80985. Misbranding of Cal-co-cin. U. S. v. George T. Lambert, David Periera, 
and George D. Lambert (Crescent-Kclvan Co.). Pleas of nolo conten- 
dere. Fines, $250. (F. & D. No. 42713. Sample Nos. 29934-D, 34424-D, 
34642-D, 34644-D, 34703-D.)
The labeling of this product bore misleading representations regarding its 
ingredients and false and fraudulent representations regarding its curative and 
therapeutic effectiveness.
On September 13, 1939, the United States attorney for the Eastern District 
of Pennsylvania, acting upon a report by the Secretary of Agriculture, filed 
in the district court an information against George T. Lambert, David Periera, 
and George D. Lambert, trading as the Crescent-Kelvan Co., a business trust, 
Philadelphia, Pa., alleging shipment by said defendants in violation of the Food 
and Drugs Act as amended, within the period from on or about June 11 to 
on or about October 20, 1938, from the State of Pennsylvania into the States 
of New Jersey and Maryland, of quantities of Cal-co-cin which was misbranded.
Analysis of a sample taken from one of the shipments showed that it contained 
1.85 grains of cinchophen, 2.55 grains of benzoic acid, and 0.47 grains of calcium 
per capsule. Analyses of samples taken from the remaining shipments showed 
that they were of substantially the same composition.
The article was alleged to be misbranded in that the statement "Bi-Calcium- 
Ortho-Benzycin," borne on the bottle label, was false and misleading in that it 
purported to set forth and indicate the composition of the article; whereas the 
article contained compounds of cinchophen, a potentially dangerous drug, in 
amounts varying from 1.5 grains to 2 grains per capsule and said statement 
gave no indication of the presence in the article of the said compounds of 
cinchophen. It was alleged to be misbranded further in that the following 
statements in the labeling were false and misleading in that they would lead 
the purchaser to believe that the article was a safe and appropriate remedy 
for the conditions set forth therein; whereas it was not a safe and appropriate 
remedy for the conditions set forth in said statements but was a dangerous 
drug: (Bottle label in certain shipments) "For Arthritis, Rheumatoid condi- 
tions and Uric Acid Eliminant. Dosage—One capsule four times a day with 
a full glass of water, after meals and on retiring"; (box label in one shipment) 
"for Arthritis, Rheumatoid conditions and Uric Acid Eliminant"; (leaflet in 
one shipment) "Cal-co-cin Clinical reports received warrants us offering the 
Medical Profession this non-toxic, non-habit forming Chemical Combination for 
Arthritis, Rheumatoid Conditions and Uric Acid Eliminant Brief Summary and 
Treatment Rheumatism generally speaking is considered to be of infectious 
origin, due to various strains of the Streptococci. To understand sensitization 
of cells is important, for Rheumatism can affect different organs and tissues of 
the body—as the joints or certain group of muscles. It may also affect the 
throat, or even some nerve register complaint may be elicited at times. Waste 
products may not be eliminated properly from the cells, hence the catabolic 
process being on an increase in its activity. Treatment consists of destroying 
the various strains of Streptococci; also to free the choked or catabolic cells of 
their waste material, dissolve and eliminate the Uric Acid and Urates. mali- 
cious is a chemical derived by the action of Benzoic and Phenyl Cinchonic 
Acids on Calcium, forming a Calcium-Benzo-Phenyl Cinchonine(Bi Calcium 
Ortho-Benzycin.) A Solvent for, also an eliminator of Uric Acid (CROWNS) 
when the Uric Acid combines with a base and Urates are formed per se, the 
use of 'Cal-co-cin' for that joint condition has given most gratifying results. 
'Cal-co-cin' has antiseptic value as well and is tolerated most favorably by the 
stomach and intestines; also the liver and Kidneys. Dr. M., Philadelphia, 
reports in several cases of long standing, very comfortable after one weeks 
treatment, one case in particular, female age 64, bedfast six weeks, after two 
weeks treatment with 'Cal-co-cin' very comfortable, better results than from' 
all other medication including injections. Dr. — New Jersey, reports patient 
after taking fifty 'Cal-co-cin' Capsules, pain and burning had almost ceased, 
Uric Acid corrected so that patient did not have to get up nights. Dr. A. E. S., 
Phila., Pa.—used 'Cal-co-cin' in combination with scholars (Saline laxative) 
with excellent results, patient much relieved after few doses. Dr. R. E. G., 
Philadelphia, Pa.—Results from 'Cal-co-cin' very satisfactory, warrants my 
reordering. Dosage—We suggest one capsule with a full glass of water after 
each meal and on retiring, can be increased at discretion of physician with 
perfect safety."
The article was alleged to be misbranded further in that statements in the 
labeling regarding its curative and therapeutic effects falsely and fraudulently
represented that it was a safe and appropriate remedy for arthritis and rheuma- 
toid conditions and was a safe and appropriate uric acid elimmant; whereas 
when used as directed, it was not a safe and appropriate treatment but was a 
dangerous drug in that said article was capable of causing serious, irreparable, 
or fatal injury to consumers.
Certain of the shipments were also alleged to be misbranded in violation of 
the Federal Food, Drug, and Cosmetic Act, as reported in notice of judgment 
No. 77 published under that act.
On December 8, 1939, pleas of nolo contendere were entered on behalf of the 
defendants. On January 5, 1940, the court imposed fines amounting to $250 
for violation of both acts.
GEOVEB B. HILL, Acting Secretary of Agriculture.