COMPLIMENTS OF THE AUTHOR. THE TREATMENT OF CHRONIC TUBERCULAR CONSUMPTION. AND THE IMPORTANCE OF THE Recognition of Its Curability, and Early Diagnosis, and Prompt, Diligent Treatment, by Home Hygiene and Drugs. BY Q. Cincinnatus Smith, M.D., AUSTIN, TEXAS. Member of American Medical Association; Life Foundation Fellow Society Science, Letters and Art, London ; Life Fellow American Association for the Advance- ment of Science; Life Member California Academy of Science ; Active Member New York Medico-Legal Society, etc., etc. THE TREATMENT OF CHRONIC TUBERCULAR PUL- MONARY CONSUMPTION: AND THE IMPORTANCE OF THE RECOGNITION OF ITS CURABILITY, AND EARLY DIAGNOSIS, AND PROMPT DILIGENT TREATMENT, BY HOME HYGIENE AND DRUGS. Q. C. SMITH, M.D., AUSTIN, TEXAS. As we will limit our remarks to the form of Consumption above referred to, we will, in this paper, for brevity sake, simply call it Phthisis. That phthisis is a curable disease, and in a certain proportion of cases, even self-limited, there remains no doubt. The late Prof. Austin Flint, in some of his later writings, recorded, that he felt safe in saying, that at least ten percent of all cases of phthisis, were self-limited, and result either in spontaneous cure, or more or less permanent cessation of active progress, without the assistance of any form of treatment whatever. And further, that in a considerable proportion of these self- limited or spontaneously cured cases, there was more or less consolidation of a portion of the lung, and some cases spon- taneously recovered even after lung cavities were unmistakably detectable. Grancher, tells us, that: “ That which distinguishes the evolution and life history of tubercle from that of cancer, is the natural tendency of tubercle to become fibrous, and self- limited ; this transformation being due to the inherent nature and character of the tubercular lesion, and not to fortuitous circumstances or changes.” Louis, said : “ Few persons are born to necessarily die of phthisis.” The carefully kept records of the large private practice of Drs. Ephraim and John A. Cutter, show that they have cured, or more or less permanently arrested, and are still curing about thirty-five percent of the many cases of phthisis they have treated. And in quite a proportion of these cured or perma- nently arrested cases, the lungs had begun to break down and cavities form before treatment was undertaken. Prof. See has recently given his opinion, that a large percent of cases of phthisis are curable, provided proper treatment be instituted during the primary or apyretic stage of the disease. Prof. Jaccoud, recently said : “ To sum up what we have to state, would say, phthisis is curable in all its stages. This is the prolific idea which presides over the whole history of the disease, and which should unceasingly inspire and direct all medical action. The incurability proclaimed by Laennec and his immediate successors is disproved by pathological anatomy and clinical observation. None should therefore allow them- selves to be influenced by such condemnation. When the exist- ence of tubercle in the lung is recognized, it should not be inferred from that moment that he who has them is doomed to death in consequence of their presence. Should it be found that the tubercles soften and a cavern forms, it should not be believed on this account that all is lost.. For it has been shown that this is not the case, and the natural tendency which tubercle has to fibrous transformation, that is to recovery, should never be forgotten. For the curability of chronic tubercular pul- monary phthisis has now been established at every stage.” Prof. N. S. Davis says : “ In the earlier stages there is a reasonable chance for the patient’s more or less permanent recovery.” The late Prof. Brehmer,—whose clinical experience in the treatment of phthisis was immense,—recorded, in his latest writ- ings on the treatment of phthisis, that he was able to cure quite a large per cent, of the cases that came under his care during the latent or apyretic state of the disease, and even a consider- able per cent, of the cases that had progressed to still graver conditions before treatment was undertaken. Prof. Brehmer’s great work, recently issued, and that of Prof. Jaccoud, are the best now before the profession, on the treat- ment of phthisis Dr. J. F. Churchill, who has placed the world under immense and lasting obligation for his long lifetime persevering devotion to the study and investigation of the clinical aspects of tuber- culosis, and the discovery of its successful treatment by the hypophosphites and inhalent remedies, has put on record—what later observers have repeatedly verified,—that he was able to cure a large majority of cases of phthisis that came under his care during the earlier stages of the disease, and a considerable proportion after cavities had formed in one lung ; and even in a few cases of cavities in both lungs, he was able to more or less permanently arrest the disease. We deem further citation of authority in reference to the curability of phthisis, unnecessary : for indeed, all that we have stated on this point, and much more to the same effect, is within easy reach of every physician. DIAGNOSIS. Of the importance of an early correct diagnosis, it seems scarcely necessary to speak, as it is axiomatic, that correctness of diagnosis is not only the basis of therapeutic experience, but alone furnishes the true light directing intelligent treat- ment. And with peculiar force, in reference to this disease, does the principle apply, that imperfection of diagnosis, leads to an underestimate of the value of therapeutic agents. And the therapeutic nihilism, so superciliously affected by many of those of large pretentions, but shallow attainments in therapeutic knowledge and skill, is one of the greatest obstacles to the advancement of clinical medicine of our time. TREATMENT. Routinism is pre-eminently the bane of consumption therapeutics. The unfortunate patient’s precious months of golden avail- ability, are often criminally wasted by the dilly-dally do-nothing policy of his nominal medical attendant; the anxious patient often being pooh poohed out of the consultation room with only a perfunctory examination, or none at all, with the jocose assur- ance, that his lungs are perfectly sound. It being a well-known and undisputed fact, that the patholo- gical status necessary to constitute the disease or process known as chronic tubercular pulmonary consumption, vary greatly in different cases, hence it must follow, that the treatment, to be more or less successful, should be adapted to meet the several indications and conditions of each patient, and modified to suit the different stages and symptoms that may come to pass, or be manifest from time to time in any given case. To be brief and definite as possible, we will suggest an illus- trative case, such as more or less frequently occur, of a class of cases that are very often dismissed, by many reputable physi- cians, with a