ON HUTCHINSON’S TREATMENT OF GONORRHOEA—A SATISFACTORY PLAN OF DEALING WITH THIS DISEASE IN THE MALE. By W. P. ARNOLD, M. D., Passed Assistant Surgeon United States Navy. Ike Georgia Journal of Medicine and Surgery. -EDITED BY- St. J. B. Graham, M D., J. 6. Van Marter, Jr., M. D., W. E. Fitch, M. D„ SAVANNAH, GA, TH EC GEORGIA JOURNAL OR MEDICINE AND SURGERY, ISSUED MONTHLY. VOL, 1. SAVANNAH, GA, AUGUST 15th, 1897 No. 2. On Hutchinson’s Treatment of Gonorrhoea—A Satisfactory Plan of Dealing with this Disease in the Male. [By W. F. Arnold, M. D., Passed Assistant Surgeon U. S. Navy.] “My treatment of gonorrhoea in all stages has for long been very monotonous. Almost without regard to stage or degree of severity, I prescribe the same reme- dies. I have long ago laid aside the tra- ditions of my student days, which taught that salines only should be used in the acute stages, and that abortive plans were dangerous. I always use abortive meas- ures, and mostly, I believe, succeed. At any rate, I never encounter ill-consequen- ces, and complications are rare. My pre- scription is a partnership of three differ- ent remedies, and it is, I believe, impor- tant that they should all be used. First, an injection of solution of chloride of zinc, two grains to the ounce; next, sandalwood oil capsules, and, lastly, a purgative night-dose, with bromide of potassium. The injection is used three or four times a day; the capsules (10 or 20 minims) taken three times a day. The ingredients of the night-dose are three drachms of Epsom salts, and half a drachm of brom- ide of potassium. It is, I believe, the action of the last named in preventing congestion of the parts which makes the abortive measures safe. Moderate pur- gation and entire abstinence from stimu- lants are essential. If the case is very acute and attended by swelling of the cor- pus spongiosum, I sometimes prescribe tartar emetic or tincture of aconite, but it is very seldom indeed that these are neces- sary. If the patient be well purged, there is no risk whatever in an abortive treat- ment from the day that he comes under treatment. The risk of orchitis, pros- tatitis, cystitis, etc., comes in cases which have been allowed to develop rather than in those treated abortively. I should as soon think of delaying to use local meas- ures in gonorrhoea as I shouhl in purulent oph th aim ia. ”-Jona than Hut chin son’s Archives of Surgery, vol. 1.11, page 236. Some time ago I published* the results of my experience with Jonathan Hutchin- son’s method of treating gonorrhoea in men; and, in my dissertation thereupon, I claimed that reasonably satisfactory progress to complete recovery and a prac- tical immunity from complications and from the usual sequelae, were attainable by adherence to it. My enthusiasm at that time afforded me much patroniza- tion upon which I exercised my patience. I recall now the advice to wait until 1 should have treated gonorrhoea acquired from Chinese women in China and gon- orrhoea in the tropics before commending so highly any plan of treating it. It is the object of the present note to emphasize everything contained in the paper referred to in commendation of this plan of treatment, and to set forth, as the basis of my statements, the results of my observations of gonorrhoea in the male subsequent to the date of that pa- per—April 15th, 1894. The present account will deal with 50 cases; 36 were met with on cruising men- of-war, 8 were presented by civilians, and 6 have been observed to ray satisfaction aboard my present ship. *Some Observations on Gonorrhoea in the Male.—“ The Southern Practitioner,” Nashville, Tennessee, June, 1894. Reprint. GEORGIA JOURNAL OF MEDICINE AND SURGERY. From April 15th, 1894, to the first of the following August, I treated quite sat- isfactorily to myself and to my patients 7 cases on board a man-of-war, that 1 shall designate A; from and including August, 1894, until late in October, 1894,1 treated 12 cases aboard another man-of-war, call- ed, for present purposes, B. The cases that the crew of B acquired were derived in great part more or less directly from the motley throng that the Mid-Winter Fair had attracted to San Francisco; and the men of this ship’s company may be fairly presumed to have lost by enforced continence much of the immunity to this disorder and of the (at present unnamed) influences that modify its severity, which repeated attacks at short intervals un- doubtedly confer, (I am not unaware that the latest views of Bumm—in Veit’s “Handbuch der Gynaekologie,” 1897 admit only immunity for the particu- lar attack and for the given, spe- cial stock of the organism by means of, possibly, functional changes in the protoplasm of the regenerated epithelial cells. But, being willing to trust some- thing to the statements of experimenters perhaps as indefatigable as that author, and certainly no whit less practical in their methods of acquiring knowledge, I am content to await with all confidence the formal announcement of the reversal of this decision.) The cases that they pre- sented were treated under circumstances that cannot be called favorable to the treatment by any stretch of construction, as the ship was either on blue water or in a port within the tropic - throughout their entire course. Nevertheless, only one pa- tient, a fireman, was excused from duty; he was allowed a respite for 4 days after I had reduced a rather severe paraphimo- sis. A patient that was incompletely treated by the Junior medical officer of the ship—without the injection, as nearly as I remember—developed orchitis and peritonitis and narrowly escaped death; and a month later another member of this crew, who had treated himself for several weeks before Hutchinson’s