A • SYNOPSIS OF JXew^emedies RARE CHEMICALS AND PREPARATIONS, AND THE Jatest :2 JVjaterials PRESENTED BY R. E. RHODE, MANUFACTURING PHARMACIST, 504- N. OLARK ST., COR. OF GOETHE, CHICAGO. R. R. DONNELLEY & SONS, PRINTERS. CHICAGO. TO PHYSICIANS AND SURGEONS. The preparations in this list are submitted for consideration with the hope that they will be found useful in practice. They are of guaranteed standard strength and purity, and prepared in accordance with officinal or other authoritative formulae. A short trial will convince the intelligent and discriminating physician of the superiority of these preparations over the vast majority of similar compounds daily launched upon the market, by parties absolutely unqualified to meet the requirements of advanced pharmacy and medicine. The administration of remedies in the fluid form has always met with more prompt and satisfactory results than when pre- scribed in the form of solids, and attention is especially invited to the Elixirs and Syrups. These preparations are always fresh, and may be relied upon as being more effective than the pro- prietary articles, for many of which satisfactory substitutes will be found in the list. The attention of Surgeons and Gynaecologists is directed to the very complete list of Antiseptic Materials and to the many new remedies in this specialty. Trusting that my endeavors will be appreciated by the medical profession in the future, as in the past, I remain, Respectfully, R. E. Rhode, Ph. G. Chicago, May i, 1890. N. B.—The National Formulary, to which frequent reference will be made in the succeeding columns, is a book of standard and authoritative formulae, devised and designed by a special committee appointed by the American Pharmaceutical Association. The object in view was to provide reliable methods of manufacture for many of the preparations to be found on the market—and which vary in character with the manufacturer— thereby insuring uniformity in taste, odor, and properties. The appointment of the committee and the source of appointment stamp official seal upon the work. It is a book found in the hands of all advanced pharmacists and is implicitly followed by them.—R. NOTICE: This new edition of the Synopsis com- prises all the recent valuable additions to the Materia-Medica the articles are arranged in alphabetical order under the different sub- headings, to facilitate speedy reference. The Author. RECENT ADDITIONS TO THE MATERIA MEDICA. The following list embraces chemicals and other preparations which have come recently in use. In order to extend the favorable reception they have received from the medical profession, a fresh supply is constantly kept on hand, and others added in accord with the progress of medicine. Aluminium Acetico-Tartrate.—This compound was introduced to medical notice by Athenstaedt as a substitute for the ordinary acetate of aluminium. The latter is solu le only when freshly prepared, speedily becom- ing less and less soluble; the former is permanently and very freely soluble in water. It is an efficient and harmless astringent and antiseptic. One part of this dissolved in io parts of water will approximate the strength of the ordinary “ liquor aluminii acetatis.” Anthrarobin.—This is an anthroquinone derivative and is an innocu- ous succedaneum for chrysarobin and the so-called '* chrysophanic acid.” It is a yellowish brown powder, insoluble in water; soluble in alkalized and borated water and in io parts of glycerine or alcohol. This new preparation may be employed wherever the two substances mentioned are indicated; it possesses the advantage of being less irritant and imparts but a pale brownish hue to the skin which may be easily removed by the ordinary detersives and water. Aseptol, Sozolic Acid, is a per cent, solution of orthophenol- sulphonic acid, of a slight phenol odor, and is used in place of carbolic and salicylic acids as an antiseptic and antiferment. It is miscible with water, alco- hol, and glycerine in all proportions, and is devoid of the irritating and toxic effects of phenol; its antiseptic properties are said to be evident in a one per mille solution. Bismuth Subiodide.—This salt occurs as a bright red powder of microcrystalline structure, not soluble in any reagent without decomposition. It was recommended first by Lister, later by Reynold, for its antiseptic virtues as an application to indolent sores, purulent wounds, etc. Suspended in water (1 per cent.) it forms a valuable injection for gonorrhcea; mixed with sugar and administered in doses of 3 to 5 grains, it has proven of incalculable benefit in typhoid fever and gastric ulcer. Camphoric Acid.—An oxidation product of camphor occurring in colorless, acicular crystals, almost insoluble in water; soluble in alcohol and ether; recommended as an antiseptic, astringent, and disinfectant of typhoid ANTISEPTICS. stools. Reichert suggests its superiority, used in i or 2 per cent, solution, as a gargle or a spray, over chlorate of potash, boracic or salicylic acids, in angina and bronchitis. Has proven beneficial in 3 to 6 per cent, solution, as a spray in laryngeal tuberculosis, internally to prevent the night-sweats of phthisis, in doses of 15 to 30 grains given 3 times daily. Creolin.—This is a derivative of coal tar, devoid of carbolic acid, em- ployed as a deodorizer, antiseptic, disinfectant. It is a brownish, viscid liquid, insoluble in water, but forming with it a milk-white emulsion. Pro- fessor Froehner and Dr. Esmarck think it much superior to the other known antiseptics; the latter has found that it neutralizes all mephitic odors in a one per 1000 solution, that it is a hemostatic, given internally prevents fermentation in the intestinal tract, and appears to possess no toxic characters. It is used in the form of a spray or gargle in diphtheria and whooping cough. Munk em- ploys it as an ointment (5-10 per cent.) for itch. Drs. Sirena and Alessi have also appeared as its champions; they suggest its use in cholera and tubercu- losis. The following combinations have been employed by some of the French confreres: Creolinated water, 5-20 in 1000; ointment, 1-3 in 100 of lard; powder, 2-4 in 100 of boric acid, for dry dressing; and compound creolin pills: n Creolin, gr. ii-v. Cerae albae, gr. xv. Opii pulver., gr. iii. Mucilaginis, q. s. M. et div in pil, No. xxx. In pulmonary tuberculosis the thirty pills may be administered in 24 hours. Eucalyptol.—A colorless, very mobile fluid, of an agreeable, peculiar aromatic, and refreshing odor and pungent, spicy flavor. Very sparingly soluble in water (1 in 13,800). Easily soluble in alcohol. Valuable as an antiseptic, and said to be three times as powerful as carbolic acid in destroying bacteria, It is used like turpentine for inhalation, etc., and is much esteemed as an anti- pyretic in intermittent fever. Hydroocylamine Hydvochlorate.—This ammonia derivative oc- curs in colorless crystals of a saline taste, and is readily soluble in water, also in alcohol and glycerine. It is a very powerful reducing agent, and for this reason was utilized by chemists and photographers long before it was suggested for remedial purposes. It was recommended by Binz as a substitute for pyro- gallic acid, chyrsarobin, chrysophanic acid, and anthrarobin, over all of which it possesses the advantage of not soiling the patient’s clothing. It has been used especially in the treatment of psoriasis. As it is very liable to be absorbed through the cutaneous structure and cause symptoms of toxicity, it is preferable not to apply the remedy to but limited spaces at a time. Ichthyol.—Ammonium sulphichthyolate and sodium sulphichthyolate are both known, according to Dr. Unna, under the name ichthyol. The action is precisely alike, the latter, owing to its density, being dispensed when pills are prescribed, the former in ointments. They are dark brown of a fetid odor, soluble in alcohol and ether. Employed internally in doses of 5 to 20 drops against lupus, angina, asthma, diabetes, etc.; externally in unguental form in the proportion of 1 to 3 parts of vaseline or 1 to 5 parts lanoline in a host of maladies, including eczema, bruises, burns, rheumatism, migraine, chilblains, etc.; also used in form of impregnated cotton, gauze, or soap. Iodoform Fitumintlte.