Laboratoire Pasteur Paris. (Ve) te... December 8, 154°
DE Rue d’Ulm, 26

INSTITUT DU RADIOM TEL.: ODEON 45-75

 

Service de Radiobiologie
de
LINSTITUT PASTEUR

Dear Lederberg:

Two days ago I ssked Nicolle,who keeps
the collection of lysogenic strains at the
Institut Pasteur, to send tou the Lisbonne
one with the Shiga indicator. I had siven
him these stocks a few davs ago. We don't
have sosre copies of ancient reprints, but
vou might find some in Bordet's leb. I
sugsest vou write to Paul Bordet in Brussels

AS recard your problem of disinfection,
it is very hard to find a selective agent
which acts more efficiently on the virus
than on the host. The only one I can think
about would be 4 temperature of about 40°C
which usually keers the cells alive, and
wills a lot of viruses in about 50 to 100
hours. You mey know that many disinfections
from virus diseases have been obtained
this way in plants.

Herewith enclosed is mv preliminary note
on radiation induced mutation in a phege.
I could add that:

Irradiation off free virus gave negative
results, aS well as irradiation of bacteria
prior to infection. At present, I am inves-
tigatine what happens when I irradiste the
free virus, then infect B with it, and
plate on the indicator before lvsis of the

4pofected B..When this experiment will be
finished, I'll write a full paper.
The possibility of selection was ruled
out.
Sincerelv yours

Mapes fting dh a

~ Pavmond Latarijet