treatment was applied was admitted to the sick list 5 days after this treatment had been adopt- ed, and a fortnight after I had been trans- ferred to another ship. The entire sum of disabilities aboard the ship B from gon- orrhoea that was acquired in the quarter of this year from July to October, are rep- resented by these 3 cases, which gave 44 sick days. I claim exemption from all but four (4) days of this disability for patients treated according to Mr. Hutchinson’s plan. Aboard 0, as I shall designate the last cruising vessel on which I served, a crew of less than 150 men and officers somewhat inured to service in Oriental countries afforded 17 cases of gonorrhoea in nine months’ sojourn in China and two months’ in Japan. In the preceding year there had been about 30 cases aboard this ship. I take this from an unofficial record of the venereal cases that were met with throughout the entire cruise of the vessel that I found on board without an owner; the number of complications, etc., that they yielded are shown in the accompany- ing table. Not one of the cases that I treated aboard C afforded either complication or sequel. Two men were excused from duty—one for two (2) and the other for six (6) days—in order to permit them to care for themselves, as there was not, at that time, an attendant of the slightest special training in the medical depart- ment of that ship. A landsman that was transferred to her from the flagship de- veloped orchitis the same week in which he came aboard; but he confessed to hav- ing treated himself for three weeks prior to his transfer to my ship. I bore a case of upffil thetw- ords of this vessel for a month; the pa- tient had been left by one of our men-of- war in a civil hospital in a port in which my ship spent some time alone. Hence only eight (8) days’ loss of service in a year may be properly charged against ury 17 gonorrhoea patients, and this small matter is a solecism in my practice. CASES SHIP B SHIP C 1893 1891 1895 1st 6 M 1891 1895 1896 1st 6 M Orchitis and Epididymitis... 6 16 8 4 1 Abscess and Adenitis 2 4 6 1 1 2 12 5 2 Gonorrhoeal Rheumatism... 1 4 1 Total sick days 125 221 251 103 8 37 This table shows the complications and sequelce that resulted upon other approved plans of treatment on board the vessels designated B and C. Un- fortunately I am not able to give the number of cases of gonorrhoea that pre- sented on board these ships for the pe* riod covered by the table. I have avoided giving any clues as to the real names of the vessels to which I refer, as far as I could do this and use the material which they have afforded me. I wish to claim ORIGINAL COMMUNICATIONS. nothing over their medical officers, who are of the very best that our Naval Ser- vice can furnish. Whatever credit may accrue hence is clearly Mr. Jonathan Hutchinson’s. tions, I found a case of urethritis—it is not, of course, embraced in the foregoing account—that presented no gonococci. In- stead, the pus from the urethra showed numerous bacilli; and a guinea-pig that had received a drop or two of it intraven- ously died on the third day in collapse, after severe diarrhoea. For that reason, I suspected infection with Bacillus coli communis, although I had not the op- portunity to prove it by examining the blood and organs of the guinea-pig. I ex- amined some pus that was derived from a woman’s urethra for Dr. S. M, Mouser in San Francisco in 1894, and I found, in company with numerous cocci that were assumed to be the common pyogenic forms, the same bacillus, to all morpholog- ical appearances, that my sailorman had presented. No gonococci were found in this case either. It is possible that either one or both of these cases were of a piece with the two cases reported by Josipovice, in “Centralb. Krankheit/- der Harn und Sexual- organen.” Band Heft 10, p. 663, as having been caused by the colon bacillus. I am most sorry to have been unable to follow up more fully the two cases that I have mentioned; and I regret likewise my inability to obtain a specimen of the ure- thral discharge from a gentleman in Northern China, who claimed such dis- charge was due to the fact that his penis had suffered frost-bite in the winter of 1894-95. It is not without interest to observe that the disability ascribable to this dm ■ease for the year 1895 for the entire Na- val Service of the United States, appears to have been about 14,000 sick days. It stands fifth in importance, the list of diseases causing loss of service in the year 1895, malarial affections, preceding it in the order given. There were more admission from wounds, sprains and contusions in the class of in- juries than from this disease, whose ad- missions are given as 330, 57 cases of the number having been treated in the various naval hospitals. The complications and sequels of the cases of gonorrhoea are not returned so as to afford an idea of the proportion which they bore to the number of cases of the disease. These figures re- late to an average strength of force of 13,191 men and officers, which afforded/ 158,495 sick days These considerations indicate to me that something more is necessary besides contagious-disease acts to increase the efficiency of the English-speaking military services. This is too large a question to be interjected here; although I must say, before I leave the subject, that I do not expect the improTement to come through the efforts of the White Cross League, of which the Archbishop of Canterbury is the President. (See 11 The Lancet,'1'1 1897, 1., p. 1633.) No culture-tests were made in any of the cases dealt with in this article. The average duration of the treatment in 43 of these cases was 23.1 days; in the remaining seven cases, it could not be as- certained