—This is a preparation-of iodoform recently introduced by Dr. Ehrmann of the Vienna clinic. It occurs in brownish mica- ceous scales, which can be readily powdered, or as a brown powder, and is desti- tute of any iodoformic odor, retaining but a slight odor of tar. It has been em- ployed chiefly and with gratifying results in the treatment of indolent ulcers; it may be used in all cases where iodoform is indicated. Iodol (Telriodopyrrol) — C4 I4 N II. Powder of pale yellow to pale brown color; containing 90 per cent, of free iodine, devoid of odor. Very sparingly soluble in water (1 in 15,000). Soluble in alcohol (also in fatty oil). It is used like iodoform, in the form of ointment, gauze, powder, or with collodion The effect is milder than that of iodoform. Should be kept in a dark place. Preferable to iodoform on account of being devoid of smell, and in not produc- ing syrr\ptoms of intoxication. It has been employed internally in place of iodide of potassium, and has also been found useful in ocular practice, in the treatment of blepharites, conjunctivitis, etc. Mercury Carbolnte. — This occurs as colorless crystals, very slightly soluble in water and alcohol. It was introduced as a remedy against syphilitic affections, being claimed to be safer than the other mercurials. The dose is % to >2 grain; best mixed with powder licorice and made into pills. Mercury Salicylate.—First introduced to the medical profession in 1881, it has of late years found a gradually increasing field of application and usefulness. It rarely, if ever, produces intestinal irritation, nor does it cause stomatitis, unless taken in very la.rge doses. Naturally it has found its greatest field of usefulness in syphilitic cases; internally, as an injection, and as a collyrium. For topical application it is mixed with vaseline 10 to 30 grs. to one ounce of vaseline. Internally it is given in pill form in doses of f grain three or four times a day. It has found a wide application in diseases of the eye. Taken internally in iritis, scleritis choroiditis, and retinitis, and applied locally in simple and purulent conjunctivitis, the most favorable results have been obtained. A solution of 15 grains to 1 ounce of water is used in the latter cases. Naphthalin CioHs.—Colorless, scaly, resplendent crystals of peculiar odor like tar, and pungent to the taste. Insoluble in water. Sparingly soluble in cold, readily in hot alcohol; also in fatty oil, if warmed. It is applied exter- nally as an antiseptic, like iodoform, and possesses the power of destroying fungi. Internally for diarrhoea, also in typhoid fever and gastro-intestinal catarrh in doses of 2-5 grains as a powder. As a corrective of taste it is very advisable to add a little oil of bergamot when dispensed. Naphthol (B Naphthol) (Isonaphthol).—CioIIsO. Resplendent crystal- line scales of aromatic odor. Very sparingly soluble in cold water; more easily in hot water. Readily soluble in alcohol; also in fatty oil. Is applied externally, similarly to tar, in skin diseases, either in the form of ointment of 3 to 5 per cent, strength or in alcohol solution of the strength of 2 to 5 per cent. .Care should be observed not to confound it with Naphthalin. Salufer is the fancy name of a patented solution of sodium fluosilicate; strength unknown. Sodium Silicofluoride or Fluosilicate.—The fluorides and fluosilicates are regarded as efficacious antiseptics by Thomson and of these he recommends particularly the sodium salt of fluosilicic acid. It is odorless, soluble in 150 parts of water, The saturated solution is not irritating to wounds yet exercises greater antiseptic virtues than a one- per mille mercuric chloride solution. Dr. Ilayward considers it admirably adapted to the practice 3 of midwifery, and recommends the addition of a few 50 grain powders to the obstetric armamentarium —50 grains being soluble in a pint of water. Sozoiodol is a substitute for iodoform and iodol. and contains 42 per cent, iodine. It is a white, crystalline powder, is absolutely without odor and of a mildly sour taste. It is soluble in about 14 parts of water and glycerine, decom- posed on the application of heat. It is not readily soluble in alcohol. So far sozoiodol has been employed in skin diseases only. It is preferable to iodoform and iodol on account of its odorlessness and more ready solubility. It is applied in powder form or in a paste. m Terebene.—Ci0Hi„—Mobile fluid, odor similar to that of turpentine. Sparingly soluble in water; readily soluble in alcohol. Applied externally as an antiseptic for diverse wounds, with 20 parts of water, and for antiseptic inhala- tions in phthisis, bronchial catarrh, bronchorrhoea, and bronchitis. It.may be utilized internally whenever turpentine is indicated, being much more agreeable than the latter. Dose 4 to 6 drops, gradually increased, 3 times daily. Thiol.—This antiseptic occurs in the dry and liquid forms, and is pro- duced by the sulphuration of certain non-saturated hydrocarbons. The dry (Thiolum siccum) occurs in dark-brown lamellae or powder of a slight bitumin- ous odor and a bitterish astringent taste. It is soluble in water and chloroform, sparingly in alcohol ; insoluble in ether and benzine. The liquid form (Thiolum liquidum) occurs as a dark, reddish-brown, syrupy fluid, miscible in all proportions with water. According to Buzzi, it can, with advantage, replace ichthyol in the treatment of skin diseases. The dry form may be employed as a dusting powder in erythema, eczema, erysipelas, intertrigo, dermatitis, impe- tigo, pemphigus, etc In these instances, a 10 to 20$ powder with talc, starch, zinc oxide, etc., will be found advantageous. The powdered form is especially adapted for internal use. Thioresorcin.—This is a substitute for iodoform aud possesses the advantage over it, iodol, and sozoiodol in being comparatively inexpensive. The favorable results first achieved by it have since been accentuated. It is a grayish powder, insoluble in the ordinary solvents but dissolving freely in the alkalies and their carbonates and sulphides. It is perfectly inodorous and de- void of toxic characters. It is a powerful and non-irritant antiseptic and bids fair to supplant the malodorous iodoform. It may be used as a powder, plain or diluted with lycopodium or talcum or as an ointment with lanolin or vaselin. ANTIPYRETICS. Acetanilid (Antifebrin).— CgHflON. Pure white crystalline powder, without odor, slightly stinging the tongue. Sparingly soluble in cold water; more readily in hot water; readily soluble in alcohol. It is given in doses of 2 to 10 grains, not more than three times a day. It has proved efficacious in typhoid fever, pneumoma, and is already much esteemed as a valuable antipyretic. One of its ohief advantages is its cheapness the dose being comparatively small. Antipyrine (dimethyloxychinizine — phenyldimethypyrazol). — Ci 1H i s ON2. Colorless crystals of a slight aromatic odor, and of a mild and not un- pleasant taste. Very easily soluble in water and in alcohol The dose varies from io to 30 grains, several times a day; for children 3, 6 to 12 grains It has proved most valuable in the short time elapsed since it was first intro- duced, reducing temperature in various hinds of febrile conditions. It acts par- ticularly promptly in acute rheumatic gout, relieving pain and swelling even when other remedies have failed. Given also as an injection subcutaneously- It often causes a bright pink rash, extending over the whole body, which is, 4 however, it is said, of no further importance. It is now exhibited in pneumonia, erysipelas, migraine, menorrhagia, typhoid and puerperal fevers, intermittent and remittent fevers, chorea, phthisis, rheumatism, gout, scarlet fever, bronchitis, etc. As a hemostatic it has been found to be superior to Monsel’s solution and ergot. Administered as an antipyrogenic, its action is more de- termined in the hyperpyretic, than in the pyretic or subpyretic zones. Antithermine (phenylhydrazinlevulinic acid).