * m d u CD d CD O .s d Ph d H 5-. O a CD tn *c3 G 'si 0 g T3 rj G2 G < n Bartlett, Boston M.& Mrs. M. 37 2, 0 Some Some edema Severe. Slight at the Size of 6th Ezra. S. J., 1846, A. young- nau- of feet; con- sixth week. month by xxxiv, 95 est six sea siderable the 12th -97- mos. and vom- debility; bedridden. week; no fluctua- 12 Bass, J. D. Tr. Texas Med. Ass., Mrs. D. M. 4 24 0 0 Very deli- cate ; at end of 1st iting. Anemic, Slight. Slight from one and a tion. Size of 7th month at 1885, XVII, mos. half mos. four mos. 382-386. month of pregnan- cy felland struck ab- domen on 13 Bennett, Thomas J- Richmond andLouis- ville M. J., Mrs. E. M. 25 0 0 chairpost. Never en- joyed good N ausea and vom- Anemic; dropsical for three Consider- able. 1872, XIII, health; iting. months. 337- amenor- rhea. Good. 14 Bernar- Unreported. Mrs. M. 30 0 0 Slight from Great dis- |Y’P. G. S. 5 the fifth tention; years. month. tumor soft, but harden- ing under contrac- 15 Bethune, Canada Mrs. M. 41 last 7, Delicate; N ausea Anemic; very Severe Slight after tions. Nor- Lancet, X. 4 be- highly from weak; bed- for i one and a reached man. 1876, VIII, three tween nervous date ridden. week half mos.; midway 161. abor- tions. 4th & 6th mo. & 3 at 2d mo. tempera- ment ; poor health for 11 years. of first hem., day and night; before deliv- ery. severe for 1 week before delivery of mole. between pubes and umbili- cus. l6 Boislin- iire. St. Louis Courier of Med., 1879, 1, 104-107. pica. Slight. For one week previous to expulsionof mass, wa- tery and sanguine- ous dis- charges, fol- lowed by alarming Great dis- tention. 17 Bookless, John. Boston M. and S. J., Mrs. A. M. 49 12 (all liV") 0 Good. None. Slight. hemorrh’es. None. Consider- able. 1852, XLV, ing), la- 80. borsdif- ficult. 7. 18 Borden, Med. News, Mrs. M. 36 0 Always re- None. Comfortable. None. Appeared at Moderate. F. W. 1884, XLV, 703- P. l8 years. young- est four years. markably healthy; menstru- ation reg- Sth week; excessive with piece of mem- 19 Browne, G. Hen- ry. Lancet, 1886, August 7, 249. Mrs. X. M. 32 Multip- ara. 0 ular. brane. Flooding be- gan at sixth week, and continued Abdomenat 3 Vz mos. size of 7 mos. of 20 Bryan, Brit. Med. Mrs. M. 38 4. I Healthy. Con- Considerably at intervals. Slight at 2d gestation. At 4 months John Journ., X. young- stant emaciated. mo., and for uterus ex- M. 1872, 11, 464. est 17 years. nau- sea and vom- iting after 2^ mos. 6 weeks af- ter there was an in- odorous sanguineo- aqueous discharge. tended quite across ab- domen, and reached the umbil- icus. Cystic Disease of the Chorion, 11 History of Molar Birth—Continued Continued. c o Puerperium. © O O X c o s .s Ph -4 > © Result. Fourth. Severe. Profuse, causing col- lapse. Mass of hydatids filling a cham- ber-pot. Expelled under the action of ergot. Seven to eight weeks. No. No, Recovery pro- tracted. Fourth. Labor- like. Consider- able. Size of mass not given. Manual extrac- tion. Death early the following morning from hemorrhage. Eighth. Moder- ate. Slight. Delivered of a dead fetus; next day hydatid mass, weighing about four pounds; fetus had been dead for probably three months. Expelled spon- taneously. Usual time. No. No. Good recovery. Term. Labor- like. Profuse. Mass of cysts and degenerated fetal membranes filling a quart measure. Manual extrac- tion. Usual time. Good recovery. Four and a half. Severe; labor- like. Consider- able. Mass of hydatids weighing two pounds ; size of vesicles pin’s head to cherry stone; many showed opaque whitish dots. Expelled spon- taneously. “ Slight. Recovery grad- ual, but per- fect. Third. Labor- like. Consider- able. Considerable mass of hydatids, resembling grapes ; no trace of fetus. Expelled spon- taneously, Usual time. “ No. Good