for various reasons. Restric- tions to the limit of the ship for about a week longer than this period was ordi- narily insisted upon with the idea of pro- tecting in a slight degree the companions (all too frequently the best ones, as bad as they are) of Jack’s hours of liberty on shore. I may say that I have found the routine character of this treatment of the great- est usefulness in my experience, which embraces more than a hundred cases. The only addition that I have presumed to make has been the early and constant use of the suspensory bandage. I have never interfered with my patients’ diet beyond stopping their beer. I have not found the oil of sandalwood to disagree seriously with any of my pa- tients further than to offend the senses of some fastidious Lotharios; but an intelli- gen pharmacist in Shanghai told me that he had seen a person or two that could not use it on account of the severe griping pains in the bowels that it invariably and immediately caused them. It is not an easy matter to get a pure article of this expensive stuff in this country; nevertheless our pharmacopoeia! tests are easily applied The popularity of the Santal Midy cap- sules is proof positive of the value of the article in the treatment of gonorrhoea. While this preparation seems usually of One week’s cessation of notable dis- charge from the urethra has served me constantly as my warrant for discontin- uing all treatment except the injection; this I like to have continued for two weeks after all of the usual symptoms of gonorrhoea have subsided. This expla- nation must be considered in connection with the average length of the treatment. For the sake of completeness in my records, I made (or procured) confirma- tion of the diagnosis with the microscope in 82 per cent, of these cases. In the course of these microscopical examina- GEORGIA JOURNAL OF MEDICINE AND SURGERY. reasonable purity, it is most needlessly expensive and quite shamelessly adver- tised in the press and on dead-walls. ate. I reason that it is necessarily a dis- pensary treatment, and that it is doubtful whether the value of a return-irrigation (or an auto-irrigation) of an infected ure- thra with a solution of potassium per- manganate that could not, before any re- duction of its strength had resulted, have exerted a sensible action as a disinfect- ant, is superior to the same action by the patient’s urine impregnated with oil of sandalwood or with products derived from it. Janet’s adherents claim cures in ten days in all temperate patients; the proprietors of the Santal Midy capsules advertise publicly that their preparation will cure in just one-half of that time. I think that the decision of the merits of these contentions may safely be left to the future. Meantime, I commend the above plan of treating opprobrious clap to the much-insulted, “under-educated,” gen- eral practitioner; to the military medical man both afield and afloat, and to such others as do not yet feel it their duty to administer manually all of the treatment to this “highest grade of parasitic adapta- tion to man.”* U. S. Receiving Ship “Richmond,” Nacy Yard, League Island, Philadelphia, Pa., June 24, 1897. I have not found the injection to cause either pain at the time of using it or irri- tation subsequently, provided the urethra be not occluded by dressings, in spite of its unusual strength. In fact, I think that its strength is its chief recommenda- tion; for I am convinced that the tena- cious prejudices against all injections, at least in the early stages of the disease, owe their origin to superadded infections that were seen to have been caused by them. And small wonder, when they were so weak, to suit the irritated urethra, that they could hardly fail to carry infection along with them. As a rule, infection with the gonococcus alone does not give the worst cases of urethritis. I do not accredit the chloride of zinc with such specific germicidal powers over the gone- coccus as I think must be yielded to sil- ver nitrate in solutions of fair strength- say, from 1-100 upward. I should use (and sometimes I have used) the latter to extinguish at once a localized, accessible gonorrhoea, just as it is used to cure gon- orrhoeal ophthalmia, and to prevent the establishment of ophthalmia neonato- rum. Still, I think that I know that zinc chloride will, in conjunction with the other agents named above, confine gon- orrhoea in the male urethra to its ante- rior portion, and that it will cure it there in a reasonable time with positive cer- tainty. * While the foregoing was in the printer’s hands, the first case of epididymitis occurred that I have known to follow the treatment commended above when ap- plied in its entirety. I know now that its subject drank much raw spirit in the course of the treatment, which was begun on the fourth day after exposure and con- tinued for two weeks. There are reasons for thinking that neither he nor my subordinate were as assiduous as thev might have been in applying the treatment from which the suspensory bandage was omitted alto- gether, although the man was doing heavy work all of the time. Holding this view, I give small heed to the numerous dispensary doctors’ present laudations of Professor Jules Janet’s method of vesical irrigations with very dilute solutions of potassium permangan- To offset this misadventure, a brother medical officer, wno was doing my work during a temporary absence of mine, released one of my cases from restriction to the ship after only 10 days of treatment for a severe case of gonorrhoea upon the strength of mistaken reprosen- tations. Although this man h«d a frightful debauch on shore from which he returned almost poisoned with bad liquor, be had no gonorrhoea.