LABORATORY NOTES 
The Wm. S. Merrell Chemkal Co. 
Manufacturing Chemists 
CINCINNATI. 
HYDRASTIS 
AND ITS 
PREPARATIONS- Special Preparations 
FOR 
PHYSICIANS’ PRESCRIPTIONS. 
Nutritive Tonies. 
Syrup Hypophosphites, with Quinine, Strychnine and Manganese* 
“ “ (Churchill’s Formula) 
“ “ Compound. 
Adjuvants. 
Aromatic Elixir Licorice. 
“ Yerba Santa. 
Tonic Astringent and Restorative. 
Alkaline Elixir Rhubarb Co., with Pancreatine. 
Antiseptics. 
Salicylic Acid, from Oil Wintergreen. 
Boro-Glyceride, 50 per cent, solution. 
Emmenagogue, etc. 
Helonias Cordial. 
Expectorant. 
Elix. Pinus Compositus 
se«d for Descriptive Circulars Relative to the above Preparations. Hydrastisand its Preparations. 
The literature of this drug is so extended that we do not consider 
any thing will be gained by entering into its history at this time. 
Hydrastis has been in use for more than fifty years ; and its reputa- 
tion has been steadily growing from the time of its first introduction to 
medical practice in the form of an infusion, to the present, when the 
advantages of perfected preparations give to the physician of the present 
day an insight into the value of all its active principles, either alone or in 
combination. 
The most prejudiced writers on materia medica accord to the late Wm. 
S. Merrell the largest share of credit for the introduction of hydrastis 
preparations; and to the present organization the reputation of being the 
largest consumers of the drug in the world. Availing ourselves of our 
own widely extended experience and that of others interested in the de- 
velopment of our vegetable materia medica, we have made this drug a 
study in our laboratory to an extent not approached by the efforts of all 
other manufacturing houses combined. 
During this introductory period we have seen the forms of adminis- 
tration change from the simple infusion of earlier years, through the sev- 
eral improvements involved in the preparations of Concentrated Tinctures, 
Essential Tinctures, Fluid Extracts, the dry and powdered Solid Extracts, 
Resinoids, (assumed to be proximate principles,) the combined white and 
yellow alkaloids in crude and unpurified form, the several salts of the 
yellow alkaloid (Berberina) and of the white alkaloid, (Hydrastia,) until 
we now present to the medical profession the most perfect representatives 
of the drug, adapted as well for use in pill or powdered form, as in the case of the crystaiLzed Sulphate of Hydrastia, (Berberina.) or in the fluid 
form, as represented by those perfect examples of pharmaceutical skill— 
the Fluid Hydrastis; Solution Bismuth and Hydrastia; and Colorless 
Hydrastis. 
SULPHATE HYDRASTIA. 
[SULPH ATE HER IS ERIN A. ] 
other salts of the hydrastis on account of its purity and greater solubility. 
We present it in the form of flaky crystals, free from excess of acid, and 
This is the sulphate of the yellow alkaloid; and is preferable to the 
absolutely pure. 
Approximate solubility in cold water, 1-2 grain to i oz, 
“ “ “ hot “ - - - 13 “ “1 “ 
Administered in powder combined with sugar of milk; or in solution ; 
“ “ alcohol ..... 3-4 “ “1 “ 
the latter is preferable. Dose, %to grain. 
SPECIAL APPLICATION. 
In gonorrhoea, after the acute stage has passed ; and in gleet, kis one 
of the most valuable remedies known. Its use, in the latter especially, is 
attended with excellent results. The following prescription of one of our 
most eminent physicians (see Prof. Bartholow’s late work on Materia 
Medica and Therapeutics) is highly recommended; its use being followed 
with marked success : 
Hydrastia sulph,—pure. - gr. xA 
Mucil— Acacia, - - - - oz. ij. VMix. Use y% oz. as an injection. 
