-?•; v /^ w * 11.. ¥<■■; j ,-f b *. 6 J * J. ... OBSERVATIONS ON THOSE DISEASES OF FEMALES WHICH ARE ATTENDED BY DISCHARGES. ILLUSTRATED BY COPPER-PLATES OF THE DISEASES, &c. BY CHARLES MANSFIELD CLARKE, UZHBER OF THE ROYAL COLLEGE OF SURGEONS J SURGEON TO THE QUEEN'S LYING-IN HOSPITAL; AND LECTURER ON MIDWIFERY IN LONDON. Helleborum frustra, cum jam cutis aegra tumebit, Poscentes videas; venieoti occurrite morbo. Pers. 3 Sat PHILADELPHIA: H. C. CAREY AND I. LEA—CHESNUT STREET, AND WELLS &• LILLY, BOSTON. 183f. C b^c GltlC TO DR. BAILLIE. DEAR SIR, In dedicating the following Work to you, I am per- forming an act of duty to a Physician who has greatly illustrated the nature of disease by investigating morbid structure. I entertain a hope also, that the imperfec- tions of this Work will Bnd some shelter under your protection: but I have especial pleasure in thus pub- licly testifying the obligations which I owe to you for many acts of kindness, undeserved, but uot unremem- bered by, Dear Sir, Your most faithful Servant, CHARLES MANSFIELD CLARKE. Saville Row, February 10, 1814. CONTENTS. Page Preface, ..... i chapter i. Remarks Introductory to the Consideration of the Diseases of the Sexual Organs, - 7 CHAPTER II. Prqfluvium Vaginale, - - - 13 CHAPTER III. General Observations on Sexual Diseases, and on the Necessity and Mode of making an Exami- nation per Vaginam, - - - - 20 CHAPTER IV. On Sympathies, . . . , 22 CHAPTER V. Procidentia Uteri, - - - - 27 CHAPTER VI. Treatment of Procidentia Uteri, - - 35 CHAPTER VII On the mode of supporting (he Uterus, - - 44 CHAPTER VIII. Procidentia Vesicae, 51 CHAPTER IX. Procidentia Vaginae, - - - -55 CHAPTER X. Inversio Uteri, ... - 58 CHAPTER XI. Haemorrhoids, or Piles, - - - - 63 vi CONTENTS. CHAPTER XII. Page JLscarides in the Rectum, - - . 67 CHAPTER XIII. Carcinoma Recti, * - - - 69 CHAPTER XIV. Carcinoma Uteri, 78 CHAPTER XV. Treatment of Carcinoma Uteri, - - - 84 CHAPTER XVI. Polypus of the Uterus, ... 88 CHAPTER XVII. Fleshy Tubercle of the Uterus, - - - 97 CHAPTER XVIII. Verrucce, or Warty Tumours, arising from the Vestibulum, - - - 103 CHAPTER XIX. Vascular Tumour of the Orifice of the Meatus Urinarius, - - - - .105 CHAPTER XX. Thickening of the Cellular Membrane surround- ing the Urethra throughout its whole Extent, accompanied by a Varicose State of the Vessels of the Parts, - - - - 107 CHAPTER XXI. On the Transparent Mucous Discharge from the Vagina, not accompanied by any Alteration of the Structure of the Sexual Organs, - - 109 CHAPTER XXII. On the Case of Transparent Mucous Discharge depending upon Debility, - - - 113 Explanation of the Plates, - - - 117 CONTENTS. OF PART II. T rage. INTRODUCTORY REMARKS, - - - 129 CHAPTER XXIII. White Mucous Discharge, - - . 131 Inflammation of the Cervix Uteri, - 131 et seq. Inflammation of the Substance of the unimpreg- nated Uterus, - . _ 140 Remarks upon Amenorrhoza, - - 144 CHAPTER XXIV. Watery Discharge, - - - 150 Cauliflower-Excrescence of the Os Uteri, 151 Symptoms of Cauliflower-Excrescence, - 160 Treatment of Cauliflower-Excrescence, - 163 Hydatids of the Uterus, - . . 17s Oozing Tumour of the Labium, - - 177 Involuntary Discharges of Urine, - - 181 CHAPTER XXV. Purulent Discharge, - - - 184 Inflammation of the Mucous Membrane of the Uterus, terminating in Secretion of Pus, 187 Inflammation of the Mucous Membrane of the Vagina, - - . . .192 viii CONTENTS. Page. Abscess of the Vagina, - - - 196 Ulceration of the Os Uteri and Cervix Uteri, 199 Corroding Ulcer of the Os Uteri, - - 300 Symptoms of Corroding Ulcer, - - 201 Treatment of Corroding Ulcer, - - 203 Ulcerated Carcinoma of the Rectum, - 206 Ulcerated Carcinoma of the Uterus, - - 209 Treatment of Ulcerated Carcinoma, - 212 Explanation of the Plates, - - - SIS PREFACE. The author has had two objects in view in laying the follow- ing observations before the public. In the first place, it appeared to him to be desirable to make some arrangement of the sexual diseases of the female. In the second, to shew that diseases having some symptoms in common, are nevertheless very dis- similar in their character, and require very different treatment; to demonstrate the impropriety of designating diseases by names which do not convey a true idea of their character; and to point out the dangerous consequences of treating symptoms instead of diseases. Having been during many years a teacher of midwifery in the school founded by Dr. Denman and Dr. Osborn, and con- tinued by his brother, Dr. Clarke, the author's attention has been naturally and necessarily led to contemplate the diseases of the sexual organs, and to consider the best mode of explaining them, so as to make the description profitable to those whom it was his duty to instruct. In preparing his notes, a question arose in his mind; whether any classification of them would assist the memory in retaining, or the judgment in discriminating and cur- ing them. The opportunities which the author has had of at- tending to these diseases, and of observing the very general and careless manner in which they are sometimes treated, have in- duced him to attempt to illustrate them by a plain, unadorned history of their nature and symptoms, and to point out what appears to be the best mode of treatment. In this work, no more hypothetical reasoning has been admitted, than was absolutely necessary. The author has endeavoured to confine himself to A 11 PREFACE. facts, and the simple narration of them: he has no new theory to offer, no new medicine to propose, the virtues of which he is desirous of establishing. How to arrange these diseases became an important subject for consideration: they are numerous, and dissimilar; arise from various causes, and produce different effects. Some are attended by no discharge from the vagina; others, on the contrary, never occur without discharge, and the nature of this discharge va- ries.—Here appeared to be a path to follow. Here, at any rate, was presented a mode of making something like a division of these complaints, which might prove serviceable to the prac- titioner: for, supposing him not to be very conversant with these disorders, and to be at fault respecting the disease; supposing, for example, that he is not quite sure whether a tumour in the vagina is a soft polypus, or a cauliflower excrescence; if he knows that one of these diseases is attended by a mucous discharge and the other by a discharge of water, he will have nothing to do but to inquire into this circumstance, and the question is imme- diately solved. The First Part of this work, now respectfully offered to the medical profession, contains those diseases which are attended by mucous discharges. Many other important diseases remain to be described under the head of purulent, watery, and white opake discharges; and there are others of equal consequence, in which no discharge of any kind is present. These will fall un- der consideration in a future part of this undertaking. The author entreats that the reader will make allowances for many inaccuracies in this work. He has endeavoured to write clearly rather than elegantly: he has not wilfully misled any one; and if these observations shall prove in the smallest degree use- ful, in diffusing information upon the subject of them, or in miti- gating the sufferings of human nature, the author will not consider his labour thrown away, nor his time misemployed. OBSERVATIONS, &c. INTRODUCTORY REMARKS. The diseases of the sexual organs in females, although so various, so distressing to those who labour under them, and not infrequently so fatal in their consequences, are perhaps less generally known and understood by practitioners, than any other complaints to which the human body is subject. They are of- ten neglected by women during the early stages of them, con- cealed from a sense of delicacy during their progress, and are often only made known to practitioners, when they have pro- ceeded so far as to be beyond the reach of remedy. In these latter stages, a disease becomes complicated with many symp- toms not originally belonging to it, which are the consequences of high irritation, of great debility, or of the general disturbance of the constitution. In many of these diseases, when physicians or surgeons are consulted, the patient mentions some prominent symptom, which is to her the apparent cause of annoyance; and this is often considered as the disease, and treated as such. With as much reason it might be expected to remove asca- rides from the rectum by making applications to the nostrils, or to diminish the effects of pressure upon the brain by medicines applied to the stomach to relieve sickness, one of the symptoms of such pressure, as to cure a woman of an uterine disease in the manner alluded to above. Yet many instances are to be found where strangury has been treated as an idiopathic affec- tion of the bladder, when it has in fact been symptomatic of a morbid state of the uterus; and also, where an itching of the external organs of generation has been attempted to be cured by a sedative lotion, when it depends upon the presence of an or- ganic disease in the neighbouring parts: or, lastly, where local astringents, and internal tonics and stimulants, have been pre- 4 INTRODUCTORY REMARKS. scribed for a case of fluor albu?,—the symptom only of a dis- ease; and that disease perhaps of an inflammatory character, which the discharge produced by the disease would be more likely tp relieve than such remedies. Upon almost all the other subjects connected with medicine, information may be obtained from a variety of sources: but upon the subject of the diseases of the female organs, many systems of physic and surgery, otherwise of deservedly high estimation, are entirely without information, and are often more apt to mis- lead than to instruct. Valuable observations are scattered through the works of different writers, and some detached papers upon the subject may be found in collections and transactions of dif- ferent Societies; but the student does not know where to look for them: they require to be collected with much labour, and a great sacrifice of time; and it is almost impossible for a student to separate that which is valuable from that which is useless. Another reason why the information of the medical student must be defective on this subject is, that in the course of medi- cal education, very few, if any, opportunities of witnessing any of the diseases of the female parts occur; there being no hospi- tal into which these complaints are expressly received: and from many public institutions they are excluded, being generally chro- nic diseases; in some instances incurable, and only admitting of palliation.* A student would even gain little if such cases were admitted; for it could not be expected that a patient would sub- mit to be exposed to the manual examination of a number of students; and without such examination, little good could arise, except in cases of disease in the external organs, which bear a very small proportion to those of the internal or remote parts. To give a history of the diseases of the female organs of ge- neration, to describe with accuracy their symptoms, to shew by means of engravings the alteration of structure which the parts undergo, and thereby to familiarize the mind to them, so that when the diseases are met with, they may be known and dis- tinguished, and to point out the mode of treating them—is the intention of this work. Owing to an imperfect knowledge, all the discharges from these parts, which are not of a red colour, have been classed under the title of fluor albus, and treated as that * It may appear at first sight, that the exclusion of chronic diseases of this kind from hospitals, is an improper regulation; but upon considering the mat- ter more closely, it will be found, that though an individual may suffer, the public is a gainer. As the funds, and consequently the means of relief are li- mited, it becomes important to extend those means to as great a number as possible. The occupation of a bed in an hospital by one patient labouring un- der phthisis or an old ulcer of a leg for six months, will prevent assistance from being given to many labouring under acute diseases which might be cur- ed in that period. INTRODUCTORY REMARKS. 5 disease; and various diseases in which there exists pain with a fetid discharge have been denominated cancer. To this confu- sion of the diseases of the female organs of generation, are to be attributed those errors in practice which are frequently ob- served. That engravings of morbid structure are likely to prove ser- viceable, in leading to the knowledge of disease in the living body, particularly when connected with a history of the disease, is the opinion of one of the first physicians of the present day, to whom medical science is indebted for a very valuable work upon morbid anatomy:—that they are really so, is demonstrated by the estimation in which that work is held.* If, then, engravings taken from internal parts of the body, af- ter death are likely to prove serviceable, it may not be presum- ing too much, to nope that those which the author proposes to lay before the public will not be useless; as every practitioner ought to be well acquainted with the diseases of the female or- gans of generation, in order to enable him by his sense of touch to discriminate between them. By the frequent employment of this sense, it becomes very acute, so as to convey with great correctness to the mind the impressions made upon it: but much time is required to perfect this sense. Many cases of disease must have presented themselves to the practitioner, before he will have obtained much knowledge respecting them: but if an engraving of the appearances of each disease is brought before his eye; if this is accompanied by a correct history of the symp- toms, and a description of the peculiar nature of the discharge from the vagina, when such discharge accompanies the com- plaint; if it can be shewn that some diseases are characterized by discharges of a watery kind, others by those of mucus, oth- ers by those of pus, or of blood,—he will meet the first case which occurs to him with a confidence founded upon know- ledge: and judging, by that which he has seen described in plates, of that which he feels, he will form a better opinion re- specting the nature of the complaint, will be able to give a prog- nostic more likely to be verified, and will direct such measures to be pursued as will tend to its alleviation or removal. To further this latter view, it is proposed also to give engrav- ings of such instruments as may be necessary for the perform- ance of the operations required in some of the diseases, and of such machines as may be serviceable in applying local remedies to them. In attendance upon the poorer class of patients, when suffer- ing under the diseases of the external organs, the author has * Dr. Baillie's Morbid Anatomy. 6 INTRODUCTORY REMARKS. been able to make drawings, shewing the appearances of some of these diseases in the living body. The other engravings are made from a collection of morbid preparations in the possession of Dr. Clarke and of the author; and occasionally from those of his friends, where he has found it necessary. 7 CHAPTER I. Respecting the Sexual. Organs in the Female, as far as their Secretions are concerned. It is not the intention of the author to increase the size of this work by giving an anatomical description of the female or- gans of generation, the dissecting-room furnishing a sufficient opportunity to the student to inform himself of their natural structure; but it must be remarked, that it is highly important that the anatomy of these parts should be well understood. Without this knowledge, diseases cannot be known, nor the de- gree of them; for as disease is a deviation from health, the natu- ral structure must be known before those deviations from it can be ascertained which constitute disease. It is also especially ne- cessary to be acquainted with the relative situation of these parts, and with the effects which arise out of this relation: this leads to a comprehension of the manner in which the disease is produced, frequently accounts for many symptoms which could not otherwise be explained, and gives a direction to the appli- cation of those modes of treatment which may prove serviceable in restoring the parts to health. As an accurate knowledge of the different secretions from these parts will very materially assist the practitioner in his in- quiries, some remarks will be made here respecting them. All the discharges from these parts come away from the os externum; but they spring from various sources, and are of dif- ferent kinds. The parts from which these secretions arise, are: 1. The internal surface of the uterus and of the fallopian tubes. 2. The inner membrane of the vagina. 3. The lacunae about the os externum. 4. The mucous membrane of the urethra.* These will be separately considered. 1. The secretions from the uterus. These are: «. The inenstruous secretion. fi. The secretion from the mucous membrane of the uterus, which extends to the cavities of the fallopian tubes. y. The secretion from the glands in the neighbourhood of the cervix of the uterus. » These are (lie surfaces from which the natural secretions arise: but dis- charges from the os externum may originate from the surfaces ot newly- fonued tumours, as the cauliflower excrescence.; or they may be the contents of cysts of hydatids. 8 RESPECTING THE SEXUAL «. The Menstruous Secretion. The menstruous secretion is a fluid of a red colour, possess- ing very little tenacity, which does not coagulate, poured out by the arteries of the uterus, once every lunar month in healthy women, if they are neither pregnant nor suckling;* it begins at puberty, and generally continues till between the age of forty and fifty in this country: so that calculating the age of puberty to be the fifteenth year, and the duration of life to be seventy years, it may be said that the menstruous secretion is performed during three-sevenths of it. A case is related in the Transactions of the Medical and Chi- rurgical Society of London, by Dr. Martin Wall, professor of clinical medicine in the University of Oxford, of a child, aged nine years, having menstruated regularly from the age of nine months; in whom also all the symptoms, which attend puberty, were present before she was two years old. It is of consequence for practical purposes to observe, that menstruation is a secretion, and not an effusion of pure blood either from arteries or veins. All blood from the sanguiferous *» vessels (with very few morbid exceptions) coagulates; whilst the fluid of the catamenia does not, whether it comes away in a stil- latilious manner, or is retained in large quantity as in the case of imperforate vagina. The quantity of the menstruous fluid is greater in warm than in cold climates: so, if a woman lives in an atmosphere artifi- cially warmed, the same effect is produced. At each period of menstruation, the average quantity lost in England, and perhaps in other countries in the same degree of latitude, may be reckoned at four ounces, which takes up about four or five days in coming away: in some women it lasts a week; in others not more than two or three days. Plethoric women are more liable to the first, and women of delicate health to the last, occurrence. Whatever is capable of increasing the determination of blood to the vessels of the uterus, may increase the quantity of this secretion; and if this determination of blood is increased above a certain point, the orifices of the vessels give way, and blood is mixed with the secreted fluid: but if, in consequence of this determination of blood to the uterus, inflammation takes place, then coagulating lymph is thrown out, as from other inflamed mucous membranes, and the secretion is diminished till the la- mina of coagulating lymph is separated. From the definition above given of the menstruous fluid, it ' * Some women who give suck do menstruate, but it is not usual. ORGANS OF THE FEMALE. 9 will be seen that it does not possess the coagulating part of the blood, and instances have occurred where the red colour has been wanting; but from the quantity of which, a woman has been obliged once in a month to take the ordinary precautions of a menstruating woman. ft. The Secretion from the Mucous Membrane of the Uterus, and of the Fallopian Tubes. The uterus is lined throughout with a mucous membrane, which also is spread along the fallopian tubes. The secretion from this membrane is permanent, and continues during the whole of life, with the exception of the period of pregnancy. At this time the internal structure of the uterus undergoes a great change, and forms the outer membrane of the ovum, called tin) Membrana Decidua, by Dr. William Hunter. This mucus re- sembles, in consistence and appearance, the uncoagulated white of an egg, and does not differ from mucus in other parts of the body.* A very small quantity of this mucus is secreted; its use being simply to lubricate the sides of these passages, so as to prevent the cohesion of them; and for this purpose very little is sufficient. In the other passages which have external openings, the mucus is to be considered likewise as a defence against sti- mulating bodies which pass through and into them. y. The Secretion from the Glands in the Cervix of the Uterus. The structure of the uterus itself is very simple. Its sides are muscular, and the muscular fibres are capable of great exertion; and it is principally owing to the contraction of these fibres that uterine hemorrhage in the impregnated state is restrained. The structure of the cervix of the uterus is more complicated; more nerves are sent to this than to any other part of the viscus; on which account the dilation of this part is attended with great pain in labour, and diseases affecting it are productive of great distress and suffering. The cervix of the uterus is also beset with a number of glands. These glands are more readily discernible in women who have died pregnant; and in some bodies they are probably much more numerous than in others. The mucus secreted by these glands contains a smaller pro- portion of water than any other mucus in the body, approaching nearer to the nature of a solid than to that of a fluid body: it is • According to the experiments of Mr. William Brande, mucus consists of albumen and soda.—See a paper in the Philosophical Trausactioni, on albu men aud some other secreted fluids. B 10 RESPECTING THE SEXUAL semi-transparent, and possessed of a great degree of tenacity : it adheres to the fingers like bird-lime; but the attraction of co- hesion between its parts is so strong, that it may be generally drawn away entire from any body to which it has adhered. If the uterus of a pregnant woman is examined after death, this mucus may be drawn out of the orifices of the glands which se- crete it.—These glands, in a state of health, perforin the office of secretion in pregnancy only; or, if at any other time, the matter secreted is of a very different kind, so resembling com- mon mucus as not to be distinguished from it. It is probable that the secretion of this viscid substance is confined to the commencement of the state of pregnancy; for if the body of a woman, in the third month of ulerogestation, is examined after death, the quantity of mucus filling the cervix uteri will be found to be quite as considerable as at the close of pregnancy. The intention of this mucus has been supposed to be, to prevent the escape of the ovum in its early state; and that when it has answered this purpose, the secretion ceases; but it is probable that it has some other use, at present not un- derstood. It is known that the uterus prepares for the reception of the ovum, before the ovum reaches its cavity, by the formation of the decidua: the cervix uteri also performs the secretion of this viscid substance immediately after impregnation has taken place.* 2. The Secretion from the inner Membrane of the Vagina. This membrane presents a very large surface for secretion, which is constantly going on. The quantity of this secretion is liable to great alterations, from causes which will be hereafter enumerated. This mucus is thinner than that formed by the mucous membrane of the uterus; for the finger, when with- drawn from the vagina of a healthy woman, after an examina- tion, is merely moistened with a fluid, evidently containing a much larger quantity of water than mucus generally, or that formed by the uterus, contains; for if, in a case of procidentia uteri, where from the extent of the disease the os uteri has be- come visible, the finger be applied to that opening, the mucus from it may be drawn out in thin filaments. The inner mem- brane of the vagina (the surface which secretes this mucus) is generally thrown into a vast number of folds, which do not fol- * Vide Medical Commentaries; and a paper, by Dr. Clarke, in vol. i. of the Transactions of a Society for the Improvement of Medical and Chirurgical Knowledge.—The parts referred to are preserved in the collection of Dr. Clarke and the author; and in the preparation both these facts are demon- strated. ORGANS OF THE FEMALE. 11 low any regular arrangement, like those within the cervix of the uterus. This corrugation of the membrane is greatest in the fe- tus and in young children: in maiden women it is very conside- rable ; but in married women, particularly in those who have borne many children, it is less observable. A number of mus- cular fibres surround the vagina; and by the action of these fibres the capacity of the vagina is diminished, and the number of the rugae increased. By means of volition these fibres may be excited to a stronger action: but this is temporary, and con- tinues only whilst the will is directed to produce this effect. A woman from whom one of the drawings of procidentia of the uterus was taken, had the uterus returned to its situation within the body, and was enabled to retain it for a short time in that position by the exertion of her will; but in a short time the tu- mour came down again, the mere tone or permanent contrac- tion of the fibres being inadequate to produce the same effect. —The number of rugae in the vagina is in proportion to the strength of the woman: for when this has been greatly dimin- ished, the lining of the vagina becomes more and more smooth, by the rug.ie being diminished in number; till at last, in those cases, when from the effect of long diseases, or great age, the powers of the body are nearly exhausted, the rugae are quite obliterated, making the inner part of the vagina perfectly smooth. If the body of a woman who has died of hemorrhage after a labour is examined, this will be evidently seen. The secretion from this membrane is least in quantity when the wrinkling is the great- est:—for example, it is very trifling in children and in maiden women ;* but is formed in the greatest quantity, and more fre- quently, in married women who have borne many children, whose vagina has been most frequently dilated. In cases of great debility, from any cause, this discharge almost always at- tends; but as the system acquires strength the discharge dimin- ishes, liil it ceases altogether.-]- If the vessels of the uterus and the vagina are injected by coloured wax thrown into the hypogastric arteries, several ves- sels of a considerable size may be seen running from the hypo- gastric arteries along the sides of the vagina towards the os ex- ternum^ and partly by these vessels and partly by some branches of the pudica artery this secretion is performed. When the muscular fibres which surround the vagina contract, the small branches of these vessels will be pressed upon, and their diam- eter will be diminished: in consequence of this diminution of ' Virgines rnr5 hoc malum (fluor mulicbris) infeslat, frequentius adullior^ — St-nriurtus, lib. 4, part i2, sect. 2, cap. 12. t «P*»ff ft XfUKDf t» TIKTI yfgXlTSfflTi Till yVVSHXi'V (MKMl yMTOU » S» TWJ Vtfc'TtflWI. 'iTTixf T'fl ymxixtivi, SiCk £ ) IS SEXUAL ORGANS OF THE FEMALE. their diameter, the stream in them will be lessened, and less blood will be sent to the parts which they supply; but if the power of contraction in the muscular fibres surrounding the va- gina be lessened or lost; then, no restraint being laid upon the vessels, more blood rushes through them, their diameter being increased; and the parts, to which they go, will be supplied more plentifully. So likewise if the canal is very much dilated by any cause, this muscular band being put upon the stretch will be un- able to act at all; and a like effect will be produced upon the blood-vessels which furnish fluids for secretion. In moist countries and climates also, where it is to be expected that the tone of the body would be diminished, this discharge is found to be very common.* 3. The Secretion from the Lacuna seated in the Vestibulum. The term vestibulum has been given to that part of the pas- sage leading to the uterus which lies upon the outside of the hy- men: beyond this membrane the canal is called the vagina. Between the clitoris and the meatus urinarius are to be seen small openings, which pour out a glutinous mucus. Two other openings of the same kind are situated upon each side of the vestibulum, at about an equal distance from the fore and back part of the passage: these are large enough to admit the end of a bristle. There are also several Fittle orifices very ne;ir to the carunculae myrtiformes. All of these openings pour out a glutin- ous mucus which has a peculiar odour. 4. The Secretion from the Mucous Membrane of the Urethra. The urethra is lined throughout with a mucous membrane which secretes a viscid mucus: this shields the membrane, and prevents the salts of the urine from stimulating it. If, however, the urine is rendered particularly acrid from substances taken into the stomach, or from improper actions going on in the sto- mach, the mucous membrane may be irritated through this mu- cus by such increased acrimony ; which, though it may be equal to defending it from ordinary stimuli, may be incapable of pro- tecting it from others which are stronger. This is the case also in other mucous membranes. Mucus secreted in diseased states of the bladder escapes occasionally in large quantity from the orifice of the meatus urinarius, so as to make the urine of a ropy consistence. "" In Holland, fluor albus is frequent, and in a manner peculiar to the place, from the dampness of its situation. I have attended more women labouring under fluor albus in autumn, than at any other season of the year, especially when the weather was extremely moist and cold. Most of them were cured by change of diet, increased perspiration, and the proper use of Peruvian bark and aromatics."—Leake's Medical Instruction?, vol. i. 13 CHAPTER II. Projluvium Vaginale, or Vaginal Discharge. Under the above term, it is proposed to comprehend those morbid discharges from the vagina which have been variously, and perhaps improperly, named by writers. If a practitioner is capable of removing that assemblage of symptoms which attends a disease, it is very immaterial what name he gives to it, or whether he affixes any name to it at all. On the other hand, the adaptation of a proper name to a disease will not always lead to the successful treatment of it. For ex- ample, if a surgeon is called to a patient who, having been sub- ject to giddiness, is attacked by a sudden privation of sense and the power of voluntary motion, whose pulse is full and slow, whose face is red, and whose breathing is stertorous; if he takes away a large quantity of blood, such a patient will be as much relieved as if the surgeon knew that the complaint was called apoplexy. And if a surgeon should be able to attribute certain symptoms to an aneurism of the aorta, the disease will be as much beyond the reach of remedy, as if no name was conferred upon it. Nevertheless, it is necessary for the purpose of descrip- tion, to designate every disease by some appellation; and great care should be taken that it should be an appropriate one, or at least that it should not mislead. Hippocrates calls the morbid discharges from the vagina which are not menstruous " yvmiMix Xsvku." Sydenham gives to these discharges the name of " fluor mu- liebris." He considers the complaint to depend upon debility, and to be allied to diabetes, respecting which he observes: "Cu- rativae indicatione ad sanguiuem invigorandum corroborandum- que." Then follow some prescriptions for medicines of a tonic and stimulating kind. After this he concludes by saying: "Ea- dem fere methodo atque iisdem remediis contumax iste, et diu- ttunus affectus fluor tnuliebris sanatur ac diabetes modo dictus; nam ulrobique indicaliones curativae eaedem sunt quantumcun- que inter se hi duo morbi dissidere videantur."—Vide Epist. 1. de morb. epidemic, ab anno 1G75 ad annum 1680. Dr. Mead describes the disease under the name of "fluor al- bus:"—"Foedus morbus est tetra ista colluvies quae colore albo ex fueminarum naturalibus interdum profluit: hunc autem humo- rem modo profundunl canales uterini, modo ex glandulis quibus ronsita est vagina erumpit. In utraque mali specie corporis ha- bitus pra?cipue habenda est ratio : ab illius enim vitio tam hie 14 VAGINAL DISCHARGE. quam iste morbus orii:inem trahit: ubi autem in ipsa vagina se- dem fixit externa etiam opus sunt."—Mead's Monita et Prae- cepta, cap. 19, sect. 3. The mode of cure recommended con- sists of the exhibition of an emetic of Vin. Ipecac, of purgatives of rhubarb with occasional closes of mercury six times sublimed: and if the fibres are lax and require to be strengthened, steel is to be exhibited. Astringent injections are recommended by him to be thrown into the vagina, which is also to be fumigated with a powder consisting of some gum resins and cinnabar of anti- mony. Dr. Cullen treats of the disease under the title of Leucor- rhaea:—"Every serous or puriform discharge from the vagina may be, and has been, comprehended under one or other of these appellations—Leucorrhaea, fluor albus, or whites. Such discharges may be various, and may proceed from various causes not yet well ascertained: but 1 confine myself here to treat of those discharges alone which may be presumed to proceed from the same vessels which in their natural state pour out the men- ses."...." As the Leucorrhaea generally depends upon a great loss of tone in the vessels of the uterus, the disease has been relieved, and sometimes cured, by certain stimulant medicines, which are commonly determined to the urinary passages, and from the vicinity of these are often communicated to the uterus: —such for example are cantharides, turpentines, and other bal- sams of a stimulating nature."—Cullen's Practice of Physic. By Dr. Denman, in his valuable Introduction to the Practice of Midwifery; and by Dr. Ileberden, in his Commentaries, pub- lished after bis death by his son; the disease is named fluor al- bus: and both have given very accurate descriptions of it. "A mucous, ichorous, or sanious discharge from the vagina or uterus, is called fluor albus: these discharges are various in their degrees as in their kinds; from a simple increase of the natural mucus of the part, to that which is of the most acrimo- nious quality; but the first is not esteemed a disease, unless it is excessive in its degree. It is the most frequent complaint to which women are liable, and is by them suspected to be the cause of every disease which they may at the time suffer; but it is generally a symptom of some local disease, or a conse- quence of great debility of the constitution, though when pro- fuse it becomes a cause of yet greater weakness."—Dr. Den- man's Introduction to the Practice of Midwifery, chap. 3, sect. 6. " Humor iste, quamquam plerumque albus ut vulgo appella- tur, et aquae similis, interdum tamen glutinosus est, et coloris subflavi, item subviridis et mali odoris, atque tarn acris ut nisi partes in quas descendit saepe eluantur levis inflammatio fiat cum prurigine et dolore: cuticula quoque deteralur, et urina reddi VAGINAL DISCHARGE. 15 nequeat sine sensu pungentis caloris."