Tbc 
Rationale 
of 
Blood 
Regeneration THE RATIONALE OF 
BLOOD REGENERATION 
ROTHSCHILD BROS. & CO., 
466 and 468 Broadway, 
NEWYORK. 
DANBURY, CONN.: 
DANBURY MEDICAL PRINTING COMPANY. 
1895. The Rationale of Blood Regeneration. 
THE blood holds in solution certain albuminous bodies 
of which the principal are serum albumin, serum 
globulin and fibrinogen; also a number of mineral sub- 
stances, the chief of which are common salt (sodium 
chloride) and sodium carbonate. These may be classed 
as the invisible constituents of the blood, and their in- 
vestigation belongs to the domain of the physiological 
chemist. The blood in addition holds in suspension 
the red and white corpuscles, which admitting of inspec- 
tion, may be classed as the visible constituents. It is 
the alteration of these latter, any abnormal change as 
regards their form, color, size, number and relative 
proportion, which produces a series of disorders, which, 
as in chlorosis, often without assignable cause, are char- 
acterized by profound disturbances. 
Prof. Frederick P. Henry, of Philadelphia, in a 
comprehensive monograph on Ancemia, says: “The func- 
tional power of the blood is dependent upon the number 
and the quality of its red blood corpuscles. When a 
deficiency exists in either of these respects, the tissues 
suffer for the want of oxygen, the most important nutri- 
tive element of the body.” The resulting condition is 
called anaemia, and Dr. William Hunter uses this term 
in its widest sense to include every condition whether 
local or general in which the blood is either qualitatively 
or quantitatively impaired. There is, however, a con- 4 
sensus of opinion among medical authors, and advanced 
clinicians, as to the kind of anaemias, and in the most 
approved nomenclature of the day are styled symtomatic 
and idiopathic, in place of primary and secondary. For 
convenience of classification, the following varieties of 
anaemia may by appropriately grouped: 
Idiopathic Ancemias. 
Chlorosis. 
Lymphatic Anaemia (Hodgkin’s disease). 
Leucocythaemia. 
Splenic Anaemia. 
Pernicious Anaemia. 
Symptomatic A ncemias. 
Anaemia of fever. 
Anaemia of hemorrhage. 
Anaemia of phthisis. 
Anaemia of heart disease. 
Anaemia of cancer. 
Anaemia of syphilis, etc. 
Anaemia of poisoning and parasitic origin. 
The Change of the Blood. 
Idiopathic anaemias must comply with the follow- 
ing conditions; 
A profound radical change in the blood, as deter- 
mined by actual examination, must of a necessity con- 
stitute a striking feature of the disease. Again the 
morbid symptoms must be directly attributable to the 
altered conditions of the blood—in chlorosis where the 
number of red blood corpuscles may be normal, but 5 
where the haemoglobin, or coloring matter of these 
blood discs is deficient—in pernicious anaemia where 
there is a numerical diminution of red blood corpuscles, 
alterations in the size and shape of the red corpuscle, 
without any marked decrease of haemoglobin. In per- 
nicious anaemia, the blood has been aptly compared to 
water in which beef has been washed. 
In this form, when the cause is known and not re- 
movable, the prognosis is hopeless, also when the origin 
is obscure, the cure is doubtful. 
In chlorosis, as is well known, the blood corpuscles 
vary abnormally in size, extremely small ones called 
poikilocytes being present, and some larger than the 
ordinary corpuscle, termed megalocytes. Many of the 
former are extremely minute. 
A comparison of the anaemia of phthisis with that 
of chlorosis or leucocythaemia, illustrates the difference 
between the symptomatic and idiopathic forms of dis- 
ease. In phthisis, the blood changes, however pro- 
found, do not by any means constitute the most marked 
clinical feature. The other symptoms—cough, night- 
sweats, fever, expectoration—are not dependent on 
hasmogenic or haemolytic disorder. The condition of 
the blood throws no light upon the nature of the disease 
or its seat. Hence the anaemia of phthisis is rightly 
classed as symptomatic. In chlorosis the blood changes, 
especially the great diminution in haemoglobin in com- 
parison with the slight lessening in the number of red 
Anaemias. 6 
blood corpuscles constitute its chief clinical (and in this 
instance the chief pathological) feature. The pallor, 
giddiness, debility, breathlessness, palpitation, etc., can 
be shown to depend on disordered blood formation, 
which is also the cause of the blood changes themselves. 
The gastro-intestinal disturbances generally associated 
with chlorosis have been shown (Bunge) to be due to 
the excess of decomposition products in the intestine 
accompanying the characteristic constipation. These 
break up the iron compounds of the food, and tend to 
prevent due absorption of iron in its only assimilable 
form, and so lead to impaired blood production. Chloro- 
sis in girls is, in fact, an idiopathic anaemia, haemogenic 
in its origin, and is due to a deficient supply of assimilable 
iron at a time when the recent onset of menstruation 
has removed a certain portion of the already small 
supply of that element present in the body. So, too, in 
leucocythaemia the blood changes—the abnormal in- 
crease in the white blood corpuscles and a diminution 
in the red—constitute the chief clinical features and 
serve to account for the other symptoms, and, with the 
alteration in the blood forming organs, present the chief 
morbid changes discoverable after death. These facts 
place leucocythaemia among the idiopathic anaemias. 