—This compound, which is chemically allied to antipyrine, has been advanced for antipyrogenic purposes by Nicot (Nouv Rem). It is a yellow substance, insoluble in water, but soluble in alcohol. But little is as yet known of its therapeutical, physiological, or posological characters. JExalgine occurs in long, clear, colorless, acicular crystals, which are difficultly soluble in water, quite easily in dilute and concentrated alcohol. It was employed by Bardet and Dujardin-Beaumetz, who lauded its antineu- ralgic effects in doses of 6 to 15 grains, exhibited several times daily. Its action was devoid of disagreeable secondary effects, such as rash, cyanosis, gastro- intestinal irritation, etc. It also possesses antipyretic characters, like antipyrine. The dose required to produce a certain desired effect is only about one-half antipyrine needed. It is eliminated by the urine, modifying the urinary excretion and dimin- ishing, in diabetic patients, the quantity of sugar in the urine and the amount of the latter eliminated. Hydracetine.—This has been recommended by Guttmann as an anti- pyretic and antineuralgic, externally in psoriasis. It was administered in doses of from 1 to 3 grains per diem, producing a reduction of 1.5 to 2° c. in temperature in about one-half hour, accompanied by a copious perspiration. It is a powerful remedy, and physicians are advised to use it with great caution, owing to its toxic characteristics Hydrocllinoue.—C«H4 (OH)2 occurs in the form of colorless prisms which are soluble in 17 parts of water; more readily in alcohol and ether. Hydrochinone deserves the highest place among the group of dihydroxylbenzoles as an antiseptic and antifermentative. In many instances it is preferred to resorcin, as it reduces temperature in much smaller doses, it also retains the mind and senses in a clear frame. As a remedy for external application, it is equally as powerful a germicide as carbolic acid, yet is not irritating, and < may be applied to diseased surfaces of the most sensitive nature. It has proved especially valuable in ophthalmic diseases, and has been successfully used in solution for saturating bandages. By virtue of its non ir.itant properties it is recommended for- subcutaneous medication. The solution for this purpose must be freshly prepared. JPhencicetine (paracetphenetidin).—This is a white crystalline powder, devoid of odor, and having a slightly burning after-taste; it is practically insol- uble in water, but dissolves readily in alcohol. It was first emplojed by Kobler, who determined its value in pyrexia; later was used by Hinsberg and Ivast, who confirmed the favorable reports. It appears to be devoid of harm- ful or pernicious secondary effects. It is also an important anti-neuralgic, not causing any lassitude or other disagreeable symptoms; its analgesic properties are quite marked; 15 to 30 grains may be administered per diem. Salol (phenyl-ether of salicylic acid) C13II10O3, is destined to supersede salicylic acid in rheumatic affections. According to Nencky it is resolvable into Phenol and Salicylic Acid by action of the pancreatic juice, both these sub- stances, without undergoing further change, being found in the urine. 5 Although containing nearly 40 per cent, of phenol, and imparting a high color to the urine, no intoxication results from its use, when administered daily; it is also said to be free from producing the disturbances caused by the sodium salt of salicylic acid. Salol is a white powder, nearly tasteless, insoluble in water, but freely soluble in alcohol. It is given is doses of 1 to 2 grams (15 to 30 grs), best administered in powder, or suspended in syrup of orange. It is employed in rheumatism, diarrhoea and intestinal irritation, typhoid fever, cystitis, diabetes, diseases of the mouth and throat, conjunctivitis, blen- orrhagia, ozsena, etc.; it is an invaluable antipyretic and antiseptic, and is devoid of the irritant properties of carbolic and salicylic acids. Thalline, used as a tartrate and sulphate, C10II13ON. Crystalline pow- der of not quite pure white color. Taste acid and bitter; smell similar to that of coumarin. Readily soluble in water, and sparingly soluble in alcohol. Dose 3 to 8 grains per day. It is best given in a solution. It is a reliable and power- ful febrifuge and can be administered in febrile diseases of all descriptions. It is also used with good effect for injections (10 grs. to 1 ounce) in gonorrhoea. Amylene Hydrate (dimethylethylcarbinol). — C5H12O—(CH3)2C(C2 H6)OH. It is a colorless liquid, soluble in eight parts of water, and in any proportion of alcohol. It possesses a peculiar ethereal odor, and a peppermint- like after-taste. Dr. J. Yon Mering, of Strasburg, compares it with chloral hydrate, and emphatically decides in favor of Amylenhydrate, for the reason that neither in taste nor in physiological effect does it possess the objections that accompany the use of the former. It is given in a dose of 30 to 50 grains at bed time, or as an enema in one-dram dose dissolved in water and mucilage of gum arabic. In sleeplessness from pain it may be advantageously combined with muriate of morphia. HYPNOTICS. Chloralaniide.—This new and valuable hypnotic appears in colorless crystals, soluble in 9 parts of water, and possessing a bitterish taste. It is decomposed by an alkali or alkaline solution with the consequent modification of the peculiar properties which render it of such value. The dose is from 20 to 40 grains, producing within one-half hour a slumber continuing for from 7 to 9 hours. In accordance with experiments made by medical authorities, it may be given in all cases of sleeplessness dependent upon nervous excitement,in neuras- thenia, phthisis, heart disease, spine disease, etc. Hyosdne Hydrobroinnte.—Utilized in delirium, mania, and in- somnia. The subcutaneous dose is about grain, cautiously increased if necessary to -fa grain. These quantities may be increased by one quarter if given internally. Hypnone (acetophenone) CsHgO. Colorless fluid of an aromatic odor, the taste reminding of creosote. Sparingly soluble in water; readily soluble in alcohol. From 1 to 5 grains produce deep sleep; it is more powerful than chloral. It is given best in capsules of gelatin in doses of one grain, mixed with a little oil or glycerine, as the pure fluid would prove very irritating. Re- garded by Dujardin Beaumetz to be superior to paraldehyde in the treatment of alcoholism. Methylal.—C3H802. Colorless fluid, taste aromatic and pungent. Soluble in water and in alcohol. Administered as an hypnotic in doses of 20 to 25 grains- Is applied externally in oil or in the form of ointment as an ano- dyne. Should be dispensed with syrup of orange peel in the proportion of Methylal 2 grains to syrup 3 fl. ozs. 6 Prof. Krafft-Ebing considers Methylal to be the best sedative and hypnotic he has used in delirium tremens. He used it by subcutaneous injections, and produced with it deep, tranquil, natural sleep, with no unpleasant after effects. Paraldehyde.—C6Hi203. Colorless fluid of a peculiar odor and dis- agreeable taste. Soluble in cold water 1 in 10; soluble in alcohol. Dose, 30 to 60 grains for producing sleep. The effect is but moderately pronounced. It is best given in a little brandy or in water with syrup of orange peel. Pyridine.