—Heberden's Comment. cap. 41. By la Motte, in his work entitled Traite complet des Accou- chemens, the complaint is called " Les fleurs blanches." Dr. Hamilton, in his Treatise on Female Complaints, consi- ders the disease under the head of "Sexual Weakness" and amongst women above the lower class of life in this coun- try the discharge is called " a weakness." The most vulgar de- nominate the discharge " the whites." In reviewing these names, we shall find that they are all ob- jectionable, with the exception of that employed by Sydenham, " fluor muliebris," which is as applicable to the menstruous dis- charge as to any other. The term " a weakness" deserves particularly to be repro- bated; because it may, and actually does, very often become the reason for prescribing tonic medicines, which may be most de- trimental to the patient. Indeed, women often spontaneously have recourse to strengthening medicines and to food in many cases in which both are injurious. The author has prefixed the expression "vaginal discharge" to this chapter; but he wishes it to be considered as a symptom, and not treated as a disease. The most simple definition of it appears to be, that it is a discharge of a fluid flowing from the vagina, varying in its consistence, quantity, and colour; either produced by weakness of the constitution, or by a change in the structure, position, or actions of the neighbouring parts, such change being the effect of natural or morbid causes. It is very important to inquire into the cause of these dis- charges; by the knowledge of which, the judgment of the prac- titioner will be directed to the best mode of treatment. If the discharge is the effect of weakness, and if by its contin- uance the original weakness is increased, tonics will be required. If it depends upon some tumour in the vagina, the removal or support of this will also remove the discharge. If it arises from inflammatory action, this must be removed before any endeavour to restrain it is employed; for as the discharge during its contin- uance lessens the violence of the disease which produced it, it should not be checked till such inflammatory action is diminish- ed. Nothing can be more injurious under such circumstances, than the exhibition of tonics and stimulants, as cantharides, tur- pentine, and steel. In many cases it is as injurious to restrain the discharge from the parts, as it would be to put an end to the natural salivation of a teething child whilst the determination of blood to the head continues, or to heal an ulcerating surface in a constitution 1(3 VAGINAL DISCHARGE. which has been long accustomed to it, without substituting some other secretion for it. In many complaints of the female organs the patient is liable to discharges, and these are of different kinds: but all the varie- ties of discharge are not met with in one patient at the same time; since in one case the discharge is mucous, in another pu- rulent, and in another watery. The author hopes that some advantage will be gained by classing these diseases according to the peculiar nature of the discharge which accompanies them.—It must be allowed, that there are mixed cases, where the discharges vary from their usu- al appearance; moreover, a discharge of one kind will mark one stage of a disease, and a discharge of another kind a different stage. As happens in diseases in other parts of the body, one disease also is sometimes blended with another, and the dis- crimination of these modifications and irregularities constitutes no small part of the skill of the practitioner.—A scirrhous tu- mour of the uterus may have been attended (for years perhaps) by an increased secretion of simple mucus; but upon this dis- ease becoming active, by inflammation attacking the tumour, so as to convert it into cancer, the discharge becomes purulent and highly irritating. The period of this conversion is indicated by the alteration in the nature of the secretion. In the cauliflower excrescence of the os uteri,* the discharge consists of little more than a clear watery fluid: blood, however, is sometimes mixed with it, or perhaps comes away alone in large quantities. Nevertheless, the discharge of blood forms no part of the peculiar character of this disease, but it is generally produced by violence or improper exertion. The discharges from the vagina may be comprised under the following heads: 1. Transparent Mucous Discharge. 2. White Mucous Discharge. 3. Watery Discharge. 4. Purulent Discharge. 5. Sanguineous Discharge. Transparent Mucous Discharge. By transparent mucous discharge is meant that which is gela- tinous, nearly transparent, and capable of being coagulated. * See a paper by Dr. Clarke, in vol. iii. of the Transactions of a Society for the Promotion of Medical and Chirurgical Knowledge. VAGINAL DISCHARGE. 17 White Mucous Discharge. The white mucous discharge is opake, of a perfectly white colour; and it resembles, in consistence, a mixture of starch and water made without heat; or thin cream. This discharge is easily washed from the finger after an exa- mination; and it is capable of being diffused through water, ren- dering it turbid.—A morbid state of the glands in the cervix of the uterus probably gives rise to this discharge; at least, the cases in which it comes away are those in which the symptoms are referred to this part; and when pressure is made upon it, the woman complains of considerable pain. Purulent Discharge. The term purulent discharge needs very little explanation, meaning simply that, in which the fluid resembles pus secreted by the surface of an ulcer. Watery Discharges.* Under the head of watery discharges are comprehended those which resemble clear water, having no colour, and which con- tain very little glutinous matter; sometimes none at all. If the discharge of blood (the quantity of which is sometimes very great) be excepted, the watery discharge exceeds in quan- tity any other which these parts furnish. The linen of the pa- tient will often appear as if drenched with water, and no care (so long as the disease continues which gives rise to it) will pre- vent the patient being rendered uncomfortable by it. By a stea- dy perseverance in a proper plan, in one,case of disease in * It is not intended under the present head to nclude involuntary dis- cbarges of urine, arising from paralysis of the neck of the bladder, or commu- nications between the bladder ana the vagina. The unfortunate subject uf these accidents deserves every attention; and whatever can be suggested by the invention, or formed by mechanical means, for the purpose of adding to the comfort of the sufferer, should be employed. The cases just mentioned may not admit of cure; but muth may be done in the way of alleviation. There will be no difficulty in distinguishing between urine and any other wa- tery fluid, if a moderate degree of attention be given .•—the smell itself will be in most cases sufficient to detect the difference: but where (as in 9ome hy- sterical cases) the urine possesses little colour or odour, the nature of the fluid may be readily ascertained by some inquiries made of the patient respecting the commencement of the disease, the supposed cause, and the accompanying symptoms; especially whether, in addition to the constant discharge of a fluid, the patient is at any time enabled to retain much urine in the bladder: for in no case of palsy of the neck of the bladder, or destruction of the parts be- tween its cavity and that of the vagina, can much urine be retained; and it generally runs off as fast as it is secreted—Obvious as the diagnostics are, it has occurred to the author to witness an instance where the mistake was made, and it may often bare happened. C 18 VAGINAL DISCHARGE. which it arises, it may be much moderated; whilst in another,* no remedy will produce any effect upon it. Sanguineous Discharge. The sanguineous discharge is that of which blood forms the principal part, or perhaps the whole, of the matter evacuated.— The appearance of blood is too well known to be mistaken; but in proportion to the quantity evacuated, or the length of time which it takes up in escaping, will be its fluidity or form. When the quantity is considerable, when it escapes from large vessels, or is quickly forced out by the energy of the action of the heart and arteries, it comes away in a fluid state: when it escapes more slowly, and the exit of it is for a while retarded, being in a state of rest, it coagulates, assuming the figure of the parts in which it lies: where very little is poured out, not enough to form a stream, or a coagulum, of much thickness, it simply covers the surfaces over which it flows, and becoming solid, escapes from the external parts, either in the form of hollow casts of the ca- vities in which it has been retained; or sometimes, spreading it- self over the surfaces of tumours, it comes away in the form of circles of coagulated blood. In this latter case, the shape of these rings of blood escapes observation generally; for being re- ceived upon the linen of the patient, by collapsing they lose their proper form: but if they are placed in water, or if they come away with the urine, they fall into the vessel which con- tains it, and demonstrate the manner of their formation.—By the action of the surrounding parts upon these coagula of blood, the serum is squeezed out of them; and the coagula themselves, having acquired a greater firmness than usually belongs to co- agulated blood, are sometimes regarded by patients as diseased tumours which had,,;een formed in the parts. The coagulating lymph of the blood sometimes comes away unmixed with the colouring matter or the serum: this happens in inflammation of the mucous membrane of the vagina and uterus. Many cases of this kind are mistaken for abortions: since the substance dis- charged resembles decidua, both in colour and thickness; and the pain which attends them makes the resemblance between the two cases greater. Periodical returns of the pain are met with in both occurrences. The difference between the two cases consists in this—The transparent membranes of the ovum will be wanting if the case is not abortion; and in inflammation of the mucous membrane of the uterus and vagina, although there will be occasional pain in the attempts to expel the adventitious matter, there will remain a permanent pain, arising from the " Hydatids of the uterus. VAGINAL DISCHARGE. 19 continuance of the morbid action of the parts, which will be wanting in abortion. Of some diseases of the uterine system, the white mucous, and the watery discharge are pathognomonic symptoms; but ihe sanguineous belongs to none exclusively, being met with occasionally in most of them: in some it appears with more vi- olence than in others: its quantity may not exceed a few drops; or it may be so profuse as to bring the life of the patient into immediate hazard.—It is unnecessary in this place to consider sanguineous discharges, because they will be described in the history of those diseases to which they belong. An evacuation of blood from the uterus takes place in some cases of disordered menstruation, without any alteration of the structure of the parts.—These cases may perhaps be the subject of future consideration. There are some diseases of the female organs which are un- attended with any discharge from the vagina.—These will also be described at some future period. Of all the discharges which come away from the vagina, those of mucus are the most frequent, as they are capable of being produced by several complaints of the parts: besides which, the mucous discharge is that which takes place frequently (in those women whose constitutions have been much weakened) from debility alone. 20 EXAMINATION NECESSARY CHAPTER III. General Observations on Sexual Diseases, and on the Necessity and Mode of making an Examination per Vaginam. There are no diseases which excite in the mind of the pa- tient a greater degree of anxiety and distress than those affect- ing the sexual organs, both male and female. The first appear- ances of disease are marked with attention, inquiries respecting them are made with earnestness, and their progress is watched with the most unremitting care. This is not only observable in persons of weak minds and fearful dispositions; but in those who possess the strongest understandings, whose minds have been used to contemplate danger, and fortified by religion and morality. So connected is the happiness of mankind with the well-being of these parts, and so diffused is the influence which these parts have upon the functions of others essential to health, that it ex- cites no surprise that the anxiety respecting them should be so great. The diseases of these parts affect either the external or the internal organs, of which complaints the latter are by far the most numerous. The existence of these diseases and their kind can only be known by an examination per vaginam: and this should be al- ways proposed and performed, whenever there is reason to be- lieve from the symptoms, that they depend upon any local cause. If it should be found, upon examination, that no such local dis- ease exists, the state of the constitution is to be inquired into, and remedies applied for its relief. If, on the other hand, it should appear that the parts are altered in structure or situation, such local remedies are to be used as will either cure or palliate. It should also be recollected, that it is no inconsiderable com- fort to a patient who believes herself to be affected by some fa- tal complaint, to be informed, after such examination, that no such complaint exists. The human mind is prone to look upon the dark side of ob- jects; and for the sacrifice which on this occasion the woman makes of her feelings to her health, she often is amply compen- sated by the information acquired. In making such examination, the person of the woman should on no account be exposed, and as much care as possible should be taken to avoid giving pain.—Even when, as in the case of a tumour in the parts, it becomes desirable to know whether that TO ASCERTAIN DISEASE. CM tumour is sensible, this should be ascertained with the greatest tenderness. The finger should be covered with some unctuous substance, in order to avoid giving any unnecessary uneasiness. After the examination has been made, the finger is to be wiped upon a clean napkin, which will shew what is the nature of the discharge. It is notorious that many practitioners prescribe for complaints of these organs, from a mere history of the symptoms given by the patient. It is quite impossible in many complaints to depend upon such descriptions; and daily experience demonstrates the futility, and in some cases the injury, arising to patients from medicines prescribed upon such vague information. From the general disinclination of practitioners to make an examination, arises in part their want of success in the treatment of these complaints; and from this omission proceeds the dislike which many patients have to an examination being made by a second practitioner, when it had not been proposed by the first. In considering the complaints of these organs, it does not appear that they are more easily discovered than those in other situa- tions. They require as much and as attentive investigation; they are not less numerous, or more simple, than those of other parts; and by conjecture truth is not likely to be elicited. But let it be granted that they are simple. Is it not customary in other instances to pay a nice attention to simple complaints? Is it usual to prescribe for a sore throat, without looking at the fauces? If a patient has a purulent discharge from the anus.it is the business of a surgeon to examine whether fistula be pre- sent. If a man advanced in life has a mucous discharge from the urethra, the practitioner would suspect disease of the pros- tate gland, and would not be satisfied without making the neces- sary examination. These instances need not be multiplied. If all this be so, it is equally right for the practitioner to examine a female patient, whenever he believes that disease is present. But the nature of his other avocations may not lead him very often to meet with uterine diseases; and he may be too little acquainted with the state of the parts to draw any just conclu- sions from this investigation. If this is an excuse for not making the examination himself, he should take care that this very ne- cessary duty should be performed by another who is compe- tent, and accustomed to make it, and who possesses ability to describe with accuracy what has been found on examination. 22 CHAPTER IV. ON SYMPATHIES. Between different parts of the body sympathies of various kinds exist; some of which are indicative of healthy actions, and others of morbid changes. On the subject of these sympathies every practitioner should be informed, as the knowledge of them is involved in almost every case respecting which a surgeon or physician may be consulted. Among the most common of the healthy sympathies may be mentioned that between the testicle and the organs of voice in the male; that between the uterus and the stomach, and between the uterus and the breasts, in the female; and that between the skin and the internal cavities in both sexes. The morbid sympathies are very numerous.—By morbid sympathy is meant that consent between one part of the body and another, which arises in consequence of a part having un- dergone some alteration in structure or actions, which excites sympathy in another. Morbid sympathy is found to exist between those parts af- fected by the sympathies of health; but it is also met with in parts between which, in health, there is no evidence of sympa- thy at all. For instance; a pain in the shoulder attends a dis- eased state of the liver: but no one, whilst the liver is in a heal- thy state, and performing its natural functions, would be led to think that any such sympathy between these parts existed. Morbid sympathy may be divided into the single or simple sympathy, the compound, and the reciprocal.—Of the single or simple sympathy, many examples present themselves: that be- tween the liver and the shoulder has been mentioned above. When the functions of the stomach are disordered, and some- times when only in a very trifling degree, the breasts become softer and more flaccid, and the gland itself seems altogether gone; and this too when the tone of the system generally is not much diminished, nor the size of the other parts at all shrunk. In this case, the return of the firmness and size of the gland be- comes the strongest mark of the returning health of the stomach. An exception to the above statement, respecting the sympa- thy between the stomach and the breasts, is observable in preg- nancy; in which state, notwithstanding the functions of the stomach are greatly deranged, the breasts continue firm and hemispherical, and become even harder and larger than at other times; but this is to be regarded in another way, and is part of a process for the maintenance of the child to be born. ON SYMPATHIES. 23 When the lower part of the intestinal canal is irritated by as- carides, there is frequently an itching of the nose. The whole constitution appears in some cases to sympathize with a part, since in large external and particularly in internal inflammations a shivering fit sometimes comes on. But it is to be observed, that these sympathies are single, and pot mutual; for when the nostrils are irritated by polypus, or in- flammation of the membrane which lines them, no increased irritability of the anus is excited, neither is any uneasiness in the region of the liver produced when the shoulder is affected by disease. There are some sympathies which are reciprocal; that is, when the parts mutually sympathize with each other. In certain affections of the brain, there is sickness of the sto- mach ; and in a disordered state of the stomach, pain is felt in the head. If a man receives a blow upon the testicles, sickness of the stomach comes on: on the other hand, when the functions of the stomach are deranged, the passions connected with and de- pendant upon the testicles are dormant. There are other cases in which the sympathies are of a com- pound nature; as where a diseased uterus produces sickness of the stomach, and the latter organ being disordered, pain in the head comes on: here the sympathy is nnt direct between the uterus and the head, but the head is affected through the me- dium of the stomach; for the same disease not being attended by any complaint of the stomach, the bead does not suffer. A lady between fifty and sixty years of age was attacked with pain in the back and at the bottom of the belly, attended by a purulent discharge from the vagina: there was nausea and vom- iting, spasmodic pains were referred to the epigastric region, and there was pain over the anterior part of the head. An examina- tion being made, the uterus was found extremely sensible to the touch, but it was not enlarged; at least no enlargement could be ascertained by examination: recourse was had to the hip bath and other remedies, and at the end of a few days the pain in the back and belly ceased, the sickness went off, and the patient was no longer troubled by head-ache. At various times since the first attack, this patient has been liable to the same symp- toms, which have come on in the same order of succession; and they have yielded to the same means. The uterus appears to be a very fertile source of sympathy, and many symptoms referred to other parts arise from it. On this subject Sennerlus has the following passage: " llibet prceterea haec pars cum multis aliis partibus consensum, unde varii morbi et symptomata varia exci- tari possunt." &1 ON SYMPATHIES. The influence of the uterus upon the stomach is one of the most remarkable of all the sympathetic affections between this organ and any other. " Uteri affectus fere omnes ventriculo no- cent." Heberden. Commentaria de Historia Morborum, cap. 97. In cancer of the uterus, the stomach is always more or less affected with vomiting. When the uterus has been ruptured, vomiting comes on; and the matter rejected is of a black colour, resembling coffee grounds. In amenorrhcea, the symptoms which belong to the stomach constitute a very important part of the disease. In dysmenorrhoea, or painful menstruation, sickness and vom- iting are present during the acute stage, and the effects of im- paired digestion or disease of the chylopoietic viscera distress the woman in the intervals between the periods of menstruation. The bladder and the rectum sympathize with the uterus; and hence strangury and tenesmus attend many of its complaints, as well as the process of labour. Frequently, however, these symp- toms are produced by mechanical causes, as by tumours of the uterus pressing upon the rectum or the meatus urinarius. It is highly important to investigate these cases fully, as from the re- lative situation of these parts, and the existence of sympathy between them, mistakes may otherwise take place. A tumour attached to the posterior part of the uterus may so compress the rectum between the os sacrum and itself, as to al- low the fasces to pass with great difficulty, or to obstruct the passage of them entirely, unless when they are of a very small size. This has led practitioners often to suspect stricture of the rectum; and upon carrying the finger into the rectum, this sus- picion is confirmed: not only the size of the faeces passing through the sphincter ani is rendered much smaller, but a resistance is offered to the passage of the finger. A pain in the back is present in many diseases of the uterus; arising perhaps partly from sympathy, and partly from the origin of the sacral nerves.* Pain in the lower extremities attends some uterine affections: previously to the appearance of the menses, and before the com- ing on of each period of menstruation, it is experienced by many women. It has been observed as a precursor of puerperal ma- nia.—This pain in the legs is very different from cramp in the lower extremities, produced by pressure upon the sciatic nerve * At the moment at which the author is writing this, he has a patient who has been taking medicines for a considerable time, under a supposition that she laboured under stone in the bladder.—She has a tumour projecting from the anterior part of the cervix of the uterus, upon which all her symptoms- depend; and there is every reason to believe that the bladder is perfectly healthy. r ON SYMPATHIES. 25 of one or both sides; and it takes place in cases where no such pressure is, or can be made. The abdominal muscles sympathize with the uterus; but not unless the muscular fibres of the uterus are in a state of con- traction. If there is any substance to be expelled from the ca- vity of the uterus, the abdominal vessels lend their assistance in expelling it; as when an ovum, a bunch of hydatids, or a poly- pus, are protruded through the cervix of the "uterus. The abdo- minal muscles assist also in expelling the contents of the sto- mach, the intestines, and the bladder. The diaphragm is apt to be affected in some diseases of the uterus, so that the patient becomes subject to hiccough. The mind also sympathizes with the uterus. This it does al- most always when the stomach is affected by disease: but this is to be considered as one of the compound sympathies: for both in men and in women, when the digestive organs are dis- ordered, the faculties of the mind are apt to be enervated; and occasionally to so great a degree, as to incapacitate the patient for attending to common business, or for enjoying the ordinary pleasures of life. But besides this affection of the mind, induced through the medium of the stomach, many cases are found where the con- nexion subsisting between the uterus and the brain appears to be more direct: as in furor uterinus, puerperal convulsions, and in those cases of madness which succeed parturition, when there is little of bodily disorder. This connexion between the uterus and the sensorium may account for the greater number of in- stances of madness which occur in females than in males; it ap- pearing that the number of women, compared with that of men, affected by madness in this country, is in the proportion of five of the former to four of the latter.* The same author observes, " The natural processes of men- struation, parturition, and preparing nutriment for the infant, to- gether with the diseases to which they are subject at these periods, and which are frequently remote causes of insanity, may perhaps serve to explain their greater disposition to this malady."—"That the peculiar states of the uterus have fre- quently a share in producing madness, appears from the fact, that between the years 1784 and 1794 eighty patients were ad- mitted into Bethlem Hospital, whose disorders followed shortly the puerperal state. It is also to be remarked, that in this spe- cies of madness, the secretion of the menstruous discharge is interrupted, but its regular flow generally precedes recovery; and that some cases are met with, when the madness is con- * See Haslam's Observations on Madness aDd Melancholy. D F 26 ON SYMPATHIES. nected with the menstruation, and has lasted for years, in which, upon the cessation of the uterine discharge, the patient has com- pletely recovered." The inferences to be deduced from these facts are; that the functions of the uterus being duly performed, the mind is very little apt to be affected: that a disordered state of the reasoning faculty is attended by an interruption to the performance of these functions: that a parturient state of the uterus is a frequent cause of madness: and that, lastly, when the functions of the uterus are at an end, when it no longer secretes menstruous fluid, and when consequently it is no longer capable of being impregnated, the disposition to mental disease generally terminates.* The mind sympathizes with the uterus in different degrees; from the case of the slightest hysterical affection, to absolute madness. Great despondency, dread of the future, ungrounded apprehension of some great misfortune, are to be looked upon as states of mind frequently originating in uterine disease. The last-mentioned mental symptoms seem most frequently to attend those cases in which there is a languor in the uterine system; whereas the more violent kinds of mania attend those cases where the uterine system is highly excited. This, however, is by no means universal: but the author's experience does not furnish him with a single case of violent madness connected with amenorrhcea attended by debility; whereas those accom- panied with dread and melancholy are exceedingly common. These states of mind form by far the most distressing part of the disease; and there are few patients who would not exchange these feelings for bodily suffering, if they could choose between them. There is a sufficient evidence of a disordered state of mind in many uterine affections in the gestures of the patient, which are hurried; the patient is almost constantly in motion. There is a restlessness of manner, a hesitation in her speech; sometimes a remarkable solicitude in her mode of interrogatijig the practi- tioner. She prefers solitude to society; although when her mind is fully engaged in the latter, she becomes less restless and dis- turbed. * The author has kept no exact register of the number of patients whom he has seen labouring under puerperal mania: but his recollection furnishes him with nearly as many cases of this disease in single as in married women; not- withstanding the proportion of single women who fall into labour, compared wilb those who are married, is very small. i 87 CHAPTER V. On certain Diseases attended by a Mucous Discharge from the Vagina. Some of these complaints consist of the displacement of parts; as Procidentia Uteri. Procidentia Vesicae. Procidentia Vagina;. Inversio Uteri. PROCIDENTIA UTERI. The nature of this disease may be understood from the name given to it: it has also been called vrrtpicTwris, Prolapsus Uteri, and Descensus Uteri; the latter term being used to express the minor degrees of the disease, the former that in which the ute- rus has fallen out of the body through the external parts. By women the disease is called "a falling of the womb," or simply "a bearing down." In the healthy unimpregnated state of these parts, the uterus is situated nearly in the centre of the cavity of the pelvis, the distance of the os uteri from the os externum being about four inches. The os uteri is not a continuation of the same line with the vagina, but it terminates in the vagina by projecting into it, the outer surface of this projection being covered by a portion of the inner membrane of the vagina tightly spread over it. In the generality of subjects the distance from the opening of the os uteri, to the part where the inner membrane of the vagina begins to be reflected over it, may be nearly an inch. This dis- tance will of course be increased in procidentia uteri, the angle of reflection being made nearer to the os externum.* Every degree of procidentia uteri may be met with; from that case in which the os uteri descends a little lower than its natural situation, to that in which the uterus projects through the external parts, dragging with it the vagina, and forming a large tumour between the thighs of the woman, equal in size to a large * In the most trifling case of procidentia uteri there must be some inversion of the vagina, and the degree depends upon the extent to which the prod dentia uteri has proceeded.—" Nam in descensu quoque vagina taritum se in- vertat quantum uterus descendit."—Morgagni de Sedibus et Causis Morbo- rum, Epist. sir. • 28 PROCIDENTIA UTERI. melon. This will cause an alteration in the relative situation of the parts within the pelvis and of the abdominal viscera, both regarding each other and also the containing parts, as the pari- etes of the abdomen, and the bones of the pelvis. The bladder, instead of being contained in the pelvis, falls down into the ex- ternal tumour, dragging with it the meatus urinarius; so that in order to introduce a catheter into the bladder, the point of the instrument must be turned towards the knees of the woman; for, being placed in the usual manner in which that instrument is introduced, it will enter the passage, but cannot be made to pass into the bladder in that direction. The rectum, instead of taking the sweep of the sacrum, first dips down into the posterior part of the tumour, and afterwards ascends into the pelvis. The fallopian tubes and ovaria will of course be dragged down with the uterus, and the centre of the tumour will be filled up by the small intestines which hang down into it (the mesentery being stretched;) whilst the omen- tum will occupy any vacant space which may be left. Many months or even years may elapse whilst the uterus is making this descent; for when the uterus has descended so far that it can rest upon the perinaeum, there it not infrequently re- mains, resting upon it as upon a shelf, the violence of the symp- toms abating; for the parts which suspend the uterus above, al- though much lengthened, are no longer put upon the stretch. The number and violence of the symptoms are by no means proportioned to the degree of the descent of the uterus; for when it has descended but little, the round ligaments are put upon the stretch, and the symptoms also which depend upon sympathy attend the minor cases of the complaint. When the tumour is external, much inconvenience is felt by the woman in consequence of the situation of it between the thighs, which obliges her to straddle, in order to prevent pres- sure upon it. The external surface of the tumour presents a near- ly equal surface; for as the uterus descends, the ruga? of the va- gina are obliterated, except where the upper part of the tumour is joined to the body; and even here they are lost, when the bladder contains much urine; but in proportion as it empties it- self, the rugae begin to form again. When the tumour becomes very large, the skin of the labia is drawn down, so that these parts are no longer distinct projec- tions; but the tumour begins close to the upper part of the thighs being covered by the cuticle of the labia, and the greater part by the membrane which, under natural circumstances, lines the vagina. The vagina, being exposed to the action of the air upon it, loses its florid colour, and acquires that of the skin of the body! PROCIDENTIA UTERI. 29 It also loses its peculiar sexual irritability; not indeed becoming insensible to pressure, but its sensations being by no means so acute as they are in the natural state. The anterior part of the abdomen, instead of possessing its usual convexity, becomes flatter, from the viscera of the abdomen having left its cavity. When the uterus and its appendages only have fallen out of the external parts, but before the other viscera have fallen into the inverted vagina, the tumour has a lengthened form, which, ta- ken together with its situation and the opening at the lower part, has made it sufficiently resemble the male organ to impose upon the credulous; and such persons have been exhibited as herma- phrodites. The difference between this disease and the male organ is too obvious to be mistaken by any one who will pay attention to it. The long diameter of the opening of the urethra in the latter is from before to behind; whereas that of the os uteri in females is from side to side; and this alone is enough to mark the difference. After some time the breadth of the tumour increases, so that it becomes of a globular form. The situation of the viscera being thus changed, they become liable to pres- sure in a greater degree than when they maintained their natu- ral situation in the cavity of the abdomen; and inflammation is sometimes the effect of this pressure. Coagulating lymph is in such cases thrown out, which unites the parts; and if either the omentum, or a portion of intestine, be thus connected with the lower part of the tumour, pain may and will be felt in those situ- ations of the belly from which such parts proceed. In the young woman from whom one of the drawings was taken,* where the omentum adhered to the fundus of the uterus, pain was felt in the region of the stomach,, and became a cause of great distress. The immediate causes of this disease are: 1. Relaxation of the broad and round ligaments above. 2. A want of due tone in the vagina below. By the first, the uterus is permitted to fall; by the second, the uterus is allowed to be received into its cavity. Whatever is capable of producing a lengthened state of the ligaments, or a relaxed state of the vagina, may become the oc- casional cause of the complaint. Weakness of the system may be looked upon as a cause of this complaint; and therefore after long diseases, which have di- minished the patient's strength, it is occasionally met with. Pro- fuse hemorrhages taking place from any part of the body may acf in the same way. But the most common cause of procidentia uteri is the long continued erect posture of the body at an early period after de- * Vide Plate. 