Rose Water, .... - oz. iv.j 
Rose Water, 
It is of especial value in the treatment of chronic derangement of the 
liver; exercising a direct influence over the hepatic structure generally. 
Constipation, dependent on deficient secretion, where the stools are 
hard and dry, may be overcome by this remedy, administered in small 
doses. Its operation is greatly enhanced by combination with Podophyl- 
lin ; and for this purpose the following formula has been highly 
recommended : 
Hydrastia sulph.—pure, -------- M grain. 
Podophyllin, . - 1-20 grain. 
In stomatitis of children; in simple ulcerations of the mucous mem- byane; in mercurial sore month and that ot nursing children it is a 
favorite remedy. Add one grain to two ounces of water arid apply every 
three or four hours. 
In catarrhal affections of the bladder, given in small and oft-repeated 
doses, it diminishes the mucus. 
In chronic Bright's disease, the excretion of albumen is lessened 
by its use. 
Valuable as a collyrium in chronic conjunctivitis; also in the latter 
stage of the acute. 
Esteemed of great value in treatment of dyspepsia; chronic affections 
of the mucous coats of the stomach; and in chronic inflammation of the 
stomach. In indigestion and general debilily arising from a languid state 
of the, stomach, it acts as a general restorative. It may also be employed 
in those cases of ■ chronic -gastritis and chronic irritation of the stomach 
with altered secretion which constitute the worst and most persistent 
forms of dyspepsia. In acid indigestion, this remedy, triturated with 
calcined magnesia, or prepared charcoal, will be found of great value, 
especially when attended by a torpid condition of the bowels. 
Recommended in nasal catarrh; catarrh of the stomach; and in all 
mucous diseases. 
UIUV.UUO uiovtmeo. 
Hydrastia has attained considerable reputation in the treatment ot 
intermittent fever, fever and ague; and other periodic affections, employed 
alone or with other tonics. 
FLUID HYDRASTIS 
Is what its name implies—the active, medicinal principles of the drug 
in natural combination and in a fluid form. It has a bright, yellow color; 
perfectly clear; free from sediment; and with an unmistakable odor of the 
fresh drug. 
Fluid Hydrastis is a pure, neutral solution of all the alkaloidal constit- 
uents of the drug; rejectingthe oil, gums, irritating and offensive resins ; 
and inert extractive matters. The success attending its introduction is the 
best evidence of its therapeutic value. 
Unsuccessful imitations and would-be substitutes are met with on c\ ciy 
hand. Preparations said to be “just as good, or “about the same 
thing,” but always " a little cheaper; ” attest the wide spread and growing 
popularity of Fluid Hydrastis. Ml such, compared with the latter as to physical appearance or as representatives of the drug, are condemned; 
when dispensed in prescriptions they are readily detected; tested thera- 
peutically, they are promptly rejected as unworthy of confidence. 
Fluid Hydrastis is applicable to the treatment of all irritable, inflam- 
matory and ulcerative conditions of the mucous tract. 
This statement of a well-known medical writer and journalist has be- 
come axiomatic : 
u Xo remedy for physicians’ use has been received with such universal approval." 
SUGGESTIONS FOR USE. 
In general, it is indicated in all affections of the mucous surfaces; cor- 
recting abnormal conditions characterized by profuse discharge of 
tenacious mucus, sub-acute inflammation, erosions and superficial 
ulcerations■ ' 
Leucorrhea, 
by injection, i to 4 drs. to one pint of water, 3 or 4 times per day. 
Ulceration of the Cervix-Uteri and Vagina, 
with thick albuminous discharge like the white of an egg—use locally 
with tenacious discharge—place in contact with the inflamed surfaces 
cotton saturated with Fluid Hydrastis, 2 to 4 drs. to glycerine 4 oz. 