—C5H5N. Colorless fluid of disagreeable, almost disgusting, odor, and of a pungent flavor. Soluble in water and alcohol. Boils at 2420. Is given for asthma in doses of about 60 grains. Pyridine is poured in a plate and inhaled. It is said to act very energetically. According to the experiments of German See, the use of Pyridine was marked with success in asthma and dyspnoea in heart diseases. Sulfonal, Sulphonal (diethylsulphondimethylmethane). — (CH3)a = C = (C2H5S02)q. This chemical was discovered and named by Prof. Baumann, and was first submitted to physiological and pathological examination by Prof. Kast, both of Freiberg University. Chemically it belongs to the group known as the “ disulphones,” and is a whitish crystalline substance, void of odor and taste, very slightly soluble in water (1 in 600), more so in warm water, alcohol, and ether. Prof. Kast determined it to be true hypnotic, devoid of pernicious secondary effects. Since his investigation of its properties, it has been extens- ively employed, both here and abroad, and has scored almost a unanimity of favor. It does not effect the metabolism of the tissues, neither does it interfere with the gastric and intestinal functions, consequently is indicated in the in- somnia of gastric derangement. In insane asylums it has proven of marked utility in the treatment of insomnia, connected with various forms of dementia, melancholia, etc. Repeated clinical trials have shown it to be of value in alco- holism, anginas, neurasthenia, cephalalgias, epilepsy, paranoia, etc. A valuable attribute of sulphonal is that prolonged use does not weaken its physiological effect, nor does it provoke the desire for a narcotic that makes the use of chloral so dangerous. By reason of its tninor solubility, its action, when exhibited in the dry form, is likely to be delayed or long continued or else cause but a feeling of somno- lency, and consequently had best be given in a cup of milk, a bowl of soup, or some beverage, consisting mainly of water. The dose is 15 to 60 grains. Urethane (carbamidate of ethyl).—NII2CO2C2H5, has been recom- mended by Von Jacksch as a hypnotic in doses of 15 to 30 grs. in all the differ- ent forms of sleeplessness, not excluding those attending the advanced stage of phthisis, fatty degeneration of the heart, and valvular insufficiencies. It pro- duces in all cases a refreshing sleep, closely resembling the natural, without producing the toxic effects of chloral hydrate or morphine. Bismuth Salicylate.—This salt of bismuth contains about 35 per cent, of salicylic acid and 65 per cent, of bismuth oxide. It is recommended in gastric and intestinal affections in doses of 5 to 15 grains, administered several times daily; in typhoid fever in 10 to 20-grain doses, repeated every hour for about 10 hours, etc. The good results are attributable, in a large measure, to the fact that the combination is readily tolerated by the stomach. MISCELLANEOUS CHEMICALS Caffeine ScClts.—Considerable difficulty has heretofore been experi- enced in preparing true salts of caffeine; the so-called “salts,” e. g., citrate, hydrobromate, etc., having been but inconstant and varying physical mixtures of caffeine and the acidulous radical. The salts mentioned below are true chemical combinations containing 50 per cent, or more of the alkaloid, and may be employed by the medical profession as desirable substitutes for the mixtures formerly in vogue. Caffeine Boro-Citrate.—A white powder, soluble in water, alcohol and chloroform, combining the therapeutic properties of boric acid with those of caffeine, and containing 50 per cent, alkaloid. Caffeine Cinnamate.—A white powder, soluble in water and dilute alcohol, containing 55 per cent, alkaloid. Caffeine Sodio-Benzoate (benzoate of caffeine and sodium).—A white powder, soluble in water, and containing 50 per cent, alkaloid; and Caffeine So(lio-Citrate (citrate of caffeine and sodium).—A white powder, soluble in water, and containing 52 per cent, alkaloid. Caffeine Sodio-Salicylate (salicylate of caffeine and sodium).—A white powder, soluble in water, containing 50 per cent, of alkaloid, and uniting the virtues of salicylic acid and caffeine. Dose: 10 grs. Colchicine.—An alkaloid derived from the root and seed of colchicum, generally regarded as the true active principle of these drugs. It is a crystalline substance of a sharp, bitter taste, soluble in alcohol. It possesses the essential medical properties of colchicum, but is not in frequent use, owing to failure to determine safe dosage. It is usually exhibited in gr. granules, gradually increased from one per day. Di-Iodo-Salicylic Acid.—Is a white powder, consisting of micro- crystalline needles, very little soluble in cold water, a little more so in hot water, and quite readily soluble in alcohol and in ether. It is recommended by V. Calalb, of Bucharest, given internally in doses of to 4 grammes daily, as an analgetic and antithermic,—at the same time exercising a retarding effect on the heart movement. Also, as an antiseptic it is excellent. Di-Iodo Salicylic Acid was shown to be of especial value in cases of arthritis, hemorrhagica, where salicylic acid and salicylates failed to act. Diuretin, the utility name fora new preparation of theobromine, Theobro- mine Sodium Salicylate. It is a powerful but harmless diuretic, easily soluble and readily absorbed. Dr. Gram’s experiments with this compound, conducted at the clinics of Copenhagen, showed that its action was exercised directly upon the kidneys, unaccompanied by a nervous excitation, producing insomnia and depression. Diuresis was effected in renal and cardiac diseases when even digitalis and strophanthus failed to give satisfaction. The dose is 15 grains, With a maximal daily limit of 90 grains, which may be dissolved in an equal weight of water. Eserine (Physostigmine) Sulphate. Eserine (Physostigmine) Salicylate. — These two alkaloidal combinations are utilized mainly in ocular therapeutics, their instillation into the eye in per cent, solution, producing a myosis lasting for two or three days. They are reputed to be much superior to pilocarpine and its salts for this purpose. Guaiacol.—During later years, creasote has been highly urged for exhibition in phthisis, but this being at times a rather indefinite mixture, Sahli recommended as a succedaneum the chief active principle designated as guaiacol. This is a definite chemical compound, exercising all the good effects accorded to creosote without the pernicious side effects of the latter. The adult dose is about f to 14 minims, administered in water, accompanied by about 10 8 per cent, of alcohol, or in a wine. It eases the respiration, allevating expectora- tion, and i creases the appetite. Guttmann states that in the proportion of one part of guaiacol to 2,coo in the blood, the bacillus tuberculosis is destroyed. Morphine Bimeconate.—It is well known that the medicinal effects of opium and the ordinary salts of morphine (sulphate, muriate, acetate) are quite different. This, it is believed, is due to the acid with which the alka- loid exists, in combination in the crude drug. This acid is known as “meconic acid,” and the natural salt, viz.: morphine bimeconate, has been isolated and placed upon the market in the hope of proving a truer substitute for the nauseous opium. Papain, Papayotin.—This is a vegetable pepsin, a vegetable pro- teolytic ferment, derived from the fruit of the papaw (Carica Papaya). Exten- sive investigations have established its value as a digestive aid and an excellent remedy for tape worm, diarrhoea, croup, and diphtheria. It is pleasant to the taste. For topical application as a membrane solvent in croup and diphtheria, a solution in slightly alkalized water is to be used every 20 or 30 minutes when danger is imminent; the beneficent effects are due, not to any escharotic action, but to its peptonizing force. For tape-worm it is used with Dover’s powder, 3 to 10 grains with 4 grains of the latter; one sixth to be taken night and morning. Like pepsin it dissolves albuminous substances, but it dissolves fibrin not only in the presence of a small quantity of acid, but even in a neutral or slightly alkaline solution. For indigestion, dyspepsia, etc , the following is recommended : ' I£ Papain, grs. xii. Glycerin, q. s. M. ft. pil. No. xii SlG.—One pill to be taken at meal-time. Taracotoin.—A neutral piinciple derived from paracoto, the bark of a South American tree. It is in yellowish crystals or powder, soluble in ether and chloroform. It has been used with success in intestinal catarrh, in doses of 1 to 3 grains, administered every 2 to 3 hours, as an efficient anti-diarrhoic, etc. Saccharin (orthosulphamidobenzoic anhydride). — This remarkable chemical belongs to a group of chemicals derived from coal tar, and denomin- ated as “ sulphinides.” It is soluble in hot water, alcohol, ether, and alkalized water, and possesses 280 times the sweetening power of cane sugar. Saccharin, introduced into the animal economy, is absorbed and excreted intact ; it passes out mainly with the urine„and, being a powerful antiseptic, prohibits theammoni- acal fermentation of this liquid. It is neither a food nor a drug, but an indif- ferent and perfectly non-toxicant substance. It may be employed as an admixture to the food of diabetic and obese patients, permitting them to enjoy the boon of sweet comestibles without the use of fermentable hydrocarbons (sugar, starch, etc ; saccharin being unfermentable); it is harmless and effective sweetener for bitter medicines (will disguise the taste of quinine in the propor- tion of 1 to 2 of quinine); lastly, it may be utilized for its anti-fermentative properties in various gastric, intestinal, and cystic disorders. Saccharin Tablets, for diabetes (see page 8). *Sodium Dithiosalicylate.