commonplace prescription (an opiate cough mixture perhaps) supposed to be sufficient to give relief from immediate suffering or inconvenience. An individual—especially those from fifteen to thirty years of age—consults us for perhaps a recent cold, cough or sore throat; for usually phthisically disposed persons take cold easily, be they ever so robust and apparently sound. A careful history of such a case may develop the probability, that perhaps phthisis, 4 may be in its earlier stages, has been (and is) insidiously creep- ing upon the patient for at least several months. Therefore, if permitted, we make a careful physical examina- tion of the lungs and heart: and may be discover the peculiar signs that warrant us to suspect the presence of phthisis, though it may be in its early beginning. However, as it is* usually difficult, and often impossible, in this class of cases, to positively decide just what proportion of their observable signs are acute or recent, and what proportion chronic; hence we deem it proper to state plainly to such patients, the nature and import of their condition; prescribe to relieve the immediate demands of the case, and make special endeavor to impress the importance of a thorough re-examina- tion in the near future, and dismiss the patient with a favorable prognosis, provided our instructions are strictly complied with. ’Tis often most difficult, or impossible, to bring this class of patients to realize the portentous importance of prompt diligent and decisive treatment in their case. For, may be with truth, they will tell us, that they have not been sick for years, always able to work more or less, never had haemoptisis, hectic fever, or night sweats, little or no habitual cough, pulse and circula- tion ordinarily good, appetite and digestion usually fairly good, and have lost little or no weight. Now many such patients, barring accidents and acute diseases, would live from two to five years, or possibly much longer, if left without treatment of any kind. Yet this is just the class of cases from which the great majority of recruits are constantly drawn to replenish the ever-rapidly thinning ranks of the vast host of irretrievable consumptives. Now is the golden opportunity with this class of patients; and if the physician make haste to utilize available therapeutic resources, such patients, with little loss of time from their ordin- ary employments, and at no great expense, can usually be, within a year or two, put in such condition that, with a reasonable degree of prudence, they may live out an ordinary lifetime, or ultimately die of other disease than phthisis. In this class of patients, the emunctories, especially the inter- nal excretal gateways, are usually sluggish and clogged with effete matters, the secretions and excretions have long been diminished and vitiated, hence the normal processes of metamor- phosis and disassimilation of the tissues and fluids of the body are more or less retarded; the gradually accumulated debris is too slowly eliminated, and its presence prevents the elabora- tion and appropriation of a good quality of new building up material. Chronic constipation, in more or less degree, usually exists,— the reverse obtains rarely,—and such persons do not usually as- similate well. These vitiated, and worn-out excretive products, resulting from normal, or perverted, tissue change, gradually accumulate wherever the economy least resists their presence, and they by degenerative changes, become or produce a slowly-acting leu- comanic or ptomainic poison, which gradually hampers and weakens the life-cell building power, until it becomes impossible for normal tissue-building material to be elaborated and utilized. Hence, while the assimilative and excretive organs move in this vicious circle, the strength of the patient cannot be per- manently built up, or his waning vitality restored: ply him as you may with so-called alcoholic stimulants, ferruginous tonics and cod liver oil. And thus, by this hypothesis, the correctness of which has been abundantly proved by clinical demonstration, we are enabled to push our research one link further back in the mysterious pathological chain of primordial causation, of at least a larger proportion of cases of chronic tubercular phthisis pulmonalis, than has heretofore been recorded for us. Jaccoud, in common with many other recent and earlier ob- servers, tell us, that the fons et origo of this disease, is organic constitutional debility. And upon this idea, as a basis for his remarkably successful treatment, he in his latest words, “ Pro- claims more earnestly than ever, that chronic tubercular phthisis pulmonalis, is curable, in a certain proportion of cases, in all its stages ; and that this encouraging idea presides over the whole history of the disease, and therefore the necessity, and proba- bility of utility of persevering well directed plan of active treat- ment.” And while our limited clinical experience, especially in recent years, strongly inclines us to indorse the hopeful views of Pro- fessor Jaccoud, See, Grancher, Brehmer, Churchill, Davis, Flint, and many others, as to the utility of timely well directed per- severing treatment of this disease; we think that the assigned predisposing causes or conditions—constitutional debility of Jac- coud ; Cutters vegetable spores in the blood ; the bacillus of Koch ; the want of phosphorus in the system of Churchill ; the mal- meteorologia of Storer, and many others—alleged as being the primary, principal or sole predisposing cause that must obtain or act, in order that the pathological phenomena recognized as constituting phthisis, may or must evolute, are inadequate to elucidate the leading manifestations that usually come to pass during the progress of this disease. Yet, a comprehensive understanding of each of these theories just referred to, will bring to the patient student much valuable light that no other window will let in. And when each and all of 6 these theories, together with the hypothesis we have advanced, with a clear philosophic idea of the value and bearings of each, are considered as a comprehensive whole, we will be enabled, as cliniciens, to move one more sure step forward, in that most dif- ficult road, the obstacles of which have so often baffled the ablest efforts of the greatest physicians of all ages and coun- tries—the successful treatment of phthisis. These retained poison-producing waste or effete products re- ferred to act as an irritant, and tend to produce—and often do produce—a reactionary fever, usually called hectic, and which is the result of an effort of the conservative powers to rid the economy of such seriously disturbing poisonous materes morbi. This persistent, auto-ptomainic toxemia,producing hectic fever, the cool stage of which often results in night sweats : the latter phenomena being plainly an effort of the conservative powers to rid the system of this subtle poison. Hence, some phthisical patients, who are not extremely debilitated, feel better