15070. Adulteration and Misbranding of codeine sulphate tablets, fluid 
extract belladonna leaves, tincture cinchona, tincture of cinchona 
compound, atropine sulphate tablets, nltrogrlycerin tablets, 
strychnine sulphate tablets, heroine hydrochloride tablets, and 
diacetyl morphine hydrochloride tablets. TJ. S. v. Smith, Kline & 
French Co. Plea of g-uilty. Fine, $300. (F. & D. No. 21560. I. S. 
Nos. 6064-x, 6069-x, 6070-x, 6126-x, 6127-x, 6128-x, 6131-x, 6134-x, 6135-x, 
6139-X, 6251-x, 6253-x, 6911-x.)
On May 23, 1927, the United States attorney for the Eastern District of Penn- 
sylvania, acting upon a report by the Secretary of Agriculture, filed in the Dis- 
trict Court of the United States for said district an information against the 
Smith, Kline & French Co., a corporation, Philadelphia, Pa., alleging shipment 
by said company, in violation of the food and drags act, in various consignments, 
from the State of Pennsylvania into the States of New York and New Jersey, 
between the approximate dates of July 6, 1925, and December 10, 1925, of quan- 
tities of codeine sulphate tablets, fluid extract belladonna leaves, tincture cin- 
chona, tincture of cinchona compound, atropine sulphate tablets, nitroglycerin 
tablets, strychnine sulphate tablets, heroine hydrochloride tablets, and diacetyl 
morphine hydrochloride tablets, which were adulterated and misbranded. The 
articles were labeled, in part: " Smith, Kline & French Co. Philadelphia," and 
were further labeled, in part, as hereinafter set forth.
Adulteration of the codeine sulphate tablets, atropine sulphate tablets, nitro- 
glycerin tablets, strychnine sulphate tablets, heroine hydrochloride tablets, and 
diacetyl morphine hydrochloride tablets was alleged in the information for the 
reason that their strength and purity fell below the professed standard and 
quality under which they were sold, in that the labels represented the said tablets 
to contain 1/2 grain of codeine sulphate, 1/100 grain of atropine sulphate, 1/60 
grain of atropine sulphate, 1/100 grain of nitroglycerin, 1/60 grain of strychnine 
sulphate, 1/30 grain of strychnine sulphate, 1/50 grain of nitroglycerin, 1/12 
grain of heroine hydrochloride, or 1/12 grain of diacetyl morphine hydrochlo- 
ride, as the case might be, whereas each of said tablets contained less of the . 
product than represented on the label thereof.
Misbranding of the said tablets was alleged for the reason that the state- 
ments, to wit, "Tablet Triturates * * * Codeine Sulphate * * * 1/2 
Grain," " Tablet Triturates * * * Atropine Sulphate 1-100 Grain," " Tablet 
Triturates * * * Atropine Sulphate 1-60 Grain," " Soluble Hypodermic 
Tablets   *    *    *   Atropine   Sulphate   1-100   Gr.,"   "Tablets   *    *    *    Nitro-
glycerin 1-100 Grain," " Soluble Hypodermic Tablets * * * Strychnine Sul- 
phate 1-60 Grain," " Tablets * * * Strychnine Sulphate 1-30 Grain," " Tab- 
lets * * * Nitroglycerin 1-50 Grain," "Tablets * * * Heroin Hydro- 
chloride 1-12 Grain," or "Tablet Triturates * * * Diacetyl Morphine Hy- 
drochloride 1-12 Gr.," as the case might be, borne on the labels of the respective 
products, were false and misleading in that the said statements represented that 
each of said tablets contained the amount of the product declared on the label 
thereof, whereas, the said tablets contained less than so declared.
Adulteration of the fluid extract belladonna leaves was alleged for the reason 
that its strength and purity fell below the professed standard and quality under 
which it was sold, in that it was represented to contain 0.3 gram of alkaloids of 
belladonna leaves in 100 cubic centimeters, whereas, it contained more than 0.3 
gram of the alkaloids of belladonna leaves in 100 cubic centimeters, to wit, 0.434 
gram of the total alkaloids.of belladonna leaves in 100 cubic centimeters.
Misbranding of the said fluid extract belladonna leaves was alleged for the 
reason that the statement, to wit, " Fluid-extract Belladonna Leaves Assayed 
and Standardized 0.3 Gm. of alkaloids in 100 Cc," borne on the label, was false 
and misleading in that the said statement represented that the article contained 
0.3 gram of alkaloids of belladonna leaves in 100 cubic centimeters, whereas it 
contained more than 0.3 gram of the alkaloids of belladonna leaves in 100 cubic 
centimeters.
Adulteration of the tincture cinchona and the tincture of cinchona compound 
was alleged for the reason that they were sold under and by names recognized 
in the United States Pharmacopoeia and differed from the standards of strength, 
quality, and purity as determined by the tests laid down in said Pharma- 
copceia official at the time of investigation of the said articles, in that the 
former yielded less than 0.8 gram of the alkaloids or cinchona per 100 mils, to 
wit, not more than 0.643 gram of the alkaloids of cinchona per 10O mils, 
whereas the said Pharmacopceia provides that tincture cinchona should yield 
not less than 0.8 gram of the alkaloids of cinchona per 100 mils, and the 
latter yielded less than 0.4 gram of the alkaloids of cinchona per 100 mils, to 
wit, not more than 0.359 gram of the alkaloids of cinchona per 100 mils, 
whereas said Pharmacopceia provides that tincture of cinchona compound 
should yield not less than 0.4 gram of the alkaloids of cinchona per 100 mils, 
and the standard of the strength, quality, and purity of the said articles was 
not declared on the containers thereof. Adulteration of the tincture cinchona 
was alleged for the further reason that its strength and purity fell below the 
professed standard and quality under which it was sold in that it was repre- 
sented to yield 0.90 gram of, to wit, the alkaloids of cinchona per 100 cubic 
centimeters, whereas it yielded less than 0.9O gram of the alkaloids of cinchona 
per 100 cubic centimeters, to wit, 0.643 gram of the alkaloids1 of cinchona per 
100 cubic centimeters.
Misbranding of the- tincture cinchona and the tincture of cinchona compound 
was alleged for the reason that the statements, to wit, " Tincture Cinchona 
U. S. P. * * * Assayed and standardized 0.90 Gm. of Alkaloids in 100 Cc." 
or "Tincture of Cinchona Compound U. S. P.," borne on the labels of the 
respective articles, were false and misleading in that the said statements 
represented that the articles conformed with the tests laid down in the United 
States Pharmacopoeia, and that the tincture cinchona contained 0.90 gram of, 
to wit, the alkaloids of cinchona per 100 cubic centimeters, whereas the articles 
did not conform with the tests laid down in the Pharmacopceia, and the tincture 
cinchona contained less than 0.90 gram of the alkaloids of cinchona per 100 
cubic centimeters.
On June 22, 1927, a plea of guilty to the information was entered on behalf 
of the defendant company and the court imposed a fine of $300.
W, M. JARDINE, Secretary of Agriculture.