recovery. Not given. Labor- like Profuse. Considerable cluster of hydatids interspersed with clots. Expelled spon- taneously. Consider- able for some hours. “ Recovery. Two and a half. None. Exces- sive. Small mass containing but four cysts. Manual etrac- tion. Usual time. No. Recovery. Three and a half. Severe. Consider- able. Expelled a “large quantity” of vesicles. Expelled under action of ergot and Barnes’s bag. Usual time. “ “ Recovery. Four and a half. Labor- like. Free. Expelled a large mass of hydatids (about two pints), and six or eight hours afterwards asmailer mass. Manual extrac- tion. Slight. Offensive lochia on sec- ondday. Gradual recov- ery. 12 W. A. Newman Borland and T. Perceval Gerson History of the Pregnancy—Continued. 6 3 3 3 bo 0) £ cn a 0 p. a 0 a 0) So u 'S Pl, a V 0 .5 "d Ph d 'S O B O) a *3 3 a-a 0 g 2s Of 21 Camp- bell, J. Mich. Med- News., 1880, in, 60. Mrs. C. M. 47 12 0 Not noted. Some. Considerable. Abdomen Size of 6th month of gestation. 22 Chad- wick, James Boston M. and S. J., 1887,CXVI, 258. Mrs. X. M. 1, 18 mos. before. 0 Good. Fre- quent and At 1 month small quan- tity of wa- At 11 weeks uterus reached severe from tery fluid which re- one inch above um- first curred in bilicus. bleed- the subse- mg. quent four 23 Champ- lin, A. P. N. Orl. M. & S. J., 1885, Mrs. X. M. 17 33 9 I, at 2 Not given. weeks. Considerable during last n.s., 273- years. mos. 5 months. 277. 24 Chowne. Lancet, No- vember 11, 1843- Not given. Not given. Not given. 25 Chunn, Maryland Mrs. M. 35 9, 0 Heart-dis- Nausea Ankles ede- Severe. None until Attwomos. W. P. M. J.,1882, B. young:- ease for and matous; in final attack. -3, ix, 550- est four sometime; vom- bed for four 552. years. menstrua- iting or five days. of gesta- tion regu- at lar and without short inter- reaching to umbili- pain. vals. cus; elas- tic, 26 Cleeman, Am. Journ. Mrs. M. i6J^ 1, 0 Small, deli- None. Anemic; doughy. R A. Obst.,1875, X. 21 10 mos. cateframe; drowsy profuse,and size of 7th viii, 172- mos. before. good afterwardat month of 27 Cremen, J- T73- health af- ter birth of child; hard frequent in- tervals. gestation; very sen- sitive. Dublin J.M. Sc.,. 1858, Mrs. E. M. M. 40 13 1, at 7 Slight, deli- cate, ca- Slight at in- About nor- mal. xxv, 473. mos. chectic- looking; fell at 3d ter- vals since mo. and fall. struck ab- 28 Cross- man, Ed- ward. British Med. Journ., 1867, 11,24. Mrs. X. M. 28 I 0 Not stated. None. Slight at in- ter- vals. Commenced at 4th mo. ; slight in amount. Consider- able. 29 Curtin, R. G. Am.J.Obst., Mrs. M. 23 0 0 Small, deli- Nausea Rapid and ex- Inter- Commenced At 4th mo. 1871-2, IV, 73I-736- JL. Cj. 2 cate, but and treme ema- mit- at end of 1st tumor ex- years. always healthy; menstru- vom- elation; ede- tent month; yel- tended rtrng ma of feet be- lowish dis- above from a nd legs tween charge, at umbili- ation reg- 2d anemic ; no albumen hem- times gru- cus; firm ular. mo. orrha- mous. to the 30 David- son, Al- exan- der. Canada Pract.,To- ronto,1885, x, 161. Mrs. W. M. 45 Sev- eral ; young- est five Menstrua- tion regu- lar. Con- stant, severe nau- in urine. „ ga- slight. During last month con- stant wa- tery dis- touch. Tumor reached one inch aboveum- 31 Davis, c. w. Cin. Lancet- Clinic, Mrs. M. M. 23 years. 0 0 Good; men- struation sea. charge. Flow for last bilicus. Not stated. 