in the rat and in many other rodents. Pineal gland has a rather superficial location which makes it easy to reach surgically on this superior view of the head of the rat, the superior sagittal sinus and the transfer sinuses are projected. The pineal gland is located just underneath the confluence of these sinuses. These relationships are shown again on this mid sagittal section of the brain. The following structures can be recognized. The scalp, the skull, the superior sagittal sinus, with its division into the transverse sinuses, the corpus callosum, the posture, your comma sure, the superior and inferior caligula and the cerebellum. The pineal gland is indicated, located just underneath the confluence of sinuses. The pioneer retains a connection with the brain By a long 10uous stock. The pineal gland can therefore be easily reached by drilling a small hole in the skull. A watchmakers forceps can then be introduced through this opening to grasp the pineal, the gland and its stock can be removed in one motion. In addition to the usual surgical instruments such as forceps scissors and wound clips. two Important pieces of equipment are necessary. A stereotype head holder and especially devised circular drill, the head holder is used to keep the rats head absolutely immovable. This is necessary as any movement will destroy the precision required during the pineal ectomy procedure to hear bars are inserted into the ear canals while a clamp and clearly holds the snout firmly. The circular drill is used to cut a small disc of bone out of the skull. It is made of a short stainless steel tube Bearing Sharp Teeth at one end and mounted on an ordinary dental drill. A collar is fitted around the drill adjusted to the desired depth of cut. After being anesthetized, the rat is placed in the stereotype axis holder and the beer bars are inserted into the ear canals, and the nose client is vertically adjusted to obtain the desired angle. The scalp is inside from between the eyes to beyond the base of the skull. The skin flaps are then reflected laterally, and the underlying fascia and muscles are scraped free in an area wider than the diameter of the drill collar. At this point the large venous sinuses of the brain are visible through the skull. The superior sagittal sinus is indicated and post eerily. It is seen to divide into the right and the left transfers sinuses. The drill is centered on the confluence of sinuses. A hole is drilled to a depth set by the adjustment of the collar. The optimal depth of cut should be not quite equal to the thickness of the skull. The disk still adherent to the dura can be removed With a delicate force it. The sinuses are then readily exposed. Although the pineal gland is not visible, it is now easy with a little practice to remove it. An open pair of watchmakers forceps is inserted into the junction of the sinuses, grasping the stock and removing the gland and a stop in one motion. The white pineal gland is about one half millimeter in diameter and is unmistakable, excessive hemorrhage is prevented by moderate compression of the wound with a cotton pad. The bone disk is returned to its original location, and possible infection is controlled by application of a potted self, a compound. The skin flaps are united by wound clips with the aid of a head holder and the special drill. This Pineal ectomy procedure can be done in 1-2 minutes per animal.