30 PROCIDENTIA UTERI. livery, and in some cases after abortion. To this cause the ma- jority of the cases is to be attributed: for at this time not only the immediate causes of the disease are present, but the uterus weighs eight or ten times more than an unimpregnated uterus, and it is carried down by its own weight. The long confinement of a patient to a warm bed after oelivery may be productive of considerable debility ; but sitting up in the erect posture is more injurious. The use of the chair is now very much laid aside, and the best practitioners direct their patients to remain in the re- cumbent posture upon a sofa, or on the outside of the bed: the advantages of a horizontal posture and coolness are thus com- bined. This posture should be observed until the uterus has nearly regained its unimpregnated size, which will be between the third and fourth week after delivery, at which lime it may be presumed that the ligaments and the vagina have acquired their former strength. In this place a question may arise: What be- comes of a women in the lower ranks of life, who have not the means of giving up this time to the recovery of their local strength? These women are liable to this complaint, and suffer from its effects very frequently. Because they are not generally found to complain, it is not to be supposed that they have not cause for complaint; nor, because they are not seen confined to a bed, is it to be thought that there is no necessity for con- finement. They are often great sufferers; but their sufferings are frequently unknown, and their humble station often pre- cludes them from obtaining relief. Women liable to violent coughs during the time of their confinement after childbirth are especially the subjects of procidentia, from the pressure made by the abdominal viscera upon the uterus in the occasional strong action of the diaphragm and the abdominal muscles, when the vagina can afford no resistance. SYMPTOMS. These arise partly from the effects produced upon the cir- cumjacent parts by the change in the situation of the uterus, and partly from sympathy. It may be a matter of surprise, that a very trifling change in the situation of the uterus should produce those inconveniences which attend some of the cases of this disease; but this surprise will be lessened by the recollection, that in other parts of the body, any derangement of the natural order or structure occa- sions much distress. A small tumour upon the inside of the eye- lid will cause great pain, and produce a plentiful effusion of tears; a trifling obstruction in the lacrj mal duct will be attended with a constantly weeping eye; a polypus of the nostrils will PROCIDENTIA UTERI. 31 occasion suffocation, interfere with the power of smelling and swallowing, and produce a considerable discharge of mucus; one tooth projecting beyond the rest will irritate the cheek, and sometimes render the speech inarticulate; and a relaxed or elon- gated uvula will sometimes produce a permanent sensation of choking. At the commencement of this ailment the women complains of pain in the back, and this symptom sometimes continues for a great length of time without any other: pain is also felt in the groins, extending towards and terminating in the labia: there is a sense of fulness in the parts, and an increased discharge of transparent mucus from the vagina. As the disease proceeds, the pain in the back is described as the pain of dragging: the patient now has a sense of bearing down, or of weight; feeling, as she expresses it, as if every thing was dropping through her. The discharge increases in quantity. The pain in the groins arises probably from the round ligaments being stretched, and that in the back perhaps from an elongation of the parts con- necting the uterus behind. As soon as the erect posture is chang- ed for the recumbent position, these symptoms go off. Strangury, although not a constant attendant, sometimes is present, and annoys the patient until the procidentia is cured.— A lady, whose constitution was weak, and who had borne seve- ral children, was attacked by pain in the groins; she had a dis- charge of mucus from the vagina, and was affected by a frequent desire to make water, voiding very little at each attempt. She had employed poppy fomentations and opium, and had taken some oily purgatives, without experiencing the least good effect. Upon further inquiry it appeared, that the pain in the groin3 left the patient at bedtime, and that at the same time the fre- quent inclination to make water went off. This led to an exam- ination of the parts, by which a procidentia uteri was discover- ed. The whole plan of treatment was now changed. She used an astringent injection, took some cinchona with sulphuric acid, and confined herself to the sofa. By pursuing these means, the strangury and all the Other symptoms left her as her strength was restored, without the use of any mechanical means. The pain in the back which attends procidentia of the uterus, should be distinguished from that which is met with in cases of separation of the joint between the os ilium and the os sacrum, after some cases of labour. It has been remarked, that the pain in the back arising from procidentia is greatest when the patient is erect, and that it subsides in the horizontal posture. In the case of separation of the joints alluded to, the patient has a great difficulty in standing, or perhaps cannot stand at all, is uneasy even in the recumbent posture, and incapable of moving in bed without great pain. B2 PROCIDENTIA UTERI. Procidentia uteri and separation between the bones of the pelvis may exist together in the same patient, as is exemplified in the following case. A young lady was delivered of her first child after a very good labour, which was very well managed by a sensible prac- titioner. The child was large. Being well after her labour, she sat up, walked about early, and considered herself remarkably well. She soon, however, became subject to a pain in the back and groins, uneasiness in the region of the stomach, and her di- gestion was impaired. She was very hysterical, and never free from a mucous discharge from the vagina. By the use of a pes- sary and an astringent injection, and the employment of some bitter tonic medicines, these symptoms diminished, and the sea-. bath completed the cure. She fell with child again in a few months, and was delivered of twins. During and after this la- bour, there was a considerable discharge of blood; but in other respects she was well. At the end of a fortnight she found her- self incapable of standing, and all the symptoms returned as after her former labour. By the use of the means above men- tioned, the fresh-water bath being used (from necessity) instead of the sea-bath, the symptoms all left her, excepting the pain in the back, and the incapability of standing for half a minute unless supported on each side. Whenever she made the attempt to Stand, she placed her hands upon the sides of her hips. This led the author to make a firm pressure there with his own hands; and as long as this was firmly applied, she could stand, but as soon as this support was withdrawn she was in danger of fall- ing. Upon this information being gained, a leathern belt was made, of about the breadth of an inch and a half, or somewhat more, which was applied round the pelvis as tight as it could be borne without producing pain. The comfort arising from this belt was felt immediately; and by the permanent use of the bandage the complaint was cured, but some time elapsed be- fore she completely recovered. In procidentia uteri, the symptoms arising from the sympathy between the stomach and the uterus are very distressing. The appetite becomes irregular, or is totally lost; the stomach and bowels lose their tone, and there is a great sense of distention in the belly arising from air, which may be heard when moving from one part to another; the spirits flag; every employment becomes irksome, and life itself is considered as scarcely desir- able. The diaphragm is sometimes affected by spasm, and hic- cough is produced. The quantity of the discharge from the vagina varies; in some cases being very profuse, in others slight. The appetite being diminished, the digestion impaired, and the secretion from the PROCIDENTIA UTERI. 33 parts being greatly increased, considerable weakness of the sys- tem is produced, and the vessels of the uterus, partaking of the general debility of the frame, permit blood as well as menstru- ous fluid to escape from their cavities: so that the patient may at the same moment labour under two diseases, one being the effect of the other; viz. menorrhagia and procidentia uteri; the former not admitting of relief by the usual means, unless atten- tion be paid to the latter. When the uterus has fallen out of the body, so as to become an external tumour covered by the vagina, the surface of the tumour (i. e. the membrane of the vagina) ceases to secrete, al- though it did so before in very considerable quantity, whilst the tumour was contained within the os externum. This circum- stance will account for a fact observable in the disease, viz. that those cases of descent of the uterus in which the tumour is not external, are attended with a much greater degree of bodily weakness than when the tumour is external; in which latter case, all that strength is saved to the woman, which would have been expended if the tumour had continued in the body. But if the parts are returned to their natural situation, if that which is the covering of an external tumour is converted into the lining of an internal cavity, the mucous membrane of the vagina be- gins again immediately to resume its functions.* It seldom happens that the vagina remains long exposed to the action of the air, without ulceration taking place upon its surface. This ulceration does not attack the whole of the expos- ed surface at once; but small spots or patches inflame and ul- cerate, and these sometimes run into each other, but the whole surface is seldom covered by them. These ulcerations are gene- rally not deep, and they have the appearance of healthy sores. Whenever these ulcerations are met with, the os uteri seldom escapes being attacked by one of them. Slight degrees of procidentia uteri can only be ascertained by great attention to the state of the parts, together with a know- ledge of the common size and length of that part of the uterus which hangs down into the vagina. There is then, in this disease, a tumour, either in the vagina, or hanging out of the external parts. But every tumour in these parts is not a prolapsed uterus. The mark which always charac- terizes procidentia of the uterus, is the existence of the os uteri at the lower part of the tumour. This being wanting, the dis- ease is proved not to be procidentia uteri. " This the author has frequently had an opportunity of demonstrating to some of the pupils attending the lectures, in the person of a poor woman la- bouring under an external prolapsus, who occasionally came to the lecture- room. i: 31 PROCIDENTIA UTERI. If a woman labouring under this complaint observes a hori- zontal posture, she experiences none of the symptoms so long as this posture is continued, but they return in the erect posture; the cause of which is, that in the recumbent posture the uterus does not fall into the vagina, and therefore the parts above are no longer stretched, nor those below distended. Any examina- tion made only whilst the patient is lying down, will, for this reason, give little information to the practitioner. She should be examined in the erect attitude also. By this means, if the dis- ease is procidentia, the uterus is not only made to fall lower, but the degree of the disease is also ascertained. 35 CHAPTER VI. Treatment of Procidentia Uteri. If nothing were done in the way of treatment for a patient labouring under this disease, she would become much distressed by all the symptoms which have been described: she might die from weakness, induced by the large discharges and the disor- dered state of the stomach; or she might die from inflammation taking place in the parts contained in the inverted vagina, which are more liable to pressure than when in their usual place, the cavity of the pelvis and abdomen. This really occurred in the young woman who died of an external procidentia in the work- house at Kensington, and whose body was inspected by Mr. Thomson junior, and the author: coagulating lymph was thrown out, and the contents of the tumour were cemented together by means of it. There was also, as is usual in cases of peritonoeal inflammation, a considerable quantity of serous fluid in the ca- vity of the abdomen. Such fatal terminations are uncommon; it much more frequently happens, that the patient drags on an un- comfortable life for a number of years, till she is destroyed by accident, or by some other disease. Few cases admit of relief more readily than procidentia uteri in the early stages of it, and the remedies should be applied as soon as the disease is discovered; for the size of the support which is to sustain the uterus must be in proportion to the de- gree of dilatation of the vagina. If a woman having this disease should again become pregnant, and will consent, after her la- bour, to a confinement for some weeks in a horizontal posture, the parts may regain their tone, so as to render any artificial as- sistance unnecessary: but as the woman may not again be preg- nant, and as, if she should, her patience may not hold out dur- ing the length .of time necessary for the natural cure of the dis- ease, the next subject of inquiry will be into the mode by which the complaint may be cured by art. It has been already remarked, that in this complaint the va- gina and the ligaments which suspend the uterus have had their tone diminished or destroyed, in consequence of which the ute- rus has fallen lower than its natural situation. From this view of the case, the curative intentions appear to be, to increase the strength of the parts which are weak, and to afford a support to the tumour, the descent of which produces the symptoms. In every case, these two objects are never to be lost sight of; but as in many cases the powers of the constitution are weakened. 36 TREATMENT OF and as we can give strength to particular parts by adding to that of the whole, those means usually employed to strengthen the constitution are not to be neglected. The tone of the weakened parts is to be restored, ]. By the application of cold. 2. By the application of astringents. Cold applied to the surface of the body produces an increase of the tone of the body, or increases the permanent contraction of the moving fibres. Thus, after the immersion of the body in the cold bath the muscles will be found firmer and harder, and will adapt themselves more closely to the parts which they co- ver; the scrotum, although before relaxed, becomes shorter in consequence of the increased tone of the muscular fibres, and the skin is consequently thrown into folds or rugae. Cold pro- duces also the temporary contraction of muscular fibres. Ap- plied suddenly to the body previously heated, it is known to produce contraction of the bladder, as may be instanced in peo- ple who come out of hot rooms and theatres: and this happens before the bladder is much distended; so that it is not the mere distention of the bladder which produces this effect, but simply the application of cold to the surface of the body. Cold produces contraction of parts in the immediate neigh- bourhood of its application in a greater degree than in those at a distance. If the hand of a man be dipped in cold water, it will shrink in size, the skin of it will become paler, and the vessels which ramify near the surface will be diminished in diameter, so as perhaps to be no longer visible, whilst the other hand will undergo no change. The application of cold to the outside of the head of a patient labouring under the effects of pressure upon the brain, will diminish these effects by taking off the pressure; and that it does so actually, is demonstrated by the vessels of the tunica conjunctiva becoming smaller in size, the face paler, and the pupil capable of contraction. But the application of cold to a small part of the body, and this too at a distance, will sometimes cause a temporary strong action of parts, particularly of internal cavities: the immersion of the hands in cold water may occasion contraction of the blad- der and the expulsion of its contents. The application of ice to the neighbourhood of the uterus, i. e. to the back or belly, is useful in uterine hemorrhage, by producing the contraction of the uterus itself; and the size of the uterus may be felt to diminish under the hand; whereas the application of ice to a surface equally large at a distance, will not produce this effect at all, or not in the same degree. Whatever produces an increased determination of blood to any part of the body, will occasion an increase of secretion from PROCIDENTIA UTERI. 37 the neighbourhood of that part. If the surface of the body is kept warm, the skin becomes red, and the quantity of the per- spiration is increased. If a larger quantity of blood is sent to the salivary glands by the exhibition of mercury, salivation in great- er quantity follows: and innumerable other instances might be brought, demonstrating the same fact. On the other hand, whatever diminishes the flow of blood to any part of the body, will produce a diminution of the secretion from the neighbourhood of that part. If the skin of the body is kept cold, the surface becomes pale, and a check is given to the perspiration: if the breasts of a woman are kept cool, the quan- tity of milk may be greatly diminished. Of the knowledge of these facts the practitioner is to avail himself in the treatment of the disease under consideration. It is desirable to increase the tone of the vagina, and so, by dimin- ishing its diameter, to prevent the descent of the uterus: it is also important to lessen the quantity of the mucus secreted: 1st, because it becomes a cause of weakness; and, 2dly, because the passage of a warm gelatinous fluid over the parts will relax them still more. The canal of the vagina is surrounded by a number of mus- cular fibres, capable of being made to contract by some appli- cations or to relax by others, subject to the same laws by which muscular fibres in other parts are governed. When these mus- cular fibres contract with force, the rugae of the vagina are great- ly increased in number; when their tone is diminished or lost, the ruga? of the vagina are diminished in number. If the vagina of a woman in perfect health and vigour be examined, the in- ternal surface of it will be corrugated strongly; but the reverse will happen in proportion as the woman becomes weak; and therefore in some cases of extreme debility the vagina will be so much relaxed, as readily to admit the whole hand : the rugae will be obliterated, the surface of the vagina will present no in- equalities, but be perfectly smooth. Cold substances applied to the vagina, or to the parts in the neighbourhood, will produce a contraction of the muscular fibres which surround it, a corrugation of the internal membrane, and a diminution of the diameter of the canal itself. Cold applied to the vagina will produce contraction of the blood-vessels which are in its neighbourhood, and the secretion from it will be diminished. Women subject to a mucous dis- charge from the vagina are sometimes inclined to employ some addition of clothing, so as to absorb it, and to keep their per- sons comfortable; although they remark at the same time, that if they have not recourse to such additional clothing, the quan- tity of the discharge is diminished. The explanation of this is, 38 TREATMENT OF that the action of the parts is increased by the addition of what- ever tends to increase the warmth. Further: It is to be observed, that cold not only produces a diminution of secretion, by causing an increased contraction of the blood-vessels, but also by throwing the vagina into folds; for in this state of the parts the blood-vessels which supply the lacunae must run in a more tortuous direction, and a resistance must be offered in a greater degree to the flow of blood through them; and this is perhaps the reason why it will generally be found, that the quantity of the secretion from the membrane of the vagina will be proportionate to the number of rugae within it, as was remarked in describing the discharges from these parts. In procidentia uteri, cold water ought to be applied to the female parts, to the belly, and to the back, by means of a sponge, three or four times a day; and the water for this pur- pose should be used as soon as it has been drawn from the spring. The water may be rendered still colder by the addition of some matter which is passing from a solid to a fluid state, as ice or salt. Cold water may also be thrown into the vagina by means of a syringe, or a piece of ice may be introduced into the vagina, and suffered to dissolve there. In very slight cases of the disease, when the symptoms are just beginning, and when they are known to proceed from the causes which have been mentioned, they will be removed by attention to these rules, assisted by the horizontal posture. Whenever it is found neces- sary to inject fluids into the vagina, and important that they should remain there for any time, the operation should be per- formed when the woman is in a recumbent position; and if a pillow is previously placed under the hips, in order to raise them a little, the fluid will be less likely to escape. The syringe to be employed should be capable of holding as much fluid as will fill the vagina; it should be furnished with a curved pipe, and the piston should play readily in the cylinder: this is a very material point, as the following case will shew. A lady whilst throwing some injection into the vagina found that great force was necessary to make the fluid pass, and she incautiously applied it. Instead of pushing the piston lower in the cylinder, she pushed the point of the pipe violently against the anterior parts. Inflammation of the bladder came on, which extended to the peritonaeum, and spread over great part of it; symptoms of the most alarming kind came on, and it was only by frequent bleedings, the use of diaphoretics, and a long con- finement, that the disease was subdued. There are two great defects in the construction of many of the syringes made for female use: one is, that they have one PROCIDENTIA UTERI. 39 large hole, or so great a number of holes at the extremity, that the fluid passes out too quickly. The other defect is in the situ- ation of those holes, which are frequently placed at the sides as well as at the point of the instrument, so that the fluid escapes at the lateral holes, and little or none perhaps reaches the upper part of the vagina. But if the holes are all placed at the extrem- ity of the pipe, the injection will be thrown to the upper part of the vagina, and will be sure of returning by the sides. In by far the greater number of cases the vagina will be found too much relaxed to have its tone restored by cold alone, and it will re- quire the additional aid of astringents. Astringent substances, applied to an animal solid, increase the force of the cohesion between the parts of it, or render it firmer. The same substances applied to the living fibre increase its power of contraction, and thus a shortening of the fibre is pro- duced. On these accounts they become very valuable applica- tions in many cases of disease depending upon a laxity of mus- cular fibres. They often become the cause of the restriction of hemorrhage from small vessels, by producing a diminution of their cavities. Stimulants will produce the same effect, but are by no means so safe or so efficacious. In procidentia of the uterus, astringent applications to the va- gina become very serviceable, by diminishing its diameter, and thus rendering it less disposed to receive the displaced uterus; and also by restraining the mucous discharge. The mineral and vegetable kingdom furnish a number of as- tringent substances, differing from each other much in power; and certainly not all equally applicable to every case. Sulphate of zinc.—This substance is more useful in cases of relaxation of the orifices of mucous glands, than where tone is required to be given to muscular fibres, as in the case of proci- dentia: for in order to this latter effect a very strong solution of it must be employed, and this will be apt to irritate the mem- brane of the vagina:—few persons can continue to apply it long on this account. The same observations apply to the compound of silver and nitric acid, and of copper and sulphuric acid. The superacetate of lead does not possess much power in contracting the vagina; and few cases of this disease will be benefited by its use, unless where inflammation has attacked the vagina. Solutions of alum will be found to be a much more powerful remedy; and even when very strong, they are little apt to irri- tate the mucous membrane. It has been the custom, from the earliest ages of medicine, to make a combination of those medi- cines, which fulfil the same intentions; and experience confirms 40 TREATMENT OF the propriety of the practice. It may reasonably be supposed, that a part not liable to be acted upon by one substance may be acted upon by another of the same class: thus one patient will be purged by senna, another by jalap, and another by salts, and either of them may be more active with one patient than the other two; but-a more certain effect will be produced by a com- bination of the three medicines and by any of them singally, or even by two of them. This fact is not confined to medicines for internal use, since we find that an indolent ulcer will sometimes be more benefited by one stimulating application than by another, and that a com- bination of stimulating substances will sometimes agree better than any one applied singly. A mixture of alum and sulphate of zinc in such 'proportions as the nature of the case may seem to require, will sometimes fulfil the intentions of the practitioner better than either employ- ed alone; and so of all the other mineral astringents which have been in use. The varieties in the shades of disease require a variety in the remedies employed; and this must be left to the skill and the judgment of the practitioner, who must accommo- date his measures to the peculiarities of each case; and who, if he expects to find all cases alike, will be much disappointed when he is called upon to treat them. In the last Pharmacopoeia published by the London College of Physicians, there is a for- mula for a solution of sulphate of zinc and alum, under the title of Liquor Aluminis Compositus,* which however will require to be diluted with different proportions of water, so as to adapt it to different cases; for the irritability of the mucous membrane of the vagina varies in different women, as well as in the same woman at different periods of time. This may make it neces- sary to begin with the application of weak astringents, and to increase their strength gradually. Amongst the vegetable astringents applicable to the case un- der consideration, may be reckoned Thea viridis, Petala Rosae rubrae, Cortex Quercus, Cortex Granati, Gallae. The two former do not possess the same degree of astringen- cy with the last-mentioned substances. The three last possess a great degree of astringency. They give out their astringent pro- perties to water more readily by boiling than by infusion, and therefore the decoctions of them are to be preferred: they may be used alone, or some of the mineral astringents may be dis- * Liquor Aluminis Compositus. R Aluminis Zinci sulphatis singulorum unciam dimidiam; Aqua? ferventis octarios duos: Alumen et zinci sulphatem in aqua simul liqua; dein per chartam cola. PROCIDENTIA UTERI. 41 solved in them. By these means are procured astringent fluids of such strength that the vagina may be so much contracted as even to render the introduction of the pipe of the female syringe difficult. Astringent injections should be thrown into the parts twice or three times a-day, or oftener; and they should be used cold. In addition to the good effects produced upon the parts by the local application of astringents, the views of the practitioner may be forwarded by exhibiting tonics internally. Substances of this kind applied to the stomach have the effect of increasing the lorce of the contraction of parts at a distance, and therefore will prove useful in many cases of this disease. From the nu- merous class of bitter tonics may be selected, according to the judgment of the practitioner, one or more which may be exhib- ited, such as gentiana, coluinba, quassia, anthemis, humulus; and the combination of two or more of these proves more useful than one only, and is besides more grateful to the stomach.* A combination of a bitter and an astringent may be more use- ful than a bitter medicine given alone. The sulphuric acid may be exhibited in any of the bitter infusions; but as the cinchona contains both of these principles in a great degree, it is perhaps to be preferred to any other medicine: this too may be advan- tageously combined with the sulphuric acid. It has been before remarked, that the stomach sympathizes with the uterus in this complaint; and that all its functions will sometimes be impaired, and its tone greatly diminished. In cases where both the stomach and the general system are weak- ened, but in which the stomach has more than its proportion of weakness, the simple bitters will be found better fitted to the purpose of giving strength than the combinations of bitters and powerful astringents: it may indeed be judicious to combine these medicines with stimulants, in order to excite the stomach * " Bitter medicines which tend to strengthen the system, as far as my ex- perience has gone, sit easier on the stomach, and tend more to strengthen the system when mixed together, than when any one of them is employed sin- gly "—See a paper, by the late Dr. George Fordyce, in the second volume of the Transactions of a Society tor the Improvement of Medical and Chirur- gical Knowledge. The snme observation had been made above a century before, by the expe- rienced Sydenham. Speaking of medicines for strengthening lh« stomach, he says:—" Eorum species aliquot affabre permislae humoribus concoquendis rrctius, ut mihi videtur, quam simplex quodlibet ex eorum tribu desumptum. Quumlinet enim quoties specifica medicamenti cujuslibet virlute opus est no- bis, regula tenet, Quo simplicius en, melius:—Tamen cum id habemus propo- siti ut huic illive iudicationi satisfaciendo aegrum sanenius, singula ingredien- tia symbolum pro morbo curando quasi conferunt. Atque in hoc casu, quanto major est simplicium numerus, tanto potcntius medicamentnm opeiabitnr.— E praedictis itaque et reliqu& ejusdem farina? materia inedica. varix remedio- rum formulae ad hunc scopuin tendentes concinuari posnint." F 42 TREATMENT OF quickly to a more vigorous action. The spicy barks, the aro- matic seeds, and volatile alkali, will be found well adapted to this purpose. In all complaints it is highly important to have a well-regu- lated state of the stomach and bowels, but in none more than in this; for the two extremes of diarrhoea and costiveness will great- ly retard the progress of the cure. The straining attendant upon tenesmus will act upon the uterus; and the endeavour to expel a costive stool has frequently displaced a pessary. The purga- tives adapted to this case are those which increase the peristal- tic motion of the intestines; such as rhubarb, or senna, to which some aromatic water or essential oil may be added, or a drachm or two of the compound tincture of rhubarb may be added to each dose of the bitter medicine. Oily purgatives are apt to offend the stomach; those of a sa- line nature diminish the strength of the system, by lessening the quantity of circulating blood: and the resinous class of purga- tives stimulate the lower part of the intestinal canal, and thereby increase the action of the vessels of the neighbouring parts. All these therefore are improper. Mention has been already made of the application of cold to the parts concerned; but it yet remains to be stated, that the cold-bath is a valuable auxiliary in the cure of the disease. It increases the strength of the muscular fibres throughout the whole body, and greatly invigorates the system; but the same observation which was made respecting other tonics is no less applicable to cold-bathing; namely, that when the stomach is weakened more than any other part of the frame, the use of it will be detrimental to the patient. In like manner, when a pa- tient labours under any inflammatory affection of the chest, the cold-bath should not be recommended on any account; although it should appear probable that the employment of it might be beneficial in the other complaints under which the patient la- bours. Women whose strength has been much exhausted, should employ this remedy less frequently than those who are not so much debilitated, beginning with it twice a-week only, and at length using it daily. There certainly is a difference between the effects of bathing in fresh and salt water in many complaints. It is also observable in this. Women who have used the fresh- water bath with little or no advantage, have derived great bene- fit from sea-bathing; but as the situation in life, or the conveni- ence of every person, does not admit of a journey to the sea, it may not be amiss to mention a plan which the author has found in some measure to compensate for the want of a sea- bath. It is observed by persons who have used both salt and PROCIDENTIA UTERI. 43 fresh-water bathing, that after the former a glow diffuses itself all over the body, which glow is not felt after the latter. The shock applied to the constitution increases the strength of the action of the heart, and the stimulus of the salt upon the skin invites the blood to the surface. Let two pounds of salt be dis- solved in a gallon of water; let some coarse towels be immersed in this water, and afterwards wrung out and dried. After bath- ing, let the patient be dried with these towels, using some fric- tion at the same time. In this way a degree of warmth will be given to the body, which will be both useful and agreeable to the patient. A solution of sea salt in water, employed as a show- er-bath, is a good substitute for bathing in the sea. In every case of procidentia much may be done by posture: the patient should lie as much as possible upon a bed or upon a sofa; and a mattrass, as presenting a flatter surface, and being less likely to debilitate, is preferable to a bed of down or fea- thers. The rooms which the patient inhabits should be kept cool. Great care should be taken to guard against every thing which may produce strong action of the abdominal muscles; which, by pressing upon the parts contained in the abdomen or pelvis, may prolong the disease: besides, if a pessary is employed, it may be expelled or displaced by these efforts. The diet of the patient should be nutritious, and a moderate quantity of wine may be allowed; but the stomach and intes- tines should never be loaded, lest the weight in the pelvis should keep up the complaint. The bladder should never be suffered to contain a large quantity of urine, for the same reason. All flatulent food, all the wines of this country, (amongst which beer is included) should be avoided, as being liable to undergo another fermentation in the body, and to inconvenience the patient by flatulency. 44 ON THE MODE OF CHAPTER VII. On the Mode of supporting the Uterus. Different modes have been employed, at various times, of supporting the weight of the uterus. Some of these possess ad- vantages over the rest. The support intended for this purpose is called a pessary. Those in common use have been made of wax, cork, cork covered with wax, sponge, and wood. All the above-mentioned substances, except the last, are liable to some objections. Wax being soft, and readily formed into any shape which may be required, would seem to be a very good material for a pessary; but in the heat of the body its shape becomes altered, and it no longer bears upon the parts on which it was intended that it should rest. Cork, although from its lightness it seems well adapted for the purposes of a pessary, is objectionable, from being porous and liable to imbibe the moisture of the parts; from which cir- cumstance it becomes offensive and irritating. Pessaries have been made of cork covered with wax; but they soon lose the wax, which either becomes soft and is rub- bed off, or it peels off in flakes. Sponge is the worst material which can be employed for pes- saries; for it is porous, and will very quickly imbibe the mois- ture of the parts. The piece of sponge must be large, compar- ed with the size of the vagina, or it will be useless; and if it is large, the vagina, (the dilated state of which was one of the causes of the disease,) will be still farther dilated: and although, whilst the sponge is worn, the uterus will rest upon it, and the symptoms-may be relieved; yet, when it is removed, the dis- ease will return with double violence. It is a matter of surprise how such a substance could have been recommended for the purpose of curing the disease; since in fistulous sores, where the object of a surgeon is to increase the size of the opening by dilatation, this substance has been selected for the purpose. A good pessary should combine firmness, lightness, and close- ness of texture:—firmness, that it may not yield to pressure; lightness, that it may not incommode by weight; and closeness of texture, that it may not imbibe the secretions of the vagina. Those made of box wood possess all these advantages; and this wood, not being scarce, can be easily procured. Pessaries are made of various shapes as well as of different materials, adapted to different cases and circumstances. For the SUPPORTING THE UTERUS. 