Stomatitis, 
pseudo-membranous, ulcerative, or gangrenous, when the inflamma- 
tion is sub-acute or characterized by profuse secretion of ropy 
mucus—use as a gargle or wash in proportion of 1 to 2 drs. to water 
4 ounces. When the breath is offensive, pot. chlorate or baptisia 
assists its action. 
Gonorrhea, 
as an injection; and in balanitis, as a wash : use Ito 2 drs. to water 
4 oz. 
Nephritis, 
acute and chronic, when mucus is found in die urine—use internally, 
Ito 4 drs. in water 4 ounces. Teaspoonfu! three or four times per 
day, as adjunct to other treatment. Cystitis, 
acute or chronic, when the urine is pale or greenish, and vtscia irom 
abundance of mucus—use internally ito 4 drs. m water 4 ounces. 
In the severer cases of chronic cystitis with phosphatic urine, rinsing 
out the bladder with tepid water, and following with Fluid Hydrastis 
1 to 2 drs. to water 4 ounces, one ounce to be used as an injection 
into the bladder, is often of great benefit. 
Dyspepsia, 
with undue activity of the mucous glands and deficient action of the 
o-astric follicles, of which the symptons are a heavily loaded tongue, 
especially at the base, and in the morning dull aching pains m the 
stomach, with sinking sensations, nausea and occasional vomiting of 
vitiated mucus, use half to one ounce Fluid Hydrastis to a pint o 
sherry or native wine. Dessert spoonful three or four times a day. 
Concurrent Testimony. 
In the Lancet, November 7, 1885, Mr. Auld directs attention to the 
value of Hydrastis in small doses in certain forms of dyspepsia. 
Given in drop doses three or four times daily, between meals, is the 
mode of administration he would recommend. Larger doses often 
produce aggravation of the symptoms and diarrhoea. In Ins expei 1 
ence there are three kinds of dyspepsia to which it is applicable. 
The first is the dyspepsia of females, characterized mainly by pain 
and sinking at the epigastrium, nausea, and constipation; and asso- 
ciated with general debility, nervousness, wandering pains and 
possible leucorrhea. The subjects of this variety are often intolerant 
of large doses of bismuth and other orthodox remedies; but, unless 
marked anemia exists, they will speedily regain health and strengt 1 
under the influence of hydrastis, which acts like a specific. The 
second form of dyspepsia which is often greatly relieved by this 
drug is that associated with certain constitutional diseases, pailicu- 
larly phthisis and malignant disease. Lastly, it is of signal benefit 
in the dyspepsia resulting from the abuse of drugs and alcoholic 
Constipation, 
either simple or of hepatic origin—in doses for an adult of gtt. 10 to 
gtt. 40, three times a day. In infantile constipation 1 to 2 1 °PS 
twice daily. 
stimulants. Bronehorrhea or Cough, 
with expectoration of yellow tenacious mucus. 
Opthalmi Tarsi, Conjunctivitis, 
and other diseases of the eye, in which occur mucus or muco- 
nurulent discharges—locally gtt. 10 to gtt. 15 in distilled or soft water 
4 ounces. 
tntermittents, 
especially of the type characterized by disease of 
mucous membrane, with nausea, heavily coated tongue, broad and 
flabby and pale, or coated with yellow, dirty mucus ; bowels consti- 
pated, or when moved, evacuations clay colored or streaked with 
mucus, use 1 to 4 drs. to water 4 ounces. Teaspoonful every three 
or four hours. 
Painful Menstruation. 
In one of the recent numbers of the Archiv. fur Gynnkologie, Prof. 
Schatz calls the attention of his colleagues to the value of hydrastis 
in many cases of painful menstruation, which hitherto have been sup- 
posed to need operative interference. The hydrastis contracts the 
vessels and lessens the genital congestion. Often by its use the pain 
attending the menstrual epoch is diminished or wholly removed. 
Catarrh of the Intestines, 
and superficial ulceration of same; in fistula-in-ano; hemorrhage 
from the rectum. Internally and locally by injection, 1 to 4 drs. to 
water 4 oz. 