during the first few hours immediately following a profuse hectic sweat. This plausible and instructive—and we believe correct—hy- pothesis, is one of the chief corner stones upon which we predi- cate our system of curative treatment of early phthisis ; the past success of which has already given us much reason to hope for still greater success in future. And, as a rule, in any given case of early phthisis, if we are able to stop the auto-toxemia, the cause of the wasting hectic fever, its concomitant debilitating phenomena, will cease, and the patient will be enabled, by further judicious treatment (and some cases without further treatment) to make more or less per- manent improvement. And our experience leads us to believe, that this desirable result can be most surely and speedily pro- duced, in many cases, by the early eliminative and specific sys- tem of treatment which we advocate. The majority of physicians are very skeptical in regard to the curability of any form or stage of phthisis. And this wide spread skepticism is the more deplorable, because its tendency leads such physicians to shut their unwilling eyes to portentous manifestations, paralyzes their energies, diminishes their already too small confidence in the value of remedial agents, and they blindly endeavor to hope for the best, and thus supinely fritter away golden days of available opportunity, the criminal waste of which will make, in many cases, all the momentous differ- ence between a prolonged valuable and happy life, and an early sad lingering death. As before intimated, it is quite fashionable, with a certain class of physicians, especially those affecting superior intelli- gence and higher education, to profess to have little or no Jaith in the healing powers of drugs, even in other diseases than phthisis ; but with arrogant vehemence do many such scout the idea, that medicinal substances may be so administered to patients suffering from well defined pulmonary consumption, as to not only render temporary relief, but so as to be the principal means of causing a more or less permanent restoration of a fair de- gree of serviceable comfortable health. And only recently, an eminent medical teacher, published : “ It remains for phthisical subjects, then, to content themselves with caring for their health by means of the inhalation of rela- tively pure air, free from dust, by good, strengthening nourish- ment, and by strict attention to the hygiene of the body.” Of course, it would be a worse than useless waste of effort, to reason with this confirmed pessimistic class of therapeutic nihil- ists, who doggedly close, the shutters to the light of later ex- perience and progress, and declare the sun of increasing thera- peutic light and success does not shine. In the treatment of phthisis, in many cases, we should keep two somewhat distinct objects in view : First, The correction of the general perversion of the func- tions of the tissue building powers and processes ; and, Second, The palliative or curative treatment of the various local or special manifestations or complications,—such as cough, fever, sweats, pleuritic or other pain—acute, temporary or oth- erwise, as may come to pass during the progress of each indi- vidual case. In our efforts to relieve or cure the second class of manifes- tations, we should beware of over-active, perturbative or de- pletive treatment. But as before hinted, ’tis often the greatest difficulty en- countered, in our efforts to timely and successfully treat phthisis, is the inability of the patient and his friends, to appreciate the portentous gravity of his threatened condition, and to realize the urgent necessity for the immediate persistent and diligent use of whatever remedial agents deemed necessary. It seems difficult or impossible, for many such patients, to fully realize the momentous fact, that their chronic morbid constitu- tionality, wffiich usually has been years in developing, and in- deed is often inherited, cannot be eradicated or more or less permanently corrected, by the use of this or that remedy for a few days or weeks, or by a brief vacation from school or business. And we are sorry to say that this dangerous lulling skepti- cism is often encouraged, if not originated, by many reputable —but inconsiderate or uninformed—physicians. Hence it is, we see so few well devised and persistently ex- ecuted plans of timely constitutional treatment adopted, for either preventing or curing this obstinate disease. In the division or classification of remedial agents and meas- 8 ures to be employed in the home treatment of phthisis, we would place first, hygiene ; second, foods ; and third, drugs. Of course, we refer to the treatment of those cases—the great majority—whose circumstances will not permit them to travel away from home, to secure the great advantages often to be derived from more or less prolonged judicious climatic treatment: which of itself, under favorable circumstances, with ample means, is often not only a most valuable auxiliary therapeutic resource, but the most powerful restorative agency or influence available. OF HOME HYGIENE. First. The patient should have, and regularly follow,—barring inclement weather and physical inability—some cheerful active out-door employment : even females should comply with this requirement as far as sex, strength and circumstances will allow. , For idleness consumeth the health as a devouring moth, and as a hungry leech it saps the strength and energies in the early morn, noontide and eve : and surely brings the wasting tor- tures of miserable introspective brooding gloom, that poisons the fountains of life, and often defies the restorative power of all healing agents and influences. This outdoor active exercise, is largely shorn of its remedial value, if performed as a slavish task or a dreaded penance. ’Tis best that it come as an incidental accompaniment to some specific more or less serviceable purpose earnestly carried out. The patient should be encouraged to resolutely take the world by the horns, and with determined spirit and energy bend its affairs to serve his laudable purposes. For many persons die prematurely, simply because they have nothing else of interest to do. And what is more: there is no bread so nutritious as that upon which open-air manual labor feeds, or viands so sweet as the trophies of the bronzed horny hand. Horseback riding, especially at a rapid pace, on an easy-going horse, is well known to be one of the best forms of exercise; and if circumstances permit, should, in many cases be preferred to heavier manual labor. But no form of labor or exercise, should be habitually taken to such an extent, as to cause the patient to be sore and wearied on rising the following morning : but the greatest amount that can be performed short of this sore-tired feeling, is not too much. Frequent short rests, through the day, preferably in the horizotal posture, and not over five to ten minutes at a time, are very beneficial. And we should not forget or