Johann Duncan, in 1867 demonstrated that in 
chlorosis the red corpuscles may be normal in number, 
while their value—the quantity of haemoglobin they 
carry—is greatly reduced, other authorities conclude 
that there must be at least two kinds of chlorosis, one 7 
with a normal number of corpuscles deficient in haemo- 
globin ; the other with a diminished number of corpuscles 
which may be either normal or deficient with regard to 
their haemoglobin. Virchow attributes some cases of 
chlorosis to imperfect development of the heart and 
blood vessels, but this theory.has not, however, met 
with general acceptance. 
Much obscurity surrounds the subject of chlorosis, 
and it is one of those pathways in the science of medi- 
cine which has been strewn with the wreck of pet 
theories. From a careful study of its clinical history, 
the only valuable therapeutic data that may be obtained 
is that iron is the specific treatment, and that form of 
iron, which is most assimilable and best equips the 
respiratory functions of the blood, increasing its cor- 
puscular activity and haemoglobin value so that it will 
as it passes through the lungs take up the extra atom of 
oxygen, for which this metal has a remarkable affinity 
and convey it to the tissues which demand nutrition. 
How Iron Acts. 
The precise mechanism by which iron enters the 
blood has long been a subject of controversy among 
physiologists. It being agreed that it is an essential 
constituent of the red blood corpuscle, there are at the 
present time three distinct theories as to its modus oper- 
and!. 
i. Since iron cures certain conditions in which the 
iron of the blood is deficient such as anaemias, chlorosis, 
etc., it has been very generally assumed that it must be 8 
absorbed, and in confirmation of this view, there is a 
considerable amount of experimental evidence. 
2. The second theory rests on the supposition 
that iron preparations given by the mouth are not ab- 
sorbed. It is argued that the iron of the food, which 
equals about 6 to 9 cc. daily in an ordinary diet, is more 
then sufficient to make up any deficiency in the blood 
and that unused iron is always being excreted from the 
bowel even in chlorosis. The intestinal mucous mem- 
brane, however, is supposed to be so bloodless, that it 
cannot properly perform its absorptive functions, hence 
the iron of the food is not taken advantage of, but when 
inorganic iron is given, it stimulates and tones up the gas- 
trointestinal mucous membrane, so that digestion and 
absorption of food takes place satisfactorily, and in a 
short time, the iron in the dietary makes good the 
deficiency in the blood. 
It is extremely doubtful whether this theory has or 
ever had many supporters. Among them however, may 
be cited, Buchheim, Kletzinsky, Kobert and Dujardin- 
Beaumetz. The last named after advancing arguments 
against the probability of the absorption of iron and 
stating that in chlorosis it acts simply by stimulating 
appetite and digestion, claims to get better results from 
arsenic, quinine, diet and hygienic measures, than from 
heroic doses of inorganic iron, and further doubt has 
been thrown on this theory of stimulation by the injec- 
tion of iron subcutaneously and its subsequent passage 
from the blood through the wall of the gastro-intestinal 9 
canal, giving to us the a priori argument that if, by the 
process of endosmosis, iron may pass from the blood 
through the walls of the alimentary canal, it may with 
equal facility by the opposite process (exosmosis) pass 
through the walls of the alimentary canal into the blood; 
on that account, although absorbed into the blood, be 
absent from the bile and urine. While the physiological 
presence of increased iron in the blood would seem to 
refute the theory of stimulation, Kobert and Cahn, ex- 
perimented with manganese, which is an element foreign 
to the body and easily detected. They have proved 
that it is not absorbed and from analogy, conclude that 
iron also is not. 
Bunge explains the usefulness of iron in chlorosis 
by its forming iron sulphide in the intestines and remov- 
ing in this way excess of sulphur from the body. In 
chlorosis there are excessive fermentative processes in 
the alimentary canal and intestines, large quantities of 
sulphuretted hydrogen being formed which destroy the 
organic compounds of iron that form haemoglobin, x 
(Stockman, British Medical Journal). 
If sulphide of iron cures anaemia and chlorosis, which 
it sometimes does when given by the mouth, it disproves 
Bunge’s theory, for if iron sulphide be the form employed, 
it cannot take up any more sulphur and it is therefore 
useless as an absorbent of the sulphuretted hydrogen, and 
being non-astringent it cannot locally stimulate the muc- 
ous membrane. If it cure anaemia it must do so by be- 
ing absorbed. If bismuth, manganese and other drugs,—which 
are just as capable as iron is of absorbing sulphuretted 
hydrogen and acting as intestinal stimulants, should 
prove inert in chlorosis, it forms an additional reason, 
says Stockman, “for regarding the absorption of iron as 
indirectly proved.” 
People in health, make up the wear and tear of physi- 
ological iron from the food they eat and this fact would 
seem to point to a logical, rational and now well estab- 
lished principle of iron administration. The employ- 
ment of a neutral organic preparation of iron,—one that 
does not convert the stomach into a miniature laboratory, 
or having any pronounced tendency to exaggerate the 
pathological conditions incident to anaemia or chlorosis. 