1887, n s., xvin, 695, regular. erate in amount. Cystic Disease of the Chorion. History of Molar Birth— Continued. d o Puerperium. Month of Gestati .s ’cs Ph 6 bn ctf rG u O a & Result. Fifth. Third. Severe labor- pains. Severe flood- ing. Free. Expelled a mass filling a great bowl, resembling small grapes ; size of vesicles snot to large pea; vesicles filled with yellow viscid water ; pieces of membrane re- sembling placental tissue. I Expelled a basinful of cysts, blood1 clots, and chorionic membranes. Expelled under action of er- got. Manual extrac- tion. No. Slow, but contin- uous oozing of dark fluid. No. Slight for few days; celluli- tis one week af- ter birth. Recovery. Recovery slow, but good. Six and a half. Labor- like. Consider- able. Weight of mass four and a half pounds; vesicles clear, grape- like ; size, pin’s head to grape ; of pearly clearness ; mixed with coagula; piece of placental tis- sue four inches in diameter; no cord- Manual extrac- tion. Usual time. No. No. Good recovery. Fifth. Severe, labor- like. Some. Expelled large quantity of hy- datid cysts, partly enveloped in pieces of membrane resembling decidua. Expelled spon- taneously. Usual time. Slight. Recovery. Two and a half. Bearing- down. Terrific. Expelled a quart of currant-like cystic bodies. Expelled after passage of soundand use of ergot. Died of hemor- rhage at time of birth. Fourth. Labor- like. Consider- able. Expelled mass larger than full- sized placenta, followed by smaller mass and blood clots- Manual extrac- tion. Two weeks. Slight. Slight; lochia fetid. Rapid recov- ery Four and a half. Labor- like. Moder- ate. Expelled small mass containing considerable placental tissue. Manual extrac- tion. “ Slight. Gradual recov- ery. Seven and a half, Slight: labor- like. Severe. Two large masses of hydatids filling a chamber-pot; a half hour later another mass half filling the vessel; no fetus or placenta; some pieces of tough white membrane; vesicles trans- parent in clusters. Expelled spon- taneously. Usual time. No. No. Good recovery. Four and a half. Strong; labor- like. Profuse. Expelled large mass of vesicles; on second day removed piece ol decidua the size of an orange. Ergot and com- pression ol uterus above. Two weeks. Some. Slight; very of- fensive lochia. Good recovery Third. Labor- like. Consider- able. Expelled large mass of hydatids size of mass not given. ! Expelled spon- taneously. Usual time. [No. No. Good recovery Six and a half. Labor- like. Some. Expelled large mass of vesicles. Expelled spon- taneously. i Usual time. “ (1 Speedy recov ery. 14 W. A. Newman Borland and T. Perceval Cerson. History of the Pregnancy—Continued. Number. Reporter. Reference. Name. J Social State. o3 < Previous Pregnan- cies. Abortions. Previous Health. Gastric Symptoms. General Symptoms. Pain. Hemorrhage- AbdominalEnlarge- ment. 32 Davis, J. Hall. Tr. Ob.Soc., Lond.,1861, Vol.iix,i77- Mrs. X. M. 33 4 I, at 2d mos. Not stated. Severe flood- ing for last 3 weeks. Not stated. 33 Doering, E. J. Am.J.Obst., 1886, XIX, 512-515. Mrs. P. M. 21 1, fifteen mos. before. 0 Slender; general health good; in- strumen- tal labor; child ten pounds. None- None. Slight hemor- rhage atend of 2d mo., soon fol- lowed by profuse flow. Uterus size of four and a half months. 34 Dorland, W.A.N. Univ.Med. Mag., May, 1896. Mrs. D. C. M. 25 4, young- est 2% years. 1 Excellent ; menstru- ation reg- ular. Very weak; emaciated; anemic. Slight; col- icky dur- ing last few wks. Slight bleed- ing at the ninth week; persisting daily until birth of mole. Fundus of uterus reached up to the umbili- cus. 35 Dulac, L. Gaz.Heb- dom.,1884. Mrs. X. M. 18 years. 37 0 0 Good; men- struation regular. Daily nau- sea and vom- iting after three and a half mos. Edema of face and ankles; urineloaded with albu- men; head- ache ; dys- pepsia. Flooding commenced in 2d mo., and re- curred fre- quently. Not stated. 36 Dunn, W. A. Boston. M. and S. J., 1885, cxiii, 612. Mrs. M. M. None. Uterus size of full term. 37 Edis, A. W. British Med. Journ., 1871, H, 353- Miss C. T. S. 17 0 0 Good. Con- stant nau- sea and vom- iting after sim- ple food. None- First at months. Uterus one and a half inches above um- bilicus ; no move- ments nor heart- sounds : soft, doughy. 