neglect the great value of regu- lar, well-directed, home gymnastic exercises. This serves a most valuable purpose, that cannot be attained by any other means. And fortunately ’tis within the reach of all, even in the humblest circumstances : and is always available, even in the most inclement weather. Blaikie’s and Lofving’s* small manuals, recently issued, give excellent practical teaching and valuable advice on the best modes and sanitary value of Home and School Gymnastics : and every Physician, and every School Teacher, and every phthisi- ually inclined patient or person, and all young persons living in cities, should procure one or both these small monographs, and heed their valuable teachings. In some cases of early phthisis, the fine dry crepitant rales, for which we so diligently seek — hoping we will not find them— and oftenest found at the apices of one or both lungs, may be made to disappear, in some cases more or less permanently, by the regular daily faithful intelligent use of respiratory gym- nastics, carried out in accordance with the instructions Prof. Lofving has laid down in his manual of gymnastics. Thus showing unmistakably the great value of this form of treatment. Home gymnastics serve an invaluable remedial purpose, that no other remedy, or form of exercise or treatment, can afford : and is of especial value as a preventive of phthisis, and also a remedy of great curative value in the earlier stages of that dreadful disease, and is always available. Nor should we forget or neglect vocal music, as a remedy of great value, in the prevention and early curative treatment of phthisis : for it furnishes a form of pulmonary strengthening exercise and gymnastics that cannot be supplied in any other way, or by any other means; and should be a part of the curric- ulum in all public and private schools. FOOD. In regard to what is proper food and feeding for phthisical patients or persons, we do not agree with the views so dogmat- ically laid down by some distinguished writers upon this sub- ject: who seem to think, that perfection of nourishing and per- manently building up phthisical patients, or phthisically inclined persons, consists in causing them to ingest the maximum amount possible of the richest concentrated nitrogenous and fatty foods—exclusive of other classes of foods—at regular stated periods every day. For we are quite sure, that the menu some such writers have specially formulated for this class of patients, would overtax the J. B. Lippincott Co., 1890, 60 c. digestive powers of even many sound robust persons in a short time. For the problem is plainly, not just how much con- densed rich, nitrogenious, fatty, or other strong food, we can induce these pattents to ingest, but what kinds, classes, and combinations of foods they can most easily and thoroughly assimilate, for more or less indefinitely prolonged periods of time. To do this to the best advantage, we must carefully study each individual case, with all available light, as an independent problem. For it is manifestly absurd to lay down cast-iron rules and rigid specifications, as to kind, class, and quality of foods, that every phthisical patient shall ingest within a given period of time. For physiological chemists have repeatecly demons- trated that a variety of food is necessary for even a fair degree of nutrition and continued health, in any given species of highly organized animals ; and man, being the highest, and inherently omniverous, naturally requires the greatest variety. Just here, we should not forget the important fact, of the indis- pensable value of certain fats, as not only being easily digested themselves, but their wonderful assisting power in aiding the digestion and assimilation of other classes of foods, notably starchy foods, and fresh herbaceous and leguminous vegetables. Physiological chemists tell us, that the assistance certain fats render the process of digestion is largely owing to their property of quick and ready combination with starchy foods and fresh herbaceous and leguminous vegetables, forming—by aid of the digestive juices—soluble albuminoid emulsions, which are the easiest forms of crude aliment from which the assimil- ative organs can draw supplies for new cell-building materials. Thus, to illustrate : See how much easier the old English dish, “ butter-bread,” is digested, than our American hot bis- cuits, or worse still if the butter be left out entirely. Again, see how much more easily the fresh raw, or cooked herbaceous salads are digested, if seasoned with a little toothsome gravy— especially that from well-cured bacon—than when eaten without such seasoning. Just here ’tis well to remember the powerful eliminative and health-restoring effects of good fresh herbaceous and legumin- ous vegetables, as so strikingly demonstrated in curing scorbu- tic sailors and soldiers. All are familiar with the phenomenal success of Prof. B. W. Dudley, who fed his surgical patients on turnip greens,—cooked with bacon,—plain corn bread and buttermilk. And this wonderful eliminative and health-restoring effect of fresh herbaceous vegetable diet, is most strikingly demonstrated every year, upon the Pacific coast Indians of Northern Califor- nia. These Indians are very subject to phthisis, and suffer most during the months that they are deprived of fresh herbaceous vegetables. But as soon as the fresh green wild salads (especially the wild clovers) become plentiful, these Indians consume large quantities of it,—eating a large portion of it raw—eating, for several weeks, little other food. During this herbaceous vege- table eating period, the improvement in the health of their sickly people is most remarkable, especially those suffering from phthisis Phthisical patients should ingest, at regular intervals, a liberal supply of good soft water; but never colder than good cistern water, and only moderate quantities at a time. This health-pro- ducing fluid is not only a veritable medicine for many diseased conditions, but, owing to its superlative solvent powers, it is at once the prime reducing agent, and also the vehicle by which the tissues are cleansed and rejuvenated, and built up. The ingestion of mineral waters, with few exceptions, is usu- ally injurious, rather than beneficial, to most consumptives, es- pecially drank freely, or for long periods of time. Hippocra- tes wrote a volume urging and explaining the remedial value of good water ; and physiological chemistry, and later clinical experience, have fully confirmed the correctness of his teach- ings. As an illustration of the bad effects of over-ingestion of too rich food, see the healthy robust young peasant mother, called to wet-nurse a rich man’s babe. Fresh from her rural cottage, with its plain food, fresh air, and plenty of physical exercise, her milk is of the best ; but so soon as she enters the palace of wealth, do her employers begin to cram her stomach with large rations of concentrated, rich foods, and drinks of ale, porter, and beer, causing her milk to