A Local Application 
to present decomposition; applied to the surface of cancerous 
growths and unhealthy ulcers and sores ; as an injection into the bow- 
els in diarrhea and dysentery; and to correct the offensive character 
of many mucous discharges. 
Many Chronic Diseases, 
in which exist undue activity of the mucous membranes in some 
portion of the body, this remedy is of marked benefit as a gene*** 
tonic. Formulae for Fluid Hydrastis Combinations. 
Wine Hydrastis : 
Fluid Hydrastis, 1 fl: ounce ; Sherry wine, 15 fl ounces. Mix. 
Tincture Hydrastis: 
Fluid Hydrastis, 2 fl. ounces; Diluted alcohol. 14 fl. ounces. Mix 
Syrup Hydrastis : 
Fluid Hydrastis, 2 fl. ounces; Simple syrup, 14 fl; ounces. Mix 
Glyeerole Hydrastis: 
A valuable application to unhealthy ulcers, old sores, etc. 
Fluid Hydrastis, 1 fl. ounce; Glycerine, 2 fl. ounces; Aqua distil, 
13 fl. ounces. Mix. 
Note.—For internal use, doses of either the above preparations, one 
dessert spoonful three or four times a day. 
Gonorrhoea Injection: 
Fluid Hydrastis, 1 to 2 drachms; Aqua distil, 4 ounces. Mix, 
Sig. Inject one drachm night and morning. 
Medical Testimonials. 
r Those at ail familiar with the salability of Fluid Hydrastis and the uni- 
versal approval with which it has been received by the Medical Profession 
readily appreciate the extent to which we could accumulate evidence in 
proof of its value. Never before in the history of any agent has so much 
attention been given to the discussion of tlm several principles character- 
istic of the drug; in these controversies we naturally accumulate a mass 
of evidence confirming the strength of our position—that in the Fluid 
Hydrastis we have the most perfect representative of the drug in fluid 
form that has ever been offered to the profession. 
M e do not present such evidence at this time, believing that a liberal 
uibv.uSiion will bring about close study and active investigation on the 
part of progressive physicians; and that to present a mass of "exparte” 
statements would be a reflection upon their intelligence and discrimination, 
The following from one of the most prominent physicians in New 
York City, and a Professor in the Post Graduate School, outlines the sen- timent which seems to be uppermost in the minds of the better class d 
physicians who are called upon to give testimonials in favor of any medi- 
cal preparation, however valuable. 
“The sample of Fluid Hydrastis left with me by your agent has more 
than met his representations; and my success attending its use has been 
most gratifying. It is, without exception, the most remarkable astringent I 
have ever used in diseases of the Nose and Throat; and in Urethral affec- 
tions it has proven very successful in every case that I have administered it 
either alone or in combination. 
“I write this, though a stranger, at your methods and c’aims have made 
me your friend; snd so far as I can extend the sale of your preparations 
through the conferences of our local Society, I am at your command; for I 
believe the practice of medicine will be elevated by the use of remedies of 
such substantial value. I have long since taken a stand aga nst medica1 tes- 
timonials for publication, and I must request that you refrain from quoting 
me by name; but my professional connection will enable me to mention the 
preparation favorably to a large number of physicians, and thus demonstrate 
the sincerity of my statements.” 
Solution Bismuth and Hy d rast i a . 
This is a combination the value of which has only begun to be appre- 
ciated by the Medical Profession. 
The value of Bismuth is too well known to justify review in this place; 
but in the form in which it has been largely used the same effect is not 
produced as when the officinal preparations are prescribed. 
The objection to the various Salts of Bismuth is in their insolubility, as 
may be readily detected in the faeces after a course of these preparations 
has been given. 
Bismuth possesses characteristics analogous to the Alkaloids of the 
Hydrastis Canadensis, in the respect that it aliays the irritability of the 
mucous membrane; and herein we have opened a wide tange tor exhibi- 
ting the action of the two agents when scientifically combined. 