Modern medical skepticism, however, seems to have 
attacked even this apparently well established doctrine 
despite the clinical teachings of Neimeyer, and the ex- 
haustive and patient researches of eminent physiologists, 
as to the passage and absorption of iron when taken 
either as a food or medicine. 
The Natural Supply of Iron. 
At the recent Congress of Internal Medicine in 
Munich, April, 1895, the therapy of iron was the main 
topic of discussion; many conceptions as to the use 
of iron handed down from former times, were cleared 
away, and exact observations based upon physiological 
facts, shown to be more consonant with nature. 
Our foods from which the body obtains its requisite 
supply of iron, contain other fixed combinations of this 11 
metal which can be absorbed and assimilated. The small 
amount of iron contained in milk is surprising. The 
young animal has its maximum supply of iron at its 
birth, this supply then rapidly decreases, and afterwards 
only becomes greater in the same proportion as the 
weight of the body increases. The absolute quantity re- 
mains small. If young animals should be nourished en- 
tirely with milk, they would become anaemic. From this 
arises the important problem whether children should be 
nourished with milk after the ninth month, and hence 
the efficacy of a pure milk diet in anaemia, simple or com- 
plex, is disputed. The inorganic salts of iron render no ma- 
terial aid for the formation of haemoglobin; being insolu- 
ble and by reason of their irritant properties, they become 
progressively inefficient, acting at best as gastrointes- 
tinal stimulants, leaving in their wake many unpleasant 
sequelae. “If you wish to give iron,” says Prof. Bunge of 
Bale, “it should rather be procured from the markets than 
the drug stores.” Many foods especially meats, eggs, 
spinach and other vegetables are so rich in iron that as 
much, says the above authority, can be supplied through 
them as by medication with ferric remedies, provided that 
the appetite of the patient is normal and good. It is this 
last inference, and proviso that renders Bunge’s theory 
untenable. Few chlorotic or anaemic patients enjoy 
good or normal appetite, per contra, every practitioner 
can call to mind the languid attempts at eating and the 
abnormal cravings of his chlorotic patients. In fact, Prof. 
Bunge’s paper read at Munich, while it attracted much attention, elicited general contradiction, Prof. Quincke of 
Kiel,emphasized the principle of adherence to established 
and approved facts. Whether there be a theory to explain 
it or not, ripe observation and clinical experience do 
not admit of any doubt as to the good effects of iron medi- 
cation, where it can be promptly absorbed, and used with 
general and universal satisfaction.” If Bunge is correct, 
says Prof. Zimmerman of Bale,” chlorosis would never 
develop in girls belonging to families in affluent circum- 
stances because they eat plenty of meat,'vegetables and 
other food containingiron.” He furthermore maintains, 
and proves, that the dietetic treatment of poor, badly fed 
chlorotic girls may bring about better nutrition, but not 
a cure of chlorosis. Zimmerman claims that the neutral 
organic preparations of iron are excellent promoters of 
nutrition and all vital functions, and that chlorosis is not 
produced by a deficient supply of foods containingiron, 
but by a want of vitality of the organs that produce blood- 
Professors Nothnagel of Vienna, Ziemssen of Mu- 
nich, Erb of Heidelberg, Bauember of Freiburg, Edlef- 
son of Kiel, Ewald of Berlin and many others of 
contemporary prestige, gave their unqualified adherence 
to the remedial value of iron, in fact, the weight of 
authority is in favor of its use, and the result of the 
recent discussions may be summed up in the statement; 
that the value of iron medication remains an indispen- 
sable and imperative factor in therapy. 
While its place seems to be assured in the domain 
of materia medica and therapeutics, iron is frequently 
The Utility of Iron. given with disappointing results, and in cases where the 
indications for its exhibition are well defined; this is 
particularly true of the inorganic forms of iron. The 
best measure of the value of iron administration, is its 
solubility and facility of absorption—the quantity taken 
up and not the quantity prescribed. Iron is not absorbed 
in the stomach, it passes through that viscus to find in 
the duodenum the conditions necessary for its absorp- 
tion, and the subsequent performance of its functions of 
oxidation as an element of the red blood corpuscle. 
From the mouth to the duodenum, the chemical changes 
which iron undergoes, is complex, varied, and in some 
respects conjectural. It is to this fact that we owe the 
multiplicity of ferric remedies, and are burdened not so 
much by an embarrassment of riches, but rather a throng 
of mediocrity from which to choose. Again, this com- 
plexity of iron transformation has led to the employ- 
ment of other drugs such as arsenic, bismuth and man- 
ganese, either alone, or when compatible, with iron. It 
would be a work of supererogation at this day, to teach 
the profession their value, as their therapeutic proper- 
ties have been thoroughly studied. Owing to its higher 
oxidizing power, manganese has some reputation as a 
hcematinic, but as it is always used as an adjuvant to 
iron, its efficacy has not been clearly established and 
it is now only used empirically upon the ground that 
in combination with iron, it helps the latter. As the 
human body only contains 2 to grammes of iron 
and no appreciable quantity of manganese, that is to say when manganese is present it is purely accidental and 
is notan essential component of any tissue or organ, but is 
derived from vegetable food which in turn gets it from the 
soil. Whatever reputation manganese enjoys is through 
the researches and advocacy of Hannon, but as he and 
others always gave iron along with it in the proportion 
of about six times as much iron as manganese, the role of 
the latter would seem to be unimportant. Glenard in 
examining the blood of forty persons in good health, 
who were bled, found in one only a trace of manganese 
and as he found none in the blood of manganese miners, 
argued that the metal could not be absorbed by any 
channel. Robert and Cahn have proved that manganese 
salts given by the mouth are not absorbed. Stockman 
states that he never saw the slightest improvement 
from the use of manganese, and that Its failure in chlo- 
rosis was marked. This brings us back again to the 
dictum of Niemeyer, “the intelligent and persistent use 
of iron,” and that form of iron which meets all the re- 
quirements of a progressive therapy and rational devel- 
opment. The value of the carbonate of iron (Blaud 
mass) is due to the fact that this salt possesses a volatile 
acid which is liberated by the acids of the gastric juice 
and the consequent formation of a more soluble base. 