soon become surcharged with nitrogenous matters, so that the nurslings are soon made sick. A knowledge of successful feeding, in health or disease, is necessarily largely empirical, both in general and special. We should adapt the feeding to the patient—not the reverse, as some would-be oracles command. As to the diet list—presuming the patient to be in a condition warranting the hope of cure, or more or less permanent improve- ment—we usually direct, that the patient take little or no coffee or tea, no tobacco in any form, no alcoholic liquors in any form (unless prescribed)—as they, even in moderate quantities, dimin- ish the power to assimilate fats—no rich pastries, sweet cakes, or sugared compounds. Plain dishes, toothsomely prepared, are preferable to rich compounds. Phthisical patients should take three good regular meals every day ; a liberal part of at least one of which should be good fresh butcher meat—beef or mutton, or other fresh and easily digested meat—prepared to suit the taste and digestion. Good well cured bacon, may be taken once or twice a week—best lightly boiled or raw—as a change. A good hearty breakfast, a moderate dinner, and a light supper. The foods should be varied from day today, as much as circum- stances will allow, but not many kinds of food at any one meal. Choice ripe fruits, cooked or raw, are valuable foods in this as in most other diseases, but should be taken as a part of the regular meals; not promiscuously through the day, especially in the afternoon. All are familiar with the notable success of the “grape cure ” of phthisis, during which the patient, for several weeks, takes little other food than fresh, ripe, sweet grapes, which are very rich in fruit sugar ; yet, if of proper variety, well ripe and fresh, rarely disagree, though several pounds of them be eaten daily for long periods of time, provided they be taken only at regular meal times—three times a day—and the patient exercise freely in the open air. Just here ’tis instructive to observe, that those grapes found beneficial to phthisical patients, are not only rich in fruit-sugar, but also strongly charged with astringenc)\ especially in their skins. Here we get a clew as to the best com- bination of tannic and pyrogallic acids, sometimes found so beneficial in the treatment of phthisis. Fresh herbaceous and leguminous vegetables, properly cooked and seasoned to suit the taste, are also a valuable class of foods. Some herbaceous vegetables—as tender white cabbage, blanched celery, cresses, etc.—digest more easily, and are more nutritious and generally beneficial, when eaten raw; and these form a valuable class of foods for consumptives. Eggs do not usually agree well with phthisical patients, unless eaten raw or slightly cooked. Choice milk —fresh rich sweet milk, or butter milk—and gooo fresh butter, with good light wheat, Graham, rye or oat bread, or good plain corn bread, are foods of indispensable value, which every phthisical patient should have. To recapitulate: No food should be eaten that the patient does not digest comfortably. The form-s and kinds of food should be varied frequently ; for, “ Variety is truly the spice of life.” But only two or three kinds of food should be taken at any one meal. Food should be taken at regular intervals, eaten slowly, and thoroughly masticated. To this end the teeth should be kept in good condition. The circumstances of mealtime should be made as pleasant and cheerful as possible. When the appetite is sharp the patient should not eat quite as much as he wants. SLEEP. “ Nature’s sweet restorer. A favorite theme of inspiration for the bards of all ages in everv land : All peoples have craved thy solace S:nce earth from chaos woke. As all know, the nervous system is divided, both as to organs and functions, into two grand divisions. And while these two divisions interfunctionate more or less in unison, as mutually assisting and complementing each other’s duties, yet each division has its specific, and somewhat exclusive work to perform. The cerebro-spinal system runs the machine during wakeful hours; while the sympathetic system is mainly engaged, during wakeful hours, in cleansing and lubricating the bearings, and otherwise preserving the machine from unnecessary injury dur- ing its outwardly active periods. And the cerebro-spinal system is not only the great executor of outward or productive labor, during wakeful hours, but is also the great consumer of organic force and new force-producing materials of the body. On the other hand, the sympathetic system does its beautiful and indispensable work, which is mainly eliminative, renova- tive, reparative, and constructive, mostly during sleeping hours. During sleep, the old worn-out effete products, the result of the previous day’s activity and kata'bolic change, must be gathered from all the organs and tissues of the body, and conveyed out of the system; and new force-storing and reparative material, the result of anabolic change and elaboration, must be carried to all parts and organs of the economy, ready for the follow- ing day’s outward activity. So we see the indispensable necessity of a regular and plen- tiful supply of comfortable sleep. And eminent physiological investigators, have proven, in this connection, two great broad propositions, both of which are of momentous importance, just here : First. That sleep, during the dark hours, is more recuperative and generally beneficial, than during the light hours. Second. That too much sleep, is injurious to the genera well being of an individual—sick or well—especially to those whose respiratory capacity is diminished below normal. Hence ’tis equally important that phthisical patients rise early as that they go to bed early; and here clinical observation substantiates physiological experiments. And Prof. Draper’s careful and repeated experiments conclu- sively show—what accords with common observation—that the excess of oxygen taken into the system during too prolonged sleep, does not serve any good purpose, unless there be in the body an excess of material the oxidation of which would either furnish increased force and vitality, or render such excess of oxidizable material less noxious or more easily removable from the econ- omy. And that too rapid or too great an oxidation in the body—as in the case of too much sleep—leads to physical feebleness and sluggish mentality, instead of increased power and vivacity—as is popularly believed. The sleeping rooms of phthisical patients should be the larg- est and best ventilated of their homes ; and the air thereof should not only be kept fresh and pure, but should also be kept at a comfortable equable temperature day and flight, by the aid of artificial heat if necessary ; an open fire place or grate being greatly preferable to a stove. But such patients—nor no other person—should sleep in a current of air, however hot the weather, for such exposure not only frequently results in serious or fatal acute attacks, but is often the first perceptible