45 majority of cases, a circular or an oval pessary answers suffi- ciently well; but the circular pessary can only be safely used in those cases where the disease has not made great progress, and where the tone of the vagina is not much impaired: for if the canal of the vagina has been much dilated, no pessary of a small size can be sustained in it; and one of a larger size, and of a circular form, might do mischief, by compressing the mea- tus urinarius and rectum, and so preventing the discharge of the faeces and urine. It will seldom be safe to introduce a circular pessary the di- ameter of which exceeds two inches and a half: below this size there can be no impropriety in using it; for it is certainly less liable to be displaced than the oval pessary. The efficacy of a pessary depends upon the nice adaptation of its size to the state of the parts: the practitioner ought therefore particularly to attend to this. It should be large enough to keep the situ- ation in which it is placed, else it will slip away; but it should not be so large as to distress the woman, or to injure the parts by its pressure. If, after the first introduction of the instrument, it should be found that it is not adapted to the state and size of the parts, its size or form should be changed. No instrument of this kind should measure in thickness at its external edge less than one-third of an inch, lest it should in- jure the parts by its edge: it should become gradually thinner as it approaches the centre, in which there should be an oval opening large enough to hold the end of the forefinger of the surgeon, in order to enable him to place the instrument. A num- ber of holes may be pierced through the instrument in different parts, by means of which it is . rendered much lighter, and the secretions from the upper part of the vagina, as well menstru- ous as mucous, can more readily pass through it.—Whatever may be the shape of the instrument employed as a support, it should be removed occasionally for the purpose of cleaning it, lest the secretions of the parts should attach themselves to it, and by retention become acrimonious and irritating. Occasion- ally also the pessary should be changed for one of a smaller size. In consequence of omitting to withdraw the pessary, the surface of it has sometimes become coated with gritty matter, which has brought on irritation, inflammation, and ulceration of the neighbouring parts. Instances too have occurred where parts of the instrument have been destroyed by a spontaneous change taking place in it, and angular portions of it have been left, which have produced similar bad effects. A lady, seventy-five years of age, who had borne children, came under the care of the author, on account of considerable 46 ON THE MODE OF pain in the vagina, attended by a very offensive discharge: the pain was constant, and was compared to that produced by a sharp instrument. Thirty-five years before, she bad a prolapsus uteri, for which a pessary had been introduced, and had never been removed. The author having reason to fear that some dis- eased structure existed, examined the patient, and found that the pessary had lost its original form, being corroded in several places, and that many irregular portions of it were left, which pressed upon the vagina, and had produced ulceration of its in- ternal surface. This lady having, as she said, suffered exceed- ingly in the introduction of the instrument (because perhaps it was incautiously performed,) would not consent to its removal, particularly after some of her symptoms had been relieved by fomentations and injections.* The pessary of an oval form is best adapted to those cases in which the tone of the vagina is so very much diminished as to make a large support necessary; because in this case the oval pessary rests by its two extremities upon the sides of the vagi- na; but lying with its long diameter applied to the short diame- ter of the lower aperture of the female pelvis, it neither inter- feres with the rectum nor with the urinary passage. If the case should require it, an oval pessary may be used, of a size so large that it may measure three inches and three quar- ters in its long diameter, without any injury to the parts: and a case will scarcely occur, where the perinaeum is not injured, and where the uterus has not descended out of the external parts, in which a pessary of this kind will not afford a sufficient sup- port. There is however an objection to the use of this instru- ment; which is, that it is more likely to be displaced in the sex- ual intercourse than a circular pessary. It may be here remark- ed, that if the patient has not passed the child-bearing age, such intercourse should not be prohibited; for if the woman should become pregnant, the disease will be naturally cured after the fourth month, by the ascent of the uterus into the cavity of the abdomen. Mode of introducing the circular or oval Pessary. The woman should be placed upon her left side, close to the edge of a bed, and her knees should be drawn up towards the * Dr. Clarke related to the author a case to which he was called, in a wo- man advanced in life, who on account of similar symptoms had been exam- ined by another practitioner, who found what he considered to be a schirrous tumour surrounding the os uteri. Dr. Clarke found that the supposed schirrous tumour was a cork pessary, introduced many years before, and rendered very rough by calculous matter deposited on its surface. It was withdrawn, and all the symptoms subsided in the course of a week. SUPPORTING THE UTERUS. 47 abdomen: the practitioner is then (having previously examined the size of the vagina) to select a pessary, according to his judg- ment, of a proper size. This instrument is then to be covered with some simple unctuous matter; and if its form is circular, it is to be placed between the labia, so that one edge will be turn- ed towards the os pubis, and the other to the rectum: it is then to be moved in a circular direction on its own axis, pressing it at the same time towards the perinaeum, till it has fairly entered the vagina. As the instrument passes the edge of the external parts, some little uneasiness is always felt by the woman; but this ceases as soon as it has reached the vagina, to the upper part of which it is to be carried; and it is to be so placed that the uterus may rest upon one of the broad surfaces of it. The instrument is now to be left in the vagina, and a syringe full of some cold astringent injection should be thrown into the parts, to give tone and contraction to the dilated os externum; as in cases where the vagina is very much relaxed, it may make a smaller pessary answer the purpose of support than would be required if no such means were resorted to. Whatever may be the shape of the pessary introduced, the woman should continue for some minutes in the recumbent posture. An oval pessary requires great care in the mode of introduc- tion; and is either a very good or a very bad instrument, accord- ing as it is well or ill applied. In the choice of it, the present size of the vagina is to be first considered, with the diameter of which the long diameter of the instrument should correspond. The extremities of the instrument should not be too acutely pointed, lest they should injure the parts. The instrument being covered with some unctuous substance, one end of it is to be placed between the labia, with the short diameter running from before to behind; and in this direction it is to be carried up into the vagina. Thy practitioner is then to insert the point of his forefinger into the opening in the centre of the instrument, and to place it across the vagina, so that the extremities may be turned towards the spinous processes of the os ischium. If the direction of the opening in the pessary is made to correspond with that of the long diameter of the instru- ment itself, this will be easily accomplished. The pessary is now to be passed as high into the vagina as it can be without giving pain, and to be left there. Procidentia uteri sometimes occurs in women whose perinae- um has been lacerated to a great extent in labour: in such a case, neither the circular nor the oval pessary can be retained; but the sacrosciatic ligaments and the os coccygis will sufficient- ly contract the lower aperture of the pelvis to enable a globular pessary to be retained. This pessary, pressing equally in all di- 48 ON THE MODE OF rections, is very conveniently borne; and it may be used in wi- dows who have lost the catamenia, with great advantage. The size of the instrument being adapted to the capacity of the parts, its surface is to be covered with unctuous matter, and it is to be placed between the labia; by a gentle pressure it is to be car- ried into the vagina, giving a degree of rotatory motion to it as if passes along, which greatly facilitates the introduction. A form of instrument has been made for these cases with a stalk, to enable the woman to secure the instrument in the parts: but this stalk is very apt to irritate the labia; and the author has hardly known a case in which it could be employed with advan- tage. Hippocrates, in the second book weg* yvvxiKtioi, describes ex- ceedingly well some cases of procidentia uteri. Amongst the causes of the disease, he mentions fatigue after delivery, carry- ing heavy burthens, fright, cutting wood, or being connected t» etvtfi tt ry texiy xct6«£ or by thickening of their extremities in the long bones; by a flabbiness of the mus- cles; by a want of tone in the integuments; by symptoms which demand the employment both of medical and culinary means of restoring the failing powers of the constitution. The cervix of the uterus is a glandular part: its secreting or- ganization can be demonstrated. It is subject to the diseases of glands in other parts of the body, and, in all .probability, will be particularly liable to take on disease in habits which are prone to other glandular complaints, namely, in weak habits. The majority of cases of disease in the breast and in the tes- ticle arise in such persons. It will accordingly be right, whenever inflammation of the cer- vix of the uterus occurs in such a frame, to endeavour to invigo- rate the system, and to equalize the balance of the circulation: an object frequently attainable by the exhibition of tonics, amongst which, the Peruvian bark and some preparations of iron, are the most serviceable. Of the former, the decoctum cincho- na?; of the latter, the tinctura ferri muriatis, will generally best fulfil the intentions of the practitioner. It must, however, be confessed that cases of unequal distri- bution of blood, whether the determination be made to the head, the chest, the uterus, or any other organ, are very unmanagea- ble, and often baffle all the endeavours of the practitioner to regulate or remove them. WHITE MUCOUS DISCHARGE. 149 In conclusion it must be observed, that a great point is gained in ascertaining the true nature of this disease, of which the milky discharge is symptomatic; for thereby the physician or surgeon is led to direct such measures as may tend to remove its cause, instead of those astringents too often employed in such cases; besides which it should be recollected that the cervix of the ute- rus is the most sensible part of the whole viscus; and that it is the cervix of the uterus which carcinoma always selects as its point of attack. Surely, then, it is not too much to apprehend that slow inflammation in the glands, seated in this part, may lay the foundation for the commencement of carcinoma; or, perhaps, for other alterations of structure in its neighbourhood. On all of these accounts, it is prudent and desirable to endea- vour to remove as quickly as possible any of its diseases, but especially one in its own nature so important as inflammation. 100 CHAPTER XXIV. WATERY DISCHARGE. By the above term is meant that form of discharge which re- sembles clear water, having no colour, and which contains very little glutinous matter, sometimes none at all. • The variety in the thickness of these discharges probably de- pends upon the greater or less quantity of albumen diffused through them. It is intended to comprehend the history of three different diseases under the head of "Watery Discharge." cauliflower-excrescence of the os uteri. hydatids of the uterus. the oozing excrescence of the labia. These three are the only diseases which, in the knowledge of the writer, are attended by watery discharge of the character described above. It is true that women are Hable to an escape of water from the os externum; but such fluid will, upon examination, be found to possess the sensible and chemical properties of urine. A few observations will be made hereafter respecting these cases. WATERY DISCHARGE. 151 CAULIFLOWER-EXCRESCENCE OF THE OS UTERI. Perhaps no organ in the body is liable to a greater variety of diseases than that which forms the residence of man during the first nine months of his existence. In consequence of affording this nidus to the ovum, and of sustaining and expelling it when labour comes on, it became necessary that its structure should be very complicated. It accordingly is found to consist of many parts, possessing different kinds of organization adapted to the purposes for which they were intended. Its outer membrane, therefore, becomes liable to diseases of the peritonaeum: its mus- cular structure to irregular actions, and to the formation of tu- mours in that structure, as well as in the cellular membrane con- necting the packets of fibres to each other. Its internal mem- brane, performing the double office of the permanent secretion of mucus, and the occasional secretion of the menstruous fluid, by the extremities of small arteries which terminate upon its surface, becomes subject to the diseases of mucous membranes; and it is, perhaps, more liable to attacks of inflammation than any mucous membrane in the body. The cervix of the uterus differs from the structure of the other parts of the organ in being glandular, and thence it be- comes subject to the diseases of glands; whilst the termination of this part in the vagina, at the os uteri, where it is covered by the inner membrane of the vaginal canal, is disposed to take on different forms of disease, one of which forms is that which stands at the head of this chapter. A more appropriate name could not have been given to this disease, than "the cauliflower-excrescence." There is a striking resemblance between itself and a portion of the upper surface of a cauliflower, or a head of brocoli. The surface is granulated, and it consists of a great number of small projections, which may be picked off from the surface, as the granules may be detached from the vegetable. The firmness of the tumour agrees also with that of the plant—here the granules will be large and irre- gular, there small and equal. A membrane, very fine in its texture, is spread over the sur- face of the tumour, and from this membrane is poured out that aqueous secretion which characterizes, in a marked manner, this disease. As the tumour occupies the upper part of the vagina, it is of course concealed from view; but in three or four cases, in which the size of the tumour was so large as to fill the whole canal, ■152 WATERY DISCHARGE. and to protrude between the labia, the author was enabled to see the disease, and the colour of the tumour was found to be that which may be called a bright flesh-colour. If the membrane covering the tumour has been injured in an examination, the blood-vessels immediately beneath it pour out their contents, which appear to be florid red blood, resembling that which is contained in the arteries of the body generally* The quantity of blood which so escapes will be proportioned to the extent of the injury inflicted upon the tumour. Similar dis- charges of blood sometimes spontaneously take place in those habits in which plethora exists, or where the circulation has been hurried by any exciting cause. The cauliflower excrescence is not endowed with sensibility, the patient never complaining when pressure is made upon it. Its attachment is to the surface of the os uteri, and to that alone; it never can be traced into the cavity of the uterus. A small part of the os uteri may give rise to the disease, or the whole circumference of the opening may be occupied by it. The growth of the tumour is sometimes very rapid; but the enlargement seems to be much influenced by the power of con- traction of the vagina; so that when this canal is very dilatable, as in married women who have borne many children, the tu- mour will very quickly increase in size; whereas, the pressure of the sides of a less capacious vagina, as in single women, will greatly tend to control its enlargement, acting like a bandage upon it. The knowledge of this fact is available in the treatment of the disease. When the tumour is of so large a size as to protrude beyond the labia, it branches out on either side, and, by pressing and irritating the surfaces between which it lies, it not unfrequently causes ulceration of them. Hitherto it has not been ascertained what circumstances pro- duce in the parts a disposition to take on the formation of this disease.' It might be conjectured, that an injury inflicted upon the os uteri in labour, either by the head of the child, or by vio- lent attempts made to dilate it, might become an exciting cause; but many examples are to be met with, in which such injury has been done to the os uteri, and no such disease has followed. Married women who have never been pregnant, nay, single wo- men, are liable to the complaint, in whom no violence can have been offered to the os uteri. It cannot be traced to any syphilitic cause. The common pros- titutes of this metropolis are by no means more liable to it thaq any similar number of women in different stations of life. The disease arises as often in the strong and robust as in the weak; in persons who live in the country, as in those who inhabit large WATERY DISCHARGE. 153 towns; in those whose situation in life obliges them to labour, as well as in those who, from their rank in society, sometimes con- sider themselves privileged to be useless members of it. No period of life, after the age of twenty, seems to be exempt from the disease. The author has known it fatal at the age of twenty; and he has met with the disease at different periods of life up to old age. The complaint may arise, perhaps, before the woman has reached her twentieth year, but no such case has occurred in the experience of the author. It has been observed above, that arterial blood escapes from the tumour when injured; indeed the tumour appears to be made up of a congeries of blood-vessels, and these blood-vessels are arteries; the infinitely small branches of these vessels, terminat- ing upon the surface of the tumour, exhale in the most abundant manner an aqueous fluid. Perhaps some small arteries near the os uteri may undergo that morbid dilatation of their coals, which is analagous to aneu- rism in larger trunks, and thus the disease may be produced. Something similar to this takes place in the arterial, or blood- red naevus, but here the surface, being covered by cutis and cu- ticle, no moisture of the part is met with; but if the surface of such a naevus should be injured, arterial blood escapes. May such a state of blood-vessels exist at the time of birth, remain concealed in early life from the very small quantity of blood which circulates in the organs of generation at this age, and be developed at that period at which blood rushes with greater force and in greater quantity, to enlarge these organs, and in the female to render them fit for the performance of new duties? It may be that the increased circulation which is present at puberty, may not be sufficient to elicit the phenomena of the complaint; the stimulus of marriage may be required in some, whilst in others, the further developement of the organs in preg- nancy, or the exertions of labour may be necessary to call forth the morbid symptoms of such hitherto dormant disease. In a paper upon the subject of the cauliflower-excrescence of the os uteri, contained in the third volume of the " Transactions of a Society for the Improvement of Medical and Surgical Know- ledge," by the author's brother, the late Dr. Clarke, it is stated " that he had never been enabled to find a specimen of the dis- ease in any collection of anatomical preparations; he sought for it in vain in the collections of the late Dr. William Hunter and of the late Mr. John Hunter; and in all the inquiries which he had made amongst those who had the best opportunities of find- ing it in the dead body, he was never able to procure a speci- men of it." u 154 WATERY DISCHARGE. No one had seen a tumour resembling a cauliflower-excres- cence in the dead body: why they had not will presently appear. Some years ago a lady died of this disease: she had been ex- amined a short time before her death; and in the vagina a tu- mour of the cauliflower-excrescence kind was found, arising from three-fifths of the circumference of the os uteri: on the day fol- lowing that upon which she died, an examination of the body was made by the author in the presence of his brother, and of Mr. Alexander Sneddon.* Upon dissecting out the uterus and its appendages, and slit- ting open the vagina, no tumour was found there; although, in the last examination which was made in the life-time of the pa- tient, an excrescence was discovered nearly as large as a hen's egg: but, from that part of the os uteri to which the tumour for- merly adhered, a soft, flaccid, slimy, whitish substance, hung down, which looked like the faetal portion of the placenta of a calf, after it has been macerated in water. The body and fundus of the uterus were sound. An attempt was afterwards made to inject this flocculent sub- stance with size and vermilion, thrown into the arteries of the uterus; but although the blood-vessels of the uterus itself were abundantly filled with the injection, and although the flocculent mass itself received the injection, the fluid escaped from its sur- face as fast as it was thrown in from the pipe of the injecting syringe. The author has the preparation at present in his collection: the flocculent mass is heightened in colour by the small quan- tity of injection which remained in its vessels; but it floats lightly in the spirit in which the preparation is suspended, as it did in the water in which it was at first macerated. Margaret Pole, the mother of eight children, discovered that she was pregnant in the beginning of the year 1810. From the commencement of the pregnancy to its termination, she had a profuse watery discharge from the vagina, which was, upon any trifling exertion, mixed with blood. The practitioner who was called to the patient on the first of July, found her in labour, and made the usual examination: upon carrying his finger into the vagina, he found a large tumour there, resembling placenta; and as, upon endeavouring to ascer- tain its extent, a large discharge of blood followed, it was deter- mined that the author should be called in. In addition to the hemorrhage, the patient was constantly vomiting; from the con- currence of which two circumstances a state of great exhaustion was produced: the pulse was very feeble and frequent, and oc- *■ An ingenious surgeon, to whom the writer is indebted for the drawings of many of the diseases described in the first volume of this work. WATERY DISCHARGE. 155 casionally appeared to be lost, when an effort to vomit, or a vi- olent struggle of the frame, which threatened to terminate the existence of the poor woman, again excited the action of the heart, and a sort of half-existence was thus carried on. When the author examined the patient, he found within the vagina a substance which nearly filled it, and which felt like the placenta; but upon tracing this upwards, he ascertained that, in- stead of coming down through the os uteri, as in presentations of the placenta, it actually constituted a portion of it, so that there was scarcely any part of the circumference of this opening to which the tumour was not attached. At this time the os uteri was not much dilated. It was agreed that the patient should be supplied frequently with nourishment, and that the usual local modes of restraining uterine hemorrhage in labour, with the ex- ception of delivery, should be resorted to. When the patient had passed over a few hours, the os uteri was more open, the uterus was in occasional action, and there was a profuse discharge of a watery fluid, tinged with blood. Under this lamentable combination of circumstances, the ex- istence of a formidable and fatal disease, and the presence of labour, the great question was, how the patient should be treated. The head was too low in the pelvis to admit of the child being turned; to open the head would have been to destroy the child, supposing it to be still alive, to afford no advantage to the wo- man; to perform the Cesarean operation, would have caused, in the deplorably weak state of the mother, her immediate death, and that when it was doubtful whether the child was alive or not. As the tumour was evidently of the cauliflower-excrescence kind, and as it was probable that, being so, it would be dimi- nished in bulk by the pressure of the child's head in its descentt the contents of the blood-vessels being thus squeezed out, it was determined to wait, and to watch the progress of the labour, the friends of the patient having been informed of her perilous situ- ation. Eventually, that which was anticipated happened; the contents of the tumour were squeezed out; the child passed na- turally through the vagina; but the woman was attacked with other symptoms of a sinking frame; apthae appeared upon the tongue and the inside of the cheeks, and she sunk upon the third day after her delivery. The body was examined; and upon cutting open the vagina, the tumour had wholly disappeared, there remaining in its stead loose irregularly-shaped flocculent portions of matter, which arose from every part of the circle of the os uteri. There was nothing else found remarkable; and the uterus was as much con- tracted as it is usually found to be about three days after deli- very. 156 WATERY DISCHARGE. An attempt was made in this case also to inject the tumour; but all efforts to do so were unavailing: the fluid escaped from the surface, and from the interstices of the flocculent mass, as quickly as it was thrown in by the injecting syringe. The above cases contain histories of a tumour arising from the os uteri, possessing a firm texture during life, but losing this firmness after death. The circumstances of the disease resem- bling a portion of the placenta, so as to be mistaken for it at first, is too remarkable to pass without further notice. A carci- nomatous thickening of the os uteri may exist during labour, and the patient has been destroyed very shortly afterwards, by ulce- ration taking place. The author has a preparation of this kind; but a carcinomatous thickening of the os uteri bears no resem- blance to the cauliflower-excrescence, and its size remains un- altered by pressure, and undiminished by death. Why then do the cauliflower-excrescence and a portion of the placenta resemble each other so closely, that the one has been mistaken for the other? They differ only in name; the structure is the same. The placenta consists of blood in blood- vessels; the cauliflower-excrescence consists of blood in blood- vessels. In a presentation of the placenta there is hemorrhage; so there is when the cauliflower-excrescence is injured. Nothing can be better marked than this similarity; and if there was no further evidence to prove that the nature of the disease was a distended set of blood-vessels, it would be rendered suffi- ciently probable from this resemblance alone. The vessels of the pia mater, in the dead subject, resemble a flocculent mass, when drawn out of the interstitial spaces be- tween the convolutions of the brain where they ramify, and they scarcely put on the appearance of having been blood-vessels; but, let injection be thrown into them, they readily become dis- tended, and their real structure is rendered immediately evident. In other parts of the body, small blood-vessels, very visible during life, are emptied of their contents into the larger trunks when death takes place; nay, in fainting, which is a near ap- proach to death;—for example, in the membrana conjunctiva, the lips, the skin, and in most parts of the body where the rami- fication of small vessels can be distinguished. If, in an examination, a small portion of the cauliflower-ex- crescence be detached, and if it be pressed between the fingers, or macerated in water, its volume will be found to decrease very rapidly; in the one case blood will be squeezed from the blood- vessels, and in the other diffused through the water; and in both a flocculent mass will remain, resembling the appearance of the cauliflower-excrescence after death. That the blood-vessels so distended in this disease, consist WATERY DISCHARGE. 157 principally, if not wholly, of arteries, is to be collected from their contents, the colour of which resembles that of arterial blood, which is not returned into the general circulation by the termination of these vessels in small veins, but is carried off prin- cipally in that profuse watery secretion which causes such ex- penditure of the powers of the frame. In the case of Margaret Pole, last related, the tumour was large enough to fill the cavity of the vagina entirely, which may- be accounted for by the greater determination of blood made to the uterus in pregnancy by the hypogastric arteries. Reasoning upon this circumstance, il may be fairly presumed, that as what- ever tends to increase the flow of blood to the uterus, aggravates the symptoms of the disease, by increasing its volume; so, what- ever has the effect of rendering the circulation less active in this organ, will diminish the growth of the tumour. Various attempts had been made by the writer to procure a specimen of this disease, which might illustrate its nature, in his lecture-room; but all his efforts were fruitless. The uteri taken from the patients whose cases have been described, and which are in the collection of the author, show the pulpy mass, but by no means demonstrate the appearance of the tumour during life. In the removal of some of these tumours by ligature, it has been hoped that, upon the coming away of the ligature, the tu- mour would have been found in the vagina; but this hope has not been realized; the supply of blood having been cut off by the ligature, the blood has oozed from the tumour, and all which has been left has been a small pulpy mass. The following case will serve as a correct picture of the dis- ease in its progress; its diminution by astringents; its arrest by the ligature; its ultimate termination in the destruction of the patient, and the appearances found after death. A lady, sixty years of age, the wife of a physician at Bath, had suffered under great debility for some months, during which time she had been liable to a profuse watery discharge. The symptoms increasing, and threatening her life, she came to Lon- don, and was placed under the care of the author. She was ge- nerally anasarcous; had great difficulty of breathing, being inca- pable of lying down, from an apprehension of suffocation. The pulse was very weak and irregular, and the lips and tongue were bleached by the constant drain from the blood. The appetite was nearly lost, and the powers of converting the small quantity of food which was taken into nourishment were almost wholly gone. These symptoms commenced six years before, and had gra- dually increased to their present degree. On examination, a tu- mour of the cauliflower-excrescence kind was found in the vagi- 158 WATERY DISCHARGE. na, nearly large enough to fill that cavity. By the frequent use of strong astringent fluids poured in the vagina, the discharge was in some degree controlled in the year 1811; but in the sum- mer of 1812, alarming hemorrhage came on, which lasted dur- ing many days. These discharges of blood took place very sud- denly, (to use the patient's expression) as if some vessel had broken. In July, 1813, small pieces of granulated flesh came away, mixed with blood; and the wate y discharge was then so con- siderable, that more than twenty napkins were required daily, to keep the patient even tolerably comfortable. Hectic fever took place; astringents ceased to produce any effect; the tumour be- gan to project through the external parts; by the straining efforts of the patient at stool, splashes of arterial blood came away; and the symptoms of weakness now became so formidable, that it was evident the patient would quickly sink under them, unless some additional mode of treatment was employed. As the danger depended upon the profuseness of the watery discharge poured out by so large a surface, which was no longer controllable by even the strongest astringents, it was proposed to the patient that a ligature should be applied round the base of the tumour, so as to remove it. The patient was willing to accede to this suggestion: a ligature, consisting of about a dozen threads of waxed silk, was passed round the excrescence, close to the origin of it. On the seventh day after the application of the ligature, it came away, but no tumour came away with it. On examining the silver canula, by means of which the ligature had been applied, a small piece of a flocculent substance was found adhering to it. From this moment all discharge ceased, the dropsical swell- ings were absorbed, and the patient recovered her health suffi- ciently to return again into society. . She was even well enough to undertake a long journey. It had, however, been explained to her, that the disease might return; and in the summer of 1815, the originally diseased sur- face gave rise to another tumour of a similar kind, which at length caused the return of the former symptoms. The patient became very solicitous that the operation, from which she had derived so much temporary benefit, should be repeated, which was accordingly done. A ligature was applied round the tumour, which was now about the size of a hen's egg, and it was tightened so as to in- terrupt the circulation, but not so as to cut through the tumour at once. On the second day the ligature was drawn yet more tight; and upon tightening it upon the third day, it came away. On introducing the finger into the vagina, the tumour was found WATERY DISCHARGE. 159 loose: it was turned out of the vagina by means of the finger; and it was immediately placed in alkohol, so as to coagulate its contents perfectly, and, by hardening it, to preserve its shape. By these means a specimen of the disease was procured, from which the engraving in this work has been made. It is the only preparation which the author has seen of the disease as it ap- pears during life. The engraving consists of the half of the tu- mour only, as the author was desirous to place a portion of it in some national collection of anatomical preparations. The tumour, when it was separated, was of a brownish red colour. Relief was again afforded to the patient by the second operation: the watery discharge ceased, as might have been expected, its source being removed. A new set of symptoms, at the end of a few months, present- ed themselves; pain in the hips came on, with cramp at the lower part of the abdomen, vomiting, and a discharge of muco- sanguineous fluid, sometimes mixed with matter; and shortly af- terwards the patient died. It was evident that some new disease had formed. The ex- amination made of the body after death will show what it was: —An incision being made through the parietes of the abdomen, the intestines were found perfectly healthy, and unconnected by adhesions; but there was in the left hypogastric region an oval tumour, of the size of a large melon; this was connected to the loins on each side by a separate adhesion, and at its upper part it adhered to the omentum. On attempting to make an incision into this tumour, it was found that the knife would not pass deep- er than an inch and a half, and in some parts not deeper than half an inch, as it met with obstruction from bony matter. The substance which surrounded this bony matter was dissected off, and it was found to resemble layers of coagulating lymph. Upon sawing through the rest of the tumour, it was found to consist of a thin layer of osseous matter, encasing a substance similar to that which covered its external surface. There was no connex- ion of this tumour with the uterus, except what must have been the effect of former inflammation, in consequence of which co- agulating lymph had been thrown out, so as to glue the surfaces together: a very small quantity of flocculent matter appeared to project from the surface of the os uteri. The cavity of the uterus was larger than natural. The fallopian tubes and ovaria were perfectly healthy. 