Without exception, the Solution Bismuth and Hydrastia is one of the 
most valuable and comprehensive combinations before the profession; and 
the beneficial action of the white alkaloid Hydrastia is largely increased 
by association with Bismuth; but unlike competing articles under similar 
names, it is not a mechanical mixture of the two elements, but a pure neu- 
tral solution of the double Salt Citrate Bismuth and Hydrastia, in perfect combination; so much so indeed, that the presence of cither element can 
not be detected by the ordinary tests for the same. 
Each fluid drachm contains grains of the double Salt, 25 per cent, 
of which is Hydrastia Citrate. 
Used in diseases of the nasal passages, of the eye, of the throat, of the 
stomach, of the intestines, of the re-productive organs and the bladder 
it is equally beneficial; recommended in cases of acute indigestion, pain- 
ful digestion with a tendency to diarrhea; in sub-acute and cmonic gas- 
tritis; in gastralgia arising from a state of irritation of tne gastric mucous 
membrane. 
As an injection or topical application, use one part solution to four parts 
water. 
This preparation is rapidly coming into use as a local remedy in the 
treatment of leucorrhoea, gonorrhoea, and as a spray in opthalmia and ca- 
tarrhal inflammation; also, for gastro-intestinal troubles of teething children. 
Colorless Hydrastis. 
The white alkaloid hydrastia exists in the Golden Seal root in propor- 
tions varying from 1-4 to 1 1-2 per cent., according to the quality of the 
drug manipulated. 
The alkaloid is unofficinal; and when pure is obtained in white, shining 
prismatic crystals—soluble in alcohol, ether, chloroform; and insoluble in 
water. 
The most competent writers on Materia Medica ascribe the medicinal 
value of the crude drug to the combined action of the associated alkaloids; 
and though both of the leading constituents have been isolated by manu- 
facturers for many years, the insolubility of the white principle has tended 
to lessen its use and reduce its commercial importance to a nominal value 
only. 
In the manufacture of the Sulphate of Berberina, commercially known 
as Sulphate Hydrastia, there has always been produced in the Men ell 
Laboratory a large quantity of the white alkaloid as a bi-product; and to 
physicians and pharmacists as well, the white crystals of hydrastia have 
hitherto been viewed almost in the light of a curiosity; and until the ex- 
hibits at pharmaceutical and medical meetings during the past eight years, 
of samples of this preparation, the supposition with many had that 
it only existed in quantity in the imagination of too zealous manufacturers. At the meetings of the American Medical Association at St. Paul. 
Cleveland, Washington, New Orleans; at the State Pharmaceutical meet- 
ings in Wisconsin, Illinois, Michigan, Minnesota and other States, the 
Wm. S. M. Chemical Co. exhibited in one jar, a mass of crystals fropa 
5,000 pounds of crude root; the small aggregate yield from which seeming 
to confirm the justice of the high price at which it is sold. 
The solution of Bismuth and Hydrastia of this manufacturer was intro- 
duced nearly ten years ago, for the purpose of bringing the white alkaloid 
to the notice of the profession by a combination through which its pecul- 
iar advantages would be indicated. 
We are still of the opinion that a simple solution of the alkaloids other 
than the yellow or Berberina, will fail to meet the expectations which have 
been raised through highly colored testimonials written in the interest of 
those who are financially benefited. 
The one only advantage which is recognized for this preparation is, 
that it does not leave the objectionable color when used as a topical appli- 
cation. But as all physicians do not depend upon the treatment of private 
diseases for a living, and as preparations of Hydrastis have a much wider 
range of application than this, we consider the objection superficial in the 
extreme. 
