POINTS NOTICEABLE IN THE EPIDEMIC OF 1889-1890.* By Benjamin E. Cotting, M.D. The affection recently and, in many places, still upon the people, demonstrates on a grand scale the doctrines frequently heard in this Society within the last thirty or forty years,—namely, that any disease, though ordinarily sporadic, or, in occasional outbreaks, usually confined to limited localities, may from time to time spread out with greater or less violence, cover large territories, and some- times nearly or quite encircle the globe; and that this takes place from apparently inherent causes of which little or nothing is as yet known—the affection passing over land and sea unrestrained and unmodified—starting up as unexpectedly perhaps and pursuing its zig-zag course, avoiding one spot and seizing upon another, as arbitrarily as the tempest or the hurricane. Sanitary cordons and governmental edicts seem to have as little influence in such cases as danger signals on the gale or the tornado. If the learned meteorologist, when asked the cause of storms, could with propriety answer “the sun,” with equal propriety may the sanitarian, mindful of Nature’s Plan, attribute diseases and their movements to humanity. However originating or propagated, all epidemics must appear where there are human beings, sedentary or in motion ; and if the morbific influence (micro-organis- mic ?) pass out beyond habitable regions, as quite likely, its presence there can be shown only by attacks on casual passers into such places. Ships, which after having left unaffected ports have had their crews attacked in mid-ocean, afford conspicuous evidence of the diffusive tenden- * Desultory remarks at a meeting of the Norfolk District Medical Society, Jan. 28,1890,—on being called upon by the President for an “ oral communication ’ bn this subject. cies of epidemics.* Other like proofs are not wanting. So far, this time (without hindrance to science) the “ traditional trunk ” has not been brought into requisition ; raiment and rags have not been charged with spreading the infection; and the postal-card has escaped with only an occasional or mild imputation.! The “authorities,” here and elsewhere, seem to have contented themselves with noting the coming and progress of the affection, numbering its victims, and counting up and tabulating the casualties. Whether the epidemic originated in the Philippines, or started from North-eastern Russia, or elsewhere, is of interest chiefly to the medical historian. It is noticeable, however, that it has gone on its own way apparently with- out any attempt to arrest it, and seems to be disappearing through laws of its own. Thus in departure as in onset, this epidemic has differed little, if any, from those of former times; or, indeed, from epidemics of other diseases. That of 1658, accord- ing to Willis, “ceased of itself,” like so many others. Some few years ago a London authority said of a small- pox epidemic of considerable duration, but then suddenly come to an end, “ whence it came no one can tell, why it has disappeared no one knows”—a conclusion worthy of commendation for truthfulness and candor. * In 1837, on board H .M.S. Thunderer, “ at sea,” the epidemic “ suddenly made its appearance while she was on her homeward passage from [unaffected] Malta, four days before she arrived in Plymouth,” her destined port. Syd. Soc. Infl., p. 359. In November, 1848, cholera broke out, nearly simultaneously, in two vessels in mid-ocean, about a thousand miles apart, one sixteen days out and the other twenty-seven, from an unaffected port.—Br. Med-Chir. Rev., No. 72, p. 444. The curious searcher may find probably many similar instances; but these are enough for examples. In 1837, a professor told me, a medical student, of a case (with names and dates) wherein after a long passage from an unaffected port in the East Indies, a passenger, the day after arrival home, without known exposure, was taken down with scarlet fever. The infection must have been far off-shore, or the attack culminated without incubation. There was not the slightest chance to attribute the disease to any kind of luggage whatever. t The weather, which, while it may occasion multifarious discomforts and dis- orders even, probably has little or nothing to do with the rise and progress of epidemics, if indeed of ordinary diseases, generally comes in for its share of blame. This year it is its variable mildness. Fortunately for those attacked there have not been any very low degrees of cold. Of the epidemic of 1698, one English writer says there was in January “ a very stinking fog" ! If the outbreak of a disease is mysterious, its continued absence occasionally from a place is equally so—abundance of material apparently always remaining. For some years, not long ago, typhoid fever was unobserved in a neighboring town, but now and for some time past the locality cannot boast of such exemption. A curious confirmation of our general doctrine has been given, ap- parently unintentionally, in a recent statement of an eminent specialist, that, without any apparent alteration in the condition or habits of the people, scabies had in his experience been more than once absent, for years at a time, so as to render it then impossible to obtain speci- mens enough to demonstrate adequately the affection to the students at the Medical School. Abroad, one of the principal questions under discussion appears to be whether this disease is itself or something else,—whether it is the same as, or akin to, the French “la grippe,” the tropical “dengue,” the English “influ- enza,” or “the grip” of this country; whether, in short, anything like it ever occurred before. This question also< is of no very great importance (our concern being with the exigencies of the present), since no two epidemics have been exactly alike any more than two individual cases of any common disease are absolutely identical. Moreover, the terms used in descriptions vary so much from generation to generation that exactness of meaning is rendered often difficult if not impossible. The passing epidemic may be peculiar, perhaps, in suddenness of attack, rapidity to a crisis, quick subsidence of urgent or distressing symptoms, disproportionate de- bility or lassitude in lengthened convalescence,—though not without parallel instances in the epidemics of old or of those within our own time. Of course, such a rushing disease must have an “ap- propriate treatment,” and many are the plans suggested; but it is doubtful whether any better can be devised than that recommended in past times (e. g. by Rainey)— namely, rest in bed, warmth, mildly modified diet, and very careful avoidance of over-exertion or exposure dur- ing the long convalescence. Such a procedure, according to most authorities, seems sufficient for even the severest cases. The French, judged by their journals, now put their chief reliance upon antipyrine and opiates ; but a writer from Paris states that there “ the symptoms put down as influenza are in many cases those described as due to overdoses of antipyrine really due to the action of the remedy.” The English methods are very varied ; and, of course, sufficiently disturbing. The rapidity of the symptoms seems to puzzle those intent on “ a course of treatment.” A last dictum, with a caution against antipyrine, suggests a return to the old fashion of treating symptoms, and, omitting venesection and mercu- rials once considered essential, offers as agents therefor “diaphoretics, anodynes, stimulants, and tonics,”—i-arange of medication one would think sufficient for the onset, progress and termination of this or any other disease. Although much good has been attributed hereabouts to some of the above mentioned drugs, antipyretics especially, some of the cases, now as of old, where the onset was of the most severe and painful form, have passed to a crisis and to a happy termination without any medication what- ever,—the severest pains disappearing spontaneously in less time than usually required for the effect of an opiate. If imaginary doses have been followed by the lucky re- sults blatantly attributed to their agency, surely “ expecta- tion ” may be resorted to without fear of unpleasant con- sequences. The total number of deaths directly or indirectly from the present disease (however named) will doubtless prove to be very large, as large perhaps as that in any epidemic of cholera, again unwisely foreboded, or of yellow fever ; yet no epidemic of like extent ever caused so little alarm among the people, chiefly because before its appearance it was not proclaimed a fatal affection,—the moral of which is self-evident.