160 WATERY DISCHARGE. On the Symptoms of Cauliflower-Excrescence of the Os Uteri. One of the first notices of this disorder is in the patient find- ing the parts more moist than usual; little attention, however, is paid to this circumstance, till the quantity of the discharge be- coming more considerable, the patient is obliged to employ some means of absorbing it, and resorts, perhaps, to the more abun- dant use of cold water, or to the usual family receipt of isinglass and milk. Still the discharge becomes more abundant; but being unattended by pain or by fastor, the complaint is neglected, until at length a quantity of blood comes away with it, or the patient finds that the colour of her cheeks is fading, or the strength of her frame diminishing; then all at once she takes alarm, and flies to medical assistance. Perhaps the entire absence of pain, and of other symptoms, leading the woman to treat the disease lightly at first, is the reason why so few opportunities are afforded of examining the tumour when of a small size. The quantity of the discharge is in proportion to the superficies of the tumour, and the action of the blood-vessels of the uterus and neighbouring parts: it may only be in quantity sufficient to render the woman's person uncomfortable, or it may require the change of twenty or thirty napkins daily. A small blood-vessel now and then allows some of its contents to ooze out, which, mixing with the dis- charge, gives a shade of colour to it, or perhaps a faintish odour; but when no blood is mixed with the discharge, or when the quantity of the watery discharge is so great as to run off as fast as it is secreted, there is little or no smell attached to it. If the patient should be a married woman, living with her husband, it will be found that hemorrhage always succeeds intercourse; and, indeed, in some instances the slightest exertion of the body, coughing, sneezing, or straining when at stool, will produce a discharge of blood from the blood-vessels of the tumour, which sometimes becomes very profuse. When a large quantity of blood has been thus lost, it is frequently observed, that the wa- tery discharge diminishes, the distention of the vessels of the tu- mour being taken off'. As the disease proceeds, the system be- comes weakened from loss of blood, and the stomach partakes of this weakness. The digestion is performed imperfectly, spon- taneous changes take place in the food, and air is either thrown up in frequent eructations, or the belly becomes tympanitic. In some measure the disturbance of the stomach may be the effect of sympathy of that organ with the uterus, but the symptoms very much resemble those met with after large hemorrhages. Hysterical symptoms are produced, and all that host of inexpli- cable symptoms which accompany cases of impaired digestion. WATERY DISCHARGE. 161 increasing the patient's stock of bodily and mental misery. As the weakness increases, the action of the absorbent vessels di- minishes, and depositions of fluid form in different parts of the body, obeying the laws of gravitation, producing oedema of the feet at night, and puffiness of the face and eyelids in the morn- ing, the particular effects produced by such accumulations of fluid being regulated by their quantities, and determined by the situations in which they are deposited. So that the patient may be destroyed by water in the chest long before she would have been exhausted by the disease itself. In some cases an alarming hemorrhage takes place, producing a state of syncope, from which the patient may not rally. Dr. Clarke has remarked, that he never met witii a single in- stance in which the tumour, upon examination, was Igss than a blackbird's egg: this has been before accounted for; it produces at first so few symptoms. In many cases, too, the practitioner overlooks the disease, contenting himself with treating symptoms without thinking of their cause. In one case, which was attended by the late Dr. Clarke and the author, the patient, a lady about forty years of age, lost her sense of vision a few days before her death. No change in the appearance of the eyes was visible. It rarely happens that great emaciation attends the complaint, the patient being drained to death by the profuse secretion, or suddenly destroyed by hemor- rhage, long before all her fat will have been absorbed. On inspecting the bodies of several women, who have been destroyed by this disease, a layer of fat of considerable thick- ness has been found covering the abdominal muscles. How dif- ferent this from the case of a patient destroyed by ulcerated car- cinoma of the uterus, in whom scarcely a bone can be found, in which it is not easy to see the form and processes, nearly as well as in a skeleton! Yet, as in this complaint, a discharge is pre- sent, as now and then it is foetid, as a tumour is found upon ex- amination, and as the disease has always, sooner or later, a fatal tendency, it has been too frequently confounded with carcinoma. The prognostic, as to the ultimate event, it is true, must be the same; but the terms sooner or later admit of considerable lati- tude, and it is a great comfort to be enabled to lengthen life un- der such circumstances. It is not here, as in carcinoma, that whilst life is lengthened by art, distress and suffering is eked out with it. A patient labouring under the cauliflower-excrescence may pass, nay, she may enjoy, several years of life, if she will be content to make some sacrifices. As the enlargement of vessels in other situations is much in- fluenced by pressure, so it will be found, that the compression x 162 WATERY DISCHARGE. of the sides of the vagina will greatly retard the growth of this tumour. Now as the quantity of the watery discharge depends upon the extent of the surface of the tumour, and as the danger of the patient is in proportion to the quantity of the discharge, it follows that whenever the vagina has lost its tone, and the tu- mour has thereby been little subject to compression, the prog- nostic to be given to the friends of the patient, as to the proba- ble duration of life, should be less favourable, than when the sides of the tumour are supported by the sides of a more con- tracted canal. Added to this, the very pressure of a contracted vagina is an evidence that the constitution still possesses a con- siderable degree of vigour: so that the capacity of the vagina forms, in this, as well as in many other cases, by no means a bad criterion of the strength remaining in the constitution.* When the tumour occupies only a small part of the os uteri, the opinion to be given should be more favourable, than when the whole circumference of the opening is involved in the dis- ease. The danger may also be increased by any violence inflict- ed upon the part, as by the pressure of the child's head in la- bour, or by any increased action going on in the vicinity, as by pregnancy. The symptoms in some cases of the disease are di- minished more easily than in others, of which circumstance no knowledge can be obtained till the experiment has been made; the greater the effect, therefore, which local remedies produce in controlling the discharge, the longer will the disease continue, ceteris paribus, without destroying the life of the patient. ' Thus in cases of great uterine hemorrhage in labour, the vagina will some- times be so dilated as readily to admit the hand. Practitioners avail them- selves also of the knowledge of this fact, in those cases of difficulty in labour, which depend upon a contracted and unyielding vagina. In this case the loss of a large quantity of blood by the lancet affords great relief to the patient, the vagina dilating afterwards so quickly that the labour is often very speedily terminated. WATERY DISCHARGE. 163 Treatment of the Cauliflower-Excrescence. If a woman labouring under the above disease is left to her- self, or if the symptoms do not meet with attention, the tumour will increase in dimensions, and partly by the perpetual watery discharge, and partly by the occasional attacks of hemorrhage, will shortly prove fatal. The enlargement of the tumour will be greatly retarded, by diminishing the action of the fulness of the blood-vessels of the neighbouring parts. There is reason also to believe, that the size of the tumour will shrink under judicious management, which is more than can be expected in most instances of chronic morbid enlargements of the viscera, when the tumour is composed of more solid materials; and if the patient has the good fortune to take notice of the earliest symptoms of the complaint, it is pro- bable that, by a steady perseverance in that kind of management which will form the subject of this chapter, the farther progress of the disease may be put a stop to. Local blood-letting is a most valuable remedy, and great reli- ance is to be placed upon it. The region of the sacrum and the hips may be scarified, and cupping-glasses afterwards applied; the quantity of blood to be taken away must be regulated by the size and degree of resistance in the tumour, and by the quantity of the watery discharge, (which is always a measure of the ex- tent of the disease) regard being paid at the same time to the strength of the patient. At the same time it must be recollected, that if, by the loss of eight or ten ounces of blood by cupping, the quantity of the watery discharge can be diminished from four ounces to two ounces daily, the patient will, at the end of a fortnight, possess more power than if she had lost four ounces of blood by cupping, and the quantity of watery discharge had been diminished to three ounces daily. By unloading the vessels of the tumour, they will also be less likely to burst spontaneously, in which case no estimate can be formed of the quantity of blood actually lost. But, although local bleeding is so valuable a remedy in many cases, it may, when employed injudiciously, hurry the patient's dissolution. Great circumspection, therefore, is necessary in the direction of it. It should not be employed when much oedema of the feet is present, or during the continuance of any symp- toms indicating great debility. Neither should blood-letting in any case be carried farther than is just necessary to produce the intended effect, particularly when il is considered that the art is in possession of many other powerful auxiliaries in curbing the progress of this malady. 16-1! WATERY DISCHARGE. If the patient should be a strong woman, and if the disease has not been of long duration, twelve or fourteen ounces of blood may be taken away: if she should possess less strength of con- stitution, it may be sufficient to order the removal of six or eight ounces only; and to repeat this once in three weeks or a month. The application of leeches is to be very little depended upon. All general and local stimuli are to be carefully shunned, or the intention of the bleeding will be defeated. The diet should be of the mildest kind, such as puddings, white fish, or vegeta- bles. Wine should be absolutely proscribed. If the patient should be married, she should be separated wholly from the bed of her husband, to which she should never return. The state of the bowels should be carefully watched, and, if possible, they should be so regulated that the patient may have one motion daily, of such a consistence as will be voided without the least attempt at straining. This is a very important caution in many diseases of the uterus; but in none does it deserve the same strict attention as the cauliflower-excrescence. The author has known several instances where a profuse discharge of blood has followed the expulsion of a costive motion. Fruit taken be- fore breakfast, honey eaten instead of butter, a little manna eaten with a few blanched almonds, or a tea-spoonful of electuary of cassia taken occasionally, will commonly obviate any inconveni- ence which may arise from costiveness. If a more powerful me- dicine should be required, the following may be tried. R Magnes. sulphat. 3vi. Infus. rosae giii. Aquae carui giift. Syrupi £tf. Acid, sulph. dil. 3fl. M. Sumat cochl. ii. vel iii. mane quotidie. The enlargement of the tumour may be greatly diminished, and the discharge consequently lessened, by the application of cold to the outside of the pelvis, and by the injection of cold fluids into the cavity of the vagina. Cold water may be applied to the external parts of generation, to the pubis, and to the loins, by means of a sponge; and this may be done, not once or twice only in the twenty-four hours, but several times: by keeping the parts in this way constantly chilled, the blood-vessels will be contracted, and the advantages resulting from such a mode of treatment will soon be made evident, in the diminution of the quantity of the discharge, and in the improvement of the consti- tutional health. The recumbent posture ought always to be insisted upon; and WATERY DISCHARGE. 165 the utility of it should be explained to the patient by familiar il- lustrations, as by adverting to the different size of the veins of the hand when held up and in a depending position. All medical men at all conversant with human nature are well aware, that patients who will readily submit to an operation, or to a long continued course of medicine, will very reluctantly yield to any privation, or be governed by moral directions, the imme- diate tendency of which they do not understand. The applications to be made to the tumour itself, with a view to cause contraction of its blood-vessels, and to influence the se- cretion from its surface, should consist of astringent substances in different forms, as may be best adapted to the variety of cases which occur. In the history which has been given of the cauliflower-excres- cence, it has been observed that the tumour increases more ra- pidly in those cases where the tone of the vagina is the least, and vice versa; so that the vagina acts as a supporting bandage in varicose veins of the legs, or as pressure upon those tumours called naevi materni.* For the purpose of applying astringent fluids to the vagina, under ordinary circumstances, the common female syringe (vide Part I. plate) is sufficiently useful; but patients labouring under the cauliflower-excrescence, as well as those in whom there is any abrasion of surface, should be very careful how they use this instrument. A woman who had a cauliflower-excrescence of the os uteri, was very much weakened by the watery discharge attending it. The author recommended an astringent injection, which was used for some time, but afterwards discontinued in consequence of the patient observing that it always produced a discharge of blood: upon inquiring into the manner in which it was employ- ed, it appeared that the pipe of the syringe was carried up so high as to injure the tumour, in consequence of which blood fol- lowed. A cylindrical syringe, the diameter of which is about three quarters of an inch, the extremity being rounded off, may be used for this purpose, and the patient should be cautioned not to introduce it farther than an inch, or an inch and a half. Even if the tumour should be touched with this form of in- strument, it will be less likely to be injured by the diffused * The author has not been so fortunate as Mr. Abernethy, in removing many of these congenital marks by pressure, although he has frequently retarded their growth by means of a compress and strips of adhesive plaister; but they have always returned when the pressure has been discontinued; and in many situations the parts beneath the nsevus are not sufficiently resisting to allow of the pressure being carried to any great extent. Nevertheless the suggestion was worthy of the mind of that humane and intelligent surgeon, whose vera- city has never been suspected, and whose integrity has never been shakcu. 166 WATERY DISCHARGE. pressure made by so large a surface, than by the partial pres- sure caused by the extremity of a small one. The common fe- male syringe may be used with less risk, if a handkerchief or a piece of linen is previously wrapped round it at the distance of about two inches from its point. In that aggravated form of the complaint in which the tumour nearly reaches the external parts, the patient should lie down upon her bed with her hips raised, and a small quantity of the astringent fluid should be poured in between the labia; a com- mon earthen butter-boat may be used for the purpose, and there can scarcely be found a belter instrument. When the tumour has actually protruded, compresses dipped in an astringent fluid may be applied, or the surface may be lightly touched with a soft sponge wetted with it. A few formulae of astringent injections applicable to tfiis case are subjoined. R Zinci sulphat. $$. Aquae rosae, ^iv. Aquae distillat. 5xvi. M. R Aluminis, ~iii. Aquae distillat. 5xv. Mucilag. gum. acaciae, 5i. M. The addition of a small quantity of mucilage renders the ap- plication sometimes more useful, by enabling a portion of the fluid to be longer retained. Or—R Infus. lini, ^xv. Aluminis, 3ii» Tinct. kino, 5i. M. R Cupri sulphat. gr. x. Aquae flor. Samb. Mist, camphorae, ^vi. M. Solutions of the mineral astringents in decoctions of astringent vegetables, constitute applications possessed of great power; as3 R Cort. granat. contus. 5$. Aquae distillat. ixiii. coque per sextam partem horae et cola, dein adde liquori colato aluminis, ^ii. R Gallarum, Jf?. Aquae distillat. |xviii. coque ad ^xvi. WATERY DISCHARGE. 167 R Liquoris colati, jxvft. Sp. roris marini, £$. Aluminis, 3iii- M. R Decocti quercus, fci. Tinct. catechu, ^{j. Aluminis, 3ii* Zinci sulphat. ^i. M. The efficacy of the latter formulae in a great measure depends upon the tannin. As this principle has the power of coagulating albumen, so as to form an insoluble precipitate, it becomes ne- cessary to prepare the patient for a circumstance which may Otherwise occasion great alarm in her mind,—the appearance of thin, whitish, or ash-coloured flakes which will come away from time to time. These are frequently thought to be portions of the body, and the agitation of the patient's mind has been very con- siderable, until it has been quieted by some explanation. In some patients the membrane of the vagina is so irritable, that it will not bear the application of the mineral astringents. In such cases a mixture of decoction of oak-bark and linseed tea will form a less irritating lotion. The principles of management being laid down, the means must be variously modified, as the circumstances of each individual case may require, or as the skill of the medical attendant may suggest. The foregoing directions have for their object the diminution ofthe expenditure of the powers of the frame; but those powers may require to be recruited; the disease may not have been dis- covered until great exhaustion of these powers may have taken place; and it will be necessary to have recourse to the employ- ment of some light tonic. The muriatic and sulphuric acids are here very appropriate medicines. Indeed, custom has so autho- rized the employment of the latter in cases of bloody discharges from the uterus, that they are frequently given by ignorant per- sons indiscriminately, blended in such a manner with medicines, possessing directly opposite properties, as to constitute ineffi- cient, or perhaps very injurious compounds.* * In abortion, many practitioners do not allow themselves time to inquire what object they have in view: whether the accident is threatened by prema- ture inordinate action ofthe muscular fibres of the uterus, or by a separaUoa of a part of the ovum from the uterus; whether the ovum be living, and may remain, or whether il be dead, and must come away; whether the patient be strong, or whether she be weak. Whatever be the concomitant circumstances of the case, the only thing thought about is that a woman is miscarrying who ought not to miscarry; and this is the signal for the exhibition of sulphuric acid and infusion of roses, joined to laudanum; so that there is one ingredient, the sulphuric acid, (a tonic) which increases the power of the muscular fibres ofthe uterus to expel its contents, and another ingredient, opium, the known 108 WATERY DISCHARGE. R Acid muriatici, gult. viii. Aquae distillat. 5i{$. Syrupi cort. aur. 3i. M. Fiat haustus ter die sumendus. R Acid sulphurici, gutt. vi. Infus. rosae, jig. Aquae carui, 5$. Syrupi, 3i. M. Fiat haustus ter die sumendus. Sulphate of zinc may be usefully employed; but care should be taken not to exhibit this medicine so as to produce vomiting, which might be highly injurious, by accelerating the circulation. It should be given in combination with some essential oil, which will reconcile the stomach to its use, when it might otherwise disagree; and it will be found to agree better in substance than in solution. R Zinci sulphat. gr. xv. Extr. humuli, 3i. Ol. cinnamomi, gr. iii. M. Dihgenter et divide in pilulas xv. aequales, e quibus sumat unam bis die. Decoction of bark may form the vehicle for the acids which have been before recommended, or it may be taken in the form of draught after the pill. R Decocti cinchonae, 5i$. Syrupi cort. aur. 3,i. M. The author is justified in repeating, that by a strict attention to, and compliance with, the rules above suggested, nearly every case of this disease may be made more tolerable; and, perhaps, such a change wrought in the size or the actions of the excres- cence, in a few instances, as to remove all the symptoms. A lady, apparently about two-and-thirty years of age, (a friend of Mr. Cooke, a respectable surgeon at Brentford) laboured un- der a continued profuse watery discharge, mixed occasionally with blood: her constitution appeared greatly weakened, she be- came very pale and emaciated, and together with a slight degree effect ot which is, to take off the contraction of muscular fibres, with which view it is exhibited in the passage of a gall-stone, or of a piece of urinary cal- culus, and also in cases of strangulated hernia, to render the return of the in- testine more easy. WATERY DISCHARGE. 169 of swelling of the ankles, she was liable to great palpitation of the heart and shortness of breath. As her weakness increased, she sought relief from tonics and a stimulating diet, under which plan the disorder increased. An examination being made, a mass was found to project from the surface of the os uteri, from which a quantity of blood issued when it was pressed by the finger. Syncope took place in consequence of this discharge of blood, although the quantity was very trifling. The tumour had no re- gular form, and as far as the author could ascertain, the whole of it could have been contained in half a walnut shell. The patient was desired to confine herself strictly to the sofa, to use cold wa- ter in a lavish manner to the pelvis, and to throw a strong astrin- gent injection into the vagina; she was directed to give up the use of wine, to live upon farinaceous food and vegetable jellies, and to lose five ounces of blood from the sacrum by cupping, when she had recovered from the effects of her journey to the author's house. Some weeks elapsed before the author again saw the patient; her watery discharge was considerably lessened, and the bloody discharge had entirely ceased: the ankles were no longer swell- ed, and the general health was improved. The patient was de- sired to repeat the cupping, and to continue the former system of management. Once in about six weeks or two months the author has seen the patient, who has followed up the same mode of treatment, occasionally losing some blood from the sacrum by cupping. At the termination of about two years from the time at which the author first saw the patient, and after an interval of three or four months, she again called upon him, when, so great was the improvement in her appearance, that he hardly knew her. There had been no watery discharge during many months, and the menstruation, which had been interrupted by the weakness of the frame, had now become perfectly regular; the only medicine which had been taken during the latter part of this period, was half a drachm of pulv. cinchonae twice a-day. As the case was al- together a very extraordinary one, it became very desirable that an examination should be made. The vagina was so much con- tracted by the continued use of the astringents, that it admitted the finger with difficulty; on carrying the examination farther, no difference could be felt between the os uteri of the patient and that of a woman in perfect health. Such are the facts of this case: in reviewing it, every one conversant with diseases of the uterus, must acknowledge that it was very extraordinary in its termination. No mystery of treatment hangs over it; very little medicine was given, except what has been mentioned: a few grains of hyoscyamus or conium to allay irritability, a little Ep- Y 170 WATERY DISCHARGE. som salt to regulate the bowels; and when little else than weak- ness remained, a few drops of tincture of muriated iron twice a- day. To the local blood-letting, the horizontal posture, and the use of astringents, then, must be attributed the removal of this disease, which had all the characters of the cauliflower-excres- cence. A lady, about forty years of age, who was a patient of Mr. Tegart, was much reduced by a perpetual drain of a watery hu- mour from the vagina. Whenever she took exercise, blood came away mixed with the other discharge. The skin of the patient was perfectly blanched: until she fell under medical manage- ment, she had eaten meat, and drank wine, suspecting that the weakness of constitution produced the discharge. An examination was made, and, as was expected, a cauli- flower-excrescence was found as large as a hen's egg: similar means to those recommended in the former case were employ- ed, and with a similar diminution of this discharge. The patient now thinking herself recovering, determined, against the advice given to her, to go into the country. The mo- tion of the carriage, during a journey of sixteen miles, produced hemorrhage, which continued; and the patient was thankful when she found herself again upon the sofa in London. Aware ofthe imprudence of having made the experiment, she then be- came rigidly attentive to all the rules laid down, which had for their object the intentions contained in the history of the treat- ment of this disease. The discharge has greatly diminished; during the space of several weeks there was no loss of blood; the patient has been allowed to take a little light animal food, and a small quantity of claret; and there is reasonable ground for hope that some favourable change has taken place in the tu- mour, either as to the membrane which covers it, or the blood- vessels which compose it. In some instances of patients who labour under cauliflower- excrescence, all the resources of the medical art are futile; no check can be imposed upon the discharge by astringents, how- ever powerful as to strength: still, even in such cases, the liga- ture holds out a prospect of relief, which has now and then been realized. The diseased surface of the os uteri may, and proba- bly will, regenerate the fungus; but a considerable length of time may elapse before a tumour of a large size may form; and in the interim, by the removal of the secreting surface, the dis- charge will be restrained, and time will be afforded for the pow- ers ofthe woman to be recruited. A case has been related where the utility of such a mode of treatment has been proved in the person of the widow of a phy- sician at Bath. WATERY DISCHARGE. 171 The operation is the s^me as that recommended for polypus of the uterus, and described in the first volume of this work. More care is required in applying the ligature round the base of a cauliflower-excrescence than round the neck of a polypus, be- cause the cauliflower-excrescence is so likely to bleed upon the least rough treatment. The shield which the author recommended to be attached to the polypus canula, is not so necessary in performing the ope- ration for this disease, because the tumour will be cut through in a much shorter time, and it will hardly be necessary to tight- en the ligature often. The objection to the use ofthe shield in this operation, is the possibility that the weight of it may tear through the tumour, before the blood has coagulated in the ves- sels above. After the removal ofthe disease, it is recommended that the vagina should be washed out with cold water, and that a solu- tion of alum in a strong decoction of oak-bark should be thrown into the vagina twice or three times a day, the external orifice being blocked up with a dossil of lint, so as to prevent the too sudden escape of the fluid. A weak solution of nitrate of silver, or of sulphate of copper, may be preferable in some cases to any other injection: it may be used in the following proportions:— R Argenli nitrat. gr. xii. Aquae distillat. ixii. or, R Cupri sulphat. gr. xviii. Aquae rosae, ^xii. In some cases it may be useful, especially when the vagina is irritable, to introduce a piece of lint wetted with this solution into the vagina, and to carry it up to the diseased part of the os uteri. By such means a slight degree of inflammation may be excited in the blood-vessels, so as to produce a consolidation of the parts diseased; and thus the regeneration ofthe tumour may be more tardy. However favourable appearances may be in that part of the uterus which can be examined by the finger, there may exist out of reach, and consequently without the knowledge of the practitioner, morbid changes of structure, which may of them- selves prove fatal. 172 WATERY DISCHARGE. HYDATIDS OF THE UTERUS. In the cavity of the uterus small vesicles containing a limpid fluid are sometimes met with, constituting the disease called Hy- datids of the Uterus. These vesicles vary considerably in size, from that of a small currant to that of a large grape. They are connected with the uterus, and with each other, by small fila- ments; and portions of a substance resembling partly blood, and partly coagulating lymph, are frequently mixed with them. A similar substance is attached to the internal part of the ute- rus, from which the footstalks of the hydatids grow. As the number of these hydatids increases, the cavity of the uterus be- comes more capacious; and when, at length, the uterus has ac- quired a large size, it seems to be offended by its contents, and contracts upon them. The cause of this complaint has not been ascertained: it some- times appears as a morbid condition of the opake membranes of the ovum; and in such cases interfering with its functions, it destroys the vitality of that body, and thus produces abortion. It is probable that the existence of pregnancy is not necessa- ry for the production of this disease; it has been believed to exist independently of this state; and perhaps a morbid condi- tion of organized coagulating lymph may have the power of originating this disease under certain circumstances, but what these circumstances are, is not known. Hydatids are met with in other parts of the body, but no very probable conjecture has been offered for their production. In many cases these vesicles possess a power of contraction; but whether this power has ever been observed in the hydatids of the uterus, the author does not know; he believes that it has not. It may admit of a doubt whether, in consequence of a morbid condition of the ovaria, some separation of the corpora Graffiani may not induce the complaint. It has been suggested, that diseases of the ovaria may originate in consequence of the excitement of the genital system, and the opinion seems to be entitled to some regard. Hydatids of the uterus do not appear to produce any peculiar symptoms, with the exception of one to be mentioned hereafter. The greater number of the inconveniences attending the dis- ease arise out of the pressure made by the enlarged uterus upon the circumjacent parts, such as retention of urine from compres- sion of the meatus urinarius; constipation of the bowels from compression of the rectum; oedema and cramp ofthe lower ex- tremities. These symptoms, however, are not necessarily pre- sent ; and instances have occurred in which they have been alto- gether wanting. WATERY DISCHARGE. 173 When the cavity of the pelvis can no longer contain the en- larged uterus, that viscus will rise into the cavity of the abdo- men, and may be felt as a circumscribed tumour through the parietes. The function of menstruation is usually interrupted. This might be expected upon the supposition that the complaint was a disease of pregnancy: but it will probably be found that, when- ever the mucous membrane of the uterus is disposed to throw out an opake membrane, resembling coagulating lymph, such as the decidua in pregnancy, or those flakes which are separated in painful menstruation, the secretion of the menstruous fluid is in- terrupted. In painful menstruation, during that period at which such flakes are separated, the secretion is very scanty; but after these flakes (which sometimes form perfect casts of the cavity of the uterus) have been separated, which usually happens about the second day of the period, the menstruation becomes more abundant. In the examination of a patient labouring under hydatids of the uterus, the body of this viscus will be found enlarged, and suddenly bulging out from the upper part of the cervix. All these symptoms attend other enlarged states of the uterus; but there remains to be mentioned one other symptom which serves to distinguish this disease from all others, and from pregnancy, —and this symptom is the discharge of an almost colourless wa- tery fluid. This watery discharge is to be distinguished from that which attends the cauliflower-excrescence, by the irregularity and suddenness of its appearance and cessation; being produced by a rupture of one or more of the coats of these hydatids, in consequence of the occasional contraction of the uterus upon them, or of any sudden violence, as in the act of coughing or sneezing; whereas the discharge from the cauliflower-excres- cence, being a secretion from its surface, is constantly escaping. The fluid watery discharge may be distinguished from those splashes of urine which sometimes come away from pregnant women, by being wholly inodorous. In some cases, the size of the uterus increases rapidly, in others slowly; but in all, sooner or later, the parietes of the ute- rus, being irritated by the distention of the cavity, are excited to contraction. From this period of time, a process resembling labour com- mences; the os uteri is dilated; the hydatids are expelled by periodical pains; and then, for the first time, danger presents it- self in the form of alarming hemorrhage. This hemorrhage is more frightful than that which follows the removal of the pla- centa from an uncontracted uterus; and the reason is obvious, the placenta covered only a limited space of the internal surface 174 WATERY DISCHARGE. of the uterus, whereas the hydatids spring from every portion of the cavity. No means have been hitherto discovered of curing this dis- ease artificially, or of arresting its progress towards its natural termination. The patient is to be informed of the nature of this disease, and the event is to be patiently waited for. As symp- toms arise, they are to be treated as.their nature demands; and the practitioner will best perform his duty by watching over the complaint, and by doing no more than is absolutely required. But when the period arrives at which the uterus is striving to unload itself of its contents, then all his skill and energy will be wanting, and all his efforts will be called forth to control the hemorrhage, and to sustain the powers ofthe constitution. With this view, the patient should be kept perfectly quiet in the hori- zontal posture; she should not be allowed to take any stimulat- ing food, or drink. Cold applications, such as cloths dipped in vinegar and water, or in iced water, are to be made to the loins, abdomen, and external organs; and portions of ice (their acute edges being rounded off by being held in the hand) may be in- troduced into the vagina, or into the uterus. Let it not, howe- ver, be forgotten, that the great remedy for uterine hemorrhage is uterine contraction, and every possible mode of exciting this is to be put in practice. The application of a bandage round the abdomen has sometimes the power of exciting this contraction; but if the hemorrhage should continue profuse, and if any portion ofthe hydatids should remain in the uterus, an attempt should be made to remove these, in order to produce complete con- traction of the muscular fibres. Two or three fingers, or the whole hand, should be covered with pomatum, and carefully introduced into the uterus, and car- ried up between the sides of the uterus and the hydatids, which are to be detached from the part to which they adhere by the most gentle efforts. The mass being now included in the hand of the operator, is to be brought out of the uterus, the surgeon recollecting always, in the performance of this operation, that the degree to which the os uteri is dilatable without laceration, is in proportion to the size of the whole uterus, both in pregnan- cy, as well as in this disease. So that, supposing the uterus in this disease to be enlarged to the size of that viscus in the sixth or seventh month of pregnancy, the whole hand of the operator may be, if necessary, introduced through the cervix; whereas, in smaller dimensions of the uterus, if any attempt is made to introduce the whole hand through the cervix, however carefully it may be attempted, a laceration of it may ensue, and thus the patient may be involved in a new danger. The contents of the uterus being naturally expelled, or artifi- WATERY DISCHARGE. 