When physiologists recognized hydrochloric and lactic 
acids, chemists produced chlorides and lactates of iron. 
Upon the further intimate association of iron with 
albumen, the albuminates of iron came into vogue, but 
all of these were stepping stones, merely “curtain raisers” to the drama of iron digestion and absorption. Just as 
true that proteid food must be peptonized, or become 
peptones in order to contribute directly to nutrition, so, 
said Claud Bernard, “all iron must enter into the 
circulation in its ultimate form of assimilation, which is 
a peptonate.” As a result of specialized effort in this 
direction, after patient research and careful investiga- 
tion, that distinguished pharmacologist, Rud. Pizzala, 
first gave to the world a true iron peptone in the form 
of his now highly esteemed elixir, not a mere ferrugin- 
ous solution, but a true combination, chemically correct 
and therefore of therapeutic importance. 
The Problem Solved. 
Rudolph Pizzala seems to have been the first one 
to solve the problem of rendering an iron preparation 
capable of being absorbed without undergoing chemical 
change. Pizzala’s Elixir Peptonate of Iron is held in 
high esteem by such authorities as Erb, Nothnagel, 
Ewald, Quincke "and other German authorites. It was 
frequently prescribed by the late Sir Andrew Clarke of 
England. It enjoys a large and increasing favor and 
stands very high in the newer materia medica. It is 
free from the objectionable characteristics of other iron 
preparations producing no plethora or hepatic congestion, 
even when pushed to the point of physiological tolerance. 
Pizzala’s Elixir of Peptonate of Iron is an impor- 
tant addition to our therapeutic resources not only as 
a potent blood reconstructive but as an ideal systemic 
tonic, because •• The chemical formula of Pizzala’s elixir so closely 
resembles that of the human oxy-hasmoglobin, the 
formula of the first being 
C H N FeS O 
600960 154 119 
and of the oxy-haemoglobin 
C H N FeS O. 
600 960 154 3 119 
In view of the above, we are justified in saying 
that Pizzala’s Peptonate of Iron is an oxy-haemo- 
globin synthetically prepared. A true peptonate of iron 
occurs as a powder, which, unless suspended in an alco- 
holic elixir will deteriorate and decompose. The basis 
of Pizzala’s is io</0 of cognac which is a better men- 
struum, than employed by other chemists, because the 
majority of them use sweet wines in preparing their so- 
called “peptonates. ” A certain amount of tannin being 
present in all wines, there is a tendency to develop a 
tannate of iron and inelegant precipitates. Cognac, being 
a distillation, is divested of its tannin and is absolutely 
neutral, therefore, Pizzala’s elixir is a classic pharma- 
ceutical preparation because; 
i. It is a finished medicament, being a true chemical 
combination of organic iron and peptone. 
2. It is permanent and palatable, requiring no 
special menstruum to facilitate its exhibition. It is a 
clear, reddish brown fluid which does not deteriorate in 
value upon exposure to light and is not affected by 
change of temperature. 17 
3. Unlike many so-called peptonates and albumin- 
ates, Pizzala’s elixir peptonate of iron, is entirely free 
from any repulsive animal odor or taste and it is not 
liable to decomposition upon contact with ordinary food. 
In reaction it is neutral, producing no discoloration or 
injury to the teeth, and being without constipating 
properties. 
This peptonate of iron is readily and easily digesti- 
ble. No preparation of iron is better assimilated. Its 
action being prompt, stimulating the appetite and the 
digestion, it enters directly into the circulation with the 
other food products, and is well borne by the most in- 
tractable stomach. 
The use or Pizzala’s elixir, has been attended with 
uniformly gratifying results in Europe and this country 
and is therefore esteemed by the advanced thinkers in 
the domain of therapeutics, as the only rational form of 
physiological iron known to the profession. 
In the treatment of anaema and chlorosis, Piz- 
zala’s elixir not only properly equips the blood for its 
respiratory functions as it passes through the lungs, but 
it stops tissue waste, from the fact of its exerting a 
double tonic influence and inducing a normal healthy 
flow of the secretions. 
The idiopathic anaemias and chlorosis of chylopoetic 
origin, the pathological feature of which is destruction 
of the blood, the rapid disintegration of the red blood 
corpuscles has been arrested more promptly by the use 
of Pizzala’s elixir than any other similar preparation of iron. Its hsematinic effect is certain, and the custom- 
ary dosage being sufficient to insure not only an in- 
crease in the number, but also an improvement in the 
quality of the corpuscles by maintaining the integrity 
of its haemoglobin. 