38 Edwards, Charles. Lancet, 1847, Vol. 1. Mrs. S. A. M. 42 7 1, I2yrs. be- fore. Bilioustem- perament; healthy; menstrua- tion regu- lar. Great ema- ciation ; paininscro- biculus cor- dis, and in bowels. Labor- like. Began at 3d month; a daily stilli- cidium of blackblood. Large size. 39 Fifield. Boston M. and S. J., 1857-8, LVII, 197. Mrs. B. M. G. M. 36 6 Occa- sional vom- |tinS- finally be- com- ing exces- sive. Began at 2j£ mos.; recur- ring almost daily; pro- fuse at third month. Uterus size of 5th mo. of gesta- tion. Cystic Disease of the Chorion. 15 History of Molar Birth—Continued. c o Puerperium. "S 8 o c3 bu d Description of Mole. Treatment. T3 V Sixth. Second. Labor- like, Labor- like. Consider- able. Consider- able. Expelled a fetus ; placenta entire and appearance healthy; subse- quently a mass of hydatids, about one and a half pints; ves- icles size of millet seed to a grape; fetus died in a few mo- ments. Entire mass about the size of a large orange; small vesicles. Manual extrac- tion. Tampon and ergot. Usual time. Fifteen days. No. Some. Slight; lochia offen- sive. Consider- able. Recovery good. Good recovery. Four and a half- Labor- like. Profuse. Mass of hydatids,'—over two quarts; no trace of a fetus ; one small piece of placental tissue, two inches by two inches , vesi- cles size from pin headto grape. Manual extrac- tion. Two weeks. No. Slight for two days ; lochia fetid. Good recovery. Fifth. Labor- like. Severe flood- ing. Expelled a mass of hydatids of considerable size, containing a small portion of placental tis- sue. Expelled spon- taneously. One month. Slight. Seventeen days after delivery had an eclamptic seizure with hemiplegia, but made a fair recovery. Sixth. Labor- like. Profuse. Expelled a large basinful of cysts. Manual extrac- tion. Usual time. “ No. Good recovery. Eighth. Labor- like. Consider- able. Expelled a mass of hydatids nearly filling an ordinary hand- basin. Manual extrac- tion. Three weeks. Good recovery. Four and a half. Labor- like. Consider- able. Expelled two quarts of hydatids without investing membrane or fetus. Expelled spon- taneously. Usual time. “ “ Good recovery. Fifth. Labor- like. Profuse. Expelled between two and three quarts of cysts. Tampon. Two weeks. Consider- able. (1 Good recovery. W. A. Newman Borland and T. Perceval Gerson. History of the Pregnancy.—Continued. fl CO 4> d a a £? bn X O O U a3 0 o3 u Ph CO > d Q o3 bo d Xi u u o s CD X U CD > X Result. Sixth. Labor- like. Consider- able. Expelled an immense mass of hydatids. Manual extrac- tion. Usual time. No- No. Good recovery. Sixth. Violent; Labor- like. Profuse. Expelled a gallon of transparent cysts; size of cysts, hempseed to walnut. Manual extrac- tion. Ten days. “ Good recovery. Four and a half. Labor- like. Flooding. Expelled one quart of hydatids ; three days later expelled three pints more ; and twelve days later a piece of decidua. Tent; sponta- neous expul- sion. Some. “ Good recovery. Third. Labor- like. Some. Expelled two quarts of cysts and a well-developed fetus of three months; cord normal. Spontaneous expulsion. U sual time. No. “ Good recovery. Fourth. Three and a half. Not given. Labor- like. Labor- like. Labor- like. Profuse. Consider- able. Some. Expelled immense mass (thou- sands of vesicles); no trace of fetus or placenta. Expelled a mass of hydatids, filling a dinner-plate ; large fragment of decidua. No description given. Manual extrac- tion. Spontaneous expulsion. Manual extrac- tion. Two weeks. Usual time. Fourteen days. “ Slight for 2 days; offensive lochia. No. Perfect recov- ery ; again pregnant in 4 months. Good recovery; 12 mos. later gave birth