17^ cially removed, and the hemorrhage being restrained, the strength is to be restored, by allowing the patient a nutritive diet, and by the exhibition of such medicines as tend to increase the tone of the system: amongst which the mineral acids and cinchona may be accounted the most serviceable; these, or other medicines possessing similar properties, should be from time to time exhi- bited, until the vigour of the system shall have been entirely re- stored. The usual cautions given to women after delivery, should be here impressed upon the patient, such as confinement to the horizontal posture until the uterus and the vagina shall have ac- quired their usual size and tone. There is another variety of hydatid of the uterus, in which the uterus is distended by one single cyst and its contents to an enormous size. The author has never seen an instance of this form of the disease; but it appears, from the accounts given of it, that the symptoms are all purely mechanical. Although the uterus may be equally and greatly enlarged, it will be difficult to determine whether such increase of bulk is produced by a single hydatid, or by a deposit of solid matter in the substance of the uterus. The fluidity of the contents of the tumour does not necessarily cause a sensible fluctuation of these contents. A full bladder felt above the pubis does not give to the hand the sensation of a fluid being contained within it. The discharge of a watery fluid in large quantities is, in this variety of the disease, the first announcement of the existence, and the presage of its speedy removal. The water having escaped, the cyst is expelled, and the dis- ease is terminated without the occurrence of any of those dis- tressing symptoms which threaten the patient's life, in the disease first described. The abdomen of the patient will require the sup- port of a bandage. This last variety of the uterine hydatid is a very uncommon disease; so that the practitioner will hardly be prepared for its occurrence. The patient will, therefore, probably be led to ex- pect a disease of long continuance, and will be agreeably sur- prised to find her complaints terminated so expeditiously. Fleshy tubercle of the uterus, being a disease of slow growth, and offering to the finger, in an examination, a considerable de- gree of resistance, may perhaps be readily distinguished from the single hydatid; but, after all, it is only with a view to the prognosis, that the discrimination between them is at all impor- tant; the symptoms which arise in both of them admitting of si- milar modes of relief,—fulness of the bladder by the use of the catheter, constipation by the employment of those purgatives which are found to diminish the consistence of the faeces, and 176 WATERY DISCHARGE. pain arising out of pressure, by the administration of conium, hyoscyamus, and other sedatives. As watery depositions are found to take place into different in- ternal cavities, constituting dropsies of such parts, as ofthe tho- rax, abdominal cavity, he, so it has been supposed that a simi- lar circumstance may take place into the cavity of the uterus, which has been mentioned by many writers under the title of dropsy of this viscus. The uterus, however, possessing an open- ing at its lower part communicating with an external outlet, it is difficult to understand how any accumulation of fluid can take place within it; for, although the sides of the cervix uteri may be agglutinated by its proper mucus, or by adhesion in conse- quence of inflammation, such an occurrence is not very likely to take place; and even if it did happen, a deposit of watery fluid into its cavity would be an extraordinary concurrent cir- cumstance. It is more than probable that the cases described as dropsy of the uterus have belonged to the class of hydatids; or if there be any such disease, in fact, as dropsy of the uterus, the author has never met with a case of it. WATERY DISCHARGE. 177 THE OOZING TUMOUR OF THE LABIUM. There is yet another disease attended by a watery discharge, to which the writer has given the above name. In the first part of this work a description has been given of warty tumours of the labia, and of the vestibulum; but there is no similarity be- tween those diseases and the tumour now under consideration. In the warty tumour, there is an increase of the mucous dis- charge from the vagina, arising simply from the increased cir- culation; but in the oozing tumour ofthe labium, the discharge arises from the surface of the tumour, or rather from interstices in the tumour. The fluid which escapes is of a watery charac- ter, and it is sometimes very abundant in quantity, being renew- ed almost immediately after the surface has been made dry by a napkin. The author has never known blood to escape from this tu- mour, even when roughly handled, so that the complaint is not by any means analogous to the cauliflower-excrescence. More- over, when removed from the body, the oozing tumour retains its form and firmness, which the cauliflower-excrescence does not. The tumour sometimes is so large as to leave scarcely any part of the labia free from it, and to extend to the mons veneris. It seldom projects far above the plane of the surrounding skin, often not more than a line or two, and rarely above one-third of an inch. The colour of the tumour varies little from that ofthe cuticle of the neighbouring parts; and* a projection, very much resem- bling it, might be made by the firm application of a piece of fine netting to an oedematous part during a few seconds, the sur- face being unequal, consisting of irregular depressions and emi- nences, from the former of which the fluid oozes. In the imme- diate neighbourhood of the tumour oedema is occasionally met with, but the tumour itself is not oedematous; soon after the sur- face of the tumour has been wiped quite dry, a watery fluid be- gins to ooze from it, and to form drops, which, having become large, at length run off, and keep the surrounding parts in a state of constant humidity; sometimes soreness and excoriation take place, as upon the upper lip, when the secretion from the nos- trils is increased, but the tumour itself is seldom rendered more sensible. The secretion from this tumour corresponds in appearance with that from the cauliflower-excrescence. Its quantity may be influenced by a variety of circumstances, but it always bears a proportion to the extent of the disease. In damp weather, and z 178 WATERY DISCHARGE. in debilitated states of the system, it will be found more abun- dant than when the atmosphere is dry, and the constitution vigo- rous. It will be seen hereafter that it is controllable by art. The disease having once began, continues to enlarge, and insulated patches of it appear in the neighbouring parts, so that at length they will be found to run into each other. At first sight the complaint may be mistaken for that form of erysipelas which is denominated shingles; but, upon a more careful inspection, it will be found that the projecting parts are solid, and that they do not, as in the disease called shingles, con- tain a fluid. The trifling degree of vitality which the labia in some cases possess, renders them liable to attacks of erysipelas, and therefore the practitioner should be careful in discriminating between the two diseases. In women who are fat and weak (by no means an uncom- mon combination,) the cuticle will sometimes peel off between the labia and the nymphae, and between the labia and the thighs, and an oozing will take place until a new cuticle shall have been formed; but there is little chance of any mistake in this case. The latter circumstance is very usual; the oozing tumour of the labium of rare occurrence. Fat women are the most frequent subjects of the oozing tu- mour of the labium, especially if they have borne many chil- dren, or have had their constitution much impaired. In such habits the complaint seems to arise spontaneously, or at least the author is ignorant ofthe cause producing it. Within the author's knowledge, the complaint does not attack young women; indeed he has never met with it, unless in that bulky state ofthe labia more common after middle life. It is more than probable that many women labour under the disease without making it the subject of complaint; and amongst those who do ask advice respecting it, little regard is paid to it, unless the neighbouring parts have been much excoriated, or considerable weakness produced by the discharge. In one patient, a poor woman, who owes much to the kind- ness of Dr. G. G. Currey, so much inconvenience and general distress was caused by the disease, that after she had been con- fined during some months in the hospital in the Borough, and had afterwards received no benefit from the author, she con- sented to have the labia themselves removed, and thus the dis- ease was cured. When the structure of a part has been greatly altered, or when the vital energy of it is greatly exhausted, a disease form- ing in its substance is not capable of being cured by the ordinary resources of art. No applications of any kind having the power of reproducing, and maintaining healthy actions; stimulants may WATERY DISCHARGE. 179 excite; pressure may control growth; but a relaxation in the employment ofthe means is followed by a return of the malady. How often this is the case in old ulcers of the legs is to be found in the experience of every surgeon. The labia, being endowed with feeble powers of life, become liable to some irreparable alterations of structure. The oozing tumour attacking one labium sometimes produces irritation upon that ofthe opposite side: but in no other way than any extrane- ous body similarly situated would do. The chief inconveniences of this disease are, itching of the parts, sometimes a preternatural sense of heat, and a watery dis- charge; which, if it should be considerable, may greatly annoy, or even weaken the patient. Relief is seldom sought for in these cases until the disease has acquired a considerable size, and even then it would probably often be concealed, unless the apprehen- sions of the patient were called forth. When excoriations of the neighbouring parts are present, or an erysipelatous blush appears upon them, more advantage will be derived from the internal exhibition of the cinchona in sub- stance, than from any other medicine; but no impression will be made upon the disease itself by this valuable remedy, and even the symptoms above mentioned will frequently recur, and call for the employment of the same remedies. As it has been observed that in most instances the vis vitae was impaired, the patient should be desired to live upon a nu- tritious diet, and to take a moderate quantity of wine. As heated rooms and warm seats will always aggravate the symptoms, they should be avoided. Much good may in many instances be done by external ap- plications; by several the discharge may be greatly controlled, and even cease for a time; but the writer has never known the disease cured by them, or even diminished in size; the vessels which exhale the fluid have their orifices either clogged up or strengthened, so that less fluid is poured out. Common starch-powder sprinkled upon the parts again and again, so as to form a cake upon them, is a very efficient reme- dy ; but it will be necessary to keep the patient in the horizon- tal posture during its use; and the posture itself has in all cases an influence upon the discharge, even when no application is made to the parts themselves. A mixture of starch-powder and cupri sulphas, very finely levigated, has been found serviceable; or a solution of cupri sul- phas, or of argentum nitraturn, may be used. A solution of gum arabic in decoctum quercus may be tried. Cold water is also a valuable remedy, and there are no cases in which it will not afford much temporary comfort. 180 WATERY DISCHARGE. Perhaps of all the preparations which may be suggested, none is so effectual as spirit. Strong new port wine has afforded great relief; but, when this has failed, brandy, or arquebusade may be employed, and even alcohol will be useful when the weaker spirits are in no respect beneficial in controlling the discharge. Although the author has made use ofthe terms "frequently," and "in several cases," he wishes it to be understood that he has had but little experience in this disease, which he considers as one of the most uncommon complaints affecting the organs of generation in women. The author has never seen the oozing tumour in the scrotum or prepuce of men, or upon the skin in any other part of the body. In one instance the writer has removed the labia at the earn- est solicitation of the patient. A woman, about forty years of age, who had been in St. Thomas's hospital on account of this disease, applied to Dr. G. G. Currey, who referred her to the author. A variety of appli- cations were made to the parts, some with a little advantage, others with none at all; and at length, the poor woman, being very anxious to get rid of her disorder, a lodging was provided for her, and the labia were removed by the scalpel. The sores granulated and healed without any trouble, and the patient got perfectly well. Such a remedy should hardly be advised until all other means of relieving the patient have been tried without ef- fect; nor even then if the inconveniences are at all sufferable. WATERY DISCHARGE. 181 INVOLUNTARY DISCHARGES OF URINE. In investigating the complaints attended by watery discbarges, the nature of the discharge itself should always be subjected to examination. It may happen that they may consist of urine alone, which, in the adult, may always be distinguished from every other watery discharge by the peculiarity of its smell, especially when the cloths upon which it has been received have been dried. The passage of urine over the labia, and over the skin covering the inside of the thighs, will also produce heat, redness, and inflammation of those parts, circumstances less frequently attended the other watery discharges. Involuntary discharges of urine from the bladder may be either constant or occasional, and they may exist with or with- out destruction of parts. These cases become distressing, be- cause they render the patient very uncomfortable, and some- times lay the foundation of troublesome ulcerations in the parts over which the urine passes. The space allotted to the bladder in a healthy state of these parts, is the cavity ofthe pelvis; and, as the bladder becomes full, it rises into the cavity of the abdo- men. If the pelvis and the cavity of the abdomen should be en- croached upon by any large tumour, there will be no space for the reception of the full bladder; and therefore, at the close of pregnancy, and in other kinds of enlargement of the uterus, the bladder will be capable of containing small quantities of urine only; and, lying between the uterus and the recti abdominis, it will be acted upon by every sudden and strong contraction of these muscles, and a part of its contents will be expelled, as in coughing, laughing, straining, &c. For this case there is no re- medy. Flat sponges sewed into the folds of a napkin should be constantly worn; and if the urine should have stimulated the neighbouring parts, they may be defended from its action upon them by being smeared with the following cerate : R Ung. cetacei, ^ij. Emplastr. plumb. 3ii. M. fiat ceratum. • In consequence of age, and sometimes from other causes, the neck of the bladder and the meatus urinarius will sometimes have so entirely lost their tone, that the urine will flow away as fast as it is secreted by the kidneys, forming a constant discharge. If, however, the patient remains perfectly still, lying at the same time upon her back, the bladder will be enabled to retain seve- ral ounces of urine. This loss of tone may be total, or partial 182 WATERY DISCHARGE. only, in which latter case the urine will not escape, unless upon the employment of some slight exertion. An examination should first be made of the parts, by means of the catheter, in order to ascertain whether any communication exists between the neck ofthe bladder and the upper part ofthe vagina; if no such communication is found, the cause ofthe ma- lady is to be farther investigated. If general debility or a tedious labour should have produced the disease, relief is to be sought for in those remedies which give local and constitutional strength. Large quantities of cold water may be dashed against the parts twice or thrice daily, and the use of the cold bath may be re- commended. Decoction of bark and the mineral acids may be employed three or four times daily; and if these should not pro- duce any good effect, advantage may be taken of the knowledge of the occasionally injurious effects produced by the exhibition ofthe cantharis on the neck of the bladder; and this remedy may be cautiously exhibited twice or three times daily. The tinct. Iyttae of the present pharmacopoeia being a good prepara- tion of this medicine, it may be given in the quantity of twenty drops, and the dose gradually and cautiously increased: blisters may also be applied to the neighbourhood of the sacrum, or of the pubis. Electricity may also prove a serviceable remedy, and should, therefore, not be withheld. Discharges from the Leyden phial may be passed through the pelvis, from before to behind. Should all these plans fail of producing a good effect, recourse may then be had to the employment of those means which, by compressing the urethra, may produce a retention of the urine; and here the mechanical talents of the surgeon may be profita- bly employed. The introduction of a globular pessary of a large size into the vagina may, by its pressure against the back part of the meatus urinarius, effect the intended purpose; and, when the blad- der becomes full, the pessary may either be removed by means of a noose of silk attached to it, or, if the patient should have any difficulty in accomplishing this, it may be pushed backwards by the finger introduced on one side of the ossa pubis; or the pa- tient may be instructed in the method of introducing a catheter. The globular pessary in this case is thus made to produce the same effect, which the pressure of the child's head in labour oc- casionally and accidentally causes. In some cases it may be ad- visable to construct an instrument, consisting of a small steel spring, (in a manner similar to that used to confine letters) to cover it with soft leather, and to introduce one part into the va- gina, so as to press upon the back part of the meatus, whilst the other end of the spring lies upon the anterior part of the ossa pubis. By such a contrivance, the strength of the spring being properly regulated, the urethra may be so compressed as to pre- WATERY DISCHARGE. 183 vent the perpetual discharge of the urine, and the patient may be enabled to remove or to apply it as the state of the bladder may render necessary. The most distressing case of involuntary discharge of urine, is that which is produced by the existence of a communication between the posterior part of the neck of the bladder, and the anterior portion of the vagina. This state of parts may have been produced by violence at the time of labour; or by the long con- tinued pressure ofthe child's head, in cases where artificial means of delivery had not been timely resorted to: and there are few inconveniences to which the human body is liable greater than this; but if the destructive ulceration of carcinoma should have spread itself towards the bladder, pitiable, indeed, will be the state of the patient; for, in addition to the misery attending such communication, there will be present the excruciating pain of this disease. When ulceration is actually present, and extending itself, little assistance can be afforded to the patient; but when the mischief, has arisen from laceration or sloughing, it may be worth while to introduce into the vagina a large thin globular pessary, made either of wood or (which is better) of silver, per- forated by a great number of holes, capable of containing a large piece of sponge. At the lower part of this pessary there should be a circular opening, through which sponges may be removed occasionally; and for this -purpose a piece of string may be at- tached to the sponge, which, being emptied of the urine contain- ed in it, may be again introduced into the cavity of the pessary, without the removal of it from the vagina. Both women and men, liable to incontinence of urine, should take especial care to drink small quantities of fluid only; and the surface of their body should be kept warm, in order to diminish the determination of blood to the interior, as it will be found that such patients are less distressed by their disease in summer than in winter, which is explicable only on this principle. 181 CHAPTER XXV. ON THE PURULENT DISCHARGE. The characters of this discharge are a heavy, yellowish, opake fluid, possessing little tenacity. With the exception of a few cases, the quantity of it is seldom very profuse, and never so considerable as that ofthe watery discharge; and yet the se- cretion of pus is sometimes the cause of so great a degree of de- bility, that the powers of the constitution are quickly expended, of which a variety of instances are to be met with in different parts of the body; perhaps, large purulent secretions may be equally injurious to the frame, with evacuations of blood in simi- lar quantity. Pus may be secreted by membranes in a state of inflammation, and also by ulcerated surfaces; and in the former case, when a part of a membrane is disposed to pour out this fluid, the inflammation which produces it spreads usually to the continuous parts of the same membrane. So long as the disease exists without any breach of surface, pus alone, or mixed with mucus, is secreted; but when pus is secreted by an ulcerated surface, the least violence will cause an admixture of blood with the pus; or, no violence being inflicted, the act of absorption alone will not uncommonly expose bleeding vessels: so that the fluid discharged will be a mixture of pus and blood: and this becomes a tolerably fair criterion, as to whether the pus is se- creted by a membrane in a state of inflammation, or by an ul- cerating surface. The irritation arising from the long continued residence of an old pessary in the vagina produces a purulent discharge, and sometimes a discharge of pus mixed with blood; but, in this latter case, if there is no other disease present, it will be invariably found, that ulceration of the vagina has been pro- duced by pressure; and the finger of the practitioner introduced into it will be capable of detecting inequalities and depressions on its surface. As many cases of purulent discharge are thus attended by a mixture of blood, it will be impossible to make a nice distinction between them. It is the intention, therefore, of the author to de- scribe first the cases of purulent discharge appearing to arise from the mucous membranes ofthe female organs of generation in a state of inflammation, and afterwards to point out those other cases in which the pus is secreted by an ulcerating surface, it being occasionally mixed with blood. THE PURULENT DISCHARGE. 185 Mucous membranes in different parts ofthe body are liable to different degrees of inflammatory action. In some the appear- ance will consist simply of an enlargement of the blood-vessels of the part, and this enlargement arising from the distention of the vessels, will continue for a considerable length of lime, and at length the inflammation will retire, the symptoms gradually subsiding, and no other action taking place; an example of which is frequently found in inflammation of the tunica conjunctiva. Another mucous membrane, taking on inflammatory action, will be attended by a great secretion of mucus, as the membrana Schneideriana; although, sometimes pus may also be secreted by it, but this occurrence is rare. The mucous membrane, which lines the trachea and the cells of the bronchiae, when inflamed, is sometimes attended by an extravasation of coagulating lymph, as in the disease called croup; whereas, in others, it will secrete pus, which will be expectorated in large quantity. The mucous membrane of the intestines, when inflamed, as in dysentery, will separate from its surface tubular flakes of coagulating lymph; and- but in few instances will pus be secreted. The mucous mem- brane, by which the vagina, the cavity of the uterus, and the Fallopian tubes are lined, seems to be very differently affected during the existence of inflammation. In the two latter cases, coagulating lymph is almost always extravasated, when the in- flammatory action is violent. In painful menstruation, (or inflam- mation ofthe mucous membrane ofthe uterus) flakes of coagu- lating lymph are almost always thrown off: in some instances pos- sessing an irregular shape, in others forming accurate casts of the cavity which gave rise to them: and it has happened, when the in- flammatory action has extended itself to the Fallopian tubes, that casts of their cavities have also been voided; sometimes in de- tached portions, in others connected with the superior angles of the triangular portions of the same substance, which lined the cavity of the uterus. In a case of a young lady, under the care of the late Dr. Reynolds and the author, a considerable number of these casts of the uterus and Fallopian tubes was voided dur- ing the space of twenty-four hours. Sometimes, however, the mucous membrane of the uterus being inflamed will secrete pus; and, probably in many cases, this fluid will escape from the va- gina, it being doubtful whether it was formed by the uterus, or by the vagina. In other cases of inflammation of the membrane lining the uterus, a retention of the pus secreted will be pro- duced, in consequence of the adhesive inflammation having at- tacked the lining membrane of the cervix uteri, so as to oblite- rate its cavity. The mucous membrane of the vagina, when un- der the influence of inflammation, rarely gives rise to the pro- 2 A 186 THE PURULENT DISCHARGE. duction of layers of coagulating lymph; but a very slight degree of inflammation will excite purulent secretion. Pus, sometimes, also escapes from the meatus urinarius in women, either gra- dually, or mixed with the urine. In the first case, it is probably secreted by the membrane of the meatus; in the second, by the bladder. THE PURULENT DISCHARGE. 187 On Inflammation of the Mucous Membrane of the Uterus, ter- minating in Secretion of Pus. In this case, when the pus secreted can readily find its way into the vagina, few symptoms will be found to exist, excepting heat and uneasiness experienced in these passages; and, as the fluid escapes out ofthe external parts, it may be doubtful whe- ther it was secreted by the vagina or by the uterus. In some cases, however, the vagina is wholly free from inflam- mation. But the patient is attacked by pain of an acute kind in the back, and at the bottom ofthe abdomen. The constancy of this pain is as great as its severity; and its continuance inducing the practitioner to make an examination per vaginam, he finds the uterus tender to the touch, and its bulk increased, resembling the viscus when in a state of impregnation; the parietes of the uterus gradually yielding, its bulk becomes very considerable. Still, however, from the unusual occurrence of the disease, the true nature of the case is involved in conjecture, until the occurrence of another symptom, which unravels the mystery. Suddenly, a burst takes place; the patient being sensible that something has given way within her, and a large quantity of pus of a very of- fensive odour escapes, when the symptoms are immediately re- lieved. For some days small quantities of pus are evacuated, and at length the patient returns to health; and if an examination of the uterus be made after the discharge of the matter, it will be found greatly reduced in bulk. An unfavourable opinion is usually formed of these cases in their progress: the practitioner fearing, and with reason, that some important morbid alteration of structure in the uterus is taking place; under this impression, (the prognostic leaning to the unfavourable side) the termination of the case, in the manner above described, is an agreeable surprise to the subject of it. And, although, the practitioner may derive credit for the ma- nagement of it, to which, notwithstanding he is not entitled, an impression will be left on the mind of the patient unfavourable to his skill in the art of prognosticating. The duration of this disease will depend upon the degree of the inflammation, and the disposition which exists in the sides of the uterus to yield. The retention of the matter in the uterus may be produced either by the adhesive inflammation taking place between the sides of the cervix uteri, or by the glands in its neighbourhood secreting a tough mucus, filling up its cavity as in pregnancy; or by a great degree of contraction ofthe cer- vix uteri itself. 188 THE PURULENT DISCHARGE. On the 12th of January, 1812, the late Dr. Clarke visited Mrs. A. B., about sixty-five years of age, who had ceased to menstruate many years. A few weeks before he saw her, she had informed Mr. Brande, who attended her, of a small san- guineous discharge from the pudenda. The discharge was not attended by any pain; but as she was rather heated, he gave her occasionally some sulphate of magnesia in infusion of roses, from which she considered that she experienced relief. After this she had, as she informed Dr. Clarke, a discharge, at first like fluor albus, and small, but which afterwards became of a brownish colour, offensive to the smell, and greater in quantity. A very short time before Dr. Clarke saw her, she had experi- enced a more considerable sanguineous discharge, but without any pain. She readily agreed to an examination per vaginam; when the os uteri was found ragged, and much harder than usual. The cervix was ofthe common length, but was hard to the touch. From the upper part of the cervix, a tumour bulged out in all directions, so as to occupy nearly the whole space from the os pubis to the os sacrum. No urgent symptoms were present; but towards the end of the month the patient sent in haste to Mr. Brande, to whom she stated, that she had been suddenly seized with violent pain in the lower part of the abdomen, attended by a sensation, as if something had suddenly given way there, and that she was still in great pain. She had passed her urine at four in the morning. After the attack of pain, however, she could pass no more; but had a frequent desire, attended with uneasiness, to empty the bladder. She was now in a state of extreme weakness and faint- ness, having a small thread-like pulse, and the extremities being cold. Cordial remedies being administered, the pulse was im- proved, and the state of faintness diminished. About half a pint of urine was drawn off from the bladder, and the patient became more easy. In the evening of the 31st of January, the day on which these symptoms appeared, the patient died, having retain- ed the faculties of her mind nearly to the last. The body was examined; and on opening the abdomen, about seven or eight ounces of a most offensive purulent fluid were found in its cavi- ty. When this was cleared away, the part of the small intestines, which presented itself, shewed very strong marks of preceding inflammation. On raising the intestines to expose the contents of the pelvis, a tumour appeared in a gangrenous state, with an opening in the upper part of it, through which, on the slightest pressure, a quantity of offensive pus issued, similar to that which was found in the cavity ofthe abdomen. About five ounces more of matter were removed from the bag which contained it, and which was afterwards discovered to be THE PURULENT DISCHARGE. 189 the uterus in a distended state. Both its external and internal surfaces were of a dark colour, exhibiting nearly the appearance of a mortified part. On the internal surface there was an appear- ance like half-coagulated lymph, but there were no traces of any cyst; so that the fluid was contained in the cavity of the uterus itself. The internal surface of the uterus had a honeycomb-like appearance. The orifice between the cavity and the cervix'was closely contracted, so as not to have allowed the contents ofthe uterus to be discharged through it. The above case proves that matter may be retained in the cavity of the uterus by a contraction of the cervix uteri alone; -it being stated, in addition to the above history, that a probe could be readily passed from the vagina into the cavity of the uterus after death. Eight or ten years ago, the author was consulted respecting a patient, about forty years of age, who laboured under symptoms of inflammation of the uterus. It is hardly necessary to detail all the particulars of this case. It may be sufficient to state, that the inflammatory symptoms ran very high; and that, on examina- tion, the uterus was found to be so much enlarged, as to fill the cavity of the pelvis. At the end of several weeks, after the pa- tient had been considerably emaciated, and a disposition to hec- tic fever had taken place, a sudden and spontaneous discharge of pus issued from the vagina, after which the symptoms ceased, and the patient recovered. In the year 1819, a lady, aged about forty, who had been married to a second husband about six weeks, was attacked with symptoms of inflammation of the uterus. The disease was treat- ed in the usual way, by bleeding, purging, warm bath, Sec. The powers of the constitution were gradually diminished by the great degree of symptomatic fever, and the patient became daily more and more debilitated, without any mitigation of the pain, except that which was produced by the exhibition of large doses of opium. Inability of making water, and of voiding the faeces next presented itself. The former was repeatedly relieved by the use of the catheter. Saline purgatives, in some degree, ob- viated the latter inconvenience. An examination, per vaginam, being again made, the pelvis was found completely filled by an enlarged uterus, which was also perceptible above the pubis. There was no reason to believe that the enlargement of the ute- rus depended upon pregnancy. From this period of the com- plaint, the patient had the additional assistance of Dr. Scuda- more. Sedative injections, repeated doses of opium, and the warm bath, constituted the chief part of the treatment. After some time, whilst in the act of voiding a stool, a sudden dis- charge of pus took place through the rectum, of a most offensive 190 THE PURULENT DISCHARGE. kind. On each succeeding day a quantity of similar pus was mixed with the faeces; and at length the discharge of matter ceased altogether. The uterus returned to its original size, men- struation took place; and when the author last saw the patient, the constitution had acquired a considerable degree of vigour. It may be presumed, that something more than mere con- traction of the cervix uteri must have taken place in the case last described; or, it is probable, that the pus would have made its way through the natural opening, instead of the circuitous mode by adhesion and ulceration. During the author's attendance upon some patients, labouring under enlargement of the uterus, supposed.to be carcinomatous, it has been occasionally remarked, that a sudden discharge has taken place,-of a small quantity of a fluid, of a yellowish-brown colour, after which the patient has remained comparatively easy for some time. As the appearance of this discharge could not be accounted for, it is not improbable that die enlargement of the uterus might, in such cases, be owing to a distention of the ca- vity with pus; the esrape of a small quantity of which from time to time might, by diminishing the degree of distention, relieve the urgency of the symptoms. The author offers this merely as a conjecture, which farther observation and experience may confirm or destroy; but, if it be so, the occurrence, not being very unusual, these cases must exist more frequently than might at first be expected; because other practitioners, whose attention has been directed to the cure of the diseases of the female organs, must often have heard simi- lar remarks made by their patients. The uneasiness attending this disease, the detection of an en- larged state of the uterus, together.with the increased sensibility of the part, will naturally lead to the employment of those reme- dies which are found useful in removing inflammation: and this mode of treatment will be equally applicable in restraining the progress of carcinoma, as in alleviating or removing the symp- toms of this disease. If the habit of the patient be plethoric, twelve or fourteen ounces of blood may be taken by cupping- glasses from the region of the sacrum; or, under any state of constitution, ten or fourteen leeches may be applied to the groins, once in a week or ten days. The use of the hip-bath will be a great source of comfort to the patient, whose hips may be im- mersed in tepid water for fifteen or twenty minutes every night and morning; at which time some warm water may be thrown into the vagina by a syringe. Opium may be exhibited in suffi- cient quantity to diminish the uneasiness of the patient; to coun- teract the astringent effect of which, as well as to lessen inflam- matory action, purgatives must be occasionally exhibited; unless, THE PURULENT DISCHARGE. 