The utility of this remedy in all diseases character- 
ized by impoverishment of the blood has been fully 
established and it has been further demonstrated to 
have a wider range of application, as its use is indicated 
in various nervous and debilitating disorders; Amenor- 
rhoea, malnutrition, nervous dyspepsia, hysteria, chronic 
uterine catarrh and the slow convalescence from acute 
diseases. In these disorders the employment of this 
remedy has been of material benefit, and inestimable 
value. In point of fact it has no rival and has revo- 
lutionized modern iron medication, European Authorities. 
What They Say. 
Prof. Dr. Edlefsen, of Kiel: 
There is no need, on my part, to write any recom- 
mendation for your preparation. There is probably no 
physician in this part of the country who has used your 
preparation as extensively as I have, and I can only say 
that, almost without exception, in every case where I 
have used it, I have had the greatest satisfaction, and 
even in cases of the weakest stomach I found the prep- 
aration easily digested. 
Prof. Dr. Erb, of Heidelberg: 
You must content yourself with knowing that I am 
prescribing your preparation to a very large extent, and 
that I very often mention Pizzala’s in my lectures as 
professor at the University at Heidelberg. 
Dr. Kobert, Freiburg i. B.: 
Just having recovered from a very severe sickness, 
I am using Pizzala’s peptonate of iron in my own case 
and find the result extremely satisfactory. I have 
used the preparation in my practice for years, and I can 
only corroborate the unanimous verdict that the same 
belongs to the best of the new tonics. The results 
are sometimes simply astonishing. 
D. Contzen, Neukirchen, County of Trier: 
Having been recommended by Prof. Erb, of Hei- 
delberg, to use your preparation, you will, therefore, 
kindly send me some by express. 20 
Privy Medicinal Councilor Dr. Bode, of Bad Nauheim: 
I have as you may have noticed from the large con- 
sumption of the drug store in this town, used your prep- 
aration last summer to a very large extent, and have 
been very much pleased with the results. 
Dr. St. Bramer, Bradford (Yorkshire, England): 
I am very much pleased with the results of the ap- 
plications of your preparation, all my patients digested 
the same splendidly even those who could not retain 
any other medicine in their stomach. The taste is 
pleasant to such an extent that some patients have got 
to like it. Especially ladies are very grateful that the 
usual damage to the teeth does not occur with Pizzala; 
*it has no effect at all on the teeth. I shall use every 
opportunity to recommend your preparation. 
Prof. Dr. Henny, of Leipzig; 
On the ist of November last, you sent me some 
bottles of the Pizzala peptonate of iron, and the reason 
why I express my thanks so late is, that I wished to ob- 
serve the results of the same in my clinic. It gives me 
pleasure to say that I am very well pleased with the 
results, and that I shall take occasion to order the prep- 
aration continually. 
Eduard Hess, of St. Petersburg: 
Professor Erb, of Heidelberg, has recommended to 
me the use of your preparation with quinine, and as I 
cannot obtain the same here, you will kindly send me 
some bottles by express. Prof. Dr. Geigel, of Wurzburg; 
Thanking you for sending repeatedly the Pizzala 
peptonate of iron, it gives me pleasure to say that I am 
using the preparation wherever I have a case of “anae- 
mia,” and that I am very well satisfied with the results. 
Prof. Dr. Reklam’s Journal “G-esundheit,”in Leipzig; 
After using your preparation for over a year, we 
can conscientiously endorse every word of your pros- 
pectus. We have used the preparation for children as 
well as adults and in every case we experienced the 
same good results. We, therefore, do not hesitate to 
warmly recommend to the medical fraternity the use of 
Pizzala’s peptonate of iron. 
Dr. Hinkeldeyn, Directing Physician of the Public 
It gives me pleasure to state to you that I am ex- 
tremely well pleased with the Pizzala peptonate you are 
making, and that I had the best results from the same. 
The value of the preparation is increased by the fact 
that it does not spoil even if kept for a long time, that 
it is easily digested, and that it has a pleasant taste. 
Hospital in Liibeck; 
County-Physician Dr. Jauert, Seehausen i/d Alt- 
mard: 
I am very well pleased with Pizzala; it does not 
disturb the digestion, and its effect is felt very soon. I 
am using it very much with the same good results in 
every case. 22 
W. Janssen, M. D., of Hamburg: 
That I value Pizzala very highly, you can judge 
from the fact that I have been using it for years and 
that I am using it now in two cases in my own family. 
Dr. Knickmever, Leichlingen near Diisseldorf: 
I am using Pizzala for four members of my own 
family and with excellent results. 
Dr. Teuffel, President of the Department for Internal 
and Women’s Diseases in the Ludwig’s Hospital, 
Charlottenhilfe, in Stuttgart: 
Pizzala peptonate of iron, which I am using for 
some time and in a great many cases, has very much 
satisfied me, especially on account of its easy digestion, 
its pleasant taste, and for the fact that it does not suf- 
fer from age. 
The originals of above testimonials are in the pos- 
session of Rudolph Pizzala, druggist, in Zwingenberg. 
a /B Hessen. 
Canada. 