beginning of phthisis. No other person should sleep in the same room with phthisi- cal patients. If there be tendency to cold feet, they should be vigorously rubbed with coarse cloth or brush, in pleasantly cool water every night, then made very dry and warm before going to bed, and kept warm all night. Thick soft cotton stockings will usually keep the feet warm better than woolen. The body underwear, for all the year round, should be made of soft wooL or silk, thick or thin, to suit the season ; and shirts should be made with long bodies and long sleeves, and to fit snugly round the neck : but the clothing should never be so close-fitting as to interfere with free full easy respiration, locomotion or circulation. The bedding should be sunned and aired at least twice a week. Once or twice a week, in a close, pleasant room, the patient’s whole person should be thoroughly and vigorously rubbed and cleansed with a brush or coarse cloth, wet in weak warm soap suds; each region being rubbed thoroughly dry and covered before another is bared, exposing as little of the person at a time as possible. The ordinary modes of bathing or washing the body usually do more harm than good ; haemoptysis and other injurious results being often produced by such exposure and chilling of the surface. A weak, continuous galvanic current, applied mobile over the body for half an hour, followed by a brisk dry brush shampoo massage, just before going to bed, will produce much comfort and some real benefit in many cases, especially if the patient be ner- vous and suffers from insomnolency. DRUGS. In the language of the latest writings of the late Professor Austin Flint, in reference to this topic, we would say : ‘‘All remedies which improve appetite, digestion, assimilation and nutrition are in greater or less degree useful.” But, upon this subject, there are two points, both of which we deem of great importance, that stand out prominently in the writings—especially his latest, of this learned physician : ist. His ideas of drug therapeutics, were seriously hampered by a theory—the bacillus theory—that even the latest lights do not enable us to successfully apply in the clinical cura- tive treatment of this or other diseases. 2d. He failed to recognize the idea of the significant impor- tance of the elimination from the system of the leucomanic or ptomainic poisons, generated by the perverted processes of disassimilation of the tissues of the body, and by the imperfect, or failure, of assimilation of ingesta, regardless of its kind, quality or quantity. (Just here, it would be instructive to note, that theories and theorists, have done far more to hinder than help the advance- ment of clinical medicine.) For it is well known, that even the normal katabolic changes and processes that daily occur, even in the bodies of the healthi- est individuals, and when they take the best foods, produce a sufficient quantity of leucomanic poisons to seriously jeopar- dize the health, if not endanger the life, of the individual, were these autogenic poisonous products not eliminated, at least to a greater or less degree, by the various emunctories. And so we find that in the treatment of all chronic constitu- tional diseases, we must direct our curative efforts to elimina- tion of those autogenic katabolic toxic materials, if we would secure any great degree of permanent improvement to the patient. And, fortunately, there are various means and methods by which the so-called vis medicatrix naturce may be impressed or assisted, in greater or less degree, in this eliminative, conserva- tive process or action. Just here, it will be profitable for us to remember that thehver is the chief of this class of conservative agents ; for, with sleep- less vigilance it stands at the great gateway of chylopoietic nu- trition, and by virtue of its sui generis metamorphosing powers, it seizes upon poisonous substances passing the round of the circulation—especially leucomanic, ptomainic, and other organic poisons—and if the toxic substances be not overwhelming in quantity or quality, it neutralizes them, in whole or in part, and the innocuous—or may be useful—product is allowed to pass on to fulfill its predestined purpose in the nutritive or repara- tive economy. In some cases, especially if the toxic substance be inorganic, the liver holds such poisons under arrest, stored up in its lym- phatic cellular substance for an indefinite more or less pro- longed period of time; and in some cases relatively large quantities will thus accumulate before steatosis progresses to such a degree as to render longer effective functionation im ■ possible. Hence, medicinal substances, especially inorganic medicines, e.g.t mercury, arsenic, phosphorus, iron, etc., should not be administered continuously for long periods of time, but exchanged for vegetable remedies, or, better, all remedies be remitted from time to time. So here we discover one of the great secrets of the why and how we may benefit our phthisical patients by the judicious use of drugs that increase hepatic functionation. And we also readily sec how our syphlographers are enabled to increase the red blood corpuscles, and improve the blood-plasma by the use of minute doses of mercurials, in the treatment of constitutional syphilis. And, again, we see how our remedies in the treatment of phthisis, especially if inorganic, as mercurials, phosphorus, arsenic, etc., may become—and sometimes do—-poisons, if admin- istered in too large doses, or continuously for too long periods. The therapeutic indications being plainly to administer reme- dies, especially of this class, in small non-perturbating doses, and with, or just after meals, that the medicinal substance may be digested with the food-mass, and pass into the long round of chylopoietic nutritive circulation, thus becoming albuminoids, the form in which they may be most quickly and thoroughly appropriated by the assimilating organs and forces, and thereby render the greatest possible service toward renovating and building up the various tissues of the body. And in this connection, we should refer to alcohol\ as it is regarded by many, even of those of eminence, as one of the remedies in the treatment cf phthisis. Alcohol, being a narcotic sedative, and an anaesthetic, and strongly tending to retard reparative physiological tissue change, and by its paralyzing effects upon the excretive forces and organs, prevents the normal physiological disintegration and elimination of effete products, thereby directly tending both to cause tubercular deposits in the lungs, and at the same time to cripple the emunctory organs : hence its ingestion in any quantity or combination, could not result otherwise than injuri- ously to phthisical patients—unless possibly, as an ancesthetic in some cases that were already hopelessly near the grave. We speak thus strongly and positively, not upon mere theory or hypothesis, nor as following or opposing the bias of tradi- tional influences or teachings. But as the result