to living child, but died on 10th or nth day (cause un- known.) Good recovery. Two and a half. Labor- like. Consider- able. Expelled small mass of small transparent cysts. Manual extrac- tion. Usual time. “ “ Good recovery; 12 mos. later another child. Six and a half. Labor- like. Some. Expelled mass of hydatids ; also a fetus ; description not given. Spontaneous expulsion. Usual time. “ Some. Good recovery. Third. Labor- like. Profuse. Expelled six or seven pounds of cysts. Spontaneous expulsion. Three months. Died in 3 mos. of septic pel- vic abscess; uterine walls infiltrated with fungous growths. Term. Three and a half. Labor- like. Labor- like. Some. Child born after two hours’ labor, followed by three pints of hy- datids, which were attached to placenta as well as to uterus. Expelled a large quantity of hy- datids resembling bunches of grapes ; no trace of fetus. Spontaneous expulsion. Spontaneous expulsion. Usual time. Usual time. Slight. No. Moder- , ate. No. Good recovery. Good recovery. History of Molar Birth.—Continued. W. A. Newman Borland and T. Perceval Gerson. History of the Pregnancy.—Continued. I 1 g 1 c/5 CD d G B ! O 1 £ 0 H d ' 6 D U ft *13 CD tfl ft a ft a >> q3 5b G W ■M id in in x G «d X s G O ft v .2 u 0 X G .2 > aS a u O s Four and a half. Labor- like. Some. Description not given. Spontaneous expulsion. Usual time. No. No. Good recovery. Four and a half. Labor- like. Consider- able. Mass of cysts and coagula; vesi- cles size of grape and less ; no vestige of embryo. Spontaneous expulsion. Usual time. Slight. Good recovery. Fourth. Consider able. Terrific. Mass of cysts weighed between two and three pounds; vesicles white ; in size from small cherry to large plum; contained a watery fluid. Manual extrac- tion. Five weeks. Consider- able at inter- vals for i mo. Fetid lochia. Retarded recov- ery. Three and a half. Severe. Consider- able. Mass of hydatids size of pin’s head to grape, of a beautiful pink color: size of mass, one and a half fetal head. Spontaneous expulsion. Usual time. No. No. Good recovery. Two and a half. Severe; labor- like. Some. Vesicular masses nearly filled half a wash-basin ; size of vesicles, currant a few larger. Spontaneous expulsion. Usual time. “ Good recovery Sixth. Labor- like. “ Weight of hydatids about four pounds; size of cysts, pin’s head to hazel-nut. Spontaneous expulsion. Usual time. “ Slight fetid lochia. Good recovery. Eight and a half. Sixth. Labor- like. Weight of hydatids six or seven pounds : size of cysts, mustard seed to large filbert. Mass of hydatids filled an ordi- nary bucket. Spontaneous expulsion. Manual extrac- Few weeks. “ Slight. Gradual but complete re- covery. Gradual recov- ery. like. able. tion. Fourth. Violent; labor- like. Some. Large quantity of vesicles min- gled with coagula and shreds of membranes and placental tis- sue ; size of vesicles, currants ; mass expelled, size of two fists. Tampon: ergot; spontaneous expulsion. No. Slow recovery. Third. Labor- like. “ Large quantity of cysts. Tampon; man- ual extrac- tion. Slight. Slow recovery. 22 IV. A. Newman Borland and T. Perceval Gerson History of the Pregnancy.—Continued. .«? SP SP ?P S 3 3. S 2 2 2 1 Number. Murphy, P. J. Oliver, James. Parish, W. H. Phillips, John. Poole. Ibid. Putnam. Rooker, Jas. I. Routh. Sackett, S. P. Schiitz. Shattuck, Geo. B. Reporter. Obst. Gaz., Cincin., 1880- in, 114- 116 Lancet, Sep. 21,1889, p. 592. Trans. Ob. Soc., Phil- adelphia, Trans. Ob. Soc., Lon- don, Vol. XXXII, 1890,p. 63 Dublin J. Med. Sc., 1881, 3 s., LXXI, 423- 426. Ibid. Am Journ. Med. Soc , 1850, n. s., xx, 37. Boston M. and S. J., 1868-69, LXXIX, 2l6. Lancet,i860, 1, 597 Obst. Gaz., Cincin., 1881- IV, 174-76. Zeitschr. f. Wunds- artzu Ge- burtsh. Boston M. 1 