—This salt of dithiosalicylic acid pos- sesses the same properties as the simple salicylate with these advantages: Greater potency, 3 grains sufficing to produce the same results as 15 or 20 grains of the simple salicylate ; absence of ill effect upon the stomach and circulation ; and failure to produce nausea, collapse, or humming of the ears. It is useful in the treatment of various forms of rheumatism ; it is also an 9 antiseptic of no mean degree (according to Hueppe). For the former, 3 grains are to be administered twice daily in the milder forms,the severer ones requiring 4 to 6 repetitions per diem. It is a grayish-white powder of an aromatic odor, soluble in water, with the separation of the acid, in resinous drops, from the aqueous solution, in the presence of an acid or acid salt. Sodium Ethylate.—A whitish powder, decomposed in the presence of water into alcohol and caustic soda, but soluble in absolute alcohol without resolution. It is a new depilatory, possessing the advantage over the older agents of this character in destroying the root. To effect this purpose the hair must be clipped close to the skin, the agent must be in solution in absolute alcohol, and it must be rubbed into the tissue with a glass rod. A crust will form, which may be detached in the course of 2 or 3 weeks, when all the hair will probably have been destroyed. If not, the operation may be repeated. If the skin be hypersesthetic, it may be treated with a 5 per cent, cocaine solu- tion Birth marks, moles and other disfigurements of the skin may be effaced by the prescribed plan. TABLETS. All officinal pills and powders are kept in stock in the form of compressed tablets, which materiarially enhances the disintegration and solubility of the drugs. All medicines ordinarily prescribed by physicians in the form of pills, powders or capsules will be dispensed in the form of compressed tablets when- ever the doctor so designates on his prescription. Lime Juice and Pepsin Tablets, containing 2 grains Crystal Pepsin to each tablet. Saccharin Tablets are used as a substitute for sugar for diabetic patients. One tablet, containing one grain Saccharin, is sufficient to sweeten one cup of coffee. Tablets of Chlorate of Potash! .5 grs. Tablets of Chlorate of Potash and Muriate of Ammonia • Chlorate of Potash 3 grs. Muriate of Ammonia \]/z grs. Tablets of Chlorate of Potash and Borax Chlorate of Potash,. o.yz grs. Borax «. iyz grs. Tablets of Bicarbonate of Soda 5 grs. Tablets of Iodide of Potash 5 grs. Tablets of Muriate of Ammonia 3 grs. “ “ and Licorice Compound Soda Mint 5 grs. Salicylic acid . _. 2 y2 and 5 grs. Salicylate of Soda 5 grs. Peptonic Tablets (or pills) 5 grs. ELIXIRS. These elegant preparations are carefully prepared according to the formulas approved by the National Formulary. The vehicle is in each case carefully adjusted so as to present preparations of permanent stability in the most pala- table form. The materials employed are selected with great care, and conse- quently it is fully believed that in point of palatability and effectiveness, these preparations are not to be surpassed by any found in the market. Attention is part'cularly directed to the Cordial Elixirs, which are espe- cially adapted as vehicles, or adjuncts, to disagreeable mixtures. CORDIAL ELIXIRS AROMATIC ELIXIR (SIMPLE). An exquisitely flavored compound; a desirable addition to any mixture where a pleasant vehicle is desired. It is colorless, but may be colored red when so directed. ADJUVANT ELIXIR. A more decidedly flavored compound, to be used as an adjuvant in mix- tures containing saline and bitter drugs. It contains the active sweet principles of several aromatic drugs of great value in masking the taste of nauseating remedies. It is of a dark-red color, and compatible with near- ly all compounds of mixtures. ELIXIR TARAXACUM COMPOUND. A very popular vehicle, the best features of which, however, are incor- porated in the foregoing. This is somewhat darker in color. ELIXIR ANISE (ANISSEED CORDIAL). A preparation of exquisite flavor, containing oil of Anise, slightly mod- ified by the oils of fennel and bitter almond. It is almost colorless and may be employed as a pleasant vehicle for saline drugs when any of the above would not be indicated. ELIXIR GLYCYRRHIZA (LICORICE). A most effective vehicle for the exhibition of quinine. Being prepared from the active principle, glycyrrhiz:n, no acid should be used but the quinine directed to be suspended in the mixture. AROMATIC ELIXIR OF YERBA SANTA (ELIXIR COR- RIGENS). A pleasant vehicle intended for the exhibition of quinine and other bitter remedies, which has been deresined (deprived of resinous matter) but re- tains the active principles intact and rendered doubly efficient by the addi- tion of suitable aromatics. No acid should be prescribed in connection with it. ELIXIR AMMONIUM BROMIDE. Containing- io grains Ammonium Bromide in each teaspoonful, rendered much acceptable by an improved formula. ELIXIR AMMONIUM VALERATE (VALERIANATE) Containing two grains of the crystallized ammonium valerate (valerianate) in each teaspoonful. This elixir, as ordinarily prepared, possesses a mawkish and very disagreeable taste and odor. In this preparation the salt is so masked that it may be administered almost without detection. ELIXIR AMMONIUM VALERATE AND QUININE. Containing, in addition to the above, l/i grain of Hydrochlorate of Qui- nine to each teaspoonful. ELIXIR BISMUTH. A palatable article, containing 2 grains Citrate of Bismuth in each tea- spoonful. MEDICINAL ELIXIRS. ELIXIR BUCHU. An excellent diuretic, each teaspoonful representing the virtues of 7 grains of Buchu. ELIXIR BUCHU COMPOUND. Possessing the advantage over the above in containing a larger amount of Buchu (about 10 grains) to each teaspoonful, its action being modified and enhanced by the addition of Cubebs, Uva Ursi, and Juniper (2 grains to a teaspoonful). ELIXIR BUCHU WITH POTASSIUM ACETATE. Containing 7 grains of Buchu and 5 grains of the Acetate in each tea- spoonful. ELIXIR CALISAYA (BARK). Each teaspoonful represents the active principles of 5 grains of the very highest grade Yellow Cinchona Bark (Calisaya). It is far superior as a tonic to preparations of the alkaloids. As it is detannated, it may be asso- ciated with iron compounds without discoloration. ELIXIR CALISAYA AND IRON. Each teaspoonful represents 5 grains Calisaya Bark and 2 grains of Am- monio-Citrate of Iron. ELIXIR CALISAYA, IRON, AND STRYCHNINE. Five grains Calisaya Bark, 2 grains Ammonio Citrate of Iron, and grain of Strychnine Sulphate to each teaspponful. ELIXIR CALISAYA, IRON, AND BEEF. Each teaspoonful contains 5 grains Calisaya Bark, 2g ains Am.