Certificate from Sir James Grant, M. D., K. C. M. G., 
Physician to (the late) Governor General, Lord 
Stanley, and Ex-President of the College of Phy- 
sicians and Surgeons of Ontario: 
Gentlemen:—l have had the elixir of peptonate of 
iron (Rud, Pizzala) under observation for the past year 
and can testify as to its value as a medicinal agent on 
the human economy. In my opinion, it enters the sys- 23 
tem readily through the gastric mucous membrane and 
rapidly takes part in the formative process of red blood 
globules. It is most pleasant to the taste, not nauseat- 
ing in its action nor injurious to the teeth. As a grate- 
ful restorer of lowered vitality depending on anaemia and 
chlorosis, this most unique preparation fills a most im- 
portant place therapeutically, and I shall continue its 
use with great pleasure. 
(Signed,) 
J. A. Grant, M. D., 
150 Elgin St., Ottawa, Ontario. 
March, 1893 
Dear Sirs:—l intend to prescribe Pizzala’s elixir 
of peptonate of iron. I find it extremely beneficial to 
my patients. 
Toronto, Feb, 4, 1892. 
Very sincerely, 
Albert A. Macdonald, M. D. 
American Authorities. 
What They Say. 
New York, Dec, 28, 1891. 
I have used to a great extent Pizzala’s elixir of 
peptonate of iron especially where a weak digestion did 
not admit the administration of other iron preparations. 
Pizzala’s preparation is very well borne and has given 
me very satisfactory results. 
Aug, F. Frech, M. D. 24 
1 have largely employed Pizzala’s elixir of pep- 
tonate of iron particularly in cases of anaemia and 
chlorosis. I find it the only iron preparation which is 
digested without disturbing the alimentary tract. In 
diseases of children especially I deem it the iron par 
excellence. Ephraim Winternitz, M. D., 
New York, Dec. 21, 1891. 
311 E. 72nd St. 
New York, Dec. 21, 1891. 
I have used Rud. Pizzala’s elixir of peptonate of 
iron in anaemia and different cases of neurasthenia and 
found it very efficient, on account of its easy assimi- 
lation. Yours truly, Dr, A. Rixa, 
Prof, of Gynecology, M. C. of New York. 
Pizzala’s peptonate of iron scarcely needs recom- 
mendation this late day, I have used and do use it ex- 
tensively in my practice and find it the most digestible 
and one of the most effective iron preparations we pos- 
sess. S. P. Cahen, M. D., 
Nov. 29, ’9l. 227 W. 44th St. 
I have used Pizzala’s peptonate of iron with qui- 
nine in a large number of anaemic and convalescent 
cases with perfect satisfaction to myself and patients. 
Edward E. Conrad, M. D. 
Pizzala’s peptonate elixir of iron is an excellent 
preparation and proved very successfully in my hands. 
Nov. 18, ’9l, Dr, Charles Roth, M. D, 25 
Extract from Clinical Report: 
CASE:—Agnes P., domestic, age 24, for past five 
years had lost flesh and color. Mucous membrane of 
the lips had no marked redness, being almost white. 
Skin of a peculiar waxy appearance. Digestion poor, 
appetite wanting. 
Iron was given in several forms, but without pro- 
ducing results, until Pizzala’s elixir peptonate of iron 
was tried. In a short time a better condition began to 
assert itself. The lips soon showed more color, the 
skin became more normal. A treatment of two months’ 
duration has showed a remarkable gain. The case was 
one of a thorough anaemic condition, and one greatly 
benefited by the use of this preparation. 
(Signed,) F. M. Johnson, M. D., 
xiy Beacon St., Boston, Mass. 
New York, Dec. 22, 1891. 
I have been prescribing Pizzala’s elixir of peptonate 
of iron for the past month and am very much pleased 
with its pleasant and beneficial effects. 
Very truly yours, Dr. F. F. Potter. 
I have prescribed elixir peptonate of iron, (Pizzala’s) 
in several casesof chlorosis with most gratifying results, 
and consider it a very fine preparation. 
R. E. Townsend, M. D. 
From the observation I have made upon patients 
taking Pizzala’s peptonate of iron, I find that it is 
well borne by the stomach and does not constipate. 
Dec. 15, ’9l. E. M. Culver, M. D. 26 
I certify with pleasure that I have seen during the 
last year several cases where the use of Pizzala’s elixir 
of peptonate of iron has given me great satisfaction, 
especially in cases of convalescence from acute disease, 
where several other iron preparations were not well 
digested. E. W. Hoeber, M. D., 
Nov. 20, ’9l. Lexington Ave., cor 52d St. 
Pizzala’s preparation of peptonate of iron is one of 
the best I have ever tried. It is easily digested and 
does not constipate. James Reilly, M. D. 
Ex-Surgeon, St. Vincent Hospital. 
I had occasion to use Pizzala’s elixir peptonate of 
iron in anaemia, chlorosis and general debility and I can 
heartily recommend it to my professional brethren on 
account of its palatable taste, its ready absorption and 
its non-constipating effects. 
New York, Dec, 21, 1891, 
165 E. 54th St. Dr, A. Walter, 
New York, Dec, 18, 1891. 