. As one of the chief advantages of the drug itself consists in its well 
known tonic properties, we do not consider that the objection to its bitter- 
ness is well founded. Some years ago, an alleged “sweet” quinine was 
claimed to have been discovered; but the history of the drug trade proves 
that the fallacy did not take deep root. Pleasant and sightly remedies are 
very desirable, but medicinal quality and therapeutic efficacy should never 
be sacrificed to physical appearance alone. In the introduction of any 
preparation for physicians’ use, there must be a proper deference paid to 
the therapeutics of reason; the rational administration of any remedy con- 
sists in its use because we know tire pathological conditions which exist in 
the disease; and know also that the pharmacological action of the drug is 
such as to render it apparent that it will remove or counteract these con- 
ditions. 
The literature respecting the white alkaloid is naturally limited, but in 
all that has been written we fail to find evidence to justify the extravagant 
statements made as to its action. 
It is our policy and privilege to prepare for physicians’ use every 
remedy for which there is a demand; and the Colorless Hydrastis we of- fer to the profession as a representative of the white principle of the drug 
possesses all the qualities possible to be obtained through a thorough 
knowledge of its characteristics and ah experience in its manipulation 
equalled by none. 
We present it, therefore, on its merits; and to those who believe or may 
be led to believe that in the white alkaloid they have the true principle of 
the drug, we commend it, and solicit their business. 
In the serial called “Drugs and Medicines of North America ” we have 
a strenuous but labored effort to laud the virtues of the white alkaloid to 
the exclusion of all the other principles with which it is associated. 
We are willing to rest the claims which we make for our Fluid Hy- 
drastis and other preparations combining the associated principles, upon 
the statements made by those writers whose opinions are introduced in 
this serial to sustain the purposes which are apparent to all familiar with 
the situation. 
As we have intimated, the white alkaloid has had little commercial 
value practically, but has been accumulated as a bi-product in the labora- 
tories of all those who manipulate the drug to any extent; as a conse- 
quence there was accumulated and destroyed in the “Merrell Laborato- 
ry,” at the fire in December, ’B5, more than 125 pounds of the pure crys- 
tals; an amount so large indeed that our smaller competitors could not 
realize that such a quantity could be in existence. 
Wre have referred to the evidence advocating the use of this alkaloid, 
but there is not the slightest ground for the assertions made as to its su- 
periority to the alkaloids in combination. 
Professor Bartholow, of Philadelphia, says: 
“As the actions of Hydrastis consist of the effects of its active constitu- 
ents, it is necessary to know how far each contributes to the results; it was 
soon ascertained that the alkaloid Hydrasline is the true active principle, for 
the very characteristics of this were simply repeated by sufficient doses of 
the Fluid Extract; the latter is, as might be expected, slower in action, but 
in respect to the manner of action there was between them no appreciable 
difference. 
Three grains of Hydrochlorate caused the death ot a frog in four min- 
utes, while forty minims of the Fluid Extract proved fatal in ten minutes; 
the mode and action of the character being the same; the results in rabbits 
were corresponding. 
In general terms the effects of Hydrastis are those of Hydrastine, (white 
alkaloid) in both classes of animals, but minute differences may hereafter 
be detected on closer examination.” COMMENTS. 
We recognize the value of such authority as Professor Bartholow, Twit 
we are not alone in our objections to his hastily drawn conclusions. 
Hydrastis yields from two to three per cent, of the yellow alkaloid and 
% to i x/z per cent, of the white', and the assumption that the latter is the 
true active principle solely, because it produces effects analogous to the 
Fluid Extract in large doses, is not well taken. The quantity of the alka- 
loid used is much larger in proportion than could be produced from forty 
minims or grains of the Fluid Extract of the drug, however well manipu- 
lated. 
Furthermore, we think it will not be denied that the special action of 
any isolated principle given in a dose proportionate to its existence in the 
drug from which it was obtained, will be more powerful than a prepara- 
tion from the drug itself; and especially so in one so imperfect as tho of- 
ficinal Fluid Extract of Hydrastis. 
