With Compliments, From Dr. Rtjschenbergee, 1932 Chestnut St., Philadelphia, CASPAR WISTER, M.D. A SKETCH OF THE LIFE OF CASPAR W1STER, M.D. BY W. S. W. RUSCHENBERGER, M.D. REPRINTED FROM THE TRANSACTIONS OF THE COLLEGE OF PHYSICIANS OF PHILADELPHIA. NOVEMBER 5, 1890. PHILADELPHIA: WM. J. DORNAN, PRINTER 1891. A SKETCH OF THE LIFE OF CASPAR WISTER, M.D., WITH NOTICES OF HIS ANCESTORS. By W. S. W. RUSCHENBERGER, M.D. [Read November 5, 1890.] Theories of heredity imply that the foundation of the natural characteristics of a man, structural and mental, is laid and gradually evolved by his ancestors very many decades before his birth ; and that a detailed record of the natural qualities of his lineal predecessors might enable an expert in the premises to foretell the general char- acter, if not the fortune of the newly-born infant, as satisfactorily at least as any forecast made by astrologers of old. In the present state of our knowledge of the complex operations of heredity, this suggestion is manifestly premature, and not likely to be realized. Professor James H. Stoller says, in an essay on Human Heredity, “All the qualities of our human nature come to us by inheritance.”1 And Dr. Oliver Wendell Holmes says—Over the Tea cups—“ What he is by nature is not determined by himself, but by his parentage.” The accuracy of this assumption maybe questioned. Even if exact, the inheritance is unequally and irregularly transmitted. Of many children of the same parentage, born and reared under the same circumstances, all may be of normal stature and intelligence or above ; but sometimes one is unaccountably an ingenious dwarf, or an idiot physically well developed, or misshaped, “ scarce half made up.” Dr. August Weismann says, in his essay on the Duration of Life, “We know that long life is hereditary.” And yet all the children of 1 Popular Science Monthly, July, 1890. 4 W. S. W. RDSCHENBERGER, octogenarian ancestors do not uniformly attain advanced age, although all alike live under the same influences. Some of them do not reach adult years. Notable fecundity, and other natural qualities of ancestors, are not always transmitted to their descendants. The sons of eminently great fathers are not always endowed in any respect above the average of men of their class and time. And very frequently the sons of clergymen are neither naturally fitted nor inclined to follow their fathers’ examples. The ancestors of distin- guished men are often obscure people. For instance, Benjamin Frank- lin. His remote origin has been traced to a family of the name, in which a farm was owned for three hundred years or more at Ecton, in Northamptonshire, sixty-six miles from London. The eldest son regu- larly inherited the farm, and was always a blacksmith. All males of the family worked at the same or other trades. Josiah Franklin, father of the Doctor, about 1685 came to Boston with his wife and three children. Lack of custom and profit in his trade of dyer, induced him to become a tallow chandler and soap boiler. In 1689, when he was thirty-five years old, his wife died, soon after the birth of their seventh child. Within a year he married Abiah, youngest daughter of Peter Folger, “a learned and godly Englishman.” Dr. Franklin was one of their ten children ; and possibly may be indebted to the Folger stock for some of his natural endowments,1 mental and physical. Be this as it may he far out-measured in every sense his uterine fellows. On the other hand peculiar qualities so fully characterize members of the same family that their kinship is easily recognized. Dramatic talent often runs in a family through several generations, but not always. And in many instances musical talent in like manner seems to be an inheritance. Observation shows that criminal classes include numerous squads of blood relations, sires and sons. This feature in heredity seems to be so clearly determined that it might be accepted as a conclusive reason for diminishing the number of criminals in the future, by legally requiring that every person, male and female, on admission into a prison on a second conviction of crime should be at once ancesthesitized and permanently sterilized by the surgeon of the institution, as the 1 Life and Times of Benjamin Franklin, by James Parton: Mason Brothers, New York, 1864. SKETCH OF CASPAR WISTER. 