PLEASE NOTICE ILLUSTRATIONS ON PAGE 17. THE PHOSPHATES IN NUTRITION AND TIIE MINERAL THEORY OF Consumption and lied Wasting Diseases, AN ENTIRELY NEW AND SUCCESSFUL TREATMENT, AS SUGGESTED BY THE OBSERVATIONS TD EXPERIMENTS OF M. F. ANDERSON, M. D„ LICENTIATE OF THE ROYAL COLLEGE OF PHYSICIANS, EDINBURGH. — MEMBER ROYAL COLLEGE SURGEONS, ENGLAND. AS PRACTICALLY CARRIED OUT EfY Charles H. Phillips, Manufacturing Chemist, NEW YORK. NEW YORK: GEORGE F. NESBITT & CO., PRINTERS, Cor. Pearl and Pine Streets. 1S83. THE PHOSPHATES IN NUTRITION. CHAPTER 1. RESULTS OF DR. M. F. ANDERSON’S EXPERIMENTS. Although up to the present day Consumption has proved intractable to almost every form of treatment, it has been and is a subject of universal interest. Its inception is so insidious, its advance so rapid, and its mortality in all classes and at all ages so great that its treatment must ever be of interest, and any research ir either the field of therapeutics or pathology, any experi- ments in chemistry or physiology that throw any light upon the subject should claim the attention of every thoughtful practitioner. Dr. M. F. Anderson, of Eng- land has recently published a book on the subject of “ Phosphates in Nutrition/’ a very able review of which may be found in the Edinburgh Medical Journal for November, 1878, and Brailhwaite$ Retrospect for January, 1879. In it he clearly sets forth the results of his experi- ments on the part the Phosphates play in causing and maintaining organic disease in the human system, and 2 draws therefrom certain conclusions in regard to thera- peutics that are well worth a careful study. He main- tains that the inorganic ingredients of the blood and tissues have hitherto received too little attention at the hands of physicians. He believes that the only form in which Phosphorus is met with in the fluids or solids is as Phosphoric Acid, and that usually in the form of a Phos- phate. This is in direct opposition to the views and teachings of many chemists and physiologists, who main- tain that Phosphorus exists, as such, in various albumi- nous compounds, or in some other form than that of Phosphoric Acid. He further states as the results of his research, that in the blood and tissues these salts are always tribasic, having in addition in nervous tissue, Phosphoric Acid as a hydrate and in combination with the albuminous material of the same. The great point upon which the whole theory hinges is that these Phosphatic salts enter largely into and are necessary for the proper nutrition of vascular tissue, and that their presence may be demonstrated in the inner coats of the arteries and the whole structure of the capillaries. In confirmation of his views he goes on to show that organs will be rich in the Phosphates in exact proportion to their vascularity. The bones are of course an excep- tion, as the Phosphate of Lime is there simply for the purpose of giving strength, its presence being explained upon purely mechanical grounds. He cites tendons and ligaments as examples of low vascularity and pro- portionally low phosphatic presence, there being but a trace. Passing then to a discussion of the function of the arterial and venous radicles and the lymphatics, he de- monstrates very clearly the fact that they serve a double purpose, viz.: that of tissue renovators and builders and of scavengers or removers of waste materials, i. e., the 3 results of tissue metamorphosis. Advancing with subject, he lays the primal, progressive and final danger in Phthisis at the door of these builders and renovators of tissue, showing that they erect almost nothing, and tear down much to supply material for combustion and the production of animal heat. He then makes applica- tion of his facts and reasoning to Consumption, Scurvy, Rickets and Cancer, in all of which he claims that the arterioles, capillaries and lymphatics are seriously affected by an absence of Phosphoric Acid and its salts: their own nutrition being below the normal, they are unable to carry on the reparative processes in a normal degree, and indeed turn upon and tear down the tissues that it is their function to nourish, to supply their own and the wants of the system. The evil is then two-fold ; (a) tissues that should be renovated are destroyed, and (b) the resulting effete material, tissue debris gradually collects in and about the cells until a thorough clogging of the machinery takes place and the vital chemistry of the part is wholly reversed or done away with. Fur- ther, the whole sjrstem is poisoned by this material and hectic and its fellow troubles result. In reference to Scurvy, Dr Anderson finds that the remedial power of lime or lemon juice in this disease lies in the Citric Acid which it contains, and that it acts thus bjr virtue of its power to render the insoluble phos- phates soluble. He says, “ The anti-scorbutic action of lemon juice is thus reduced to its citric acid, and the efficacj' of this depends on the conversion of insoluble phosphates into soluble for the formation of tissue phos- phates. He shows that while two samples of fresh meat yielded respectively .256 and .230 percent, of Phospho- ric acid, salt meat such as is used on ship-board had but .147 per cent, before soaking; the prolonged soaking which it got before use still further removing the soluble phosphates. 4 Turning again to Consumption, Dr. Anderson says that this condition of rapid tissue destruction to supply material for combustion, and t>he maintenance of heat, is, in a certain measure, relieved by the judicious exhi- bition of Cod Liver Oil; but says that the resulting im- provement will not be permanent, and ascribes it to the absence of the proper form or amount of Phosphates in the food or medicine. As we all know, it is nonsensical to attempt to heal the lung lesion while the body is being cornumed. Once the general health improves, the pul- monary troubles begin to mend or remain stationar}^. That the tissues may cease to waste as rapidly as before the oil was given, does not prove that the oil will exert a curative effect. There is another block in the path : the results of tissue metamorphosis, that are interfering with local nutrition and poisoning the system. Plow shall we rid the tissues of this material ? Dalton*, in speaking of the Potassium and Sodium Phosphate, says: “ Of all the internal fluids, the most essential is the plasma of the blood, since it affords the materials of nu- trition for the entire system ; and its alkaline reaction, which is distinctly marked, has been found to be invari- ably present, not only in the human subject, but also in every species of animal in which it has been examined. “ This reaction of the blood is, moreover, necessary to life, since Bernardf has shown that if an injection of dilute acetic or lactic acid be made into the veins of the living animal, death always results before the point oi neutralization has been reached. “ The alkaline reaction of the blood plasma gives to this fluid its extraordinary capacity for dissolving Car- bonic Acid. According to Liebig, water, which holds in solution one percent, of Sodium Phosphate, is enabled * Human Physiology. Phila., 1875, p. 49. f Li