and S. J., 1888, CXIX, 10. Reference. Mrs. L.N., col- ored. Mrs. A. T. Mrs C. Mrs. X. Mrs. X. Mrs. X. Mrs X. Mrs. W. Mrs. B. Mrs. B. W. Miss S. C. Name g g S S ' g 8 ■ s»' Social State. $ £ £ ! -3unoA 8, “ m 0 2 S Age. in in OOSOMO 2 OJ OJ 2 OJ p p “to Previous Pregnan- cies. 00000*0 0 • 00 Abortions. Never strong; puberty at 18. Puberty at 14; men- ses always lasted 7 days. Generally poor. Poor. Good. Menstrua- tion regu- lar. Always good; men- struation regular. Good. Previous Health. Con- stant nau- sea and vom- iting. Nausea and vom- iting. — Con- stant nau- sea and vom- iting. Irrita- ble stom- ach. Nausea and 1 vom- iting. Nausea and vom- iting. Nausea and vom- iting for 6 w’ks. Gastric Symptoms. Edema ot feet; ane- mia. Edema of legs; ane- mic. Exhaustion ; bedridden. Edema of feet and legs and hands; no albumen in urine. Extreme de- bility ; in bed 1 mo. Emaciated. Anemic, Exhaustion; faintness ; emaciation. None. General Symptoms. Col- icky. None. None. I Some. Slight. None. Pain. Severe at ir- regular in- tervals after 2d month; profuse at 6th month. More or less daily for n weeks. Slight. Incessant flooding for 3 weeks. Commenced at fifteenth week. Commenced at 4th mo.; at first cof- fee-grounds, later free blood. Began at mid- dle of 4th mo ; slight , at first, gradually increasing. Constant. Began at 4th mo.; slight in amount. Profuse. Slight in Sth week. Hemorrhage Rapid; at 2d mo. size of 6th mo. of gestation. T umor reached one inch above umbili- cus. T umor reached above umbili- cus ; bi- lobed with verti- cal me- dian fur- row ; reg- ular uter- ine con- tractions. Uterus two inches above umbili- cus : no fetal heart- sounds. At 4th mo. tumor equal to 6th mo. of gestation; resisting. Rapid and consider- able. 1 Consider- able. ; Gradual. j Consider- i able. Consider- able. Consider- able. Tumor reached umbili- cus ; no bruit. AbdominalEnlarge- ment. Cystic Disease of the Chorion. 23 History of Molar Birth.—Continued. c o Puerperium. "rt Result. Sixth. Consider- able. Profuse- Large mass of hydatids ; two and three-fifths pounds: vesicles size of pin’s head to grape. Ergot; sponta- neous expul- sion. No. Slight for 3, to 4 days. Good recovery. Four and a half. Some. Consider- able. Weight of mass, two pounds. Spontaneous expulsion. Usual time. (( No. Good recovery. Three and a half. None. Slight. Mass removed size of fetal head at term ; no placenta ; no fetus. Manual extrac- tion. Some. Slow recovery Fourth. Labor- like. Some. Large mass of vesicles ; no trace of fetus. Manual extrac- tion. Usual time. No. “ Recovery. Fourth. Labor- like. Slight. Expelled three pints of vesicles, resembling boiled sago, mixed with clotted blood; no decidua. Spontaneous expulsion. Two weeks. “ > Good recovery. Fourth. Labor- like. Some. Mass of cysts: vesicles quite large, some size of plum; shreds of decidua. Spontaneous expulsion. Two weeks. “ “ Good recovery. Four and a half- Labor- like. “ Mass more than filled a half-pint bowl; size of vesicles, pin’s head to half an inch in diameter; no fetus; but decidua distinct. Spontaneous expulsion. Some. “ Slow but good recovery. Five and a half. Labor- like. Profuse. Mass weighed about five pounds ; vesicles size of pin’s head to large grape. Manual extrac- tion. Usual time. No. “ Slow but good recovery. Two and a half. Labor- like. Consider- able. Large number of cysts, pinkish in color, and containing an albuminous fluid, of acid reac- tion. Spontaneous expulsion. Usual time. “ Good recovery. Four and a half. Labor- like. Free. Considerable quantity of vesicles. Manual extrac- tion. Two weeks. Slight. Slow but steady recovery. Five and a half. Labor- like. Some. No description given. Spontaneous expulsion. Three weeks. “ No. Good recovery. Three and a half. Labor- like. Slight. Mass filled one-third of a pail; cysts and clots. Manual extrac- tion. Usual time. “ “ Good recovery. 