-Cit. Iron, and the essence of 2 drams of Beef. ELIXIR CALISAYA, IRON, AND BISMUTH. Each teaspoonful contains 5 grains Calisaya Bark, 2 grains Iron Phos- phate, and 1 grain Bismuth Am. Citrate. ELIXIR CALISAYA, IRON, BISMUTH, AND STRYCH- NINE. Each teaspoonful contains 5 grains Calisaya Bark, 2 grains Iron Phos- phate, 1 grain Bismuth Am. Cit., and grain Strychnine Sulphate. ELIXIR CALISAYA, IRON, AND PEPSIN. Each teaspoonful contains 5 grains Calisaya Bark, 2 grains Ammonio- Citrate of Iron, and 1 grain of Pepsin. ELIXIR CALISAYA, PEPSIN, AND STRYCHNINE. Each teaspoonful represents 5 grains Calisaya Bark, 1 grain of Pepsin, and T-J-T grain Strychnine Sulphate. ELIXIR CALISAYA WITH HYPOPHOSPHITES. Each teaspoonful represents 5 grains Calisaya Bark, and r grain each of the Hypophosphites of Calcium and Sodium. ELIXIR COCA WITH BEEF. One teaspoonful contains 15 grains of Erytliroxylon Coca and the nutritive properties of 2 drams of choice beef. This is a true nutritive tonic, combining the well known medicinal virtues of Coca with extract of Beef, without the large proportion of alcohol usually introduced in wines of Coca and similar preparations to the above. This elixir is intended to be dispensed on physicians’ prescriptions only and its superior potency can be relied upon. Dose : 1 teaspoonful 4 to 5 times a day. 12 ELIXIR COCA. Each teaspoonful represents 7\ grains of the choice leaves. ELIXIR COCA WITH GUARANA. Each teaspoonful represents the virtues of grains each of Coca and Guarana. These Coca preparations are useful substitutions for opium in the opium habit. ELIXIR CASCARA SAGRADA. Containing 15 grains of Cascara Sagrada to each teaspoonful, flavored and modified by suitable aromatics. ELIXIR CASCARA SAGRADA COMP. (LAXATIVE ELIXIR.) Each fluid dram contains 15 grains of the genuine Cascara Sagrada Bark, with Senna, Juglans, and Aroma'ics. A safe and efficient cathartic, the bitterness of the Cascara being almost masked by the addition of aro- matics and correctives—which also prevent any tendency to gripe. ELIXIR CHLORAL HYDRATE. Containing 5 grains of this valuable hypnotic in each teaspoonful. See also Elixir Potass. Brom. and Chloral Comp. ELIXIR CAFFEINE. Containing one grain of Caffeine to each teaspoonful, flavored with aro- matics and syrup of coffee. ELIXIR CATHARTIC COMPOUND. A pleasant and efficient preparation, which may be used in lieu of the pills. It contains Senna, Podophyllum, Leptandra, Jalap, Rochelle Salt, Sodium Bicarbonate, correctives, and aromatics. It is to be well shaken before use. Average adult dose, 2 teaspoonfuls. ELIXIR CALCIUM BROMIDE. Containing 5 grains of the salt to each teaspoonful. ELIXIR CALCIUM H YPOPHOSPHITE. Containing 2 grains of Calcium Hypophosphite to each teaspoonful. ELIXIR CELERY COMPOUND. Each teaspoonful represents 5 grains each of Celery, Cocoa, Viburnum, and Kola Nut. A satisfactory substitute for the patent article. ELIXIR DAM I ANA. Each teaspoonful contains the virtues of 10 grains Damiana deprived of the resin (deresined). ELIXIR GENTIAN. Each teaspoonful representing 2 grains Gentian combined with suitable aromatics. It is a pleasant tonic bitter. ELIXIR GENTIAN WITH PHOSPHATE OF IRON (FERRATED OR FERROPHOSPH ATED ELIXIR GENTIAN). Containing, in addition to the above, 1 grain iron phosphate to each teaspoonful. ELIXIR GENTIAN WITH TINCTURE CHLORIDE OF IRON, This preparation contains in addition to the Gentian, 5 drops of Tinc- ture of Chloride (or Muriate) of Iron. 13 ELIXIR OF GUARANA. 5 Representing the virtues of io grains Guarana in each teaspoonful. This drug has attained considerable reputation as a prompt remedy for nervous headache, neuralgia, and nervous debility. Adult dose of elixir for head- ache, 2 teaspoonfuls, repeated every hour until improvement sets in. j See also Elixir Celery with Guarana. ELIXIR IRON HYPOPHOSPHITE. Containing i grain of Iron Hypophosphite to each teaspoonful. ELIXIR IRON LACTATE. Containing one grain of the salt in each teaspoonful. ELIXIR IRON PHOSPHATE. Two grains soluble Phosphate of Iron in each teaspoonful. ELIXIR IRON, QUININE, AND STRYCHNINE (PHOS- PHATES). This is the most popular of all the Elixirs. The form of iron used is the officinal soluble Iron Phospha'e, which is superior to the pyrophos- phate in yielding a permanent and otherwise satisfactory preparation. Each teaspoonful contains Iron Phosphate 2 grains, Quinine r grain, and grain Strychnine Sulphate. (JgpThis Elixir is dispensed for Iron, Quinine, and Strychnine unless other- wise specified. ELIXIR IRON AND QUININE (PHOSPHATE). One grain Quinine and 2 grains Iron Phosphate in each teaspoonful. ELIXIR IRON PYROPHOSPHATE. Containing 2 grains soluble Iron Pyrophosphate in each teaspoonful. ELIXIR IRON WITH MALT. Containing I grain soluble Iron Phosphate and 15 minims Malt Extract to each teaspoonful. For other Iron Elixirs, see the Calisaya and the Pepsin combinations. ELIXIR LITHIUM BROMIDE. Containing 5 grains Lithium Bromide in each teaspoonful. It must be recollected that for a given amount of salt, the Lithium Salts contain a greater proportion of the acid radical than the corresponding Sodium, Potassium, Ammonium, or Calcium compounds. This is due to the low atomic weight, and consequent high saturating power of Lithium. The dose, therefore, need not be as large as when the salts of the other metals are prescribed. ELIXIR LITHIUM CITRATE. Containing 5 grains Lithium Citrate to each teaspoonful. ELIXIR LITHIUM SALICYLATE. Each teaspoonful represents 2 grains of the salt. ELIXIR MALT AND IRON. See Elixir Iron with Malt. ELIXIR LIME JUICE AND PEPSIN.- (Succut Limonis cum Pepsin.') Each teaspoonful contains 10 grains of Saccharated Pepsin dissolved in fresh Lime juice combined with aromatics. This preparation has received most favorable mention in the treatment of indigestion, flatulency, and eruptions of the skin due to disturbances of the 14 digestive functions. None but the choicest materials are used in the manu- facture of this Elixir. Dose.—One teaspoonful three times a day, after meals. ELIXIR PEPSIN. Each teaspoonful contains i grain pure Pepsin, representing about 5 grains of Pepsin of pharmacopceial strength. ELIXIR PEPSIN AND BISMUTH. Five grains of Pepsin and 2 grains Bismuth Citrate in each teaspoonful. ELIXIR PEPSIN, BISMUTH, AND STRYCHNINE. Five grains Pepsin, 2 grains Bismuth Citrate, and grain Strychnine Sulph. in each teaspoonful. Note.—These combinations of Bismuth rapidly deteriorate and require to be freshly prepared. Commercial specimens are usually inert. ELIXIR PEPSIN WITH IRON. Each teaspoonful containing 4 minims Tincture Chloride of Iron and 1 grain of Pepsin. ELIXIR POTASSIUM ACETATE. Containing 5 grains Potassium Acetate to each teaspoonful. ELIXIR POTASSIUM ACETATE WITH JUNIPER. Containing, in addition to the above, the virtues of 7J4 drops of Fluid Extract of Juniper. See also Elixir Buchu with Potassium Acetate. ELIXIR POTASSIUM BROMIDE. Containing 10 grains of the salt to each teaspoonful. ELIXIR POTASSIUM BROMIDE AND CHLORAL COMPOUND. Each teaspoonful contains 15 grains each Potassium Bromide and Chloral and }i grain each Extracts Cannabis Ind. and Hyoscyamus. This is a more reliable and uniform preparation than the patent article. ELIXIR SALICYLIC ACID. Each teaspoonful contains 5 grains acid. It is much superior to a patent article of a similar name. ELIXIR SODIUM BROMIDE. Each teaspoonful contains 10 grains of the salt. ELIXIR SODIUM SALICYLATE, Containing 5 grains of Sodium Salicylic to each teaspoonful. ELIXIR STILLINGIA COMPOUND. Each teaspoonful represents 15 minims of Compound Fluid Extract of Stillingia. ELIXIR VALERIANATE OF STRYCHNINE. Each teaspoonful containing grain Strychnine Valerianate. A valu- able nervine stimulant and antispasmodic. ELIXIR VALERIANATE OF STRYCHNINE AND QUININE. Containing 1 grain of Quinine Valerianate and grain Strychnine Sulphate. A happy combination of tonic, nervine, and antispasmodic. ELIXIR VALERIANATE OF ZINC. Containing 1 grain of Zinc Valerianate to each teaspoonful. 15 ELIXIR VIBURNUM PRUNIFOLIUM {Black I/aw.). Each teaspoonful represents the virtues of 7y2 grains of Black Haw Bark. Of reputed value in threatened abortion. ELIXIR WAHOO, Each teaspoonful represents 10 grains of the bark of the root of Wahoo. A cholagogue cathartic. TINCTURES of Hare Drugs. Strophanthus. —Prepared from the seeds deprived of the comose appendages, of the strength recommended by Prof. Frazer of Edinburgh, viz: 5 per cent, or 1 in 20. It is a pale yellowish-green, limpid liquid, of peculiar odor and bitter taste. It is a valuable cardiac tonic, producing a rapid subsidence of an excited pulse within a few minutes, is devoid of cumulative secondary effect (differing from digitalis), and does not interfere with the digestive functions. The dose is 2 to 10 drops. Syzygium (Jambul).—The drug consists of the seeds of a myrtaceous tree indigenous to the East Indies. A 20 per cent, tincture anff a fluid extract are employed in medicine. Dose of the former, % to 1 teaspoonful, of the latter. 