of many years’ close observation, and clin- ical experience : therefore we know whereof we speak. And it is scarcely necessary to state, that the foregoing opinion, coin- cides with the latest and best authority, as touching this subject. And just here, en passant, permit us to say, that the problem, of general and special therapeutic application, as to what hour of the day, in reference to meal-time, etc., is the best time to ad- minister medicines, is a question of vital importance—but too much neglected—and well worthy of the profound attention of every physician. But it remains to the knowledge, judgment, and sagacity of the physician, to select the most appropriate means and methods, and to properly direct their use and appli- cation, in order to obtain the greatest possible curative results in any given case. For, indeed, herein lies the supreme con- summation of therapeutic skill, and which has been truly termed, the poetry of medicine. When we consider the many medicinal substances that have been found more or less useful in the treatment of phthisis, in its several stages and different types, and in individuals of dis- similar constitutionality temperament, age etc., the bare men- tion of their names might bewilder us, if we do not keep well before our minds some definite idea of their real or supposed modus operandi. Probably the most numerous class of remedies referred to, are treated of in works of materia medica, under the general title of vegetable alteratives. The most palpable manifestations of the remedial value of this class of medicines, are to be observed either upon the cutaneous surface, or the respiratory and gas- trointestinal mucous membranes, or more directly upon the adenoid tissues of the body. Another notable characteristic and valuable therapeutic prop- erty of vegetable alteratives, is, that they do not accumulate in the system, and thereby become poisons rather than medi- cines, as mineral alteratives are prone to do, especially if admin- istered continuously for long periods of time, even in small medicinal doses. Another important therapeutic peculiarity of vegetable alter- atives, is their tendency to gradually lose their medicinal effect, if administered continuously for long periods of time ; hence more or less frequent change of them is necessary to obtain their best remedial effects. To be both brief and specific, we will simply name some of the drug-remedies we have found most useful in the general or special treatment of phthisis. Beginning with the vegetable alteratives, we would note: Extracts, or active principles, of ipecac, wahoo, burdock and yellow dock root, stillingia, wafer ash, phylocoa, leptandrin, lupulin, collinsonia, chionanthus, sarsaparilla, golden seal, inulain, asclepias tuberosa, gelsemium, sanguinaria, senega, tag-alder ergot, nux vomica, buchu, red and black pepper, cubebs, and aloes. The mineral acids—muriatic, nitric, and phosphoric—we find most useful for internal use; and lactic acid, in form of spray, for laryngeal phthisis. The balsamic remedies, as several of the refined turpentines: as oleum templinum,oleum pini sylves- tris, light oil eucalyptus, oil cinnamon, oil cloves, sweet gum, oil camphor, oil sassafras, menthol, balsam Peru, oil sandal- wood, and others of the same class. These oils and balsams are used, some for inhalation, some by the stomach, and some by both modes of administration, and are an invaluable class of remedies in the treatment of phthisis. Assafoetida, in pill com- bination, and soluble balsam tolu, in fluid combination, are both useful remedies, in this disease. Of the specific remedies, we would note, as most important, the alkaline hypophosphites, especially that of soda, as being most frequently applicable. But to secure good results from the use of the hypophos- phites, it is of indispensable importance, that they be of pure quality, and be given judiciously. For several years, we have given the hypophosphites (in syrups), manufactured by R. W. Gardner, of New York, and believe them to be the best made in the United States, and equal to those manufactured by Swann, of Paris. The dose of the hypophosphites, as directed in the U. S. Dis- pensatory, is much too large, and will more frequently prove in- jurious than beneficial. To adults, we usually administer the syrups of the hypophosphites (but never mix them,) teaspoonful (about two and one half grains) three times a day, just before meals. Arsenic and the hypophosphites, should not be administered simultaneously: but vegetable alteratives, tonics, and laxatives— as indicated—should always be administered simultaneously with either or both. The syrup of hydriodic acid, is often a useful remedy, especi- ally in dry, asthmatic or feverish cases: whether the fever be purely hectic, or a more or less malarial complication. Just here, we should state: that the febrile exacerbations—which are often followed by profuse sweats—from which phthisical pa- tients often suffer, are in many cases aggravated and prolonged by the administration of quinine: regardless of the fact, that these febrile exacerbations may or may not be complicated with more or less malarial poisoning. In slow, dry asthmatic cases, where there is no fever, the hypophosphite of potassium, will often render valuable service; but its effects should be closely watched, for when given long or in too large doses, its pathological tendency is to cause a deliquescence of the tissues. A small proportion of cases, especially babes and small chil- dren, and those with strong tendency to more or less rapid break- ing down of the lungs, may be benefited by the judicious use of hypophosphite lime. Bromide of arsenic, and mercurials—the cyanide, bichloride, and biniodide, of mercury, we most frequently use—all in very small doses, and intermitted from time to time, are valuable rem- edies in some cases. Guaiacol, one to three drops, t. i. d., just after meals, in pleas- ant emulsion, is an invaluable remedy; and in cases of strong tendency to fever, will supersede the hypophosphites until the fever is subdued. Myrtol, is also an invaluable inhalent remedy. A diligent, judicious, and persistent use of inhalent remedies, will usually not only preclude the necessity of cough mixtures—one of the greatest curses of pulmonary sufferers—but will, in many cases, also produce great generally beneficial results, that could not so well be secured by any other means. The inhalation of dilute aqueous spray of wine of ipecac, is also a valuable cough remedy. In dry asthmatic, or eczematous cases of early phthisis, bi- sulphite soda, given in small doses in dilute solution, for several weeks, is often a valuable remedy. If night sweats give trouble, oxide zinc with sulphate hydra- stis, will usually soon stop them, though the timely and judici- ous use of vegetable alteratives and inhalent remedies, will usually prevent or cure night sweats. As a rule, with rare exceptions, the hypophosphites should never be administered when there is fever, or the