5 initiatory, radical means of their reformation. Such an economic application of a doctrine of heredity might be opposed by those who do not believe in it, as well as by those whose clemency for criminals makes them forgetful of the welfare of honest people. Besides virtues and vices, according to both popular and medical opinion, diseases are inherited. Insanity, gout, drunkenness, tubercu- losis run in families from parents to children. The inheritance of tuberculosis may be now considered questionable by some since hosts of observations, it is asserted, demonstrate that tuberculosis is a specific infectious disease, caused alone by the bacillus tuberculosis. But in spite of the earnest, ceaseless and praiseworthy labors of Dr. Koch and many others during several years, to ascertain the origin and habits of this bacillus with a view to discover means for its destruction, it still carries on its ravages with impunity; and notwithstanding the indictment found against it by most astute detectives, the mortality from tuberculosis remains unchanged. The many problems of heredity remain to be solved. Mr. Francis Dalton, who has studied the subject during the past quarter of a cen- tury and published several essays and books about it, says, in his last work, that “no complete theory of inheritance has yet been propounded that meets with general acceptance.”1 And Dr. August Weismann says, “ I am unable to indicate the molecular and chemical properties of the cell upon which the duration of its powrer of reproduction depends; to ask this is to demand an ex- planation of the nature of heredity—a problem the solution of which may still occupy many generations of scientists. At present we can hardly venture to propose any explanation of the nature of heredity.”2 And recently it has been asserted, that we of the present generation are wrong to be unconcerned for the physical and mental qualities, not only of the next but of all generations in the remotest future. Heredity and evolution, in obedience to the will of the omniscient Creator, have wrought alone from the beginning, to increase, raise the physical and mental powers of the human race from the lowest level to the highest degree of excellence; but now, the cooperative assistance 1 Natural Inheritance, by Francis Galton, etc.: Macmillan & Co., London and New York, 1889, 8vo., pp. 259. 2 Essays upon Heredity and Kindred Biological Problems, by Dr. August Weis- mann, Professor in the University of Freiburg in Breisgau. Authorized Translation edited by Edward B. Poulton, M.A , etc., Selmar Schonland, Ph.D., etc., and Arthur E. Shipley, M.A., etc., 8vo., pp. 455. Oxford, At the Clarendon Press, 1889. 6 W. S. W. RUSCHEXBERQER, of all men of to-day is needed to prevent the rate of progress from being lessened. Over-work of all kinds, and many other excesses are impairing our vigor, and for this reason it is a duty to secure for our- selves, by appropriate hygienic means, the highest degree of physical and mental force attainable for the benevolent object of transmitting the same to our posterity. Accepting an assumption that the characteristics of man may have come to him through the functions of reproductive cells in the bodies of remote ancestors, this sketch of the life of Dr. Caspar Wister begins with brief notices of his great-great-grandparents and their lineal offspring. The family names, Wister and Wistar, have been traced back about two centuries. The Great-Great Grandfather of the Wisters. Hans Caspar Wiister, and his wife, Anna Katarina, resided at Hilsbach, a village seventeen miles S.S.E. from Heidelberg, in the Duchy of Baden. He was Jager, that is, Hunter or gamekeeper of the prince Palatine—a prince entitled to privileges in the palace. The Rector of the Lutheran church at Hilsbach has in his keeping a book in which are recorded the baptisms of the parish, from 1699. The register used in the church for the purpose prior to that date had been accidentally consumed by fire. This one contains the names of five of their six children, with the date of birth of each. The name of Caspar, the oldest, is not in it, because he was born February 3, 1696, before the Rector’s old church book was opened for entries. Though not recorded, it seems fairly supposable that Hans Caspar and his wife knew who were their parents, grand parents, and great grand parents, though comparatively obscure people, and for this reason it may be admitted that knowledge of the family existed as far back at least as the middle of the seventeenth century. Unfortu- nately, the individual characteristics of Hans Caspar and his ancestors have not been recorded. Theories of evolution and heredity suggest that all pedigrees started alike and at the same time with the beginning of the human race, and that, under natural law, their growth and duration were the same. In this condition of perfect equality in this respect, every one knew that he had forefathers as a matter of course, and did not appraise himself more highly than his neighbors on that account. In the course of SKETCH OF CASPAR WISTER. 