We are especially interested, however, in this writer’s very exhaustive 
review of the uses of Hydrastis, for our position is confirmed thereby to an 
extent hardly expected in a communication written for a Journal of its 
semi-advertising character. 
Professor Bartholow makes the following statement which confirms the 
position of the Merrell Company; for their Fluid Hydrastis is of the same 
medicinal strength as the Fluid Extract, devoid of the offensive and irri- 
table resin, acrid oil, etc., characteristic of the officinal preparation. 
“As the Fluid Extract contains all the constituents of Hydrastis it is the 
most concentrated form available for administration; and therefore will be 
the best preparation for procuring the effects of the remedy as a whole—- 
whether given by the stomach or applied externally. 
Other writers speak in the same terms of the relative value of the 
white alkaloid in solution and preparations containing the combined ac- 
tive constituents of the drug; and the conclusions drawn in every case 
warrant the assertion that aside from the objectionable staining qualities 
of the latter, there exists no ground whatever for the assertions made in 
respect to this candidate for favor of the medical profession. 
The general statement that the Colorless Plydrastis may be used in all 
cases and in the same manner as the officinal Fluid Extract, or the im- 
proved form, as illustrated in the well known Fluid Hydrastis of the 
“Merrell Laboratory,” is, we think, unwarranted; and experience has al- 
ready demonstrated that it is overdrawn. The same effects cannot be produced without the use of the Colorless 
Solution in much larger proportionate closes; and this claim is maintained 
regardless of the manufacturer or the name under which it is sold. 
THERAPEUTICS. 
To further emphasize our statement relative to the value of the white 
alkaloid in solution, we would call attention to the absence of sufficient 
data to determine its range of action. 
Professors Bartholow, Hale, Scudder, King and Sattler, so far as they 
touch the cjuestion, practically coincide in the assertion that until the lethal 
dose of Hydrastia (white alkaloid) is determined, the power of its physi- 
ological relations cannot he established with any degree of accuracy. Of 
what value, therefore, are the “alleged testimonials” from unknown prac- 
titioners with which the profession is flooded ? 
It is, however, reasonable to assume that the white alkaloid shares 
•with its associated constituents a measure of influence which a representa- 
tive preparation of the drug would exert; hence, we outline in general the 
class of diseases to which it may be applied. 
Internally. 
In Gastro-intestinal Disorders—when the stomach is in a condition of 
debility; in atonic Dyspepsia and in convalesence from acute disease. 
Dose 13 to 30 drops in water 
Catarrh of the Stomach, accompanied with fermentative changes in 
certain foods. Dose 20 to 40 drops. 
Jn Malarial Troubles, the action of the solution will not be found sat- 
isfactory unless associated with quinine in full doses. 
In Diarrhea and Dysentery, it may be used to advantage in doses of 5 
to 20 drops in water, either alone or combined with other agents. 
In Diarrhea of Children, it is of unquestioned value, especially when 
combined with Bismuth. In such cases, however, we recommend the So- 
lution Bismuth and Hydrastia. 
Local Application. In Gonorrhoea, vaginal or uterine, leucorrhea, 
stomatitis, nasal catarrh, ulceration of the coat of the bladder, chronic 
pharyngitis and laryngitis, Colorless Hydrastis may be used either alone 
or in combination with distilled Witch Hazel, Pinus Canadensis, etc. Approved Preparations of- Golden Seal 
Liquid. 
Fluid Hydrastis. 
Sol. Bismuth and Hydrastia. 
Colorless Hydrastis. 
Powder. 
Sulphate Hydrastia, in Crystals (Berberina). 
Muriate Hydrastia, (Berberina). 
Hydrastrine—principles combined. 
Hydrastia, White Alkaloid. 
Hydrastia, Hydro-chlorate. 
Pill. 
Podophyllin and Hydrastia. 
Hydrastine (P. C.) % gr. 
Hydrastia Co.