5 to 10 drops. It possesses astringent properties, and has been found useful in diarrhoea and dysentery. Its chief value resides, however, in the inhibitory action upon the diastatic ferments, rendering it of prime importance in the treatment of diabetes mellitus. Dr. Fenwick (Lancet, 1887) found that its internal administration in the treatment of ulcers of diabetic origin or of wounds in diabelies would granulate and heal with surprising rapidity. w drburg’s.-—Prepared according to the original recipe. Also capsules and pill's representing one drachm of the Tincture. The preparation enjoys great reputation as an antiperiodic in the treatment of the seveier type of inter- mittent and remittent fever. Simulo.—Prepared from the seeds of Capparis and introduced by Christy of London. Dr. White (Lancet) ascribes to it the properties of a nervine tonic of esrecial value in treatment of epilepsy and hysteria. Dose, to 2 teaspoon- fuls per diem. TINCTURES, RADEMACHER’S. Tinctura Artemisice radicis (Radewacker), a 20 per cent, tincture of artemisia root. Efficacious in the treatment of epilepsy and epilepti- form convulsions. to 2 teaspoonfuls 4 times daily. Tinctura Bursae Pastoris (Radetnacher).— Prepared from the fresh herb. Beneficial in menorrhagia, epistaxis, expectoration of blood, diarrhoea, etc. to 1 teaspoonful every 3 to 4 hours. Tinctura Coccioneliae (Radetnacher).—A 10 per cent, tincture of coccus cacti. Used as a cardiac tonic, a lithontriptic, an anti-cachectic, and in atony of the renal apparatus. One to two teaspoonfuls repeated several times daily. Tinctura, Clielidonii (Radetnacher).—Prepared from the fresh herb. Dose, 15 to 30 drops, given 3 or 4 times daily in water, for bilious fever, in stagnant conditions of the liver, etc. Tinctura Cupri Acetici (Pademacher).—Contains xo per cent, of cupric acetate, and is employed as an antisyphilitic and antispasmodic, in doses ranging from 2 to 8 drops. Tinctura Cynosbati {Pademacher).—This is an astringent of no mean value, and may be administered in teaspoonful doses. Tinctura Ferri Acetici {Pademacher).—An excellent ferrugi- nous tonic, administered in doses of % to ]/2 teaspoonful. The Mistura Ferti {Rademacher) is frequently employed by German physicians in the treatment of pulmonary inflammation. Dose for this purpose, 1 tablespoonful every hour. Tinctura Virgaureee {Pademacher).—Prepared from the fresh herb. Exhibited in 25 to 40-drop doses several times daily, in the treatment of renal derangements, enuresis, etc. FLUID EXTRACTS of Pare Drugs. CheJcen, CheJcail, ChequeTl'—This is prepared from the herb of Eugenia Chequen, a South American plant, and is the remedy par excellence for chronic catarrhs, particularly in weak, illy nourished, or aged patients. It should be given in teaspoonful doses, gradually increased to three or four, between meals and at bed time. It is also useful for gastric and intestinal catarrh and is a tonic of no mean rank. Embelilt,—Prepared from the seeds of Embelia Ribes, an East Indian plant. For the destruction of tsenia solium it has proven effective where the usual remedies were found to be of no avail. Dr. Harris administered it in doses of i to 4 teaspoonfuls on an empty stomach, and followed by a dose of castor oil. Kava Kava.—Derived from the Sandwich Islands. An efficient remedy in gonorrhoea, gleet, rheumatism, and gout. Kola.—From the nuts of Slerculia Acuminata, an African tree. Pos- sesses properties and constituents similar to coca. It is said to exert almost a specific effect in combatting the intoxicating influences of alcoholics. Manaca.—Derived from Brazil, where it is considered a specific for rheumatism. Employed as well for its antisyphilitic, purgative, diuretic, and emmenagogue properties. Pichi.—Prepared from the leaves of a South American plant, Eabiana imbticata. It is especially useful with treatment of diseases of the urinary apparatus and liver. In cases of vesical catarrh, chronic or acute, following a mechanical cause such as gravel or calculus, or in uric diathesis, it quickly modifies the urinary secretions, calms the irritabdity, and favors the expuls on of the gravel and calculi that can be passed through the uiethra. Owing to its oleoresinous constituents, upon which its virtues depend, it should not be pre- scribed in combination with water or aqueous liquids. 4 to 6 teaspoonfuls may be administered per diem. Syzygium.—See the tincture. 17 SYRUPS. Prepared in strict accord with officinal or magistral formulae of standard authorities. The following are most largely prescribed: IRON ,—Soluble Oxide or Saccharate (Syrupus Ferri Oxydati Saccharati Solubile, Ph Germ.) The most valuable of all iron preparations because: (1). It contains the iron in a form nearest approaching that in the blood. '(2). It does not constipate, and may be administered to persons having idiosyncrasies toward iron preparations, without causing any disturbances. (31. It is the most palatable of all iron compounds and may be prescribed in conjunction with other preparations, even astringents. It contains 33 per cent, of saccharated iron, equivalent to 3 per cent, of oxide of iron or 1 per cent, metallic iron. Dose.—From one to two teaspoonfuls. HYPOPHOSPHITES. U. S.—Containing nearly 5 grains of the Hypophosphites of Calcium, Potassium, and Sodium in each teaspoon- ful. HYPOPHOSPHITES WITH IRON, U. S.—Containing 5 grains of Hypophosphites Calcium, Iron, Potassium, and Sodium and 1 grain Lactate of Iron to each teaspoonful. HYPOPHOSPHITES COMPOUND.-l iach teaspoonful contains 2 grains Calcium Hypophosphite, 1 grain each Potassium and Sodium Hypophosphites, }/% gra'n each of Iron and Manganese Hypophos- phites, and a small proportion of Strychnine. This preparation is made after the National Formulary, and is more elegant and at least equally reliable to the patent articles of similar composition. should be observed not to confuse the above with the titles of the officinal syrups of hypophosphites. EMULSIONS. The following are frequently prescribed and are perfectly reliable and con- stant preparations, made according to the directions of the National Formulary. The peculiar taste of the medicamental agent is, in every case, completely, or almost entirely disguised: CHLOROFORM .—Each teaspoonful represents rzx/-2. minims of chloro- form. COD LIVER OIL WITH HYPOPHOSPHITES (Calcium, Sodium, and Potassium). A most perfect and palatable emulsion, prepared without the use of alkalies, therefore capable of being administered for an extended period without producing gastric disturbances; the sweetest Norwegian Cod Liver Oil is used in a form which renders it of easy assimilation as well as administration. Each tablespoonful contains 8 grains of pure Hypophosphite salts and 50 per cent, of Cod Liver Oil. COD LIVER OIL (plain). Containing 50 per cent, of oil. COD LIVER OIL WITH CALCIUM AND SODIUM PHOSPHATES.—i grain of each of the Phosphates and 50 per cent, of Oil to each teaspoonful. COD LIVER OIL WITH CALCIUM LACTOPHOS- . PH ATE.—3 grains of the salt to each teaspoonful. COD LIVER OIL WITH CALCIUM PHOSPHATE.— Containing 2 grains of Calcium Phosphate in each teaspoonful. COD LIVER OIL WITH EXTRACT OF MALT.—Containing 50 per cent, of Oil and 40 per cent, of Malt Extract. It is a perfectly palatable combination, and may be administered ad libitum to children as well as to adults. COD LIVER OIL WITH WILD CHERRY.—Each tablespoonful represents, in addition to the Oil, the efficacy of 15 grains of Wild Cherry. PEPSIN AND ITS PREPARATIONS. THE PEPSIN employed by us in the manufacture of the various combina- tions is the best German scale Pepsin. Recognizing at an early day, the fact that, with so many so-called pepsins afloat upon the market, it is highly improbable that any great number of them possess any intrinsic value, we have subjected the most of them to the physiolo- gical test, and have found the above to be the most active medicinally, converting the greatest amount of albumin into peptone, the diffusible form of albuminoid, in a given space of time. The Pepsin referred to is entirely soluble, forming a clear, elegant solution. OUR SACCHARATED PEPSIN is also very active and is employed when a pulverulent preparation is to be made or dispensed. AROMATIC PEPSIN is a Saccharated Pepsin associated with Aro matics and with Tartaric Acid and Chloride of Sodium to accelerate . the peptic action. COMPOUND POWDER OF PEPSIN (PULVIS DIGES- T1VUS) is made after the same formula as the proprietary article which appears under such a variety of titles. AROMATIC LIQUID PEPSIN is an active solution of Pepsin, pleasantly acidulated and exquisitely flavored with aromatics. Dose, a teaspoonful to a tablespoonful. WINE OF PEPSIN .