7 time, however, views changed and men were pleased to believe they were better for the virtues of parents. Then it came to be conven- tionally agreed that a pedigree worthy of mention must be traceable through a line of ancestors, each being named with his relative posi- tion and connection in the line clearly designated. Therefore, the value of a pedigree is commensurate with the length of the period during which it can be traced. As early as 1683, William Penn invited Mennonites in Holland, Germany, and elsewhere to settle in the new country, and offered to sell them land in his province. Numbers accepted the invitation, and, to escape persecutions they suffered from religious intolerance at home, became valuable citizens of the English colonies. Among the early Mennonite settlers in Germantown were many weavers. The Friends and the Mennonites were peaceable neighbors; both sects con- scientiously believing that war and bearing arms under any circum- stances are repugnant to their sense of religious duty. These immigrants no doubt reported to their kinsmen and friends in Europe the advantages of living in America in a manner to induce many to follow them. Caspar, the eldest son of Hans Caspar, dissatisfied with the aspect of the probable opportunities to increase his means of livelihood in Germany, started, as soon his age authorized him legally to act independently of his father, to seek better chances of happiness and fortune in the new world. He arrived in Philadelphia September 16, 1717. His Jiiger rifle, which he brought with him, is still an heirloom in the family. When Caspar Wiister settled in Philadelphia the inhabitants were subjects of George I., King of England, and were English in their modes of thinking, their political affiliations and language. Accord- ing to a family tradition his name was anglicized by his American associates. As he spelled it aloud as he had done in his native land, they substituted in place of the German u, marked by an umlaut, the English i, which letter in sound was supposed to approximate nearest to his pronunciation of it; and for like reason, the German e was superseded by the English broad a, and so they wrote his name Caspar Wistar; and concordantly he signed his oath of allegiance to King George I., in 1721. In the first years of his residence in Philadelphia he carried on the business of button-maker, and was successful. The Colonial Assembly enacted a law “ for the better enabling Caspar Wistar and John 8 W. S. W. RUSCHENBEEGEE, Crapo, merchants, and Nicolay Gateau to trade and hold lands in the Province.” Hd and other born subjects of the Emperor of Germany had petitioned for such legislation, April 27, 1724. The Weekly Mercury, in 1726, recorded him among “the principal merchants of the city.” He purchased land where North Broad Street and the Ridge Avenue are now; .some of it is still owned by his descendants. In 1726 he married Katherine Johnson of Germantown. His son Richard, born in 1727, the eldest of his seven children, married in 1751, Sarah, daughter of Bartholomew Wyatt, of Mannington town- ship, Salem County, N. J. He bought between two and three thou- sand acres of land in that county, and established, about a mile and a half from Allowaystown, a glass factory, said to be the first in this country. The immediate management of it was confided to a super- intendent, for the reason that he resided in Philadelphia. He had eight children. One of them was Dr. Caspar Wistar, the eminent professor of anatomy in the University of Pennsylvania, and the fourth President of the American Philosophical Society—from January, 1815, to January, 1818.1 As soon as his observation and experience had satisfied him that Philadelphia afforded better opportunities than Hilsbach for a young man to seek a fortune, Caspar advised his younger brother John to settle here without delay. John, however, declined the invitation, because he was not willing to leave Germany while his father was living. Not very long after the death of Hans Caspar Wiister, January 13, 1726, and about the time that George II. became King of Eng- land, June 11, 1727, he left Hilsbach, and, at the end of a four months’ voyage, landed in Philadelphia, September, 1727, in the nineteeth year of his age. He was born November 7, 1708. These two brothers, who were the founders of the Wistar and Wister families of Philadelphia and New Jersey, probably had no more education and training at home than were usually given to hunters and gamekeepers in Germany at the beginning of the eighteenth century. 1 History of the Counties of Gloucester, Salem and Cumberland, Hew Jersey, with Biographical Sketches of their Prominent Citizens. By Thomas Cushing, M.D., and Charles E. Sheppard, Esq. Quarto, pp. 728. Everts