191 indeed, sufficient relief can be procured by the administration of hyoscyamus or hemlock, which possess the advantage of not in- ducing constipation. When the uterus has acquired the size which it is found to possess at the fourth month of pregnancy, it is to be presumed that the disease is not carcinoma, strictly so called; no tumour of this character, which the author has seen, having acquired this size; that is to say, ulceration does not take place in such tumours. A reference to a great number of prepa- rations, illustrative of this disease, demonstrates the truth of this assertion. The rapidity of the enlargement of the uterus in cases of col- lection of pus in the cavity of the uterus, comparatively with that of fleshy tubercle, may throw some light upon the nature of the case; and if there is reason to believe that the uterus is dis- tended by pus, it may be advisable gently to introduce the ex- tremity of a bougie, or of a male catheter, into the os uteri, and to pass it onwards, until it has reached the cavity of the uterus. By such a mode of proceeding no harm can be done, and an opportunity may be given to the patient to be quickly freed of her disease. 192 THE PURULENT DISCHARGE. INFLAMMATION OF THE MUCOUS MEMBRANE OF THE VAGINA. The membrane ofthe vagina is liable to take on inflammato- ry action from many causes; and, inflammation being once pro- duced, the membrane is quickly excited to the secretion of a puriform fluid. When the very extensive surface of this mem- brane is considered, it will not be a matter of surprise that the quantity of fluid secreted by it, should be very considerable. In the corrugated state of this membrane, the canal is of small di- ameter; but, when distended to its greatest degree, a very large surface is exposed, the whole of which is endowed with a pow- er of secretion. Inflammation of this part may be caused by the application of any of those circumstances, which excite inflam- mation elsewhere; but the vagina is more especially subject to inflammation in consequence ofthe performance of those func- tions, which succeed to communication between the sexes, the very act of which, in some women, produces the disease. The complaint may also originate from the pressure to which it is liable in the act of parturition. Inflammation also of this passage may arise from specific contagion, which form of the disease is denominated gonorrhoea. In the greater number of the cases of inflammation of the vagina, the disease extends to the neighbour- ing membrane ofthe urethra, as the symptoms appear to show. The disease, being once excited, is much disposed to continue in a chronic form; and after the inflammatory symptoms have all subsided, the discharge will continue profuse for a great length, of time, even under the best management. The symptoms attending both common and specific inflam- mation of this membrane, are not dissimilar. The disease begins by a sense of heat referred to the orifice of the passage and ex- tending "up the body*," the uneasiness is sometimes described as a burning pain, affecting all the internal parts: an intolerable degree of itching of all the external organs is not an unusual concomitant; and the labia themselves become distended, by a greater determination of blood being made to them. If the mat- ter be not carefully washed from the folds of the part, the sur- face becomes superficially abraded; and if it be examined at- tentively, a number of small round spots will be found to cover it. The sexual feelings become stronger during the continuance ofthe disease; a sense of burning is experienced in the act of making water, arising partly from the disease affecting the ure- thra, and partly from the passage of the urine over the neigh- * This is the term usually employed by the patient. THE PURULENT DISCHARGE. 193 bouring irritable parts; and the patient is excited very frequent- ly to void the contents of the bladder, the urine being passed in small quantities only at a time. The interval between the application of the cause and the first appearance of the symptoms in the case of specific conta- gion, differs in length in different persons; depending upon the irritability ofthe parts concerned, the cleanliness ofthe person, or perhaps upon the degree of virulence of the disease in the person communicating the infection. In the generality of cases, the first notice of the existence of disease is given at the end of about eight-and-forty hours; some- times a little earlier; in other cases much later. If the suspicions ofthe patient are excited, the first symptoms will be observed sooner, than by women whose fears are not alive to the subject. Attempts have been made to discriminate between the ap- pearances of the matter secreted in common, and in specific in- flammation; and there are not wanting practitioners who fancy that the matter of gonorrhoea produces a stain upon the linen of a darker or more green colour than common pus. Such persons, in all probability, impose upon themselves; and too frequently, it is to be feared, voluntarily mislead credulous patients. The lymphatic glands in the groin sometimes enlarge, seldom in common, more frequently in specific inflammation of the va- gina; and in some instances, these glands are found to inflame, and to suppurate, although this is a rare occurrence. Where ma- ny glands inflame at once, suppuration is less likely to take place, than when one gland only takes on enlargement. The en- largement of the glands subsides, as the inflammation is removed from the vagina. In simple inflammation ofthe mucous membrane ofthe vagi- na, the purulent discharge being established in large quantity, the inflammatory symptoms frequently subside very rapidly, after which a termination is put to the secretion; the parts re- turning to a state of health, provided there be no acting cause producing its continuance; in which case the symptoms will continue until its removal, when they will speedily cease. In the case arising from specific contagion, the duration ofthe disease is greater; and the discharge, once established, contin- ues for weeks, or perhaps for months, although not always ac- companied by the other local symptoms. It is difficult, if not impossible, to determine at what period ofthe disease the power of communicating infection ceases. A prudent practitioner will be careful to give no decisive opinion respecting the non-existence of this power, as there are no cri- teria by which its presence can be ascertained; and it may per- haps be presumed, that no person is secure from danger who 194 THE PURULENT DISCHARGE. indulges in intercourse with a woman so long as the discharge continues. It is a curious fact, that in young subjects, both male and fe- male, purulent discharge from the urethra and from the vagina takes place in consequence of the existence of irritation in dis- tant par's; thus, during dentition, whilst the capsule of the tooth, or the gum covering it, is violently pressed upon by the crown of the tooth, the above circumstance is not unusual; medical men, therefore, should be careful to avoid denominating this symptom venereal; since, were it actually so, it would lead to nothing useful in the treatment; and discussions, highly de- structive of the peace of families, might be thereby introduced. Histories of cases of gonorrhoea virulenta and gonorrhoea be- nigna, by which names inflammation of the mucous membrane ofthe vagina has been treated of, are to'be found in the works of many excellent writers on surgery, who have also laid down the best directions for the management of the different forms of the disease. It remains only for the author to state, that it ap- pears to him that the mode of treating venereal gonorrhoea dif- fers little, if at all, from that which is applicable to the manage- ment of the case depending upon the application of common causes. It is rarely necessary to carry the employment of anti- phlogistic remedies to any great extent. Temperance, rest, care in avoiding general and local stimulants, mild purgatives, tepid bathing, constitute, perhaps, almost all the necessary remedies. Mucilaginous drinks are generally recommended; and, inasmuch as the salts of the urine being abundantly diluted, will be less likely to stimulate than when in a state of concentration, such diluting drinks may be advantageously employed. Nitiate of potash is frequently exhibited: the author has prescribed it, but perhaps more in compliance with custom, than for any better reason. Great stress has been laid by a writer of deserved celebrity upon the effects of Peruvian bark, in diminishing the irritability of the urethra in this disease.* Upon the authority of this writer, the author has exhibited it; but he has not been happy enough to observe any beneficial effects from it. When inflammatory symptoms have subsided, and when the purulent discharge appears to continue, either from a relaxation of the secreting vessels, or from what has been termed a habit of secreting, the exhibition of Peruvian bark, of the resins, tur- pentine, and above all, of the true balsam of copaiva, has been attended with the best effects. Astringent injections thrown into the vagina, will also be found serviceable; and they may be em- * Dr. George Fordyce. THE PURULENT DISCHARGE. 195 ployed at a much earlier period of the disease, than in the other sex, in whom it has been thought that a foundation has been laid by them for the production of strictures in the urethra. It is true that such strictures have been frequently attributed to the too great strength of the injection employed; but when it is considered that the urethra of different persons varies in its degree of irritability, that man must acknowledge himself to be a very nice prescriber, who can accommodate precisely the strength of bis injection to the peculiar susceptibility of the ure- thra in every individual case. Practitioners of deserved celebrity have differed much upon the subject of gonorrhoea virulenta being followed by secondary symptoms. Few surgeons think it necessary to subject a patient to a long continued mercurial course; many direct the employ- ment of small quantities of mercury only, whilst the majority ne- glect it altogether. The question is of great importance; and the author declines to offer an opinion upon the subject. He has certainly seen cop- per-coloured spots on the bodies of patients, who have laboured under gonorrhoea virulenta, removable only by the oxymuriate of mercury and sarsaparilla: but be thinks that he has seen simi- lar appearances upon the skin of patients, whose chastity could not be suspected. The author has certainly known several instances of married women, who have laboured under a purulent discharge, which might possibly be the effect of contagion, bringing forih children prematurely; some of which have been born dead, and others possessing a dark-coloured furfuraceous cuticle in different parts of their bodies, which appearances have yielded to the use of the milder preparations of mercury. 196 THE PURULENT DISCHARGE. ABSCESS OF THE VAGINA. The labia and the nymphae, but especially the former, are li- able to take on inflammation, which frequently terminates in the formation of matter. The symptoms of this disease and its treat- ment differ so little from those of inflammation in other external parts of loose structure, that nothing need be said respecting them in this place; but purulent discharges from the vagina occasion- ally issue from the cavities of abscesses, which form in the cel- lular membrane surrounding this canal. Such cases, not admit- ting of those modes of cure, which are applicable to other puru- lent discharges from these parts, some observations will be here made upon the subject. In the first place, it is to be remarked, that such cases are of very infrequent occurrence; the common causes of inflammation being much more apt to produce this action in the uterus, or in the membrane of the vagina, than in the cellular membrane which surrounds the passage. At the commencement of the disease, there are no especial circumstances which point out its existence; the practitioner finds symptoms present which denote local inflammatory action, and treats them accordingly. At length a discharge of matter takes place, which shortly ceases, and the patient believes that her complaint is cured. After some time she is again attacked with uneasiness in the part affected, attended with a sense of fulness and of pressure; and again a quantity of pus escapes. These circumstances lead to an examination, when a soft tumour will be found behind the vagina; and pressure being made upon it, pus will escape. After the disease has continued for some time, the general health will be found to suffer, and occasionally, the parts in the neighbourhood will become more than commonly irritable. In the few cases of this disease which have fallen under the care of the author, the menstruation has been usually profuse; which, indeed, might be expected, when it is considered that inflammatory action is taking place in the neighbourhood of the uterus. The author has known this disease arise in single women of lax fibre, in whom no cause for its production could be assigned. Indeed, whenever the disease has occurred, the subjects of it have been weak and irritable women. At different periods of tijne, the glands of the groin become enlarged and hard, and sometimes suppurate. When a collection of matter has taken place in any part of the THE PURULENT DISCHARGE. 197 body, the absorbents are disposed, by their action, to form a communication either with the surface of the body, or with an internal cavity having an external opening, provided such cavity lies adjacent: and, ceteris paribus, the abscess will break where the action of the parts is the most considerable, and the tempe- rature the highest. For instance, if an abscess takes place in one of the labia, a natural opening will be more likely to occur in that part which is in contact with the labium of the opposite side, than externally. When abscess takes place in the cellular mem- brane surrounding the rectum, it will frequently burst into that gut, instead of on the outside of the anus. So, in like manner, when abscess takes place in the cellular membrane, surrounding the vagina, it will be found to break more frequently at the up- per part, where the action of the vessels of the parts is the great- est, than at the lower part, notwithstanding the pressure made upon it by the matter contained; and, out of this circumstance arises one of the greatest inconveniences attending the disease; the abscess in this way being seldom emptied of its contents, which become, from retention, highly offensive; the supernatant quautity escaping out of the mouth of the abscess, when its ca- vity can contain no more. Cases of the above description become very unmanageable, even when clearly understood. It is evident that no astringents can restrain the discharge, that no stimulant can be thrown into the cavity of the abscess, so as to induce a contraction of it, ad- hesion between its sides, or granulations; and unless the most depending part of the abscess should be situated so low, as to be capable of being brought within sight of the surgeon, it would be hazardous to attempt an operation, so as to expose its cavity, or to introduce any extraneous body, such as a seton, to excite a new action within it. In the year 1818, a young lady, recently married, laboured under an offensive purulent discharge, not constant, but occa- sional, and which always followed communication with her hus- band; so that the case was involved in some obscurity. A ten- derness of the surrounding parts was present, and the general health was a good deal impaired. It was ascertained, that, al- though some uneasiness attended connexion, the patient was rendered more comfortable for several days afterwards. The lady (who lived in the country) came to London, and placed herself under the care of the author. Mr. Cline also saw the patient two or three times in consultation. On examination, a bag distended with fluid could be felt behind the vagina, and the lower part of this being pressed upon, a highly offensive pu- rulent discharge of a greenish colour came from the Ujjper part of the vagina. The pressure being continued, all the matter es- 198 THE PURULENT DISCHARGE. caped, and the bag could be no longer felt. Thus it was satis- factorily explained why the symptoms were diminished by the coition, and how this produced an evacuation of the contents of the bag. It was not judged proper to resort to any chirurgical opera- tion: a plan of treatment was directed, having for its intention the improvement of the health of the patient, and the prevention of accumulation in the cavity of the abscess. The patient returned into the country; the powers of her con- stitution were restored; the discharge diminished, and ceased to be offensive; pregnancy took place, and the patient was deliver- ed prematurely, in consequence of some exertion which she had undergone. Another case, not very unlike the preceding, occurred in a lady in the country, who fell under the care of Mr. Dairymple, of Norwich, and the author. It is hardly worth while to describa the particular circumstances of this case. It is to be observed, however, that it terminated equally favourably with the former, in consequence ofthe employment of similar means. A young lady was attacked with pain about the pelvis, attend- ed with soreness of the vagina, and she was incapable of bearing the slightest exercise in a carriage without an aggravation of all the symptoms. A brownish puriforrn discharge, of an offensive smell, was occasionally voided; the functions of the stomach were disturbed; the powers of the constitution flagged, as well as those ofthe mind. An examination was made by the author; but he discovered little, except that, on the removal of the fin- ger, a purulent discharge followed. The uterus was perfectly healthy. This case was also attended by Mr. Murray Forbes. The patient employed a variety of different remedies, both local and general; and although she gained strength, and her spirits improved, the author cannot flatter himself that the means which he suggested were of the least service in removing the disease itself. It is to be observed that in all the cases of this disease, the discharge is not constant, as from an ulcerated surface; but that the patient is sometimes entirely free from it, whilst at others the quantity of puriforrn fluid is very considerable. THE PURULENT DISCHARGE. 199 ON ULCERATION ATTACKING THE OS UTERI AND THE CERVIX UTERI. It has been too much the custom with practitioners to consi- der all the different kinds of ulceration, taking place in these parts, as terminations of the disease called scirrhus or carcino- ma. This opinion has been strengthened by the fatal termination of such ulcerations. But there are two varieties of ulceration at- tacking these parts, which, although both fatal in their conse- quences, produce symptoms differing very much from each other. In the second edition of Dr. Baillie's work on Morbid Anatomy, a disease called Malignant Ulcer of the Uterus is described, and Dr. Baillie has the candour to state that, in his first edition, he confounded this disease with scirrhous enlargement, considering these as varieties of the same complaint. It has been the custom of the author, during a period of six- teen years as a teacher, to describe two different kinds of ulce- ration of the uterus, both of which may be considered as malign; the one under the denomination ofthe corroding ulcer ofthe os uteri, the other under the name of carcinomatous ulcer. These will be separately considered. 200 THE PURULENT DISCHARGE. ON THE CORRODING ULCER OF THE OS UTERI. This complaint usually occurs at that period of life at which the secretion of the menstruous fluid becomes naturally inter- rupted. The age at which this happens, it is well known, varies in different women. The author does not recollect having met with an instance of the disease before the age of forty, and it commonly takes place between that age and fifty-five. It would be expected, a priori, that diseases of increased ac- tion would be especially likely to arise at this time, in conse- quence of the cessation of a long-continued secretion. Even when no change of structure lakes place in the uterus, that viscus is commonly found of a larger size than is usually met with in the unimpregnated state in an earlier period of life, and it is not until the balance of the constitution has been re- stored, that the organ is again brought back to its original size. It is not here meant, that any considerable degree of enlarge- ment takes place, but just what might be expected to occur in a part to which the usual determination of blood is made, but from which the accustomed secretion has been removed. When inflammation attacks a part, if its progress be not ar- rested, it sometimes happens, especially in situations where loose texture prevails, that abscess takes place. In situations possess- ing a firmer texture, it more usually happens that an extravasa- tion of coagulating lymph is formed, occasioning a thickening of the part. The inflammation proceeding, ulceration takes place in the part so thickened. Sometimes, however, this is not the case, and the symptoms of inflammation retire when the arteries have effected this change of structure. In other cases, especially where inflammation attacks mem- branes, the morbid action proceeds to another stage, in which the action of the absorbents produces what is termed ulceration, no intermediate thickening of the parts concerned having been effected; and this is the peculiarity of that disease which is called the corroding ulcer of the os uteri. It has been so much the custom with writers to have recourse to other languages to designate different diseases, that it may be thought that a better name might be given to this complaint than that of " the corroding ulcer of the os uteri." But as it is the object of the author to be understood, he prefers the above name. If another reason for employing this term should be ex- pected, it is briefly this,—that it was employed by the late Dr. Clarke, whose acuteness and talents were only equalled by the THE PURULENT DISCHARGE. 201 simplicity of his manners at the bed-side, and in the lecture- room: and who strove, not to be admired, but to be useful. When once ulceration has produced a breach of surface in a membrane, il frequently happens that such ulceration extends itself over continuous parts of such membrane, so as to enlarge its surface; in other instances the process involves the more deep- seated parts, causing an excavation, with no enlargement of the original boundary of the ulcer. In the corroding ulcer of the os uteri, the membrane which covers it first takes on disease, and very shortly afterwards the ulcer extends to the whole circumference of the opening, and to the parts immediately beneath it; so that the natural shape of the os uteri is destroyed. Thence the ulceration proceeds to the cervix, and consumes it; so that, if the patient should die in this Stage of the disease, nothing will be found, after death, but the body and fundus of the uterus. Sometimes the disease does not stop here, but, before the patient is destroyed, the absorbents employed in the process of ulceration will have taken up nearly the whole body of the uterus, so that very little more than the fundus will remain. In the author's collection, there are three preparations show- ing the disease in all of these different stages. This does not happen in the carcinomatous ulcer, by which the patient is worn out before there is time for such a degree of absorption to have happened. If an examination be made per vaginam, the breach of surface may be readily distinguished^ and the extent ofthe disease ascertained; but no hardness ofthe parts will be present, no thickening, no deposit of new matter. If the body of the patient be inspected after death, there will appear abundant evidences of the destructive process, but no hardness, no thickening, no deposit of new matter; so that, dur- ing life, and after death, there is a tangible and visible difference between the corroding ulcer, and the ulceration of cancer.—A manifest distinction between these two diseases will be met with also in the Symptoms. Changes in the temperature of different parts of the body so frequently occur, that but little attention is usually paid to them. A sense of extraordinary heat in a part may be noticed; it may subside, and be forgotten: so, in this disease, a sense of warmth referred to the upper part ofthe vagina, may arrest the attention of the patient, but may not excite apprehensions respecting its cause, until either it has been greatly increased in degree, or ac- companied by other symptoms. Sc 202 THE PURULENT DISCHARGE. It is not unusual with women to refer all extraordinary sensa- tions, arising at the time ofthe cessation ofthe menses, to what they term "the change of life;" and to consider that, when they have thus accounted for their diseases, they have at the same time cured them. The menstruous secretion, it has been already said, has ceased; in its stead a yellowish discharge escapes, perhaps trifling in quantity, and now and then mixed with a streak of blood; by degrees the sense of warmth is converted into a glowing heat, affecting the region ofthe uterus; and it is by-no means uncom- mon with patients to state, that they feel " as if a hot coal was within them." As this sensation of.heat increases, so the quantity of the dis- charge increases, the ulceration extending more rapidly. The perpetual drain necessarily diminishes the quantity of circulating blood; in consequence of which the countenance be- comes pallid, and weakness of the whole system is produced. The effects of weakness upon the muscles, the arteries, the heart, and the absorbent system, are too well known to need any de- scription here. It will be sufficient to state that the effects of de- bility will be visible in the want of the due performance of the functions of these and other parts. Supposing that this disease were carcinomatous ulceration, amongst an assemblage of other symptoms the most prominent would be, the lancinating pain, which invariably attends that complaint. In the corroding ulcer, lancinating pain forms no part of the symptoms. By this assertion, it is not intended to convey a no- tion that a disease so formidable as that which has been described can exist wholly without uneasiness; an ulceration of the leg will be attended with pain, but by no means comparable with that at- tendant upon cancerous ulceration of the scrotum or mammae. It appears, then, that pain of an intense and acute kind is not a character of the corroding ulcer of the os uteri. When a finger, introduced into the vagina, is made to pass over the ulceration, the patient does not complain of pain; she does not suddenly shrink from pressure, as when carcinomatous ulceration is present: but if asked what sensation she experi- ences, she will commonly reply, that she has a sense of soreness. From what has been said, the author trusts that a disease has been described of a distinct kind, being nevertheless allied to what has been called cancer in its termination, possessing uni- formly a fatal tendency, although the corroding ulcer will last during a much greater length of time, unless attended by violent hemorrhages, which arise sometimes from the exposure of blood- vessels, the coats of which are destroyed by the ulcerative pro- cess. THE PURULENT DISCHARGE. 208 Treatment. In no disease is it more important to attend to the early symp- toms, than in inflammation. By so doing the most frightful con- sequences are frequently prevented, and the safety of many or- gans thereby ensured; as when this process attacks the brain, the eye, the lungs, &tc. It is true that the uterus performs no office in the constitution when menstruation has ceased; it re- mains an inactive, and thenceforward a useless part, liable, how- ever, to suffer materially from morbid changes, and to involve the constitution at the same time in destruction. When once the ulcerative process has commenced in this disease, the part at- tacked by it never, as far as the author's experience has gone, recovers its healthy structure; but increased action ofthe blood- vessels of the os uteri, which would eventually terminate in ul- ceration, may probably be diminished or controlled, so that no ulceration may take place, and, by such a mode of treatment, much advantage is gained. Whenever, therefore, a patient in whom the menstruous se- cretion has recently ceased, complains of an increase of heat in the lower part of the back, or of the abdomen, or in the parts of generation themselves, a prudent practitioner, foreseeing the probable result, will direct the loss of some blood from the neigh- bouring parts. The most precise mode of obtaining this blood will be by cupping; although, if the patient be averse to the ope- ration, leeches may be applied; but, upon the whole, they do not afford the same certain and immediate relief, neither can the quantity of blood removed by them be so exactly estimated. The operation of cupping should be repeated at the termina- tion of a fortnight or three weeks; and, if the sense of heat should continue, the further loss of blood should be directed. The only disadvantage which can arise from this practice, will be a tempo- rary weakness,—a circumstance of no importance when com- pared with the magnitude of the complaint which it is the object of the treatment to remove. General bleedings from the system will afford little or no re- lief; and will, as is well known, induce a greater degree of de- bility. The immersion of the hips of the patient in warm water twice a-day will be found highly serviceable; and the hip-bath will be the most convenient mode of employing this remedy. The heat of the water should be so regulated that it should not exceed ninety- four degrees; neither should the temperature be such as to in- duce any feeling of chilliness. Some of the water in which the patient sits may be thrown into the vagina by a female syringe. 204 THE PURULENT DISCHARGE. If this remedy be useful in the early stage of the complaint, it is no less so in that in which ulceration has taken place, as by means of it the parts will be kept clean, and the pus removed soon after it has been secreted. When the patient has not the means of procuring the convenience of the hip-bath, she may apply warm water by sponges to the lower part of the abdomen, and to the external organs of generation; and the use of the sy- ringe with warm water will be still more essential than when more perfect modes of ablution can be attended to. Saline purgatives, exhibited in very small doses, possess not only the power of allaying inflammation, by the watery secre- tions which they produce from the intestines, but they appear also to possess a specific power of tranquillizing the system, when in a state of disturbance and increased action, even when they produce very little sensible effect. Twenty, thirty, or forty grains of magnesiae sulphas, or potas- sa? sulphas, may be exhibited twice in each twenty-four hours; and the beneficial effect of these medicines may be still further increased by combining them with very moderate quantities of extractum conii, or extractum hyoscyami. The neutral salts may be made more agreeable by the addi- tion of a small quantity of some aromatic water; and, if nausea should be produced, four or five drops of tinctura opii may he added to each dose, instead of the other vegetable sedatives. There can be no objection to the employment of sarsaparilla, or of any medicine supposed to produce an alterative effect, pro- vided that such medicines are not found to derange the func- tions of the stomach, or in any way to impair the powers of the constitution. There is too much reason to fear that both of these effects are unintentionally produced, when patients are desired to swallow a quart or three pints of decoctum sarsae in the course of each twenty-four hours. An abstemious diet should be enjoined; and the food should be of such a nature as will neither form blood readily, nor stimu- late the patient, nor oppress the stomach. Fish, puddings, boil- ed fruits, and vegetables, will constitute the best kind of nourish- ment. It need hardly be stated, that every thing which can excite die action of the parts concerned should be studiously avoided. Hitherto it has been supposed, that the disease has been in its infancy; but, let it be allowed that ulceration is proceeding, and that the patient is already weakened by the quantity of the pu- rulent discharge, what supports that ulceration but the inflamma- tory process? what remedies will be more serviceable than those which retard it? so that, even in this second stage of the disease* THE PURULENT DISCHARGE. 205 the remedies applied to the first stage will be equally proper. At length, however, it may happen, that the patient may be so much weakened by the purulent secretion, as to render it probable that she may sink under its effects. Mild astringent fluids, in the form of injection, may then be thrown into the vagina, the posture ofthe patient during the use of them being such as to favour their application to the seat of the disease. In the progress of the ulceration, hemorrhage may arise; to restrain which, some stronger applications will be necessary, such as solutions of sulphas aluminae in decoctum corticis grana- ti; or, if this should be inefficacious, solutions of cupri sulphas, or argenti nitras. Small doses of acidum sulphuricum, given in equal parts of decoctum cinchonae and infusum rosae, will sometimes be found useful auxiliaries; and both in the early and the latter stage of the disease, the patient should remain constantly in the horizon- tal posture, if she sets any value upon the continuance of life; and the necessity of attending to this latter direction should be enforced in the strongest manner by the practitioner. 