—An efficacious preparation of vinous character, exhibited in doses of from 1 to 2 teaspoonfuls. ELIXIR OF PEPSIN. ELIXIR OF PEPSIN AND BISMUTH. ELIXIR OF PEPSIN AND IRON. ELIXIR OF PEPSIN, BISMUTH, AND STRYCHNINE. Refer to the Elixirs. SOLUTION OF PEPSIN, made after the U. S. Pharmacopceial formula. PEPTONIZING POWDER (N. F.)J or Compound Pancreatic Powder.—Composed of the most active Pancreatin and Bicarbonate of Sodium. 30 grains of this powder are sufficient to peptonize one pint of fresh cow’s milk, by proceeding in the following man- ner : Add the amount of powder specified above to 4 fluidounces of tepid water, contained in a suitable vessel (a bottle capable of containing 1% or 2 pints of fluid) and afterwards add one pint of fresh cow’s milk previously heated to 100° F. Maintain the mixture at this temperature for 30 minutes, then close the flask and place it in a cold place. At no time must the temperature be al- lowed to materially exceed that given above. Milk thus peptonized must not be used when it has developed a bitter taste, which will be in about 24 hours after manufacture. OLEATES. Made chemically by double decomposition; these Oleates will be found more stable and efficient than the so-called Oleates made by solution. The following comprises the list on hand; others will be added when required : OLEATUM— Bismnthi.—Of ointment consistence, it may be used undiluted wherever the external use of Bismuth is indicated. Cupri.—Of the consistence of wax. An ointment made with petro- latum of io to 20 per cent, strength ; has been used very successfully in ringworm, chancroid, etc. Uyd rargyri,—An ointment of io and 20 per cent, strength; is far more stable and efficient than the officinal Oleate, which is simply a solution of the oxide in oleic acid. Manganesi.—A soft solid, used by inunction as a substitute for pills of potassium permanganate; has been used with much success in the sup- pression of the menses by cold. Zinci.—In the form of a light, impalpable, pearly white powder, is used undiluted as a dusting-powder on excoriated surfaces. A most valua- ble remedy in eczema, hyperidrosis, etc. Also the following Oleates, solutions in oleic acid : Atropinw 2 per cent. | Morphins, by its gentle stimulating quality, is the food par excellence. There are three grades of Kumyss: new, medium, and old. New Kumyss is suitable for infants and for catarrhal conditions of the stomach in adults; it is slightly purgative. Medium for dyspepsia, feeble or imperfect digestion, and as a dietetic for convalescents after fevers, etc. Old Kumyss is drank as a tonic and invigorator. During the summer Kumyss must be kept on ice: in winter it may be kept in a cool cellar, where the temperature is about 50° F. Price per bottle, 35 cents; per dozen, $4 00; Champagne tap, 75c. Antiseptic Materials BANDAGES, ETC. Carbol., 10 p*er cdnt. 5 yd. cans, per yard $0.11 “ 10 “ 60 yd. boxes, “ 09 Corros. Subl., 1 gr. per yard, 5 yd. cans, per yard .11 “ 1 gr. “ 60 yd. boxes “ 09 Iodoform, 10 per cent., 5 yd. cans, per yard 25 “ 10 “ 60 yd. boxes “ 23 We medicate only the White Hygroscopic Gauze. The binding material used is not oily or resinous. The prepared gauze is soft and pliable. ANTISEPTIC GAUZE. MEDICATED COTTONS. Carbolic Acid, 10 per cent. Boracic Acid, 10 per cent. Corros. Subl., )4 gr. to 1 oz. 1-lb. cans or bundles, perlb $0.90 J4-lb. “ “ “ 1.00 j£-lb. “ “ “ 1.20 1 oz. boxes, per lb 1.30 Iedoform. 10 per cent. 1-lb, cans, per lb. . 2.20 *,.lb. “ “ 2.30 &-lb. “ * 2.40 l.oz. boxes, “ 2.50 Salicylic Acid, 10 per cent., 1-lb. bundles, or boxes, per lb 1.00 “ “ 10 “ %-\b. “ “ “ 1.10 “ “ 10 “ M.\b. “ “ “ 1.30 “ “ 10 “ 1 oz. “ “ “ 1.40 Medicated Jute in Layers, Carbolic Acid, 10 per cent., per lb - .40 Plain Jute in Layers, perlb - 25 CATGUT LIGATURES, CARBOL. 6 yards on spools, assorted $o.75 3 “ in vial, “ - .25 1 “ “ (specify sizes wanted) - 10 SICK LIGATURES, CARBOL. Surgeon’s 6 skeins, assorted, on spools $0.50 Braided (4 sizes), 3 yards (specify sizes wanted) - 40 McIntosh Cloth, red, per yard 1.60 Protective Oil Silk, green, per yard ... 1.60 Gutta Percha Tissue, heavy, per yard 50 Bone Drainage Tubes, Decale., 2 in., per dozen 2.40 “ “ “ “ 2)4 in., “ 3.00 “ “ “ “ 3 in , “ 3.60 Rubber Drainage Tubes, 4 sizes, per foot $ .05, .06, .07, .08 “ “ ,k Carbol., 6 assorted, in vial 25 Elastic Web Bandages, 2)4 in., per yard 20 Woodwool, per lb 15 Oakum, per lb 26 Absorbent Cotton, 1 and )4 lb. rolls, per lb 65 “ “ H " ™ “ “ 2 and 1 oz. “ “ 75 “ “ 1 oz. bozes “ 85 Antiseptic Sponges, small, per dozen 2.40 “ “ large, “ 9.00 Flannel Bandages, 2 in. x 5 yds., per dozen 2.00 “ “ 2)4!n. x 5 yds., “ 3.00 “ “ 3 in. x 5 yds., “ 3.50 “ “ 4 in. x 5 yds., “ 4 00 1 Assorted Set of Antiseptic Dressings and Bandages 5.00 Crinoline Bandages, fllled with the very best. Dental Plaster, 1 in. x 3 yds., per dozen 70 “ “ 2 in. x 3 yds., “ . 90 “ 3 in.'x 3 yds , “ 1.00 “ “ 2 in. x 6 yds., “ 1.25 “ “ 3 in x 6 yds., “ ....... 1.50 Subject to discounts and changes in the markets. Special figures on large contracts. 26 Cascara Laxative. FORMULA* Cascara Sagrada (genuine) 60.00 Rhamnus Frangula 120.00 Berberis Aquifolia 20.00 Aromatics and Carminatives to prevent griping. Aromatic Elixir, q. s. ad. 1000.00. N.B.—One tablespoonful contains 1 5 grains of Cascara Sagrada. This preparation, which is intended to be dispensed on Physicians’ pre- scriptions only, has been placed on the market with a view of meeting the demand of the Profession for a reliable laxative that shall embody the peculiar virtues of Cascara Sagrada, without its objectionable taste. To this end it has been combined with suitable aromatics, and double its quantity of Rhamnus Frangula, “ Buckthorn,” whose virtues, so closely allied to those of Cascara Sagrada, have but recently regained a well merited recognition at the hands of the Medical Profession. The proportion of Cascara Sagrada in this laxative conforms to the dose which, in the experience of many writers, most effectually secures the characteristic action of the drug. It has been found that the well known tonic action of Berberis Aquifolia on the mucous surfaces of the diges- tive organs appears to accelerate the action of Cascara, and a small quantity of it has been incorporated. W ine of Coca OR VINUM ERYTHROXYLI. This is an agreeable and pleasant preparation, devoid of astringent properties, representing the virtues of 60 grains of prime and select Coca leaf in combination with each fluid ounce of an old and high-grade Sherry Wine It commends itself to medical practitioners for its property of sustaining the vital powers under conditions of exhaustion, fatigue, and privation, as well as for the beneficial effects exerted upon persons of a delicate, nervous organization which is easily unbalanced. It is especially useful in mental depression, nervous exhaus- tion, hysteria, and migraine, the nervous form of sick headache ; and as a general nerve tonic and stimulant in exhaustive mala- dies. It is also of great utility in assisting victims of the opium habit to recovery, enabling them to resist and combat the vicious desire for the narcotic, also sustaining their physical systems during this hour of trial. Several doses of this wine taken before any prolonged vocal exercise will increase the strength and volume of the voice, and is consequently of value to singers, clergymen, and public speakers. Being free of astringent and irritating properties, it is not liable to effect gastric or intestinal disturbance or constipation. The dose of this preparation is from one dessertspoonful to one or two tablespoonfuls, repeated as occasion demands. Quite frequently it will be found advantageous to combine it with liquor acidi phosphorici (solution of phosphatic acids). R. E. Rhode, MANUFACTURING CHEMIST, CHICAGO