This certifies that I have found Rud. Pizzala’s elixir 
of peptonate of iron very beneficial in those cases when 
iron is indicated. Where the stomach is weak it answers 
better than some other preparations of iron I have tried. 
I take pleasure in recommending it to the profession. 
J. P. Ogden, M. D. 
I have used Pizzala’s peptonate of iron and am 
well satisfied with its action. 
Dec. 19, ’9l. G. W. Boskowitz. 27 
Gentlemen:—I have for several years prescribed 
the elixir of peptonate of iron (Rud. Pizzala’s,) must 
say that it is the only preparation of iron that thus far 
has given me any satisfactory results. The stomach is 
not disturbed, as in taking other preparations of iron. 
It has many advantages in treating anaemia, as I say 
over other forms of iron. 
New York, Dec. 13, 1891. 
This preparation must be welcomed to our profes- 
sion at large. Dr. J. Mount Bleyer. 
New York, Dec. 9, 1891, 
I have used Pizzala’s peptonate of iron and find it 
tolerated by the stomach better than any other prepara- 
tion which I have tried. 
115 E. 59th St. W. Scoonover, M. D,, 
I have used Pizzala’s elixir peptonate of iron in 
convalescence from typhoid malaria with the best suc- 
cess and like its action very much. 
Respectfully, Floyd P. Sheldon, M. D., 
237 W. 127 th St 
This is to say that I have used Pizzala’s peptonate 
of iron successfully in cases of anaemia and recommend 
it as one of the very best preparations. It does not 
constipate and does not produce digestive disturbance. 
2162 Fifth Avenue. D. M. Smagg, M. D. 
I have made extensive use of Pizzala’s peptonate of 
iron and have had most beneficial results therefrom. 
Dec. 15, ’9l. R. F, Burke, M, D. 28 
Milwaukee, Wis., Sept. 20, 1892. 
I have employed Rud. Pizzala’s elixir of peptonate 
of iron in many cases, in fact in all cases marked by 
anaemia, etc., and have been pleased to note perfect 
assimilation of the preparation and rapid improvement 
in the patient’s condition from the outset. Among 
many other cases I was especially pleased with the re- 
sult of its employment in convalescence from a severe 
attack of articular rheumatism, in which case the pa- 
tient had been in a condition of extreme anaemia and 
general debility. The improvement after the use of 
Pizzala’s peptonate of iron was noticeable almost imme- 
diately. 
. It is, in short, the only preparation of iron I pre- 
scribe now-a-days, Louis G. Nolte, M. D. 
Physician to Milwaukee Hosp., Surgeon to Emer- 
gency Hosp., Milwaukee, Wis. 
New York, Nov. 27, 1891. 
I have used Pizzala’s preparation of peptonate of 
iron for some years past and find it an excellent form 
for the administration of iron especially where a patient 
requires some tonic before operations. 
235 E. 78th St. H. J. Schiff, M. D., 
Pizzala’s elixir of peptonate of iron can be used 
where acid preparations of iron act as irritants, and is 
therefore a boon. Especially in this the case in scarlet 
fever and diphtheria in the case of children; as also in 
convalescence from typhoid fever. 
Dec. x, 1891. Adolph Rupp, M. D. 29 
I have prescribed the elix. ferri pept. (Pizzala’s) in 
cases of chlorosis and anaemia with excellent results, 
noting in particular the absence of any digestive dis- 
turbance after prolonged use. 
A. C. Grimm, M. D., 
Dec. 4, ’92. 1812 Lexington Ave., N. Y. 
From my understanding of Pizzala’s peptonate of 
iron I believe it to be an excellent preparation. 
Dec. 16, ’9l. E.. F. Chapman, M. D. 
I take the pleasure to certify that of all iron prep- 
arations I have used in my practice, the Pizzala’s elixir 
peptonate of iron has proved the most efficient in my 
experience. It is even superior to the blood pills which 
are so highly appreciated by the practitioner. 
Nov. 18, ’9x. Dr. H. Loebinger. 
I have used Pizzala’s iron elixir and obtained very 
favorable results. 
Dec. ’9l. B. Gardner Cooke, M. D. 
You asked me about my experience regarding Piz- 
zala’s iron preparations. I have used the peptonate of 
iron elixir (Pizzala’s) since it was imported, with great 
satisfaction, and although I employed also the later 
iron solutions (albuminata) I found that patients pre- 
ferred the Pizzala’s, and myself saw the result of this 
peptone to be at least as good as that of the other. 
New York, Dec. 18, 1891. 
Yours sincerely, L. Schonev, M. D., 
68 E. 104 th St. I am constantly using Rud. Pizzala’s elixir of pep- 
tonate of iron and prefer it to all other iron prepara- 
tions, on account of its easy absorption. 
Nov. 7, 1891. 240 E, 86th St. 
J. A. Moore, M. D., 
Chicago, July 2, 1895. 
Gentlemen;—Through your esteemed kindness 
received lately sample Pizzala elixir. 