206 THE PURULENT DISCHARGE. ULCERATED CARCINOMA OF THE RECTUM. The vicinity of the rectum to the uterus, the sympathy be- tween these parts, and the effect produced by the action of the one upon the other, will account for an assemblage of symptoms in diseases of both of these organs, of a mixed nature; so that without an accurate inquiry and an examination, it will be diffi- cult to determine which part has become affected. Many instan- ces have occurred in which a complaint of the rectum has been treated as a disease of the uterus; and even a greater number, where alterations in the structure of the uterus have been re- ferred to the rectum. In proportion as the practitioner is engaged in treating the complaints of one or the other of these parts, he will be led to attribute the symptoms to that organ to which his attention has been chiefly directed. Whenever, therefore, symptoms of carcinoma in the rectum or in the uterus present themselves, it should be first recollected that, as the latter part is more liable to the complaint than the former, it is probable that the uterus is the seat of the disease. In the first volume of this work, the first stage of carcinoma, both ofthe uterus and ofthe rectum, has been considered; and it now becomes necessary to record those changes which take place in consequence of the ulcerating process commencing, which converts the complaint into what has been familiarly call- ed cancer. The mucous discharge which attends the early stage of car- cinoma of the rectum, becomes gradually of a purulent nature, and the quantity of pus secreted will be found to be in propor- tion to the length of the intestine included in the disease. The appearance of pus at the anus may lead to a suspicion that fistula exists; but an examination of the parts will shortly put this question at rest. If the finger of the practitioner be carried into the rectum, it will be girt by a constriction of considerable thickness, through which it cannot be passed; and if any attempt is made to sur- mount the difiiculty by violence, the patient will suffer excruci- ating pain, and a discharge of blood will be the consequence of such a rude inquiry. The surface of the constricted part, instead of possessing the smoothness of the villous coat of the intestine, will be sensibly abraded; and it will be scarcely possible to conduct the investi- gation without producing some discharge of blood. The existence of the disease being once known, the surgeon should not be too solicitous to ascertain its extent, as no advan- THE PURULENT DISCHARGE. 207 tage can arise from such knowledge even when acquired; be- cause it is not here, as in the more superficial situations of the disease, that it can be removed by operation; previously to de- termining upon which, it would of course become necessary to be acquainted with the boundaries of the disease. The most tri- fling case of carcinoma existing in an internal part requires the same vigilant care, as one in which the disease has proceeded to a much greater extent; and the same fatal consequences will be found to ensue from a small carcinomatous thickening of the intestinal canal, as from a larger portion being involved in the disease, the patient being frequently cut off not so much by the symptoms arising from the disease itself, as from the effects pro- duced by such disease upon the functions of the organ which is the seat of it. A large tubercle of the liver may exist during many years without proving fatal; but a small tumour of that organ, situated so as to compress the gall ducts, may destroy the patient in a much shorter time by producing jaundice, dyspepsia, emaciation, and dropsy. Very little is known respecting the diseases ofthe pancreas; but a trifling thickening of the head of that viscus pressing upon the gall ducts may produce irremediable jaundice, dropsy, and death. An enlargement of the mesenteric glands may exist to a con- siderable extent, attended only by symptoms of debility; but such a consolidation of them may be produced as may com- press the large blood-vessels at the posterior part of the cavity ofthe abdomen, and as to cause convulsions and death; a pre- paration of which the author has in his collection. In like manner, carcinoma affecting not more than a quarter of an inch of the rectum may, by obstructing the passage of the foeces, cause a distention of the whole colon; and the patient may die of inflammation of the coats of the gut produced by such distention. If three inches of the intestine had been involved in the disease, the symptoms would only have been the same; so that neither will the treatment be improved, nor the prognos- tic be assisted by the knowledge of the extent ofthe complaint. When common ulceration attacks a part, such part is destroy- ed by it; but where the ulceration of carcinoma exists, the de- posit of new matter by the arteries more than counterbalances the effect produced by the action of the absorbents, and the thickening and the destructive process proceed simultaneously. The functions of the rectum, as a reservoir for the foeces, and as a canal through and by which they are to be ejected, render it impossible to maintain this part in a slate of rest; and the con- stant pain belonging to the disease will be materially aggravated by the disturbance to which the parts will be occasionally subject. 208 THE PURULENT DISCHARGE. If the constipation attendant upon carcinoma of the rectum be not referred to its true cause, and if the patient be frequently ex- posed to the action of purgatives, the symptoms of the disease will be increased by the very means employed to alleviate them. All the symptoms which attend the first stage of this disease will be found to exist in a greater degree in the second. The darting pain will be increased both in frequency and in violence; the action of the heart will be greatly, and permanently accele- rated; the functions ofthe stomach will become more and more impaired; vomiting will be almost constantly present; temporary relief will be found only in opium; and permanent rest only in the grave. In the progress of the ulceration, blood-vessels will be exposed which will pour out, according to their size, a larger or smaller quantity of blood; and ha^py would it be for the pa- tient if such hemorrhage should prove fatal; but such an event is hardly to be expected; and, unless in parts more abundantly supplied with blood than the rectum, such an occurrence is sel- dom met with. The ravages of carcinoma extend in all directions; most where the disease is least resisted. Thus it will occasionally happen that the parts which form the barrier between the rectum and the va- gina will be destroyed, and a communication will be formed be- tween the two cavities; or it may happen that distention ofthe upper part of the rectum by foeces above the seat of the disease may cause common ulceration of the coats ofthe intestine and of the vagina; and the foeces may from this cause also be voided through the latter passage during the continuance of the patient's life. From this point of time, the disease in the rectum proceeds after the manner of external carcinoma; the part in which it ex- ists, having ceased to perform its accustomed functions, becomes no longer annoyed by serving the purpose of a canal. Great stress has been laid upon the fcetor of the discharges from cancerous sores; that they are offensive is beyond doubt, but it is probably in consequence ofthe sloughing progress which commonly in some degree exists in such sores, and not from any peculiarity of the discharges themselves. Common pus to which the access of air is allowed will become putrid; and it will be difficult to wash away the discharges from the parts, as soon as they are secreted. • In those instances where a communication is formed between the rectum and the vagina, the mixture ofthe contents of the intes- tinal canal with the discharges will give them a fa*culent odour. As ulcerated carcinoma of the rectum, and of the uterus, re- quire a mode of treatment nearly similar, the reader is referred to the observations which will be made upon the subject of ul- cerated carcinoma of the uterus, with regard to that point. THE PURULENT DISCHARGE. 209 ULCERATED CARCINOMA OF THE UTERUS. A carcinomatous tumour ofthe cervix ofthe uterus, or a thick- ening of that part, may arise between the age of thirty and forty, and the woman may die of some other disease during its con- tinuance; or she may live many years under proper manage- ment, and provided she will submit to certain privations. 1 he treatment of the first stage of this disease will be found in the first volume of this work. Sometimes, however, notwithstanding all the means employed on the part of the practitioner, and all the disposition to submit to the rules laid down, upon the part ofthe patient, a new action will take place upon the surface of the tumour, or thickening; namely, absorption, or the ulcerative process. .. In one patient, ulceration will be found to attack a small part only of the surface of the tumour; in another, the process wiU commence all at once over a more extended surface. In the former instance, the disease will be a longer time be- fore it proves fatal; in the latter, cateris paribus, the progress of the disease will be more rapid. A great difference is also ob- servable in the quickness with which the disease proceeds at the commencement of the ulcerative process, and after it has con- tinued some time; and this is attributable to the failing powers of the patient, in which case the action of the absorbents being lessened, the ulcerative change proceeds more slowly. Practi- tioners should be well aware of this fact, or they will be led has- tily to make a false prognostic respecting the duration of the complaint, estimating the future steps of the disease*, by the for- mer. . , , Thus a number of instances will be found, in which the pa- tient will exist in a state of exreme weakness during many weeks or even months, contrary to the expectations of the medical at- tendant. Spontaneous bleedings from the ulcerated surface, pro- ducing more sudden debility, will have the same effect in retard- ing the progress of the disorder. m # At the commencement of the ulcerative process, it is not un- usual for the patient to complain of a puffy and enlarged stale of the external organs, which owes its origin simply to the in- creased action and distention of the vessels in the neighbour- hood. A great degree of itching is another frequent attendant, and erisypelas occasionally takes place in the vicinity. The cuticle is often found to desquamate; a trifling oozing ensues, which dries upon the surface, forms furfuraceous scales, and constitutes a new source of irritation. These latter inconve- 2d 210 THE PURULENT DISCHARGE. niences, are by no means confined to the external organs of ge- neration, as they are usually called; but they extend themselves towards the groins, and to the inside of the thighs; the vestibu- lum becomes irritated by the discharge, which assumes an icho- rous, and shortly afterwards a purulent appearance. But the quantity of the discharge, is by no means comparable with that which is met with in some other diseases of those organs. The pus discharged in these cases, has usually a foetid odour, the reason of which has been before i^iven. The quantity of the discharge sometimes greatly diminishes, although the disease advances, in consequence ofthe diminished quantity of blood in the circulation; streaks of blood are occasionally mixed with the pus which escapes; or small coagula come away; or hemorrhage may take place in quantity sufficient to cause syncope, and to excite great alarm in the mind of the patient. If the bladder and the rectum have not sympathized with the disease in its early stage, they will seldom escape at this period, not only from the consent which obtains between all these or- gans, but also from the disease extending itself to these in com- mon with all the adjacent parts. Such a degree of thickening of the meatus urinarius, sometimes takes place, as to impede the passage of the urine, and to require the use of the catheter; shortly after which the urine will gradually and spontaneously escape, not through the urinary passage, but from a communi- cation formed between the posterior part of the neck ofthe blad- der and the vagina. Portions of coagulating lymph will frequent- ly be washed away from the parts in the passage of the urine. When the vicinity of the rectum to the uterus is considered, it will be expected that a communication between the former part and the vagina would at the same time take place; but this is not so, as in many cases where there is a fistula of the blad- der, there will be found no communication between the intestine and the vagina. Still, however, this circumstance is now and then met with, and from the moment that it is established, no faeces pass through the anus; the external parts forming the channel through which urine from the bladder, faeces from the rectum, and pus from the ulceration, are discharged. The stench now becomes intole- rable, and the hips of the patient, lying almost always immersed in the excreted matters, the soft parts inflame, and sloughing lakes place. Whilst these changes are going on in the organs which are the seat of the disease, others no less visible and distressing are met with elsewhere: the circulation becomes hurried, and the additional wear and tear, produced by this circumstance, in- creases the emaciation always attendant upon this complaint. THE PURULENT DISCHARGE. 211 The fat is absorbed in every part of the body, so as to expose the shape of the skeleton; the muscles shrink, and by degrees the blood-vessels become drained of their contents, the pulse ac- quiring a character of hardness, from the necessarily increased action ofthe coats of the arteries upon the diminished quantity of their contents. The constitution possesses no power of com- pensating for this waste of strength and of substance; the func- tions ofthe stomach fail; little food is received, less is digested; and sometimes incessant vomiting takes place, first of ihe mat- ters usually contained in the stomach, and afterwards of bile, which regurgitates into the stomach from the violent efforts of retching. Small ill-conditioned sores arise in the angles of the mouth, and teaze the patient not a little, the tongue becomes sore, its surface being sometimes pale, dry, and glossy, and some- times having a dark red colour. The mucous membrane which lines the mouth is liable to small ulcerations, having a languid base; and these are called aphthae. Perhaps none of the mucous membranes in the body are exempt from these appearances, in certain states of weak- ness produced by long-continued disease. They are occasionally seen about the margin of the anus, and the author has frequently noticed them upon the surface ofthe vestibulum. A burning heat of the stomach, and of the intestinal canal, be- comes another cause of distress to the patient; this sensation may be dependant in part upon the irritating quality of the flu- ids of the stomach, and in part upon the presence of aphthae in the primae viae. Another symptom, by which the patient is much distressed, is an insatiable thirst, which nothing can allay. This greediness of liquids is not present during the whole of the dis- ease, but it arises at that part of the complaint at which so little blood remains in the blood-vessels as not to furnish fluids for secretions. Something like this takes place in hemorrhages when they become profuse. To sum up the patient's misery, to ren- der her situation more distressing, she is tortured by a violent, acute, and darting pain, sometimes resembling a sharp instrument piercing the pelvis in different parts; becoming sometimes so in- tense as to cause the most patient woman to exclaim; and de- priving her of all quiet by day, and all repose by night. Thus it appears that the situation of a woman labouring under ulcerated carcinoma of the uterus is infinitely more pitiable than that of a woman who has the disease in her breast; for not only are the symptoms more numerous, and more insufferable, but she has not the good fortune to be cut offin the progress ofthe disease by accidental symptoms. In ulcerated carcinoma oi the breast, the patient is usually destroyed by hydrothoiax; but no $uch blessing is afforded to the subject of this disease in the ute- 212 THE PURULENT DISCHARGE. rus, the sufferer being compelled to endure till her frame is ex- hausted by pain, by vomiting, by want of sleep, by discharge, by an offensive atmosphere, or by gangrene of the integuments. Treatment. In considering the mode of treating ulcerated carcinoma of the uterus, regard must be had to the cause of this disease, which, although not obeying the laws by which common inflam- mation is governed, is nevertheless controlled by the employ- ment of those means which subdue that process when arising from the application of common causes. Whenever a patient, labouring under carcinoma of the uterus, has placed herself un- der the constant care of a physician or surgeon, it will be neces- sary that he should watch with attention the changes which take place in her constitution. If he should find the circulation be- coming accelerated, the skin more than usually hot, flabbiness ofthe integuments, softness and shrinking of the muscles in dif- ferent parts of the body, he may presume that some important change has taken place in the diseased organ. If, together with these symptoms, the lancinating pain has been rendered more acute; if the sympathies between the uterus and the adjacent parts, or between that organ and the stomach, have been more than usually called forth; or if, lastly, the mucous discharge has assumed a puriforrn character, there can be little doubt that a breach of surface has taken place, and that the complaint has acquired its most frightful and distressing character. Sometimes considerable itching ushers in this change: from this point of time, all those cautions which were offered to the patient in the earlier stages of the disease should be insisted upon, as circum- stances essential to her future comfort, and necessary to her pre- servation. If the patient should possess a vigorous constitution, and if she has been in the habit of living freely, the pulse being full, and strong, and hard, it will scarcely be justifiable to omit general blood-letting. Such a practice is, however, seldom re- quisite: and the propriety of adopting it must be left to the judg- ment of the practitioner, who must take into consideration this circumstance, that the disease does not exist in an organ essen- tial to life, and that time will be allowed him to repeat local blood-lettings if he should think them to be more proper. So that the treatment should not only be adapted to the symptoms themselves, but should have relation to the organ involved in the disease. Some blood having been taken away by the lancet, the prac- titioner will determine upon the propriety of a second blood- letting, by the greater or less degree of the inflammatory crust, THE PURULENT. DISCHARGE. 213 and by the proportion of the solid to the serous part of this fluid. By a single general blood-letting, the symptoms may be arrest- ed, and the ulcerative process may remain nearly stationary, as far as it may be judged of by the subsidence or diminution of the symptoms. When the disease occurs in less plethoric constitutions, where general blood-letting would be contra-indicated, local bleeding will be found eminently serviceable; and, by a timely use, and repetition of this remedy, there is reason to believe that essen- tial benefit is obtained. It has been already observed that, during the process of ulceration in this disease, the deposit of new mat- ter continues, so that it is by no means uncommon to find, on opening the bodies of women who die in the ulcerated forms of this complaint, a much greater thickening of the parts than ac- tually existed many months previously to death. Local blood- letting, then, diminishes the action of the arteries, by which new lymph is effused. The quantity of blood to be taken by cupping may vary from six to twelve ounces, and the cupping-glasses should be applied just above the fissure between the nates. It is not always practicable to procure a sufficient quantity of blood from the lower part ofthe abdomen; and even if it were so, wo- men are very naturally and properly averse to the operation be- ing done at that part. If, therefore, it should be thought right to take away blood from the lower part of the abdomen, the ob- ject must be effected by the application of leeches scattered above the pubis, from one groin to the other. From a variety of circumstances, it becomes impossible to estimate the precise quantity of blood taken away by these means; but it may be presumed that three or four drachms will be taken by each leech, including the quantity which afterwards escapes from the orifice. In the progress ofthe complaint, leeches may be applied to the labia, or even within the vestibulum, by means of which more relief is sometimes obtained than by their application to the pu- bus. It will not be sufficient to order local blood-letting once or twice, but it will be desirable to prescribe it once in three werks or a month, provided the patient should not be much weakened by it, or exhausted by pain, or by discharge of any kind. In some instances, a profuse spontaneous bleeding has arisen from some vessel exposed by the ulceration, to the extent of producing syncope; the result of such a circumstance is fre- quently found to be favourable to the patient, the progress of the symptoms being thereby, for the time, arrested. Even in the latter stages of the disease, when the loss of blood could hardly be considered to be warranted, it may, nevertheless, be proper to recommend it. It is a well known fact that -arciiioina ofthe uterus involves, in its ulcerated stage, all the parts in its neigh- 2ll< THE PURULENT DISCHARGE. bourhood; but the author is not aware, that the manner in which this communication is made has been described by other wri- ters. When the process of ulceration is simply confined to ihe uterus, and cellular membrane surrounding it, the symptoms proceed with a degree of regularity and uniformity; but when a new organ is attacked, new symptoms arise, appertaining to and characteristic of inflammation in such organ. For instance, when the rectum is attacked, there is tenesmus, great heat in that part, increased distress on voiding the faeces, exquisite tenderness of the gut if the finger be carried into it. So, in like manner, if the disease proceeds to the bladder, shivering usually comes on, succeeded by heat, great pain, which is fixed and constant, to- gether with strangury; if the disease makes its way, which, how- ever, is not very common, into the cavity of the abdomen, symp- toms of peritoneal inflammation will present themselves; such as tenderness of the belly, distention of its cavity, and a small frequent pulse. Now, if these symptoms are allowed to proceed, the patient will die, as she would do if attacked by acute inflam- mation of the bladder, or of the peritoneum. Thus the presence of these symptoms, even in a late period of the disease, may call for the loss of blood, although, under any other circumstances, it would be improper to direct such a remedy. The management ofthe discharge from carcinomatous sores, is a circumstance deserving the best attention ofthe surgeon. This discharge appears to have the power of converting the neighbouring parts to which it is applied, in some instances, into sores of a similar character to that by which it was itself secret- ed; and there is reason to believe that the spreading of carcino- matous ulceration may be greatly retarded by the employment of those means which absorb or remove the ichorous fluid se- creted by them. Common aphthous sores, which frequently arise in the vestibulum of women who have long laboured under diseases of the female organs, may also possibly be converted into malignant ulcerations. These observations especially apply to carcinomatous ulcerations of internal parts, in which the dis- charges are more likely to be retained than where the disease attacks external surfaces. If it were only that the fcetor attend- ing such sores, would be removed by cleanliness, attention to this circumstance would be of great consequence, inasmuch as the patient's health, and that of such persons as may associate with her, will be less likely to suffer than when constantly breath- ing an impure atmosphere. Of all the modes of applying water to sores at the upper part ofthe vagina, none is so effectual as the use ofthe hip-bath; in the employment of which, the water is brought into contact with the sore without any risk of injuring the latter. By these means THE PURULENT DISCHARGE. 215 the object of maintaining cleanliness is not only obtained, but a soothing application is made to an irritable surface; ihe careful injection of warm water into the vagina, by a syringe, or the agi- tation of the water by the hand, will render it more likely to re- move any portions of coagulating lymph or thickened matter which may adhere to the inside of the vagina. The heat of the water employed should depend upon the feeling of the patient in some measure; but, generally speaking, it may vary from about 860 to 940. Where the patient is too weak to bear the ex- ertion of being placed in a hip-bath, her hips may be brought over the edge of the bed, and warm water may be carefully in- jected into the vagina by a female syringe. The quantity of the discharge is frequently increased by the means above-mentioned, but the comfort which the patient will derive from it will abun- dantly compensate her for any debility which may be produced by the remedy; and excruciating attacks of pain are sometimes rendered very sufferable by a frequent recurrence to it. Strong decoction of carrots, sometimes used for the same purpose, has the happiest effects. Warm water may also be made the vehicle for a variety of sedative applications, which are found by expe- rience to tranquillize all irritable sores; and, in some, to expedite the healing process. Amongst the different applications for this purpose, the extractum conii, or extractum hyoscyami, may be mentioned, either of which may be employed in the proportion of about three or four drachms to a pint of water. Solutions of opi- um, or of extract of poppy, may also be used; of the former, two drachms of the latter, half an ounce, may be dissolved in each pint of water. Starch, or mucilage of squince-seed, form good menstrua for these applications; their adhesive property ena- bling them to cling to surfaces to which they are applied. Three or four ounces of either of these fluids, impregnated with seda- tive substances, may be thrown into the rectum in those cases where relief is not obtained by their application to the vagina; but when opium is used for this purpose, the practitioner should be very careful to watch over its effects, as it has sometimes hap- pened that unpleasant consequences have arisen from the appli- cation of this drug to the rectum, such as, vomiting, syncope, cold extremities, and irregularity of the circulation. The action of the absorbents of the rectum is, in all probability, in these cases, increased by the inflammatory process which exists in the vicinity; besides which, the action of the rectum itself is temporarily taken off, so that the enema will probably be re- tained during a considerable length of time. Plasters and lini- ments, into the composition of which, opium enters largely, will sometimes be found serviceable in allaying pain, and are useful auxiliaries in a disease in which all the resources of the practi- tioner may be required to diminish the sufferings of the patient. 216 THE PURULENT DISCHARGE. There are some applications which produce a sedative, or a stimulating effect, according to the strength of which they are used. A very diluted mixture of acetic acid, or of nitric acid in water, will form a soothing application to an irritable part, whilst in different proportions they will become highly irritating. Either ofthe lotions mentioned beneath may be employed. R Acidi acetici, §ss. Aquae distillatae, Oi. M. fiat injectio. R Acidi nitrici, gutt. x. Aquae distillatae, Oi. M. fiat injectio. R Liquoris plumbi acetatis, 3i- Acidi acetici, 3ii» Sp. vinosi, $. Aquae distillatae, ^xvss. M. fiat injectio. If the discharge should become so profuse as to induce great debility, injections which possess an astringent power must be sought for. R Decocti corticis granati, Oi. Sulphatis aluminas, ^ss. M. fiat injectio. R Zinci sulphatis, 3ss. Aquae distillatae, §xv. Tinct. kino, §i. M. fiat injectio. If the discharge should assume a sanguineous appearance, it should be considered, how far it would be safe to permit its con- tinuance. If the patient should be in great pain at the time, it may be right not to restrain it hastily, unless the patient's strength should have been previously much exhausted; but if it should appear desirable to diminish the hemorrhage, the astringents which have been before recommended may be employed, and their strength may be increased, or the following may be em- ployed in their stead. R Argenti nitratis, gr. x. Aquae distillatae, Oi. M. R Cupri sulphatis, 3ss. Decocti cinchonae, Oi. M. THE PURULENT DISCHARGE. 217 Respecting internal remedies, although no one has as yet dis- covered any medicine capable of removing the disease, it may not be too much to state, that there is scarcely a medicine of any class, which may not, in some way or other, or at some pe- riod or other, be useful in this complaint. Various are the symp- toms which may arise; various must be the means of obviating them; and he will be ihe best practitioner, who best understands the adaptation of these means to their end. To point them out here, would be an endless labour, and a waste of the reader's time. It may be sufficient to observe, that the patient should be treat- ed upon general principles, bearing in mind, on the one hand, the hitherto intractable nature of the malady, and on the other, the sufferings of humanity, which call loudly for relief. Pain, the great evil of life, is the symptom by which the pa- tient will be most distressed; and, happily, in the sedative class of medicines there are to be found many capable of relieving it. It should be a rule of practice, never to exhibit a sedative of great power, when a milder will produce equal relief; because the disease is one of long duration, of increasing suffering, and every medicine will at length fail in producing its effect. Hyoscyamus and conium may be amongst the first employed, and the dose of each may vary from three to eight, or ten grains; larger doses have been exhibited; but the object is not to know how much of these, or of any other drug can be taken with im- punity, but how much is necessary to produce the desired effect. If they are wantonly employed, the patient will be exposed to another set of symptoms, arising from a disturbed state of the stomach, and of the brain, as flatulence, heartburn, eructations, delirium: the necessity for the exhibition of these medicines must regulate, not only their dose, but the frequency of their exhibition. Extractum stramonii, is another serviceable remedy, in allay- ing pain, and it may be given in doses of a grain. The writer is not in the habit of exhibiting Belladonna, hav- ing once seen a patient nearly destroyed by two small doses of it. Other practitioners, however, have employed it, it is said, with advantage. Mr. Brodie has informed the writer, that he has seen the happiest effects produced by a suppository containing extracti Belladonna? gr. j. in cases of irritable bladder, and also of carcinoma of the rectum. Perhaps, therefore, in those in- stances, in which, the administration of other sedatives is una- vailing, it may be advisable to administer the above medicine in the form alluded to. As the symptoms become more pressing, and as the suffer- ings of the patient increase, still there will remain to the pracli- 2 E • 218 THE PURULENT DISCHARGE. tioner one resource, and to the patient one solace, in opium, by means of which, her distresses may be alleviated, and her pas- sage from this world to another, rendered less agonizing. It will not be sufficient simply to prescribe a dose of opium, at stated intervals; that dose must be proportioned to the necessity for its use; and the skilful combination of it with other medicines, and the selection of its different preparations will call forth the hap- piest efforts of the practitioner: in one case opium, in a solid form, will be found to agree; in another, the tinctura opii, of the Pharmacopoeia will better answer the purpose; in a third, the preparation known by the name of black drop; in a fourth, the liquor opii sedalivus, of Mr. Battley, will quiet the patient, and at the same time produce the least disturbance in the system; whilst the irritable state into which some patients fall, will be most successfully diminished by the very small quantity of opi- um which enters into the composition of the tinctura camphorae composita. In the greater number of painful diseases which call for the use of opium, less care is required; but the sympathy of the sto- mach is so actively called forth, when the uterus is the seat of this disease, that it will be capriciously inclined towards one medicine, whilst it receives another with great comfort and ad- vantage. If, as always happens towards the close of ulcerated carcinoma of the uterus, vomiting should come on, the combina- tion of spices, with opium, will render this medicine more agree- able to the stomach. The julepum menthae, cinnamon-water, and, in some cases, weak brandy and water, will form the best vehi- cles for the different preparations of opium; sometimes a mix- ture of confeciio opiata and spiritus aetheris sulphunci composi- tus, given in peppermint-water, in small doses, at short intervals, will relieve, in an expeditious and certain manner, the vomiting, singultus, and eructations, more effectually than any other com- binations of medicines. The writer forbears to enter into speculative discussions, re- specting the employment of several medicines, which have been suggested for the cure of carcinoma; and he does so, because the profession have not yet had sufficient experience of the ef- fect of such medicines; or, because he himself has not known them Used with benefit. In thus concluding his work, the writer can conscientiously assert, that he has made no statements which, in his opinion, are not founded in fact, and that he has withheld nothing which might in any way tend to the advantage of the practitioner, or to the comfort of the patient. THE END, I 6 >%i ft f ! Eng'd by J.Druyton EXPLANATION OF THE PLATES. PLATE I. This plate shows a-portion of hydatids of the uterus. The quantity voided by the patient would have filled a gallon mea- sure. The preparation is suspended in the spirit by a portion of organized coagulating lymph, from which the hydatids spring, being connected with it by means of small filaments ofthe same substance. The cysts vary in size; some of them contain a fluid, whilst others have collapsed in consequence of its escape. 220 EXPLANATION OF THE PLATES. PLATE II. In this plate are two figures of the cauliflower-excrescence of the uterus. Fig. 1. Conveys an exceedingly good idea of the disease, as met with in the living body, the surface being studded with a number of little granules heaped upon each other, forming masses -of an irregular shape. The lines drawn from letters A. and B. terminate in different parts of the mass. The letter A. in a por- tion which has a granulated appearance; the letter B. in a small flocculent portion, which, having lost the blood originally contained in it, forms a fine light sub- stance, which floats in the spirit. Fig. 2. Shows the uterus of a patient who died of the cauli- flower-excrescence. The preparation is suspended by the fallopian tubes. A. Points to the loose flocculent substance always found af- ter death in patients who have laboured under the dis- ease. During life the flocculent substances, being vas- cular, is filled with blood, and a solid mass is thereby formed; but these small vessels emptying themselves, nothing remains but their coats, which are seen lightly floating in the spirit in which the preparation is placed. B. Shows a part of the os uteri which remains perfectly healthy. Perhaps this part may be about two-fifths of its whole circumference. C. C. The ovaria. D. An incision made through the parietes of the uterus, which are somewhat thickened. PLATE II- 222 EXPLANATION OF THE PLATES. PLATE IV. Ulcerated carcinoma of the uterus. This plate, when contrasted with the former, shows the uterus altogether much thickened, the cervix of the uterus especially. Two lines meet at A.; these diverging, lead to the upper and lower, or rather to the anterior and posterior parts of the cervix uteri. All traces of the os uteri are destroyed. The points particularly deserving of notice in these plates are, ulceration without thickening in the corroding ulcer, and ulcera- tion with great thickening in carcinoma. B. The fallopian tube. PLATE 4 Ifr0n, Ir, ./#»• Steitrt Jr (M-C(, :* .ir: 7j^***' ftir-- *& ^ ?W®^ & •<-**■ ■-■ ■ ct.. & .?"■ so»V rt % .•'* ./* 1 * _ '•*' '4nMT'i!