tongue foul or unnaturally red ; nor given conti?iuously for longer than one or two weeks. Nor should the different hypophosphites ever be mixed, in any case, as they are therapeutically incompatible. We usually give the syrup of the hypophosphite soda, tea- spoonful three times a day, just before meals, for one or two weeks, then leave it off for one week, then—if not contra-indi- cated—resume its use, thus using it for two weeks out of every three weeks, for several months if no contra-indication inter venes—then alternate with some other remedy. In many cases, especially in non-febrile early phthisis, this invaluable remedy may be thus used ; with proper intermissions and precautions, and in connection with vegetable alteratives and tonics, and other indicated remedies, for many months, or even for several years, with most beneficial results. The syrup of lactophosphate lime, is often a valuable ap- petizing building up tonic remedy, especially for babes, young- children and for advanced cases. We have prescribed (and taken several gallons) large quanti- ties of cod liver oil, plain and in various combinations, and of the best quality the markets of the world afforded, and in ac- cordance with directions from the most distinguished authori- ties, but usually with discouraging results ; hence, rarely pre- scribed it during the last few years. Professors Williams, father and son, of Brompton Hospital, have treated about 15,000 cases of consumption, mainly with cod liver oil, as the constitutional remedy, resulting in a mortality of about 99 per cent. The malt extracts, if not too sweet, or charged with too much alcohol—as most all of them are—act well in some cases, as an appetizer and aid to digestion : large tablespoonful in half a glass of water, three times a day, with meals. Hoff's and Wyeth’s malt extracts, are the best we have tried : but even these would be more valuable, and more frequently applicable, if they con- tained no alcohol. In the curative treatment of phthisis, the bowels should be caused to move in a free, natural, comfortable manner, at least once every twenty-four hours ; and during acute or feverish ex- acerbations it is usual ly best that the bowels move twice in twenty- four hours. But in no case should drastic purgatives be used, or free pur- gation be induced. During acute exacerbations, which are usually attended with circumscribed dry pleurisy, pain in upper chest, and fever, even in the earliest stages of phthisis, the patient should be kept quietlyin bed; feet andlimbs kept very warm, free—Croton oil— counter-irritation over the chest, and such other general or spe- cial remedies administered or applied as may be necessary, until all acute pain and inflammatory symptoms are relieved. By a judicious use of vegetable alteratives, laxatives and tonics, proper food and exercise, we are usually able to keep the bowels in good condition without purgatives. We usually give two to four vegetable alteratives, with one or two vegetable tonics, in coated pill form, simultaneously with some of the balsamic remedies, by inhalation or otherwise, and such special remedy as may be indicated. But we make it a cardinal point that our medicines must be given in small, non-perturbative doses, made pleasant to take, and never to disturb the stomach or hinder digestion ; and very rarely administer any remedy oftener than three times a day. Just here it may be well to note, that the chinchova salts are rarely beneficial in the treatment of any stage of phthisis, or any of its complications ; but they often produce injury, even in mod- erate doses, by increasing the tendency to nervousness, hectic fever and night-sweats. The compound sulphur lozenges, serve a valuable purpose, as a cholagogue laxative in some cases, and may be (in hepatic de- rangements independent, of phthisis) given for several weeks or months, one to three lozenges three times a day. The following formula is a good one : 1$ Pure Sulphur, gr. 5. Pure Cream of Tartar, gr. 2. Ext. Ipecac., gr. 1-100. Ext Capsicum, gr. 1-500. Arsenious Acid, gr. t-iooo. Bisulphite Calcium, gr. 1-8. M. ft. lozenge. Messrs. John Wyeth & Brother, manufacture them for us, by compression, and they are stable, elegant and pleasant to take. Cases that are attended with hemoptysis in the early stages, especially if the bleedings are not large, are usually the most easily cured. For such cases, the extracts of ipecac, ergot, with sulphate hydrastis, extract viburnum prunifolium, and pyro- gallic acid, given for long periods of time, are of special value. For the immediate arrest of hemoptysis, give large doses of ipecac, well diluted. Should the phthisical patient suffer with fistula in ano, it should be cured soon as possible : as the emunctorial capacity of fistula—if indeed they ever exercise any such powers—are far more than counterbalanced by the injury they do the victim, as a source of pain and irritation ; to say nothing of the far more serious danger incurred, of steatosis or amyloid degene- ration of the kidneys, or metastatic hepatic abscess. While all must allow, that such means as the ulcerating surface of a fistulous tract—or any other ulcerating surface, regardless of its extent or locality—is a miserable lame (and often dangerous) way or means, to say the least of it, of eliminating peccant humors from the system, or purifying the fluids and tissues of the body. Owing to their occupation, prostitutes are specially liable to hemoptysis, and some of them bleed from the lungs more or less.frequently for several years or longer without developing phthisis, or any apparent serious decline of health; and the first attack of hemoptysis, in other persons than prostitutes, often occurs during sexual intercourse, regardless of sex. To recapitulate briefly, we would say: That it is well established that chronic tubercular pulmonary consumption is, in a considerable proportion of cases, a curable disease : provided, proper treatment is undertaken and pertistent- ly, diligently and judiciously carried out, from the date that the earliest diagnosis of the disease can be made, (and in some cases, much later) until the disease is cured, which will usually re- quire from one to three years, and in some cases longer. That this treatment can often be carried out to successful issue without the patient making distant journeys, or expensive sojourns at this or that health resort, provided his home climate, employment, and environment be not specially unfavorable. That a recognition of the correctness of the hypothesis we have advanced, as to one of the great predisposing causes of chronic tubercular pulmonary phthisis, brings us one link nearer to the primordial origin of at least many—if not most—cases of this disease, which, therefore, indicates a plan of treatment most likely to be successful. Lastly: clinical experience and observation has confirmed the correctness of our herein expressed views in reference to the prognosis and treatment of this disease. Austin, Texas, October 1890.