Administered same as indicated in anaemia to an 
excessively chlorotic girl. The improvement was marked 
and progressive. This secured at Elkhart, Ind , last 
week. I make some monthly visits to said city and 
called the attention of some physicians there to the 
efficacy of your preparation. Also to Wm. Berky, 
pharmacist, Main St., Elkhart. Will return thither next 
week. Would be pleased to receive larger supply of 
Pizzala elixir, as well as samples of other unique prepara- 
tions. Remaining with renewed esteem, lam 
Yours very respectfully, 
Dr. Ph. Sydney Allis, 
16 Newton St. 
The originalst)f above testimonials, and numerous 
others, are in possession of Rothschild Bros. & Co., 466 
& 468 Broadway, N. Y., Sole Agents. 
Beware of imitations! Every bottle must bear 
our firm name. 
ROTHSCHILD BROS. & CO., 
Sole Agents. RUD. PIZZALA’S 
Elixir of Peptonate of Iron. 
An essential and constituent part of the human blood, which im- 
parts to it the red color and strengthens the body, is peptonized iron, 
a chemical combination of pepton and iron. It owes its value to 
the digestive process; the iron entering at first in the stomach in com- 
bination with albumen it is converted by hydrochloric acid and pepsin 
into pepton of iron, and as such is directly carried to the blood. 
Supported by these facts, established and generally accepted by 
scientists, I have succeeded, after many experiments, in obtaining by 
a special process, a chemical combination of iron and pepton 
perfectly equal in its physiological and chemical qualities to the one 
formed by the natural process of digestion, and possessing the same 
power of absorption and assimilation. 
I have been induced to produce such a rationally physiological 
preparation, so much the more as the experience of many years has 
shown me of how little service and benefit the forms of iron which are 
commonly employed as remedial agents have been. The employment 
of inorganic iron, hitherto in use, has, in many instances, been rendered 
inadvisable, as the stomach, in spite of the greatest exertions, is not 
able to digest more than very minute quantities of such iron. Persons 
who suffer from anaemia, chlorosis, diseases of the stomach and nerves, 
if, as is most frequently the case, these disorders are accompanied by 
weakened digestion, want of appetite, agitation of the nervous system 
and insomnia, such inorganic iron is inapplicable. 
In consequence of these well-established facts, the pepton of iron 
prepared by me is a i per cent, solution mixed with 10 per cent, of 
the purest cognac. The preparation is prepared in two different ways, 
viz., pepton of iron aromatic and pepton of iron prepared with 
half per cent, of quinine. In this preparation as “elixir ferri pep- 
tonati Pizzala,” it is in all the cases mentioned above the best 
haematinic at present known, superior to any other remedy con- 
taining iron in any form. It may be used without the least incon- 
venience, and its efficacy is certain and reliable. 
Advantages over all other iron preparations—i. It 
does not produce digestive disturbances of any kind, but aids diges- 
tion and stimulates the appetite. 2. It does not constipate. 3. It 
neither injures nor stains the teeth. 4. It is quite agreeable to the 
taste. 
(Elixir ferri peptonati Pizzala.) 
Thorough and comprehensive investigations by eminent European 
and American medical authorities of extensive practice, have confirmed 
the excellent virtues claimed for this remedy, and have yeilded gratifying results, in consequence of which it is largly used in 
universities, hospitals lunatic asylums, sanitariums and gynsecological 
retreats at home and abroad. It enjoys among medical men and pa- 
tients an ever-increasing popularity—certainly the most eloquent 
acknowledgement of its value as well as its best recommendation for 
its future employment and utility. 
The preparation should be prescribed in original bottles as: Es- 
sentia, or Liquor, or Elixir ferri peptonati (Pizzala). Thorough 
guarantee is offered that it will always be the same in its prepara- 
tion as well as in its composition. 
RUD. PIZZALA, Apothecary, 
Zwingenberg, a/8., Germany. 
ANALYSIS 
Of the Essentia ferri peptonati, Pizzala, made by Dr. E. Geis- 
sler, of Dresden, in the Public Chemical Laboratory of the Phar- 
maceutical CentraLHalle. 
“The two bottles of Essentia ferri peptonati, a reddish-brown 
fluid, contain pepton of iron, besides traces of hydrochloric acid, 
sugar, alcohol and water. According to the results of the analysis, 
it is proved that pepton and iron exist in the preparation in a state 
of true chemical combination. The presence of iron in the fluid 
cannot be shown by the ordinary reagents, and this iron, together 
with pepton, is completely precipitated by a solution of common 
salt. The quantity of the precipitate produced by the solution of 
kitchen salt amounts to 1.06 per cent., and is almost perfectly sol- 
uble again in pure water. This amount (viz., 1.06 per cent.) agrees 
with the quantity of pepton calculated from the estimation of nitro- 
gen (the absence of albumen was especially proved) and with the 
quantity of -sesquioxide of iron found in the residue after the boiling 
down of the fluid. Your preparation therefore contains exactly I per 
cent, of true pepton of iron.” 
Directions for Use:—A teaspoonful three times daily for children, 
a dessert to a tablespoonful for adults three times a day, either be- 
fore or after meals. Taken before meals it acts, besides its 
tonic effects, as a stimulant to the appetite; given after meals 
it aids digestion. 
As many worthless imitations of this universally known and 
highly recommended medicine have been attempted, Physicians are 
requested to prescribe it in the original bottles containing 250 c. c. 
(half pint), and bearing the firm name of the sole agents of the whole 
American Continent. 
ROTHSCHILD BROS. & CO., 
466 and 468 Broadway, New York.