24 W. A. Newman Borland and T. Perceval Gerson. History of the Pregnancy.—Continued. 0 g CO a 4) fciD bp 0) u Oh jd 6 O U 4) 6 73 o; k a a in a a in 4) bO d Xi C W 73 a 4) 6 si U O Oh Result. Fifth. Labor- like. Slight. Chamberful of “bladdery, sea- weedy’’ material; vesicles size of pea to hazel-nut; no fetus ; three years before had dis- charged the same. Spontaneous expulsion. Usual time. No. No. Good recovery. Fourth. Severe. Profuse. About a quart of cysts, size of currants and grapes. Manual extrac- tion. Usual time. Good recovery. Three and a half. “ “ Half a gallon of cystic bodies. Manual extrac- tion. Usual time. “ “ Good recovery. Third. Labor- like. Some. Mass of hydatids, size not given ; no embryo. Spontaneous expulsion. Usual time. Good recovery. Not given. Labor- like. “ Weight of mass of hydatids, three and three-quarters pounds. Spontaneous expulsion. Usual time. “ “ Rapid recov- ery. Four and half. Labor- lit e. Consider- able. Large basinful of cysts ; no fetus. Spontaneous expulsion. Usual time. * * Good recovery. Third. Labor- like. Some. Two quarts of vesicles. Manual extrac- tion. Five months. Free. Consider- able. Tedious conva- lescence, but good recov- ery. Fourth. Labor- like. Consider- able. Three quarts of cysts and clots. Ergot; sponta- neous expul- sion. No. Some. Slow recovery. Five and a half. Labor- like. Moder- ate. Mass of cysts; no trace of fetus or placenta. Spontaneous expulsion. Yes. Died six weeks after delivery, of sepsis. Five and a half. Labor- like. Moder- ate. Mass of cysts ; about one-eighth of normal placenta remained. Spontaneous expulsion. Usual time. Slight. No. Good recovery. Five and a half. Labor- like. Some. Mass of cysts. Spontaneous expulsion. Usual time. No. Good recovery. Third. Labor- like. Four or five quarts of hydatids expelled. Spontaneous expulsion. Usual time. “ “ Good recovery. Fourth. Consider- able. Profuse flood- ing. Chamber-pot two-thirds full; size of cysts from large shot to inch in diameter; no fetus or pla- centa. Manual extrac- tion. Usual time. “ “ Good recovery. Three and a half. Labor- like. Consider- able. Large mass found after death in uterine cavity ; mass of cysts expelled. Spontaneous expulsion. Died of uterine rupture; masses of cysts embed- ded in wall. Sixth. Labor- like. Profuse. Great mass of hydatids and clots. Spontaneous expulsion. Died of uterine rupture; ragged ulcer size of shilling in upper ante- rior wall. 26 W. A. Newman Borland and T. Perceval Gerson. History of the Pregnancy.—Concluded. 99 100 Number. Wood- man, W. B. Ibid. Reporter. Trans. Ob. Soc., Lon- don, 1S65. Ibid. Reference. Miss E. II. Mrs. M.K. Name. l/l Social State. CO K) ON Age. 0 Previous Pregnan- cies. M O Abortions. Previous Health. Gastric Symptoms. General ana- sarca ; pul- monary edema: urine scan- ty ; enor- mous am’t of albumen; few casts. General ana- sarca; urine scanty, al buminous ; no casts. General Symptoms. Pain. Constant flowing from \Vi months. Some for last week. Hemorrhage. Size of tu- mor equal to seventh month of gestation. Enormous- A bdominal Enlarge- ment. Cystic Disease of the Chorion 27 History of Molar Birth.—Concluded. Month of Gestation. Pain. Hemorrhage. Description of Mole. Treatment. Days in Bed. 1 hj JERPERIU 6 bo Ut u O 6 0 X g Fever. Result. Flooding. Yes. and a like. datids ; size of vesicles, pin’s expulsion. day, of sepsis. half. head to grape. Six and a Labor- Profuse. Two to three pounds of hydatids; Spontaneous Usual No. No. Good recovery. half. like. size of vesicles, pin’s head to expulsion. time. gooseberry; some degenerated spongy placental tissue.